| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways. |
2002-06-12 |
2023-08-12 |
mouse |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
despite these pivotal relationships, mice nullizygous for acetylcholinesterase established all principal anatomical components of central cholinergic pathways. |
2002-06-12 |
2023-08-12 |
mouse |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
these experiments lead to the unexpected conclusion that acetylcholinesterase is not necessary for the establishment of cholinergic pathways. |
2002-06-12 |
2023-08-12 |
mouse |
| Analía Richeri, Lorena Viettro, Rebeca Chávez-Genaro, Geoffrey Burnstock, Timothy Cowen, M Mónica Braue. Effects of infantile/prepubertal chronic estrogen treatment and chemical sympathectomy with guanethidine on developing cholinergic nerves of the rat uterus. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 6. 2002-06-11. PMID:12019300. |
cholinergic nerves were visualized using a combination of acetylcholinesterase histochemistry and the immunohistochemical demonstration of the vesicular acetylcholine transporter (vacht). |
2002-06-11 |
2023-08-12 |
rat |
| Corrado Blandizzi, Romano Danesi, Barbara De Paolis, Antonello Di Paolo, Rocchina Colucci, Alfredo Falcone, Mario Del Tacc. Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role. Clinical pharmacology and therapeutics. vol 71. issue 4. 2002-05-14. PMID:11956509. |
cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role. |
2002-05-14 |
2023-08-12 |
Not clear |
| Corrado Blandizzi, Romano Danesi, Barbara De Paolis, Antonello Di Paolo, Rocchina Colucci, Alfredo Falcone, Mario Del Tacc. Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role. Clinical pharmacology and therapeutics. vol 71. issue 4. 2002-05-14. PMID:11956509. |
the anticancer drug irinotecan induces cholinergic side effects that are currently ascribed to the blockade of acetylcholinesterase. |
2002-05-14 |
2023-08-12 |
Not clear |
| Julia M Adam, D Jonathan Bennett, Anton Bom, John K Clark, Helen Feilden, Edward J Hutchinson, Ronald Palin, Alan Prosser, David C Rees, Georgina M Rosair, Donald Stevenson, Gary J Tarver, Ming-Qiang Zhan. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. Journal of medicinal chemistry. vol 45. issue 9. 2002-05-10. PMID:11960492. |
because this supramolecular mechanism of action does not involve direct interaction with the cholinergic system, the reversal by these compounds, e.g., compound 14 (org 25969), is not accompanied by cardiovascular side effects usually attendant with acetylcholinesterase inhibitors such as neostigmine. |
2002-05-10 |
2023-08-12 |
Not clear |
| Sonia Boncristiano, Michael E Calhoun, Peter H Kelly, Michelle Pfeifer, Luca Bondolfi, Martina Stalder, Amie L Phinney, Dorothee Abramowski, Christine Sturchler-Pierrat, Albert Enz, Bernd Sommer, Matthias Staufenbiel, Mathias Jucke. Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943824. |
in the neocortex, there is a loss of cholinergic fibers and receptors and a decrease of both choline acetyltransferase (chat) and acetylcholinesterase enzyme activities. |
2002-04-22 |
2023-08-12 |
mouse |
| Jen-Tzer Gau, Michelle L Steinhilb, Tzu-Cheg Kao, Constance J D'Amato, James R Gaut, Kirk A Frey, R Scott Turne. Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice. The American journal of pathology. vol 160. issue 2. 2002-03-19. PMID:11839594. |
at 14, 18, and 23 months of age there were no significant differences between wild-type and transgenic mice in four distinct central nervous system cholinergic indices--choline acetyltransferase and acetylcholinesterase activities, and binding to vesicular acetylcholine transporter and na(+)-dependent high-affinity choline uptake sites. |
2002-03-19 |
2023-08-12 |
mouse |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |
| T Harkany, J Mulder, K M Horvath, J Keijser, E K van der Meeberg, C Nyakas, P G Luite. Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738499. |
effects of repinotan hcl treatment on the survival of cholinergic magnocellular nucleus basalis neurons and their cortical projections were determined by quantitative acetylcholinesterase (ache) and choline-acetyltransferase (chat) histochemistry. |
2002-03-14 |
2023-08-12 |
rat |
| P Piomboni, B Baccetti, E Moretti, L Gambera, C Angelini, C Falug. Localization of molecules related to cholinergic signaling in eggs and zygotes of the sea urchin, Paracentrotus lividus. Journal of submicroscopic cytology and pathology. vol 33. issue 1-2. 2002-03-13. PMID:11686401. |
the presence of a cholinergic signaling pattern was also suggested by the presence of molecules immunologically related to acetylcholinesterase (ache), performing ache enzyme activity, detected by both immunofluorescent and histochemical methods in membranous organelles belonging to the cortical region of unfertilized eggs. |
2002-03-13 |
2023-08-12 |
Not clear |
| D Combes, Y Fedon, J P Toutant, M Arpagau. Acetylcholinesterase genes in the nematode Caenorhabditis elegans. International review of cytology. vol 209. 2002-03-04. PMID:11580201. |
acetylcholinesterase (ache, ec 3.1.1.7) is responsible for the termination of cholinergic nerve transmission. |
2002-03-04 |
2023-08-12 |
caenorhabditis_elegans |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| S Gauthie. Cholinergic adverse effects of cholinesterase inhibitors in Alzheimer's disease: epidemiology and management. Drugs & aging. vol 18. issue 11. 2002-02-19. PMID:11772125. |
cholinergic adverse effects of acetylcholinesterase inhibitors (acheis) are caused by their central and peripheral pharmacological actions on a variety of organ tissues. |
2002-02-19 |
2023-08-12 |
Not clear |
| B H Hsieh, J F Deng, J Ger, W J Tsa. Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Neurotoxicology. vol 22. issue 4. 2002-02-14. PMID:11577800. |
acute cholinergic crisis caused by the inhibition of synaptic acetylcholinesterase is the major manifestation of organophosphate poisoning and may cause death within minutes. |
2002-02-14 |
2023-08-12 |
Not clear |
| M Keller, A Robitzki, P G Laye. Heterologous expression of acetylcholinesterase affects proliferation and glial cytoskeleton of adherent chicken retinal cells. Cell and tissue research. vol 306. issue 2. 2002-01-22. PMID:11702230. |
besides its function at cholinergic synapses, acetylcholinesterase (ache) exerts structural functions on neural differentiation, independent of its enzymatic activity. |
2002-01-22 |
2023-08-12 |
rabbit |
| C Blandizzi, B De Paolis, R Colucci, A Di Paolo, R Danesi, M Del Tacc. Acetylcholinesterase blockade does not account for the adverse cardiovascular effects of the antitumor drug irinotecan: a preclinical study. Toxicology and applied pharmacology. vol 177. issue 2. 2002-01-17. PMID:11740913. |
a direct activation of cholinergic receptors or an interaction with central nervous sites does not appear to account for these inhibitory actions, whereas a blockade of acetylcholinesterase seems to occur at concentrations of irinotecan that may not be relevant in clinical settings. |
2002-01-17 |
2023-08-12 |
human |
| U Gies, T J Görcs, J Mulder, O Planz, L Stitz, T Bilzer, P G Luiten, T Harkan. Cortical cholinergic decline parallels the progression of Borna virus encephalitis. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726791. |
changes in choline acetyltransferase (chat) and acetylcholinesterase (ache) activities were therefore determined in the cerebral cortex, hippocampus, striatum, amygdala and cholinergic basal forebrain nuclei (chbfn) of rats infected with bdv. |
2002-01-11 |
2023-08-12 |
rat |
| I Litvan, M Phipps, V L Pharr, M Hallett, J Grafman, A Salaza. Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy. Neurology. vol 57. issue 3. 2002-01-03. PMID:11502915. |
because results of immunochemical and pharmacologic studies suggest that the cholinergic system may play a role in the cognitive and motor features of psp, the authors investigated the effects of donepezil (10 mg/day), an acetylcholinesterase inhibitor, in 21 patients with psp (mean age +/- sd; 65.7 +/- 4.7 years) by a randomized, double-blind, placebo-controlled crossover trial. |
2002-01-03 |
2023-08-12 |
Not clear |