| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nibaldo C Inestrosa, Juan Paulo Sagal, Marcela Colombre. Acetylcholinesterase interaction with Alzheimer amyloid beta. Sub-cellular biochemistry. vol 38. 2005-04-12. PMID:15709485. |
acetylcholinesterase (ache) is an enzyme involved in cholinergic and non-cholinergic functions in both the central and peripheral nervous system, most of the ache is found as a tetrameric form bound to neuronal membranes. |
2005-04-12 |
2023-08-12 |
rat |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| Lisa C Pi. Novel pharmacological approaches for the antagonism of neuromuscular blockade. AANA journal. vol 73. issue 1. 2005-03-29. PMID:15727282. |
both of these agents are devoid of cholinergic stimulation and the accompanying side effects because their action is independent of acetylcholinesterase inhibition. |
2005-03-29 |
2023-08-12 |
human |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
in both cases, the therapeutic effect is mediated by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2005-03-18 |
2023-08-12 |
human |
| Emma Ankarberg, Anders Fredriksson, Per Eriksso. Increased susceptibility to adult paraoxon exposure in mice neonatally exposed to nicotine. Toxicological sciences : an official journal of the Society of Toxicology. vol 82. issue 2. 2005-03-16. PMID:15356346. |
organophosphorus insecticides are known to affect the cholinergic system by inhibition of acetylcholinesterase. |
2005-03-16 |
2023-08-12 |
mouse |
| W Meier-Ruge, M Kolbe, J Sattle. Investigations of the cholinergic deficit hypothesis in the hippocampus of the aged rat brain with physostigmine and scopolamine. Archives of gerontology and geriatrics. vol 12. issue 2-3. 2005-03-10. PMID:15374451. |
using histochemically demonstrated acetylcholinesterase activity and (14)c-2-deoxyglucose uptake as the respective indices, a study was set up to determine whether cerebral (hippocampal) metabolism was stimulated by a cholinergic agonist and/or inhibited by a cholinergic antagonist. |
2005-03-10 |
2023-08-12 |
rat |
| Vincenzo Rispoli, Domenicantonio Rotiroti, Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Rosario Marra, Silvano Tortorella, Barbara Di Rienz. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301920. |
the results of the present work allow us to put forward the hypothesis that the eeg effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ach) consequent upon acetylcholinesterase (ache) inhibition by choline pivaloyl esters. |
2005-03-04 |
2023-08-12 |
rat |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
[pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: pet study in conscious monkeys]. |
2005-03-01 |
2023-08-12 |
monkey |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
the present review described the effects of acetylcholinesterase (ache) inhibition on the cerebral cholinergic neuronal system in the conscious monkey brains with pet. |
2005-03-01 |
2023-08-12 |
monkey |
| Marco Racchi, Michela Mazzucchelli, Emanuela Porrello, Cristina Lanni, Stefano Govon. Acetylcholinesterase inhibitors: novel activities of old molecules. Pharmacological research. vol 50. issue 4. 2005-02-04. PMID:15304241. |
the therapeutic approach for improving the cognitive function in patients with alzheimer's disease (ad) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (ache) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. |
2005-02-04 |
2023-08-12 |
Not clear |
| Colette A Inkson, Alex C Brabbs, Tarlochan S Grewal, Timothy M Skerry, Paul G Geneve. Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone. vol 35. issue 4. 2005-02-02. PMID:15454088. |
although best known for its role in cholinergic signalling, a substantial body of evidence suggests that acetylcholinesterase (ache) has multiple biological functions. |
2005-02-02 |
2023-08-12 |
Not clear |
| Stephen Jackson, Richard J Ham, David Wilkinso. The safety and tolerability of donepezil in patients with Alzheimer's disease. British journal of clinical pharmacology. vol 58 Suppl 1. 2005-02-02. PMID:15496217. |
donepezil is a potent, selective inhibitor of acetylcholinesterase, and selective inhibition of central as opposed to peripheral ches might be expected to reduce the incidence of aes, thus this may explain the lower incidence of cholinergic aes observed following treatment with donepezil, compared with nonselective che inhibitors. |
2005-02-02 |
2023-08-12 |
Not clear |
| Chukwuemeka S Okereke, Louis Kirby, Dinesh Kumar, Edward I Cullen, Raymond D Pratt, William A Hahn. Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses. British journal of clinical pharmacology. vol 58 Suppl 1. 2005-02-02. PMID:15496222. |
the use of acetylcholinesterase inhibitors for the treatment of comorbid alzheimer's disease in parkinson's disease (pd) patients stabilized on a levodopa regimen may potentially disrupt cholinergic balance. |
2005-02-02 |
2023-08-12 |
Not clear |
| Thomas C Chou, Stephen R Rotman, Clifford B Sape. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488307. |
the lateral hypothalamic area (lha) contains a large population of neurons that express the enzyme acetylcholinesterase (ache), but are not themselves cholinergic. |
2005-01-31 |
2023-08-12 |
Not clear |
| Marie M Svedberg, Ivan Bednar, Agneta Nordber. Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic mice overexpressing human acetylcholinesterase. Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380373. |
overexpression of acetylcholinesterase (ache) in mice causes cholinergic deficits with memory impairment. |
2005-01-18 |
2023-08-12 |
mouse |
| P Francotte, E Graindorge, S Boverie, P de Tullio, B Pirott. New trends in the design of drugs against Alzheimer's disease. Current medicinal chemistry. vol 11. issue 13. 2005-01-07. PMID:15279580. |
ad is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors, based on the cholinergic hypothesis (1976). |
2005-01-07 |
2023-08-12 |
Not clear |
| Sang-Yoon Lee, Yearn Seong Choe, Yu Ri Kim, Jin-Young Paik, Byoung Wook Choi, Sang Eun Kim, Kyung-Han Lee, Yong Choi, Byung-Tae Ki. Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. Nuclear medicine communications. vol 25. issue 6. 2004-12-20. PMID:15167519. |
acetylcholinesterase (ache) is an important cholinergic marker for the diagnosis of alzheimer's disease (ad). |
2004-12-20 |
2023-08-12 |
Not clear |
| Patrícia F Gardino, Alice R Schmal, Karin da C Calaz. Identification of neurons with acetylcholinesterase and NADPH-diaphorase activities in the centrifugal visual system of the chick. Journal of chemical neuroanatomy. vol 27. issue 4. 2004-10-18. PMID:15261333. |
then, double labeled with acetylcholinesterase histochemistry to reveal cholinergic synapses, or nadph-diaphorase histochemistry as a nitrergic marker. |
2004-10-18 |
2023-08-12 |
chicken |
| Lu-Tai Tien, Lir-Wan Fan, Chiharu Sogawa, Tangeng Ma, Horance H Loh, Ing-Kang H. Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice. Brain research. Molecular brain research. vol 126. issue 1. 2004-10-07. PMID:15207914. |
in the present study, we investigated whether there are compensatory changes of acetylcholinesterase activity and cholinergic receptors in mice lacking mu-opioid receptor gene. |
2004-10-07 |
2023-08-12 |
mouse |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
until recently, the only established function of acetylcholinesterase (ache) was the termination of cholinergic neurotransmission. |
2004-09-27 |
2023-08-12 |
Not clear |