| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad A Kamal, Peter Klein, Qian-Sheng Yu, David Tweedie, Yazhou Li, Harold W Holloway, Nigel H Grei. Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. Journal of Alzheimer's disease : JAD. vol 10. issue 1. 2007-02-20. PMID:16988481. |
ad, although an irreversible and progressive disorder, is currently treated with palliative, symptomatic therapy: primarily with acetylcholinesterase (ache) inhibitors to amplify remaining cholinergic activity. |
2007-02-20 |
2023-08-12 |
human |
| Reinhard Schliebs, Kristin Heidel, Jenny Apelt, Magdalena Gniezdzinska, Ludmil Kirazov, Andrzej Szutowic. Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17026971. |
to reveal whether il-1beta affects muscarinic acetylcholine receptor (machr)-mediated intracellular signaling, cholinergically differentiated sh-sy5y cells were exposed to il-1beta for various periods of time followed by stimulation of machr with carbachol for 1 h, and key molecules of cholinergic signaling cascades were determined including phosphoinositide hydrolysis, dna-binding capacity of nfkappab and ap-1, and activity of acetylcholinesterase (ache). |
2007-01-30 |
2023-08-12 |
Not clear |
| R T Robertson, J Baratta, J Yu, K M Guthri. A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17049175. |
patterns of expression of nt-3 (defined by beta-galactosidase reporter expression in heterozygous offspring of transgenic nt-3(laczneo/+) mice) revealed that limbic cortical regions (including frontal, cingulate, and insular cortex, as well as the dentate gyrus) express nt-3 and that these cortical regions receive early and relatively dense cholinergic axons (stained for acetylcholinesterase, ache). |
2007-01-26 |
2023-08-12 |
mouse |
| Gabriel Zimmerman, Hermona Sore. Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research. vol 326. issue 2. 2007-01-23. PMID:16802134. |
this unique termination mechanism makes acetylcholinesterase (ache), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. |
2007-01-23 |
2023-08-12 |
Not clear |
| Jessica S Keverne, Wee Chuang R Low, Iryna Ziabreva, Jenny A Court, Arthur E Oakley, Raj N Kalari. Cholinergic neuronal deficits in CADASIL. Stroke. vol 38. issue 1. 2007-01-19. PMID:17122431. |
previous evidence from mri and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil). |
2007-01-19 |
2023-08-12 |
Not clear |
| Tonmoy Sharma, Catherine Reed, Ingrid Aasen, Veena Kumar. Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: a randomized, placebo-controlled, double-blind investigation. Schizophrenia research. vol 85. issue 1-3. 2006-12-28. PMID:16797163. |
acetylcholinesterase inhibitors, such as physostigmine and rivastigmine, are considered effective treatments for cognitive decline in alzheimer's disease, where the loss of cholinergic neurons is thought to be responsible for various cognitive deficits. |
2006-12-28 |
2023-08-12 |
Not clear |
| Daniel B C Queiróz, Adilson M da Silva, Gabriel Gutiérrez-Ospina, Catarina S Porto, Gail Grossman, Peter Petrusz, Maria C W Avella. Cells positive for microtubule-associated protein 1B (MAP 1B) are present along rat and human efferent ductules and epididymis. Cell and tissue research. vol 325. issue 1. 2006-12-06. PMID:16541288. |
these immunoreactive cells did not stain for dopamine beta-hydroxylase or acetylcholinesterase, indicating that they were not adrenergic or cholinergic in nature. |
2006-12-06 |
2023-08-12 |
human |
| L D Sanford, L Yang, X Tang, E Dong, R J Ross, A R Morriso. Cholinergic regulation of the central nucleus of the amygdala in rats: effects of local microinjections of cholinomimetics and cholinergic antagonists on arousal and sleep. Neuroscience. vol 141. issue 4. 2006-12-04. PMID:16843604. |
we examined sleep and the encephalogram for 8 h following bilateral microinjections into the central nucleus of the amygdala (cna) of the cholinergic agonist, carbachol (carb(l): 0.3 microg; carb(h): 3.0 microg), the acetylcholinesterase inhibitor, neostigmine (neo(l): 0.3 microg; neo(h): 3.0 microg), the muscarinic antagonist, scopolamine (sco(l): 0.3 microg; sco(h): 1.0 microg), the nicotinic antagonist, mecamylamine (mec(l): 0.3 microg; mec(h): 1.0 microg) and saline (sal, 0.2 microl) alone. |
2006-12-04 |
2023-08-12 |
rat |
| Wolfgang Singer, Tonette L Opfer-Gehrking, Kim K Nickander, Stacy M Hines, Phillip A Lo. Acetylcholinesterase inhibition in patients with orthostatic intolerance. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 23. issue 5. 2006-11-20. PMID:17016160. |
based on the hypothesis that acetylcholinesterase inhibition, by improving the safety factor of cholinergic transmission, will result in enhanced vascular adrenergic tone and a vagal shift in cardiac sympathovagal balance, we evaluated the role of acetylcholinesterase inhibition in the treatment of patients with oi. |
2006-11-20 |
2023-08-12 |
Not clear |
| Ana Martinez, Ana Castr. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease. Expert opinion on investigational drugs. vol 15. issue 1. 2006-11-14. PMID:16370929. |
these drugs, known as acetylcholinesterase inhibitors, have been shown to improve cognition and global functions but have little impact on improving the eventual progression of the disease; however, there is evidence that other cholinesterases such as butyrylcholinesterase can play an important role in cholinergic function in the brain, and the long-suspected non-cholinergic actions of acetylcholinesterase, mainly the interference with the beta-amyloid protein cascade, have recently driven a profound revolution in cholinesterase drug research. |
2006-11-14 |
2023-08-12 |
Not clear |
| Chaitali Sinha, Kavita Seth, Fakhrul Islam, Rajnish Kumar Chaturvedi, Shubha Shukla, Neeraj Mathur, N Srivastava, Ashok Kumar Agrawa. Behavioral and neurochemical effects induced by pyrethroid-based mosquito repellent exposure in rat offsprings during prenatal and early postnatal period. Neurotoxicology and teratology. vol 28. issue 4. 2006-11-07. PMID:16842967. |
the hippocampus was the most affected region and further exhibited altered cholinergic functioning in the form of significant decrease in cholinergic (muscarinic) receptor binding (prenatal 32%, postnatal 35%, perinatal 38%) and inhibition in acetylcholinesterase activity (prenatal 20%, postnatal 31% and perinatal 33%). |
2006-11-07 |
2023-08-12 |
rat |
| Keith N Darrow, Emmanuel J Simons, Leslie Dodds, M Charles Liberma. Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871528. |
consistent with cochlear projections, double staining for the cholinergic marker acetylcholinesterase suggested that th-positive somata are not cholinergic and vice versa. |
2006-10-03 |
2023-08-12 |
mouse |
| Deqiang Zhang, J Andrew McCammo. The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis. PLoS computational biology. vol 1. issue 6. 2006-09-29. PMID:16299589. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. |
2006-09-29 |
2023-08-12 |
mouse |
| Koichiro Kawashima, Takeshi Fuji. Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Frontiers in bioscience : a journal and virtual library. vol 9. 2006-09-28. PMID:15353271. |
lymphocytes express most components of the cholinergic system including acetylcholine (ach), muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), choline acetyltransferase (chat), high affinity choline transporter and acetylcholinesterase. |
2006-09-28 |
2023-08-12 |
Not clear |
| Yasuharu Tokuda, Makiko Kikuchi, Osamu Takahashi, Gerald H Stei. Prehospital management of sarin nerve gas terrorism in urban settings: 10 years of progress after the Tokyo subway sarin attack. Resuscitation. vol 68. issue 2. 2006-09-26. PMID:16325985. |
it causes the clinical syndrome of cholinergic hyperstimulation by inhibition of the crucial enzyme acetylcholinesterase. |
2006-09-26 |
2023-08-12 |
Not clear |
| Paulo Correia-de-Sá, Sara Adães, M Alexandrina Timóteo, Cátia Vieira, Teresa Magalhães-Cardoso, Carlos Nascimento, Margarida Duarte-Araúj. Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase. Autonomic neuroscience : basic & clinical. vol 126-127. 2006-09-25. PMID:16563876. |
data using the acetylcholinesterase inhibitor, physiostigmine (10 microm), and several subtype-specific muscarinic receptor antagonists, 4-damp (100 nm), af-dx 116 (10 microm) and muscarinic toxin-7 (1 nm), suggest that cholinergic motoneurons are endowed with muscarinic m3 autoreceptors facilitating the outflow of adenosine. |
2006-09-25 |
2023-08-12 |
rat |
| C T Sadashiva, J N Narendra Sharath Chandra, K C Ponnappa, T Veerabasappa Gowda, Kanchugarakoppal S Rangapp. Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 16. issue 15. 2006-09-11. PMID:16735118. |
synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in alzheimer's disease. |
2006-09-11 |
2023-08-12 |
Not clear |
| Ora Kofman, Andrea Berger, Ali Massarwa, Alon Friedman, Abed Abu Jaffa. Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy. Pediatric research. vol 60. issue 1. 2006-09-11. PMID:16788088. |
despite the critical role of acetylcholinesterase (ache) in cortical function and development, no long-term studies have been conducted in humans on the long-term sequelae of the disruption of the cholinergic system in early childhood. |
2006-09-11 |
2023-08-12 |
Not clear |
| Claudio Babiloni, Emanuele Cassetta, Gloria Dal Forno, Claudio Del Percio, Florinda Ferreri, Raffaele Ferri, Bartolo Lanuzza, Carlo Miniussi, Davide V Moretti, Flavio Nobili, Roberto D Pascual-Marqui, Guido Rodriguez, Gian Luca Romani, Serenella Salinari, Orazio Zanetti, Paolo M Rossin. Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders. NeuroImage. vol 31. issue 4. 2006-08-09. PMID:16600641. |
acetylcholinesterase inhibitors (achei) such as donepezil act in mild alzheimer's disease (ad) by increasing cholinergic tone. |
2006-08-09 |
2023-08-12 |
Not clear |
| Robert M Cohen, Richard E Carson, Francesca Filbey, Joanna Szczepanik, Trey Sunderlan. Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP. Synapse (New York, N.Y.). vol 60. issue 1. 2006-08-04. PMID:16598702. |
to examine the effects of aging and the apoe-epsilon4 allele on the response of the muscarinic component of cholinergic pathway to pharmacologic augmentation, two [18f]fp-tztp pet scans were conducted in 19 subjects varying in age from 22 to 74 years, the first served as baseline for the second scan that was performed while the subjects were either infused with saline (n = 6) or with the acetylcholinesterase inhibitor physostigmine (6 with an apoe-epsilon4 allele and 7 without an apoe-epsilon4 allele). |
2006-08-04 |
2023-08-12 |
human |