| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Simonsen, D Triguero, A García-Sacristán, D Priet. Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs. Pflugers Archiv : European journal of physiology. vol 438. issue 2. 1999-08-03. PMID:10370104. |
the presence of cholinergic innervation of small coronary arteries in the lamb was investigated by measuring choline acetyltransferase (chat) and acetylcholinesterase (ache) activities and by performing in vitro experiments in a microvascular myograph to establish whether or not there is a cholinergic component in the response to electrical field stimulation (efs). |
1999-08-03 |
2023-08-12 |
Not clear |
| H Shinotoh, H Namba, M Yamaguchi, K Fukushi, S Nagatsuka, M Iyo, M Asahina, T Hattori, S Tanada, T Iri. Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy. Annals of neurology. vol 46. issue 1. 1999-08-02. PMID:10401781. |
positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in parkinson's disease and progressive supranuclear palsy. |
1999-08-02 |
2023-08-12 |
human |
| G Bicke. Histochemistry of classical neurotransmitters in antennal lobes and mushroom bodies of the honeybee. Microscopy research and technique. vol 45. issue 3. 1999-07-15. PMID:10344769. |
acetylcholinesterase histochemistry, immunocytochemical staining for nicotinic acetylcholine receptors, and mapping for alpha-bungarotoxin binding sites indicate cholinergic synaptic interactions in the antennal lobe and a cholinergic pathway via a subset of olfactory projection neurons into the mushroom bodies. |
1999-07-15 |
2023-08-12 |
bee |
| R E Papka, H H Traurig, M Schemann, J Collins, T Copelin, K Wilso. Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382273. |
uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (ache) histochemistry. |
1999-07-12 |
2023-08-12 |
rat |
| R E Papka, H H Traurig, M Schemann, J Collins, T Copelin, K Wilso. Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382273. |
however, the histochemical reaction for acetylcholinesterase provides only indirect evidence of acetylcholine location and is a nonspecific marker for cholinergic nerves. |
1999-07-12 |
2023-08-12 |
rat |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
to address this question enzyme activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in both csf and parietal cortex were assayed following selective lesion of basal forebrain cholinergic neurons by a single intracerebroventricular application of the cholinergic immunotoxin 192igg-saporin. |
1999-07-07 |
2023-08-12 |
Not clear |
| G Mehlhorn, T Löffler, J Apelt, S Rossner, T Urabe, N Hattori, S Nagamatsu, V Bigl, R Schlieb. Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198816. |
basal forebrain cholinergic lesion resulted in transient increases in glucose transporter binding in cortical regions displaying reduced acetylcholinesterase activity, already detectable seven days after lesion with peak values around 30 days post lesion. |
1999-07-07 |
2023-08-12 |
rat |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221754. |
in addition to its action at cholinergic synapses acetylcholinesterase (ache) has been proposed to modulate neuronal activity by mechanisms unrelated to the hydrolysis of acetylcholine. |
1999-07-02 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
tak-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. |
1999-06-18 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
tak-147, a potent acetylcholinesterase (ache) inhibitor, potentiated choline acetyltransferase (chat) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an ec50 value of 4.47 nm. |
1999-06-18 |
2023-08-12 |
rat |
| A Roy, A K Agrawal, R Husain, M P Dubey, P K Set. Cholinergic and serotonergic alterations in the rat hippocampus following trimethyltin exposure and fetal neural transplantation. Neuroscience letters. vol 259. issue 3. 1999-05-24. PMID:10025586. |
fetal septal transplants (rich in cholinergic neurons) significantly restored the deficits in cholinergic (muscarinic) receptor binding and acetylcholinesterase activity caused by tmt exposure. |
1999-05-24 |
2023-08-12 |
rat |
| Z Gu, J Yu, J R Perez-Pol. Long term changes in brain cholinergic markers and nerve growth factor levels after partial immunolesion. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729378. |
we measured two cholinergic markers, choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ngf protein levels at 10 days, 1, 6 and 12 months postlesion. |
1999-05-12 |
2023-08-12 |
Not clear |
| B R Reed, W J Jagus. Opening a window on cerebral cholinergic function: PET imaging of acetylcholinesterase. Neurology. vol 52. issue 4. 1999-04-30. PMID:10078708. |
opening a window on cerebral cholinergic function: pet imaging of acetylcholinesterase. |
1999-04-30 |
2023-08-12 |
Not clear |
| C Crespo, J G Briñón, A Porteros, R Arévalo, B Rico, J Aijón, J R Alons. Distribution of acetylcholinesterase and choline acetyltransferase in the main and accessory olfactory bulbs of the hedgehog (Erinaceus europaeus). The Journal of comparative neurology. vol 403. issue 1. 1999-04-27. PMID:10075443. |
the distribution of cholinergic markers was studied in the main olfactory bulb (mob) and accessory olfactory bulb (aob) of the western european hedgehog (erinaceus europaeus) by using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry. |
1999-04-27 |
2023-08-12 |
Not clear |
| B Heiland, S A Greenfiel. Rat locomotion and release of acetylcholinesterase. Pharmacology, biochemistry, and behavior. vol 62. issue 1. 1999-04-13. PMID:9972849. |
in the substantia nigra acetylcholinesterase is released from the dopamine cells of the pars compacta independent of cholinergic transmission. |
1999-04-13 |
2023-08-12 |
rat |
| J I Friedman, H Temporini, K L Davi. Pharmacologic strategies for augmenting cognitive performance in schizophrenia. Biological psychiatry. vol 45. issue 1. 1999-04-01. PMID:9894570. |
two potential types of cholinomimetics for use in schizophrenics are the acetylcholinesterase inhibitors and m1/m4 muscarinic agonists, both of which increase cortical cholinergic activity. |
1999-04-01 |
2023-08-12 |
human |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
daily injections (20 days) of paraoxon (0.09 mg/kg) led to a cumulative dose that was 9.0-fold higher than the acute ed50 of 0.20 mg/kg, s.c. during this period, the rats did not demonstrate visible signs of cholinergic hyperactivity nor did they die, despite the persistence of critically reduced brain acetylcholinesterase (ache) activity (20-30% of control). |
1999-03-30 |
2023-08-12 |
rat |
| J E Lachowicz, D Lowe, R A Duffy, V Ruperto, L A Taylor, H Guzik, J Brown, J G Berger, M Tice, R McQuade, J Kozlowski, J Clader, C D Strader, N Murgol. SCH 57790: a novel M2 receptor selective antagonist. Life sciences. vol 64. issue 6-7. 1999-03-25. PMID:10069520. |
as a decrease in cholinergic neurons has been observed in alzheimer's disease (ad), therapeutic approaches to ad include inhibition of acetylcholinesterase to increase acetylcholine levels. |
1999-03-25 |
2023-08-12 |
human |
| M A Pombal, J Yáñez, O Marín, A González, R Anadó. Cholinergic and GABAergic neuronal elements in the pineal organ of lampreys, and tract-tracing observations of differential connections of pinealofugal neurons. Cell and tissue research. vol 295. issue 2. 1999-02-26. PMID:9931367. |
the putative cholinergic and gabaergic elements of the pineal organ of lampreys were investigated with immunocytochemistry to choline acetyltransferase (chat) and gamma-aminobutyric acid (gaba), and by acetylcholinesterase (ache) histochemistry. |
1999-02-26 |
2023-08-12 |
Not clear |
| M F Shadlen, E B Larso. What's new in Alzheimer's disease treatment? Reasons for optimism about future pharmacologic options. Postgraduate medicine. vol 105. issue 1. 1999-02-11. PMID:9924498. |
augmentation of cholinergic function through the use of acetylcholinesterase inhibitors with favorable side-effect profiles (e.g., donepezil, possibly metrifonate) can create the potential for improved memory and cognition. |
1999-02-11 |
2023-08-12 |
human |