| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan Newmar. Nerve agents: pathophysiology and treatment of poisoning. Seminars in neurology. vol 24. issue 2. 2004-09-17. PMID:15257516. |
nerve agents, the deadliest of the classical chemical warfare agents, primarily function as acetylcholinesterase inhibitors and cause a rapidly progressive cholinergic crisis. |
2004-09-17 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Doni. Organophosphorus ester-induced chronic neurotoxicity. Archives of environmental health. vol 58. issue 8. 2004-07-29. PMID:15259428. |
the primary action is the irreversible inhibition of acetylcholinesterase, resulting in the accumulation of acetylcholine and subsequent overstimulation of the nicotinic and muscarinic acetylcholine receptors, resulting in cholinergic effects. |
2004-07-29 |
2023-08-12 |
human |
| Donald B Hoover, Charles E Ganote, Shawn M Ferguson, Randy D Blakely, Rodney L Parson. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovascular research. vol 62. issue 1. 2004-07-20. PMID:15023558. |
previous studies have used acetylcholinesterase (ache) histochemistry to identify cholinergic nerves in the heart, but this enzyme is not a selective marker for cholinergic neurons. |
2004-07-20 |
2023-08-12 |
human |
| Stevan R Emmett, Susan A Greenfiel. A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra. Neuroscience letters. vol 358. issue 3. 2004-07-16. PMID:15039118. |
it is well established that acetylcholinesterase (ache) has 'non-classical' functions independent of cholinergic transmission. |
2004-07-16 |
2023-08-12 |
human |
| David H Smal. Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends in neurosciences. vol 27. issue 5. 2004-07-06. PMID:15111005. |
it is suggested that increased cholinergic activity during the early stages of ad contributes to synaptic scaling and that acetylcholinesterase inhibitors improve cognition in ad patients by boosting this mechanism. |
2004-07-06 |
2023-08-12 |
Not clear |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Burt M Sharp, M Yatsula, Yitong F. Effects of galantamine, a nicotinic allosteric potentiating ligand, on nicotine-induced catecholamine release in hippocampus and nucleus accumbens of rats. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14769831. |
galantamine, a drug for treatment of alzheimer's disease, is a novel cholinergic agent with a dual mode of action that inhibits acetylcholinesterase and allosterically modulates nicotinic cholinergic receptors (nachrs). |
2004-07-01 |
2023-08-12 |
rat |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |
| Neal Slatkin, Michelle Rhine. Treatment of opioid-induced delirium with acetylcholinesterase inhibitors: a case report. Journal of pain and symptom management. vol 27. issue 3. 2004-05-19. PMID:15038335. |
evidence for a disorder of cholinergic neurotransmission in opioid-induced delirium is discussed, as is the rationale for treatment with acetylcholinesterase inhibitors and other cholinomimetic agents. |
2004-05-19 |
2023-08-12 |
Not clear |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: functional imaging of the conscious monkey brain using animal pet in combination with microdialysis. |
2004-05-07 |
2023-08-12 |
monkey |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
this study demonstrated the effects of acute acetylcholinesterase (ache) inhibition by donepezil (aricept) on the cerebral cholinergic neuronal system in the brains of young (5.2 +/- 1.1 years old) and aged (20.3 +/- 2.6 years old) monkeys (macaca mulatta) in the conscious state. |
2004-05-07 |
2023-08-12 |
monkey |
| Agneta Nordber. Toward an early diagnosis and treatment of Alzheimer's disease. International psychogeriatrics. vol 15. issue 3. 2004-05-06. PMID:14756159. |
an obvious impairment in central cholinergic transmitter function and its close relation to cognitive function led to the development of the acetylcholinesterase inhibitors that now are used as symptomatic therapy. |
2004-05-06 |
2023-08-12 |
mouse |
| Christophe Praud, Philippe Sebe, Fabrice Mondet, Alain Sebill. The striated urethral sphincter in female rats. Anatomy and embryology. vol 207. issue 2. 2004-05-05. PMID:12937977. |
they are innervated by cholinergic endplates as shown by acetylcholinesterase techniques and alpha-bungarotoxin binding. |
2004-05-05 |
2023-08-12 |
rat |
| Barbara B Simon, Bryan Knuckley, Donald A Powel. Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits. Learning & memory (Cold Spring Harbor, N.Y.). vol 11. issue 1. 2004-04-30. PMID:14747525. |
the present study assessed whether galantamine (gal), an allosteric modulator of nicotinic cholinergic receptors and weak acetylcholinesterase inhibitor, could improve acquisition and retention of an eyeblink (eb) classical conditioning task in healthy, young animals. |
2004-04-30 |
2023-08-12 |
Not clear |
| Takeshi Fuji. [An independent, non-neuronal cholinergic system in lymphocytes and its roles in regulation of immune function]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 123. issue 3. 2004-04-21. PMID:14993730. |
however, lymphocytes express most of the cholinergic components found in the nervous system, including ach, choline acetyltransferase (chat), high-affinity choline transporter, and acetylcholinesterase as well as both muscarinic and nicotinic ach receptors (machrs and nachrs, respectively). |
2004-04-21 |
2023-08-12 |
Not clear |
| Dorota Religa, Bengt Winbla. Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms. Acta neurobiologiae experimentalis. vol 63. issue 4. 2004-04-19. PMID:15053264. |
currently available treatment used in ad is based on acetylcholinesterase inhibitors, since in the course of ad there is a substantial loss in cholinergic neurons. |
2004-04-19 |
2023-08-12 |
Not clear |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
although there is a loss of acetylcholinesterase (ache) from both cholinergic and non-cholinergic neurones in the brain of alzheimer patients, the level of ache is increased around amyloid plaques. |
2004-03-30 |
2023-08-12 |
mouse |
| Peter Kasa, Henrietta Papp, Peter Kasa, Magdolna Pakaski, Lajos Balaspir. Effects of amyloid-beta on cholinergic and acetylcholinesterase-positive cells in cultured basal forebrain neurons of embryonic rat brain. Brain research. vol 998. issue 1. 2004-03-22. PMID:14725970. |
the cholinergic neurons and their axon terminals were revealed by vesicular acetylcholine transporter immunohistochemistry and the cholinoceptive cells by acetylcholinesterase histochemical staining. |
2004-03-22 |
2023-08-12 |
rat |
| S Brassen, G Adle. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry. vol 36. issue 6. 2004-03-17. PMID:14663655. |
acetylcholinesterase inhibitor treatment enhances cholinergic neurotransmission and may thus partially reverse eeg slowing and memory impairment in alzheimer patients within short time. |
2004-03-17 |
2023-08-12 |
Not clear |
| Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacso. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750653. |
the density of the dendritic marker map2 was significantly decreased in the hippocampal formation of middle-aged trisomic mice (9-15 months old), and the density of cholinergic neurites (acetylcholinesterase [ache] histochemistry) was also decreased in specific layers of the hippocampus. |
2004-03-12 |
2023-08-12 |
mouse |