| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Banni, Z Bouraoui, C Clerandeau, J F Narbonne, H Boussett. Mixture toxicity assessment of cadmium and benzo[a]pyrene in the sea worm Hediste diversicolor. Chemosphere. vol 77. issue 7. 2009-12-21. PMID:19758679. |
the cholinergic system was evaluated using the acetylcholinesterase activity (ache). |
2009-12-21 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |
| Anne Dick, Rodney For. Cholinergic and oxidative stress mechanisms in sudden infant death syndrome. Acta paediatrica (Oslo, Norway : 1992). vol 98. issue 11. 2009-12-11. PMID:19706020. |
to determine whether biochemical parameters of cholinergic and oxidative stress function including red cell acetylcholinesterase (ache), serum/plasma thyroglobulin, selenium, iron, ferritin, vitamins c, e, and a affect risk in apparent life-threatening event (alte), sudden infant death syndrome (sids), and sudden unexpected death in infancy (sudi). |
2009-12-11 |
2023-08-12 |
Not clear |
| K Campbell-Dittmeyer, G A Hicks, D L Earnest, B Greenwood-Van Meervel. Increased colonic transit in rats produced by a combination of a cholinesterase inhibitor with a 5-HT4 receptor agonist. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 11. 2009-12-04. PMID:19210632. |
the acetylcholinesterase inhibitor, neostigmine, and the 5-ht(4) receptor partial agonist tegaserod, are two agents with known prokinetic activity which work by different mechanisms that result in increased levels of ach at cholinergic synapses innervating intestinal smooth muscle. |
2009-12-04 |
2023-08-12 |
rat |
| H R Girisha, J N Narendra Sharath Chandra, Sriramamurthy Boppana, Manish Malviya, C T Sadashiva, Kanchugarakoppal S Rangapp. Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase. European journal of medicinal chemistry. vol 44. issue 10. 2009-10-14. PMID:19493592. |
hypocholinergic function associated with alzheimer's disease (ad) is well-accepted hypothesis, in this regard, many research attempts have been made to elevate the reduced cholinergic neurotransmission, among them two main treatment strategies were widely explored, namely stimulation of muscarinic receptor 1 and/or reversible inhibition of acetylcholinesterase (ache) enzyme. |
2009-10-14 |
2023-08-12 |
rat |
| Ramanna V Rajesh, Loganathan Chitra, Paul G Layer, Rathanam Boopath. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. vol 91. issue 9. 2009-10-14. PMID:19607873. |
the appearance of cholinergic trait often precedes synaptogenesis, indicating the involvement of cholinesterase proteins in nervous system development, particularly so acetylcholinesterase (ache). |
2009-10-14 |
2023-08-12 |
chicken |
| Laura Cucurachi, Paolo Immovilli, Franco Granella, Giovanni Pavesi, Luigi Cattane. Short-latency afferent inhibition predicts verbal memory performance in patients with multiple sclerosis. Journal of neurology. vol 255. issue 12. 2009-10-12. PMID:18854915. |
acetylcholinesterase inhibitors have been proposed in the treatment of cognitive impairment in ms. short-latency afferent inhibition (sai) is a cortical phenomenon assessed by a transcranial magnetic stimulation protocol that provides an in vivo index of central cholinergic function. |
2009-10-12 |
2023-08-12 |
human |
| Yuanxin Chen, Victor V Dyakin, Craig A Branch, Babak Ardekani, Dunsheng Yang, David N Guilfoyle, Jesse Peterson, Corrinne Peterhoff, Stephen D Ginsberg, Anne M Cataldo, Ralph A Nixo. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18180075. |
basal forebrain cholinergic neurons (bfcns) in the msn, identified by choline acetyltransferase (chat) and nerve growth factor receptors p75(ntr) and trka immunolabeling were reduced in ts65dn brains and in situ acetylcholinesterase (ache) activity was depleted distally along projecting cholinergic fibers, and selectively on pre- and postsynaptic profiles in these target areas. |
2009-10-09 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Daniele Tomassoni, Francesco Ament. Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats. Journal of the neurological sciences. vol 283. issue 1-2. 2009-10-08. PMID:19304299. |
the present study was designed to assess if treatment with acetylcholinesterase inhibitor galantamine and the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphoryl-choline) alone or in association has any protective effect on brain microanatomy in spontaneously hypertensive rats (shr) used as an animal model of vascular dementia (vad). |
2009-10-08 |
2023-08-12 |
rat |
| Deborah Siegal, Mark A Kotowycz, Michelle Methot, Adrian Baranchu. Complete heart block following intentional carbamate ingestion. The Canadian journal of cardiology. vol 25. issue 8. 2009-10-08. PMID:19668791. |
organophosphates and carbamate compounds are acetylcholinesterase inhibitors used as agricultural insecticides and represent a common cause of cholinergic toxicity. |
2009-10-08 |
2023-08-12 |
Not clear |
| Atsushi Tanaka, Shoichi Koga, Yoshihiro Hiramats. Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. Internal medicine (Tokyo, Japan). vol 48. issue 14. 2009-10-01. PMID:19602789. |
acetylcholinesterase inhibitors (achis) are widely used in the treatment of mild-to-moderate alzheimer's disease (ad), but their cholinergic effects could generate adverse side effects in the cardiovascular system. |
2009-10-01 |
2023-08-12 |
Not clear |
| Runa S Naik, Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 12. issue 1. 2009-09-25. PMID:19470293. |
alzheimer s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (ache). |
2009-09-25 |
2023-08-12 |
mouse |
| Nadine Gravett, Adhil Bhagwandin, Kjell Fuxe, Paul R Mange. Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the rock hyrax, Procavia capensis. Journal of chemical neuroanatomy. vol 38. issue 1. 2009-09-18. PMID:19559986. |
the nuclear subdivisions of the cholinergic, putative catecholaminergic and serotonergic systems within the brain of the rock hyrax (procavia capensis) were identified following immunohistochemistry for acetylcholinesterase, tyrosine hydroxylase and serotonin. |
2009-09-18 |
2023-08-12 |
Not clear |
| Jazmin I Acosta, Loretta Mayer, Joshua S Talboom, Candy Wing S Tsang, Constance J Smith, Craig K Enders, Heather A Bimonte-Nelso. Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system. Endocrinology. vol 150. issue 9. 2009-09-16. PMID:19470706. |
we directly compared vcd and ovx models to examine whether type of hormone loss (transitional vs. surgical) impacted cognition as assessed on a maze battery as well as the cholinergic system tested via scopolamine mnemonic challenge and brain acetylcholinesterase activity. |
2009-09-16 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| José Pedro Almeida, Filomena Almeida Carvalho, Teresa Freitas, Carlota Saldanh. Modulation of hemorheological parameters by the erythrocyte redox thiol status. Clinical hemorheology and microcirculation. vol 40. issue 2. 2009-08-18. PMID:19029635. |
effects of the non-neuronal cholinergic elements, especially acetylcholinesterase, on the erythrocyte hemorheological parameters were characterized in the past. |
2009-08-18 |
2023-08-12 |
Not clear |
| Debora Cutuli, Francesca Foti, Laura Mandolesi, Paola De Bartolo, Francesca Gelfo, Francesca Federico, Laura Petrosin. Cognitive performances of cholinergically depleted rats following chronic donepezil administration. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19221411. |
since acute and chronic administration of the acetylcholinesterase inhibitors, namely donepezil, improves cognitive functions in patients afflicted by mild to moderate dementia and reverses memory deficits in experimental models of learning and memory, it seemed interesting to assess the effects of chronic donepezil treatment on cognitive functions in adult rats with forebrain cholinergic depletion. |
2009-08-12 |
2023-08-12 |
rat |
| Debora Cutuli, Francesca Foti, Laura Mandolesi, Paola De Bartolo, Francesca Gelfo, Francesca Federico, Laura Petrosin. Cognitive performances of cholinergically depleted rats following chronic donepezil administration. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19221411. |
the present data indicate positive effects of chronic donepezil treatment on specific cognitive performances, suggesting that an aimed use of acetylcholinesterase inhibitors, targeting some symptoms more than others, may be beneficial in the case of cholinergic hypofunction. |
2009-08-12 |
2023-08-12 |
rat |
| Paola De Bartolo, Francesca Gelfo, Laura Mandolesi, Francesca Foti, Debora Cutuli, Laura Petrosin. Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19494441. |
although clinical and experimental research has demonstrated that acetylcholinesterase inhibitors, such as donepezil, are able to enhance cognitive functioning in intact subjects as well as in patients affected by different degrees of dementia, no morphological study has ever analyzed whether donepezil treatment is able to modify neocortical neuronal morphology in the intact brain and in response to cholinergic depletion. |
2009-08-12 |
2023-08-12 |
human |
| Renato Scacchi, Giuseppe Gambina, Giuseppe Moretto, Rosa Maria Corb. Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 4. 2009-07-30. PMID:18780301. |
we have studied the variation at the genes of three enzymes of the cholinergic system: acetylcholinesterase, butyrylcholinesterase, and choline acetyltransferase. |
2009-07-30 |
2023-08-12 |
human |