| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Jeyarasasingam, M Yeluashvili, M Qui. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817586. |
tacrine, an acetylcholinesterase (ache) inhibitor that has been used in the treatment of alzheimer's disease, increases available acetylcholine (ach) levels in the synaptic cleft thereby enhancing the activity of cholinergic pathways. |
2000-07-17 |
2023-08-12 |
rat |
| M Pakaski, Z Rakonczay, I Fakla, H Papp, P Kas. In vitro effects of metrifonate on neuronal amyloid precursor protein processing and protein kinase C level. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773217. |
it has been suggested that acetylcholinesterase (ache) inhibitors, which promote the cholinergic function and consequently improve the cognitive deficits, may also exert a neuroprotective effect by activating normal app processing. |
2000-07-14 |
2023-08-12 |
Not clear |
| W Xie, J A Stribley, A Chatonnet, P J Wilder, A Rizzino, R D McComb, P Taylor, S H Hinrichs, O Lockridg. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869390. |
acetylcholinesterase (ache; ec 3.1.1.7) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development. |
2000-07-14 |
2023-08-12 |
mouse |
| D Carcenac, C Martin-Hunyadi, M Kiesmann, C Demuynck-Roegel, M Alt, F Kuntzman. [Extra-pyramidal syndrome induced by donepezil]. Presse medicale (Paris, France : 1983). vol 29. issue 18. 2000-07-07. PMID:10862247. |
the cholinergic hypothesis of alzheimer's disease is the basis of a new class of drugs: acetylcholinesterase inhibitors. |
2000-07-07 |
2023-08-12 |
Not clear |
| J Birks, V Iakovidou, M Tsolak. Rivastigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2000-07-06. PMID:10796621. |
one of the most successful therapeutic strategies for alzheimer's disease has been the use of acetylcholinesterase inhibitors to enhance surviving cholinergic neurotransmission by inhibiting breakdown of released acetylcholine. |
2000-07-06 |
2023-08-12 |
Not clear |
| M C Lintern, J R Wetherell, M E Smit. Effect of halothane administration on acetylcholinesterase activity in guinea-pig muscle and brain. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771172. |
these findings show that halothane can have prolonged effects on acetylcholinesterase activity in both muscle and brain, and may have important implications for the use of halothane and other volatile anaesthetics in studies of the cholinergic system. |
2000-07-03 |
2023-08-12 |
Not clear |
| J S HANKER, A GELBERG, B WITTE. Colorimetric estimation of some cholinergic esters; application to the demonstration of acetylcholinesterase activity. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. vol 47. issue 10. 2000-07-01. PMID:13587304. |
colorimetric estimation of some cholinergic esters; application to the demonstration of acetylcholinesterase activity. |
2000-07-01 |
2023-08-12 |
Not clear |
| D H Overstree. Organophosphate pesticides, cholinergic function and cognitive performance in advanced age. Neurotoxicology. vol 21. issue 1-2. 2000-06-30. PMID:10794387. |
there is considerable evidence for a decline in cholinergic indices (choline acetyltransferase, acetylcholinesterase, and muscarinic acetylcholine receptors) with aging. |
2000-06-30 |
2023-08-12 |
Not clear |
| K Kawashima, T Fuji. Extraneuronal cholinergic system in lymphocytes. Pharmacology & therapeutics. vol 86. issue 1. 2000-06-20. PMID:10760545. |
stimulation of t-lymphocytes with phytohemagglutinin activates the lymphoid cholinergic system, as evidenced by increased synthesis and release of ach, increased acetylcholinesterase activity, and the increased expression of mrna encoding choline acetyltransferase and ach receptors. |
2000-06-20 |
2023-08-12 |
human |
| C J Gordon, B K Padno. Prolonged elevation in blood pressure in the unrestrained rat exposed to chlorpyrifos. Toxicology. vol 146. issue 1. 2000-06-19. PMID:10773358. |
organophosphate (op) pesticides are likely to alter the regulation of blood pressure (bp) because (i) bp control centers in the brain stem utilize cholinergic synapses and (ii) the irreversible inhibition of acetylcholinesterase activity by op's causes cholinergic stimulation in the cns. |
2000-06-19 |
2023-08-12 |
rat |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| G T Trevisani, N H Hyman, J M Churc. Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Diseases of the colon and rectum. vol 43. issue 5. 2000-06-06. PMID:10826417. |
neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. |
2000-06-06 |
2023-08-12 |
Not clear |
| N L Ward, T Hag. BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739636. |
the cholinergic hippocampal innervation in bdnf-/- mice expanded to a lesser extent than in controls and had reduced levels of acetylcholinesterase staining at p15. |
2000-05-23 |
2023-08-12 |
mouse |
| C Lega. Why so many forms of acetylcholinesterase? Microscopy research and technique. vol 49. issue 1. 2000-05-15. PMID:10757879. |
acetylcholinesterase is a key molecule in the control of cholinergic transmission. |
2000-05-15 |
2023-08-12 |
Not clear |
| J Cartaud, A Cartaud, E Kordeli, M A Ludosky, S Marchand, F Stetzkowski-Marde. The torpedo electrocyte: a model system to study membrane-cytoskeleton interactions at the postsynaptic membrane. Microscopy research and technique. vol 49. issue 1. 2000-05-15. PMID:10757880. |
as a remarquable source of cholinergic synapses, the torpedo electrocyte model has served to identify the most important components involved in synaptic transmission such as the nicotinic acetylcholine receptor and the enzyme acetylcholinesterase, as well as proteins associated with the subsynaptic cytoskeleton and the extracellular matrix involved in the assembly of the postsynaptic membrane, namely the 43-kda protein-rapsyn, the dystrophin/utrophin complex, agrin, and others. |
2000-05-15 |
2023-08-12 |
Not clear |
| C Bessou, J B Giugia, C J Franks, L Holden-Dye, L Ségala. Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission. Neurogenetics. vol 2. issue 1. 2000-04-07. PMID:9933302. |
finally, the dys-1 mutants are hypersensitive to acetylcholine and to the acetylcholinesterase inhibitor aldicarb, suggesting that dys-1 mutations affect cholinergic transmission. |
2000-04-07 |
2023-08-12 |
human |
| G L Wenk, G Quack, H J Moebius, W Danys. No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life sciences. vol 66. issue 12. 2000-03-31. PMID:10737358. |
new drug therapies have been designed to either enhance cholinergic function by inhibition acetylcholinesterase (ache), e.g. |
2000-03-31 |
2023-08-12 |
Not clear |
| D Kaufer, H Sore. Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms. Current opinion in neurology. vol 12. issue 6. 2000-03-10. PMID:10676758. |
cholinergic hyperexcitation can be induced by both acute psychological stress and exposure to acetylcholinesterase inhibitors. |
2000-03-10 |
2023-08-12 |
Not clear |
| D Fletcher, A Triantafyllou, J Scot. Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry. Archives of oral biology. vol 44. issue 12. 2000-02-23. PMID:10669082. |
acetylcholinesterase staining was associated with nerve trunks in the interlobular stroma and an extensive intralobular network of nerve fibres, presumably of a cholinergic type, embracing acini and ducts. |
2000-02-23 |
2023-08-12 |
Not clear |
| J Pavía, J Alberch, I Alvárez, A Toledano, M L de Ceballo. Repeated intracerebroventricular administration of beta-amyloid(25-35) to rats decreases muscarinic receptors in cerebral cortex. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643803. |
however, in betaa(25-35)-treated rats hypertrophic/hyperactive positive acetylcholinesterase nucleus basalis cholinergic neurons were observed at 2 weeks survival, while the density of acetylcholinesterase-positive fibers of cerebral cortex was increased along with the number of cortical positive neurons at 3 weeks survival. |
2000-02-22 |
2023-08-12 |
rat |