| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir V Malygin, Vladimir B Sokolov, Rudy J Richardson, Galina F Makhaev. Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. Journal of toxicology and environmental health. Part A. vol 66. issue 7. 2003-06-02. PMID:12746136. |
inhibition of acetylcholinesterase (ache) versus inhibition and aging of neuropathy target esterase (nte) by organophosphorus (op) compounds in vivo can give rise to distinct neurological consequences: acute cholinergic toxicity versus op compound-induced delayed neurotoxicity (opidn). |
2003-06-02 |
2023-08-12 |
Not clear |
| Julio J Ramirez, Jennifer L Caldwell, Melanie Majure, David R Wessner, Ronald L Klein, Edwin M Meyer, Michael A Kin. Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684466. |
optical densitometric analyses revealed a significant increase in acetylcholinesterase label (a marker for cholinergic septodentate sprouting) in the ipsilateral outer molecular layer of the dentate gyrus in rats injected with raav vector expressing ngf. |
2003-05-30 |
2023-08-12 |
rat |
| G B KOELL. The histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. The Journal of pharmacology and experimental therapeutics. vol 114. issue 2. 2003-05-01. PMID:14392585. |
the histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. |
2003-05-01 |
2023-08-12 |
Not clear |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |
| H Sugimot. Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chemical record (New York, N.Y.). vol 1. issue 1. 2003-04-22. PMID:11893059. |
the role of the cholinergic system with respect to cognitive deficits characteristic of alzheimer's disease (ad) has led to a number of studies focusing on the development of acetylcholinesterase (ache) inhibitors as a drug for treating this disease. |
2003-04-22 |
2023-08-12 |
Not clear |
| E S Tsai, S J Haraldson, J Baratta, A D Lander, J Yu, R T Robertso. Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435420. |
cultures processed for acetylcholinesterase (ache) histochemistry demonstrated non-random patterns of cholinergic cells and their neurites. |
2003-04-07 |
2023-08-12 |
mouse |
| Vu Thuong Nguyen, Juan Arredondo, Alexander I Chernyavsky, Yasuo Kitajima, Sergei A Grand. Keratinocyte acetylcholine receptors regulate cell adhesion. Life sciences. vol 72. issue 18-19. 2003-04-04. PMID:12628460. |
monolayers of kc were treated overnight with 0.25 mm of the cholinergic agonist carbachol (cch) or the acetylcholinesterase inhibitor pyridostigmine bromide (pbr). |
2003-04-04 |
2023-08-12 |
human |
| Valtteri Kaasinen, Kjell Någren, Tarja Järvenpää, Anne Roivainen, Meixiang Yu, Vesa Oikonen, Timo Kurki, Juha O Rinn. Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. Journal of clinical psychopharmacology. vol 22. issue 6. 2003-03-31. PMID:12454562. |
donepezil and rivastigmine are acetylcholinesterase (ache) inhibitors used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease (ad). |
2003-03-31 |
2023-08-12 |
human |
| Udo Rolle, Boris Chertin, Laszlo Nemeth, Prem Pur. Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract. Pediatric surgery international. vol 18. issue 5-6. 2003-03-21. PMID:12415346. |
to investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract, (uut) whole-mount preparations and frozen sections were stained with nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase and acetylcholinesterase (ache) histochemistry. |
2003-03-21 |
2023-08-12 |
human |
| Christopher J Gordon, Cina M Mac. Influence of gender on thermoregulation and cholinesterase inhibition in the long-evans rat exposed to diazinon. Journal of toxicology and environmental health. Part A. vol 66. issue 3. 2003-03-13. PMID:12521673. |
diazinon is an organophosphate (op)-based, anticholinesterase insecticide that irreversibly inhibits acetylcholinesterase activity and produces cholinergic stimulation in central nervous system (cns) and peripheral tissues. |
2003-03-13 |
2023-08-12 |
rat |
| Tangeng Ma, Robert E Kramer, Rodney C Baker, Lir-Wan Fan, Ing K H. Effects of chronic dermal exposure to nonlethal doses of methyl parathion on brain regional acetylcholinesterase and muscarinic cholinergic receptors in female rats. Journal of neuroscience research. vol 71. issue 1. 2003-03-12. PMID:12478623. |
effects of chronic dermal exposure to nonlethal doses of methyl parathion on brain regional acetylcholinesterase and muscarinic cholinergic receptors in female rats. |
2003-03-12 |
2023-08-12 |
rat |
| D Pesando, P Huitorel, V Dolcini, C Angelini, P Guidetti, C Falug. Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin, Paracentrotus lividus. Marine environmental research. vol 55. issue 1. 2003-03-11. PMID:12469775. |
from the gastrulation stage onwards, the main effects were exerted on the rate of primary mesenchyme cells migration, larval size, perioral arm length, and acetylcholinesterase activity distribution, thus deregulating the cholinergic system, which modulates cell-to-cell communication mediated by the signal molecule acetylcholine. |
2003-03-11 |
2023-08-12 |
Not clear |
| L Masoud, C Vijayasarathy, M Fernandez-Cabezudo, G Petroianu, A M Sale. Effect of malathion on apoptosis of murine L929 fibroblasts: a possible mechanism for toxicity in low dose exposure. Toxicology. vol 185. issue 1-2. 2003-03-11. PMID:12505448. |
while acute organophosphorous compound poisoning due to inhibition of acetylcholinesterase is a well-established clinical entity, the existence of chronic poisoning due to exposure to low levels of organophosphorous compounds (below the threshold required for cholinergic clinical symptoms) is a hotly debated issue. |
2003-03-11 |
2023-08-12 |
Not clear |
| E L Mukhin, E I Zakharova, E A Kiktev. Comparison of the cholinergic system in neocortical field Ep in cats with strong and weak cognitive abilities. Neuroscience and behavioral physiology. vol 32. issue 4. 2003-03-10. PMID:12243259. |
comparative analysis of the cholinergic system of the neocortex, consisting of the terminals of neurons from the magnocellular basal nuclei and intracortical neurons, in cats with strong and weak abilities to solve abstraction and generalization tasks was performed by isolating subfractions of synaptic membranes and synaptoplasm from "light" (c) and "heavy" (d) synaptosomes from associative field ep and measuring choline acetyltransferase and acetylcholinesterase activities, protein content, and sulfhydryl group concentrations. |
2003-03-10 |
2023-08-12 |
Not clear |
| Angelo Moretto, Marcello Lott. The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Archives of toxicology. vol 76. issue 5-6. 2003-03-04. PMID:12107655. |
to explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced opidp; (2) whereas neuropathy target esterase (nte) is thought to be the target of opidp, activation of isofenphos by liver microsomes causes the formation of more potent nte inhibitor(s) in humans than in hens; (3) in contrast to hen nte, the sensitivity of the human enzyme to such inhibitor(s) is higher than that of acetylcholinesterase (ache), the target of cholinergic toxicity. |
2003-03-04 |
2023-08-12 |
human |
| Talma Brenner, Yasmine Hamra-Amitay, Tama Evron, Neli Boneva, Shlomo Seidman, Hermona Sore. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 2. 2003-02-28. PMID:12554700. |
alternative splicing induces, under abnormal cholinergic neurotransmission, overproduction of the rare "readthrough" acetylcholinesterase variant ache-r. we explored the pathophysiological relevance of this phenomenon in patients with myasthenia gravis (mg) and rats with experimental autoimmune mg (eamg), neuromuscular junction diseases with depleted acetylcholine receptors. |
2003-02-28 |
2023-08-12 |
rat |
| Marie M Svedberg, Anne-Lie Svensson, Mary Johnson, Mandy Lee, Osnat Cohen, Jennifer Court, Hermona Soreq, Elaine Perry, Agneta Nordber. Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase. Journal of molecular neuroscience : MN. vol 18. issue 3. 2003-02-26. PMID:12059039. |
our results suggest that disruption of balanced cholinergic transmission by constitutive overexpression of acetylcholinesterase is accompanied by variable upregulation of several nicotinic receptor subtypes, in particular these associated with cholinergic terminals participating in compensatory response. |
2003-02-26 |
2023-08-12 |
mouse |
| Olga A Timofeeva, Christopher J Gordo. EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos. Pharmacology, biochemistry, and behavior. vol 72. issue 3. 2003-02-05. PMID:12175464. |
ops inhibit acetylcholinesterase (ache) activity, leading to a hyperactivity of the brain cholinergic systems that are involved in sleep regulation. |
2003-02-05 |
2023-08-12 |
rat |
| X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H Jin, L H Guo, M Alemany, L Y Zhang, Y F Sh. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107822. |
acetylcholinesterase (ache) plays a key role in terminating neurotransmission at cholinergic synapses. |
2003-01-31 |
2023-08-12 |
Not clear |
| Sebastian Lazareno, Angela Popham, Nigel J M Birdsal. Towards a high-affinity allosteric enhancer at muscarinic M1 receptors. Journal of molecular neuroscience : MN. vol 19. issue 1-2. 2003-01-28. PMID:12212769. |
that search has so far been unsuccessful, but acetylcholinesterase inhibitors such as donepezil (aricept), which potentiate cholinergic neurotransmission, have a therapeutic role in the management of ad; so the m1 receptor remains a therapeutic target. |
2003-01-28 |
2023-08-12 |
Not clear |