| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luigia Trabace, Tommaso Cassano, Marilena Colaianna, Silvia Castrignanò, Arcangela Giustino, Salvatore Amoroso, Luca Steardo, Vincenzo Cuom. Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel acetylcholinesterase inhibitor, in rat prefrontal cortex: an in vivo study. Pharmacological research. vol 56. issue 4. 2008-02-11. PMID:17822918. |
ganstigmine (chf2819) is a novel, orally active acetylcholinesterase inhibitor that induces a stimulation of brain cholinergic transmission. |
2008-02-11 |
2023-08-12 |
rat |
| Alemayehu A Gorfe, Chia-en A Chang, Ivaylo Ivanov, J Andrew McCammo. Dynamics of the acetylcholinesterase tetramer. Biophysical journal. vol 94. issue 4. 2008-02-11. PMID:17921202. |
acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. |
2008-02-11 |
2023-08-12 |
Not clear |
| Satvinder Kaur, Adrienne Junek, Michelle A Black, Kazue Semb. Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 2. 2008-02-08. PMID:18184792. |
relative to artificial csf (acsf) controls, ibo injections decreased parvalbumin and cholinergic neurons in the caudal bf by 43 and 21%, respectively, and cortical acetylcholinesterase staining by 41%. |
2008-02-08 |
2023-08-12 |
rat |
| Satvinder Kaur, Adrienne Junek, Michelle A Black, Kazue Semb. Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 2. 2008-02-08. PMID:18184792. |
sap injections nonsignificantly decreased parvalbumin neurons by 11%, but significantly decreased cholinergic neurons by 69% and cortical acetylcholinesterase by 84%. |
2008-02-08 |
2023-08-12 |
rat |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
understanding the mechanism of action of organophosphates (op)/nerve agents -- irreversible acetylcholinesterase (ache, ec 3.1.1.7) inhibition at the cholinergic synapses followed by metabolic dysbalance of the organism -- two therapeutic principles for antidotal treatment are derived. |
2008-02-04 |
2023-08-12 |
Not clear |
| Jacques-Philippe Colletier, Antoine Royant, Alexandre Specht, Benoît Sanson, Florian Nachon, Patrick Masson, Giuseppe Zaccai, Joel L Sussman, Maurice Goeldner, Israel Silman, Dominique Bourgeois, Martin Wei. Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Acta crystallographica. Section D, Biological crystallography. vol 63. issue Pt 11. 2008-01-25. PMID:18007027. |
acetylcholinesterase plays a crucial role in nerve-impulse transmission at cholinergic synapses. |
2008-01-25 |
2023-08-12 |
Not clear |
| I Swapna, K V SathyaSaikumar, Ch R K Murthy, A Dutta Gupta, B Senthilkumara. Alterations in kinetic and thermotropic properties of cerebral membrane-bound acetylcholineesterase during thioacetamide-induced hepatic encephalopathy: correlation with membrane lipid changes. Brain research. vol 1153. 2008-01-09. PMID:17482580. |
acetylcholinesterase (ache) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. |
2008-01-09 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences. vol 80. issue 21. 2008-01-02. PMID:17395211. |
interleukin-2 (il-2) and isoforms of acetylcholinesterase (ache) were estimated in different brain areas as marker for neuroinflammation and cholinergic activity respectively. |
2008-01-02 |
2023-08-12 |
mouse |
| Yoram Finkelstein, Dejan Milatovic, Michael Aschne. Modulation of cholinergic systems by manganese. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17920128. |
in fact, a number of cholinergic synaptic mechanisms are putative targets for manganese activity: presynaptic choline uptake, quantal release of acetylcholine into the synaptic cleft, postsynaptic binding of acetylcholine to receptors and its synaptic degradation by acetylcholinesterase. |
2007-12-26 |
2023-08-12 |
Not clear |
| Dong Hyun Kim, Byung Hoon Yoon, Yong-Won Kim, Seungjoo Lee, Bum Young Shin, Ji Wook Jung, Hyoung Ja Kim, Yong Sup Lee, Jae Sue Choi, Sun Yeou Kim, Kyung-Tae Lee, Jong Hoon Ry. The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Journal of pharmacological sciences. vol 105. issue 1. 2007-12-20. PMID:17895591. |
these results suggest that coe attenuates memory impairment induced by scopolamine or 2vo and that these effects are mediated by enhancing the cholinergic nervous system via acetylcholinesterase inhibition. |
2007-12-20 |
2023-08-12 |
mouse |
| Gregory P Mullen, Eleanor A Mathews, Mai H Vu, Jerrod W Hunter, Dennis L Frisby, Angie Duke, Kiely Grundahl, Jamie D Osborne, John A Crowell, James B Ran. Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons. Genetics. vol 177. issue 1. 2007-12-18. PMID:17603106. |
cho-1 null mutants are viable and exhibit mild deficits in cholinergic behavior; they are slightly resistant to the acetylcholinesterase inhibitor aldicarb, and they exhibit reduced swimming rates in liquid. |
2007-12-18 |
2023-08-12 |
caenorhabditis_elegans |
| A Baydin, D Aygun, M Yazici, A Karatas, T Deniz, T Yarda. Is there a relationship between the blood cholinesterase and QTc interval in the patients with acute organophosphate poisoning? International journal of clinical practice. vol 61. issue 6. 2007-12-17. PMID:17504354. |
organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (che). |
2007-12-17 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Lester G Sultato. Concentration-dependent binding of chlorpyrifos oxon to acetylcholinesterase. Toxicological sciences : an official journal of the Society of Toxicology. vol 100. issue 1. 2007-12-06. PMID:17702992. |
the organophosphorus insecticides have been known for many years to cause cholinergic crisis in humans as a result of the inhibition of the critical enzyme acetylcholinesterase. |
2007-12-06 |
2023-08-12 |
human |
| Seung-O Ko, Tak-Heun Kim, Hye Kyung Lee, Jeong-Chae Lee, Eui-Sic Ch. Temporospatial localization of acetylcholinesterase activity in the dental epithelium during mouse tooth development. Life sciences. vol 81. issue 15. 2007-12-06. PMID:17905311. |
acetylcholinesterase (ache), a principal modulator of cholinergic neurotransmission, also has been demonstrated to be involved in the morphogenetic processes of neuronal and non-neuronal tissues. |
2007-12-06 |
2023-08-12 |
mouse |
| Irene Simintzi, Kleopatra H Schulpis, Panagoula Angelogianni, Charis Liapi, Stylianos Tsakiri. The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats. Pharmacological research. vol 56. issue 2. 2007-11-01. PMID:17580119. |
neurological disturbances have been implicated with aspartame (asp) consumption and the cholinergic system with acetylcholinesterase (ache) seems actively involved. |
2007-11-01 |
2023-08-12 |
rat |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| Joseph S Ulphani, Rishi Arora, Jack H Cain, Roger Villuendas, Sharon Shen, David Gordon, Firdous Inderyas, Laura A Harvey, Alexander Morris, Jeffrey J Goldberger, Alan H Kadis. The ligament of Marshall as a parasympathetic conduit. American journal of physiology. Heart and circulatory physiology. vol 293. issue 3. 2007-10-19. PMID:17545480. |
hearts were also stained for acetylcholinesterase to identify epicardial cholinergic nerves. |
2007-10-19 |
2023-08-12 |
Not clear |
| I V Coutinho-Abreu, V Q Balbino, J G Valenzuela, I V Sonoda, J M Ramalho-Ortigã. Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae). Journal of medical entomology. vol 44. issue 4. 2007-10-19. PMID:17695019. |
acetylcholinesterase (ache) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides. |
2007-10-19 |
2023-08-12 |
Not clear |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |