| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Woodruff-Pak, R W Vogel, G L Wen. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172080. |
the allosterically potentiating ligand galantamine (gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (ache) inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| S Dronfield, K Egan, C A Marsden, A R Gree. Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat. Journal of psychopharmacology (Oxford, England). vol 14. issue 3. 2001-03-29. PMID:11106308. |
there are now several acetylcholinesterase inhibitors in clinical use for the treatment of alzheimer's disease, however, no systematic comparative studies of their central and peripheral cholinergic mediated effects in rats appear to have been reported. |
2001-03-29 |
2023-08-12 |
rat |
| W H Kwong, W Y Chan, K K Lee, M Fan, D T Ye. Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: a review. The Histochemical journal. vol 32. issue 9. 2001-03-08. PMID:11127973. |
cholinergic neurons, as revealed by immunoreactivities towards choline acetyltransferase or acetylcholinesterase, appear early at 23 weeks of gestation in the cerebellar cortex and deep nuclei. |
2001-03-08 |
2023-08-12 |
human |
| P Kasa, H Papp, P Kasa, I Toro. Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Neuroscience. vol 101. issue 1. 2001-02-15. PMID:11068139. |
donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. |
2001-02-15 |
2023-08-12 |
human |
| P Kasa, H Papp, P Kasa, I Toro. Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Neuroscience. vol 101. issue 1. 2001-02-15. PMID:11068139. |
these histochemical results provide the first morphological evidence that, under in vitro circumstances, donepezil is not a general acetylcholinesterase inhibitor in the cns, but rather selectively affects the different brain areas and, within these, the cholinoceptive and cholinergic structures. |
2001-02-15 |
2023-08-12 |
human |
| M Grundman, L J Tha. Treatment of Alzheimer's disease: rationale and strategies. Neurologic clinics. vol 18. issue 4. 2001-02-02. PMID:11072262. |
various therapeutic areas are discussed, including acetylcholinesterase inhibitors and other cholinergic agents, antioxidants, anti-inflammatory drugs, hormone replacement therapy, antiamyloid treatment, and neurotrophic agents. |
2001-02-02 |
2023-08-12 |
Not clear |
| G Guidry, S C Landi. Absence of cholinergic sympathetic innervation from limb muscle vasculature in rats and mice. Autonomic neuroscience : basic & clinical. vol 82. issue 3. 2001-01-25. PMID:11023615. |
in contrast, cholinergic phenotypic markers,vacht-ir and acetylcholinesterase (ache) activity, are absent. |
2001-01-25 |
2023-08-12 |
mouse |
| W A Tursk. Pilocarpine-induced seizures in rodents--17 years on. Polish journal of pharmacology. vol 52. issue 1. 2001-01-16. PMID:10949124. |
seizures can by produced by cholinergic agonists acting directly at muscarinic receptors or by drugs enhancing cholinergic transmission due to the inhibition of acetylcholinesterase activity. |
2001-01-16 |
2023-08-12 |
Not clear |
| K M Horvath, I M Abrahám, T Harkany, P Meerlo, B G Bohus, C Nyakas, P G Luite. Postnatal treatment with ACTH-(4-9) analog ORG 2766 attenuates N-methyl-D-aspartate-induced excitotoxicity in rat nucleus basalis in adulthood. European journal of pharmacology. vol 405. issue 1-3. 2001-01-08. PMID:11033312. |
however, 12 days post-surgery, the nmda-induced loss of cholinergic neurons, as well as the decrease of their acetylcholinesterase -positive fibre projections in the cortex, were less in acth-(4-9) animals. |
2001-01-08 |
2023-08-12 |
rat |
| D S Woodruff-Pak, I S Santo. Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942028. |
galantamine induces allosteric modulation of nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase inhibitor. |
2001-01-03 |
2023-08-12 |
Not clear |
| A Maelick. Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971047. |
the two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ach) by inhibiting acetylcholinesterase (ache), or to mimic the effects of ach (nicotinic agonists) by acting directly on nicotinic receptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| J D Stone, A V Terry, J R Pauly, M A Prendergast, J J Buccafusc. Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056179. |
the current studies attempt to show a temporal relationship between the dfp-induced impairment in performance of a spatial memory task and the protracted decrease in the expression of cholinergic receptors and acetylcholinesterase in specific brain regions. |
2000-12-28 |
2023-08-12 |
rat |
| J D Stone, A V Terry, J R Pauly, M A Prendergast, J J Buccafusc. Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056179. |
cholinergic receptors labeled with the ligands [(3)h]epibatidine and [(3)h]afdx-384 were affected to a much greater extent and for a longer period of time than were both acetylcholinesterase activities and cholinergic receptors labeled with [(3)h]qnb. |
2000-12-28 |
2023-08-12 |
rat |
| S A Kardos, L G Sultato. Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase. Toxicological sciences : an official journal of the Society of Toxicology. vol 58. issue 1. 2000-11-30. PMID:11053548. |
the mechanism of acute toxicity of the organophosphorus insecticides has been known for many years to be inhibition of the critical enzyme acetylcholinesterase (ec 3.1.1.7), with the resulting excess acetylcholine accumulation leading to symptoms of cholinergic excess. |
2000-11-30 |
2023-08-12 |
mouse |
| F C Bronfman, I Tesseur, M H Hofker, L M Havekens, F Van Leuve. No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice. Neuroscience. vol 97. issue 3. 2000-09-14. PMID:10828523. |
we analysed the distribution of cholinergic fibers, the number and morphology of cholinergic neurons and the enzymatic activity of acetylcholinesterase and choline acetyltransferase in different brain regions. |
2000-09-14 |
2023-08-12 |
mouse |
| R C Gupta, J T Goad, D Milatovic, W D Dettbar. Cholinergic and noncholinergic brain biomarkers of insecticide exposure and effects. Human & experimental toxicology. vol 19. issue 5. 2000-09-07. PMID:10918524. |
in controls, analyses of the brain regions revealed a wide variability in the values of cholinergic (acetylcholinesterase, ache) and noncholinergic (creatine kinase, ck; and lactic dehydrogenase, ldh, and their isoenzymes) biomarkers. |
2000-09-07 |
2023-08-12 |
rat |
| X Sun, X B Liu, J R Martinez, G H Zhan. Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY. Archives of oral biology. vol 45. issue 8. 2000-08-18. PMID:10869474. |
inhibition of acetylcholinesterase (ache) by ops leads to a decrease in acetylcholine (ach) breakdown that results in overstimulation of muscarinic cholinergic receptors (mchr). |
2000-08-18 |
2023-08-12 |
human |
| K D Bornemann, M Staufenbie. Transgenic mouse models of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 908. 2000-08-17. PMID:10911965. |
strong staining for acetylcholinesterase activity is found throughout the plaques and is accompanied by local distortion of the cholinergic fiber network. |
2000-08-17 |
2023-08-12 |
mouse |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| L Trabace, T Cassano, L Steardo, C Pietra, G Villetti, K M Kendrick, V Cuom. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease. The Journal of pharmacology and experimental therapeutics. vol 294. issue 1. 2000-07-24. PMID:10871311. |
1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo¿2,3-bĭndol-5-ol 2-ethylphenylcarbamate n-oxide hydrochloride (3as-cis) (chf2819) is a novel acetylcholinesterase inhibitor that produces central cholinergic stimulation after oral administration in rats. |
2000-07-24 |
2023-08-12 |
rat |