| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| J N Narendra Sharath Chandra, Manish Malviya, C T Sadashiva, M N Subhash, Kanchugarakoppal S Rangapp. Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models. Neurochemistry international. vol 52. issue 3. 2008-06-20. PMID:17719699. |
among these are cholinergic agents, which include muscarinic agonists, acetylcholinesterase inhibitors, and acetylcholine releasing agents. |
2008-06-20 |
2023-08-12 |
rat |
| H Aardema, J H J M Meertens, J J M Ligtenberg, O M Peters-Polman, J E Tulleken, J G Zijlstr. Organophosphorus pesticide poisoning: cases and developments. The Netherlands journal of medicine. vol 66. issue 4. 2008-06-20. PMID:18424861. |
through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. |
2008-06-20 |
2023-08-12 |
Not clear |
| Hua Jiang, Xue-Jun Zhan. Acetylcholinesterase and apoptosis. A novel perspective for an old enzyme. The FEBS journal. vol 275. issue 4. 2008-06-17. PMID:18205833. |
acetylcholinesterase is indispensable for terminating acetylcholine-mediated neurotransmission at cholinergic synapses. |
2008-06-17 |
2023-08-12 |
Not clear |
| L R Vieira, A Sousa, M F Frasco, I Lima, F Morgado, L Guilhermin. Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae). The Science of the total environment. vol 395. issue 2-3. 2008-06-09. PMID:18346779. |
all the substances inhibited p. microps acetylcholinesterase (ache) indicating that they have at least one mechanism of neurotoxicity in common: the disruption of cholinergic transmission by inhibition of ache. |
2008-06-09 |
2023-08-12 |
Not clear |
| Anurag Kuhad, Kanwaljit Chopr. Effect of sesamol on diabetes-associated cognitive decline in rats. Experimental brain research. vol 185. issue 3. 2008-06-03. PMID:17955223. |
acetylcholinesterase activity, a marker of cholinergic dysfunction, was increased by 80% in the cerebral cortex of diabetic rats. |
2008-06-03 |
2023-08-12 |
rat |
| Koichiro Kawashima, Takeshi Fuji. Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance. Journal of pharmacological sciences. vol 106. issue 2. 2008-05-22. PMID:18285657. |
cholinergic components, including ach, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ach receptors (machrs and nachrs, respectively) have been identified in numerous non-neuronal cells and tissues, including keratinocytes, cancer cells, immune cells, urinary bladder, airway epithelial cells, vascular endothelial cells, and reproductive organs, among many others. |
2008-05-22 |
2023-08-12 |
Not clear |
| Antonio Contestabile, Elisabetta Ciani, Andrea Contestabil. The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases. Neurochemical research. vol 33. issue 2. 2008-05-05. PMID:17940885. |
during the last few years, indeed, cholinergic replacement therapies, mainly based on the use of acetylcholinesterase inhibitors to increase synaptic availability of acetylcholine, have been exploited on the assumption that they could ameliorate the progression of the dementia from its initial stages. |
2008-05-05 |
2023-08-12 |
mouse |
| F Amenta, S K Tayebat. Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction. Current medicinal chemistry. vol 15. issue 5. 2008-05-01. PMID:18289004. |
ach released from cholinergic synapses is hydrolyzed by acetylcholinesterase into choline and acetyl coenzyme a and almost 50% of choline derived from ach hydrolysis is recovered by a high-affinity choline transporter. |
2008-05-01 |
2023-08-12 |
Not clear |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |
| Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pop. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. vol 50. issue 2. 2008-04-23. PMID:18166255. |
as with other organophosphates, tcvp elicits toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and cholinergic signs. |
2008-04-23 |
2023-08-12 |
Not clear |
| Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pop. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. vol 50. issue 2. 2008-04-23. PMID:18166255. |
furthermore, the results suggest that recommended dosing levels of the tcvp-containing larvacide in horses are unlikely to affect acetylcholinesterase activities or disrupt cholinergic neurotransmission in target tissues. |
2008-04-23 |
2023-08-12 |
Not clear |
| Ora Kofman, Yehoshua Shavit, Sarit Ashkenazi, Shai Gaba. Habituation, discrimination and anxiety in transgenic mice overexpressing acetylcholinesterase splice variants. Brain research. vol 1185. 2008-03-28. PMID:17963737. |
tgs and tgr transgenic mice overexpress different splice variants of acetylcholinesterase and serve as models for genetic disruption of the cholinergic system. |
2008-03-28 |
2023-08-12 |
mouse |
| E Bruder, Y Knecht, M Kasper, R Chaffard, S Ipsen, L Terracciano, W A Meier-Rug. [Enzyme histochemical diagnosis of gastrointestinal motility disorders. A laboratory guide]. Der Pathologe. vol 28. issue 2. 2008-03-12. PMID:17308909. |
the acetylcholinesterase staining reaction shows the cholinergic nerve fibre network of the muscularis mucosae and muscularis propria, and correlates with their acetylcholinesterase activity. |
2008-03-12 |
2023-08-12 |
Not clear |
| Anurag Kuhad, Kanwaljit Chopr. Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. European journal of pharmacology. vol 576. issue 1-3. 2008-03-06. PMID:17822693. |
acetylcholinesterase activity, a marker of cholinergic dysfunction, was increased by 80% in the cerebral cortex of diabetic rats. |
2008-03-06 |
2023-08-12 |
rat |
| J E Cohen, G Zimmerman, N Melamed-Book, A Friedman, A Dori, H Sore. Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells. Hippocampus. vol 18. issue 2. 2008-03-03. PMID:17960645. |
because cholinergic neurotransmission influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (ache) activity, expression level, and alternative splicing, may provide a link between these processes. |
2008-03-03 |
2023-08-12 |
mouse |
| Chen-Chang Yang, Jou-Fang Den. Intermediate syndrome following organophosphate insecticide poisoning. Journal of the Chinese Medical Association : JCMA. vol 70. issue 11. 2008-02-26. PMID:18063499. |
previously proposed mechanisms of ims include different susceptibility of various cholinergic receptors, muscle necrosis, prolonged acetylcholinesterase inhibition, inadequate oxime therapy, downregulation or desensitization of postsynaptic acetylcholine receptors, failure of postsynaptic acetylcholine release, and oxidative stress-related myopathy. |
2008-02-26 |
2023-08-12 |
Not clear |
| V A Campbell, A Gowra. Alzheimer's disease; taking the edge off with cannabinoids? British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17828287. |
delta 9-tetrahydrocannabinol can also inhibit acetylcholinesterase activity and limit amyloidogenesis which may improve cholinergic transmission and delay disease progression. |
2008-02-25 |
2023-08-12 |
Not clear |
| Pravesh Solanki, Alina M Cuprian-Beltechi, Thomas C Cunnan. Cholinergic innervation of the guinea-pig isolated vas deferens. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 4. 2008-02-21. PMID:17992517. |
these experimental data show that there is a functional cholinergic innervation in the guinea-pig vas deferens whose action is limited by acetylcholinesterase, blocked by cyclopentolate and mediated through m3 receptors. |
2008-02-21 |
2023-08-12 |
mouse |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |