| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| Eran Nizri, Yasmine Hamra-Amitay, Camille Sicsic, Iris Lavon, Talma Brenne. Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors. Neuropharmacology. vol 50. issue 5. 2006-07-06. PMID:16336980. |
anti-inflammatory properties of cholinergic up-regulation: a new role for acetylcholinesterase inhibitors. |
2006-07-06 |
2023-08-12 |
Not clear |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
experimental manipulations suggest that in vivo administration of cholinergic agonists or inhibitors of acetylcholinesterase (ache) increases the concentration of acetylcholine. |
2006-06-30 |
2023-08-12 |
rat |
| Niamh Durcan, Richard W Costello, W Graham McLean, Jan Blusztajn, Beata Madziar, Anthony G Fenech, Ian P Hall, Gerard J Gleich, Lorcan McGarvey, Marie-Therese Wals. Eosinophil-mediated cholinergic nerve remodeling. American journal of respiratory cell and molecular biology. vol 34. issue 6. 2006-06-29. PMID:16456188. |
eosinophils also induced the expression of several cholinergic genes involved in the synthesis, storage, and metabolism of acetylcholine, including the enzymes choline acetyltransferase, vesicular acetylcholine transferase, and acetylcholinesterase. |
2006-06-29 |
2023-08-12 |
Not clear |
| Salvatore Oddo, Frank M LaFerl. The role of nicotinic acetylcholine receptors in Alzheimer's disease. Journal of physiology, Paris. vol 99. issue 2-3. 2006-06-28. PMID:16448808. |
this observation has had a major impact on therapeutic treatments, as efforts to restore cholinergic function such as the administration of acetylcholinesterase inhibitors have been, until recently, the major treatment options available for ad. |
2006-06-28 |
2023-08-12 |
mouse |
| T Zuchner, N Schliebe, R Schlieb. Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 24. issue 1. 2006-06-26. PMID:16406470. |
apart from cholinergic markers like choline acetyltransferase and acetylcholinesterase, there have been reports on changes in muscarinic acetylcholine receptors (machr) as well as on influences of zinc metabolism in the disease. |
2006-06-26 |
2023-08-12 |
human |
| Sang-Yoon Lee, Yearn Seong Choe, Eun Kyoung Ryu, Yoichi Iimura, Yong Choi, Kyung-Han Lee, Byung-Tae Ki. Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase? Studies on 18F-labeled G379. Nuclear medicine and biology. vol 33. issue 1. 2006-06-19. PMID:16459263. |
acetylcholinesterase (ache) is an important cholinergic marker of alzheimer's disease (ad) and shows reduced activity in postmortem ad brain tissues. |
2006-06-19 |
2023-08-12 |
mouse |
| Lucio G Cost. Current issues in organophosphate toxicology. Clinica chimica acta; international journal of clinical chemistry. vol 366. issue 1-2. 2006-06-09. PMID:16337171. |
because of the phosphorylation of acetylcholinesterase, they exert primarily a cholinergic toxicity, however, some can also cause a delayed polyneuropathy. |
2006-06-09 |
2023-08-12 |
Not clear |
| Andrea Contestabile, Tatiana Fila, Renata Bartesaghi, Antonio Contestabile, Elisabetta Cian. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. Journal of neurochemistry. vol 97. issue 2. 2006-06-08. PMID:16539660. |
we have measured in ts65dn mice the catalytic activity of the cholinergic marker, choline acetyltransferase (chat), as well as the activity of the acetylcholine-degrading enzyme acetylcholinesterase (ache), in the hippocampus and in cortical targets of basal forebrain cholinergic neurons. |
2006-06-08 |
2023-08-12 |
mouse |
| Eric Krejci, Isabel Martinez-Pena y Valenzuela, Rafiqa Ameziane, Mohammed Akaaboun. Acetylcholinesterase dynamics at the neuromuscular junction of live animals. The Journal of biological chemistry. vol 281. issue 15. 2006-06-05. PMID:16455662. |
at cholinergic synapses, acetylcholinesterase (ache) is critical for ensuring normal synaptic transmission. |
2006-06-05 |
2023-08-12 |
mouse |
| C Bussy, P Lestaevel, B Dhieux, C Amourette, F Paquet, P Gourmelon, P Houper. Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain. Neurotoxicology. vol 27. issue 2. 2006-05-22. PMID:16325913. |
in the present study, the effects during 1.5, 6 and 9-month periods of chronic ingestion of uranyl nitrate (un) in drinking water (40 mg of uranium per litre) on cholinergic acetylcholinesterase (ache) activity and on dopaminergic and serotoninergic metabolisms were investigated in several areas of male srague dawley rat brains. |
2006-05-22 |
2023-08-12 |
rat |
| Mohammad A Kamal, Abdulaziz A Al-Jafari, Qian-Sheng Yu, Nigel H Grei. Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine. Biochimica et biophysica acta. vol 1760. issue 2. 2006-04-27. PMID:16309845. |
the enzyme, acetylcholinesterase (ache), along with other elements of the cholinergic system is depleted in the ad brain. |
2006-04-27 |
2023-08-12 |
human |
| Roger Bulloc. Galantamine: use in Alzheimer's disease and related disorders. Expert review of neurotherapeutics. vol 4. issue 2. 2006-04-25. PMID:15853556. |
galantamine (reminyl) has long been used as a traditional medicine and has an interesting pharmacology as it is both a reversible acetylcholinesterase inhibitor and an allosteric potentiator of nicotinic cholinergic receptors. |
2006-04-25 |
2023-08-12 |
Not clear |
| Thitiya Pung, Bradley Klein, Dennis Blodgett, Bernard Jortner, Marion Ehric. Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions. International journal of toxicology. vol 25. issue 1. 2006-04-25. PMID:16510359. |
effects of concurrent exposure to repeated stress and chlorpyrifos on activities of acetylcholinesterase (ache), carboxylesterase, and choline acetyltransferase (chat); concentrations of excitatory amino acids, monoamines, and their metabolites; and maximum binding densities (b(max)) and equilibrium dissociation rate constants (k(d)) of glutamatergic n-methyl-d-aspartate (nmda) and total muscarinic cholinergic receptors were studied in the blood, hippocampus, cerebral cortex, or hypothalamus of adult long-evans rats. |
2006-04-25 |
2023-08-12 |
rat |
| Da-Ming Du, Paul R Carlie. Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544504. |
at present the only fda-approved therapy for alzheimer's disease involves the administration of acetylcholinesterase inhibitors, to alleviate the cholinergic deficit associated with this disease. |
2006-04-10 |
2023-08-12 |
Not clear |
| M C Carreiras, J L Marc. Recent approaches to novel anti-Alzheimer therapy. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544506. |
the cholinergic hypothesis has provided the rationale for the current treatment approaches based on acetylcholinesterase inhibitors. |
2006-04-10 |
2023-08-12 |
Not clear |
| J Birk. Cholinesterase inhibitors for Alzheimer's disease. The Cochrane database of systematic reviews. issue 1. 2006-04-07. PMID:16437532. |
since the introduction of the first cholinesterase inhibitor (chei) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate alzheimer's disease.the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2006-04-07 |
2023-08-12 |
Not clear |
| C M Hernandez, D A Gearhart, V Parikh, E J Hohnadel, L W Davis, M L Middlemore, S P Warsi, J L Waller, A V Terr. Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16214877. |
this study was designed to determine 1) whether repeated exposures to the acetylcholinesterase inhibitors (acheis) galantamine (gal) or donepezil (don) resulted in positive effects on nerve growth factor (ngf) and its receptors, cholinergic proteins, and cognitive function in the aged rat, and 2) whether gal had any advantages over don given its allosteric potentiating ligand (apl) activity at nicotinic acetylcholine receptors. |
2006-04-04 |
2023-08-12 |
rat |
| C M Hernandez, D A Gearhart, V Parikh, E J Hohnadel, L W Davis, M L Middlemore, S P Warsi, J L Waller, A V Terr. Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16214877. |
the results suggest that repeated exposures to either gal or don results in positive (and sustained) behavioral and cholinergic effects in the aged mammalian brain but that the apl activity of gal may not afford any advantage over acetylcholinesterase inhibition alone. |
2006-04-04 |
2023-08-12 |
rat |
| Pedro Martínez-Moreno, Susana Nieto-Cerón, Juan Torres-Lanzas, Francisco Ruiz-Espejo, Isabel Tovar-Zapata, Pedro Martínez-Hernández, José N Rodríguez-López, Cecilio J Vidal, Juan Cabezas-Herrer. Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16272577. |
the probable involvement of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in cancer and the relevance of cholinergic responses for lung cancer growth prompted us to study whether cholinesterase activity of human lung is altered by malignancy. |
2006-04-04 |
2023-08-12 |
human |