| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wolfgang Härtig, Johannes Kacza, Bernd-Reiner Paulke, Jens Grosche, Ute Bauer, Anke Hoffmann, Paul W Elsinghorst, Michael Gütscho. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. The European journal of neuroscience. vol 31. issue 1. 2010-04-16. PMID:20092557. |
the drastic loss of cholinergic projection neurons in the basal forebrain is a hallmark of alzheimer's disease (ad), and drugs most frequently applied for the treatment of dementia include inhibitors of the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2010-04-16 |
2023-08-12 |
mouse |
| Iuga Liepelt, Alexandra Gaenslen, Jana Godau, Adriana Di Santo, Katharine J Schweitzer, Thomas Gasser, Daniela Ber. Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 1. 2010-04-16. PMID:20129321. |
based on the known involvement of the cholinergic system in psp patients, and because rivastigmine, in contrast to other cholinesterase inhibitors, inhibits both acetylcholinesterase and butyrylcholinesterase, we discuss clinical observations of five patients suffering from psp and dementia who were all treated with rivastigmine over a period of 3 to 6 months. |
2010-04-16 |
2023-08-12 |
Not clear |
| N Suganthy, S Karutha Pandian, K Pandima Dev. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19897016. |
until date the only symptomatic treatment for this disease is based on the "cholinergic hypothesis" where the drugs enhance acetylcholine levels in the brain by inhibiting acetylcholinesterase (ache). |
2010-04-06 |
2023-08-12 |
Not clear |
| Jessica J Roland, Michelle Levinson, Ryan P Vetreno, Lisa M Savag. Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006600. |
several lines of evidence suggest that acetylcholinesterase inhibitors (ache) have their cognitive enhancing effects by stimulating cholinergic receptors within the medial septum. |
2010-03-30 |
2023-08-12 |
rat |
| W A Prado, T B Dia. Postoperative analgesia induced by intrathecal neostigmine or bethanechol in rats. Clinical and experimental pharmacology & physiology. vol 36. issue 7. 2010-03-11. PMID:19076163. |
cholinergic agonists and acetylcholinesterase inhibitors, such as neostigmine, produce a muscarinic receptor-mediated antinociception in several animal species that depends on activation of spinal cholinergic neurons. |
2010-03-11 |
2023-08-12 |
rat |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effect of Bupleurum falcatum on the stress-induced impairment of spatial working memory in rats. Biological & pharmaceutical bulletin. vol 32. issue 8. 2010-02-22. PMID:19652379. |
in addition, we examined the effects of bf treatment on the cholinergic system, as indicated by changes in neuronal choline acetyltransferase (chat) and acetylcholinesterase (ache) immunoreactivity in the hippocampus. |
2010-02-22 |
2023-08-12 |
rat |
| Iftach Shaked, Ari Meerson, Yochai Wolf, Ran Avni, David Greenberg, Adi Gilboa-Geffen, Hermona Sore. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity. vol 31. issue 6. 2010-02-09. PMID:20005135. |
microrna-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. |
2010-02-09 |
2023-08-12 |
mouse |
| R T Robertson, J Baratta, J Yu, F M LaFerl. Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19772895. |
axonal tract tracing techniques demonstrated that the pattern of axon terminal labeling in layer iii of rsg, following placement of dii in medial septum, is remarkably similar to the pattern of cholinergic axons in rsg, as detected by acetylcholinesterase histochemical staining, choline acetyltransferase immunoreactivity, or p75 receptor immunoreactivity; this pattern also is strikingly similar to the band of abeta immunoreactivity. |
2010-02-08 |
2023-08-12 |
mouse |
| Antonio M G de Dieg. Electrophysiological and morphological features underlying neurotransmission efficacy at the splanchnic nerve-chromaffin cell synapse of bovine adrenal medulla. American journal of physiology. Cell physiology. vol 298. issue 2. 2010-02-04. PMID:19940070. |
cholinergic innervation was assessed using the acetylcholinesterase staining technique on the supposition that the innervation pattern is a determinant of the kind of stimuli chromaffin cells can receive. |
2010-02-04 |
2023-08-12 |
cattle |
| Antonio M G de Dieg. Electrophysiological and morphological features underlying neurotransmission efficacy at the splanchnic nerve-chromaffin cell synapse of bovine adrenal medulla. American journal of physiology. Cell physiology. vol 298. issue 2. 2010-02-04. PMID:19940070. |
it is concluded that 1) a reliable method to produce frequency-controlled aps by applying defined current injection waveforms is achieved; 2) the aps thus generated have essentially the same features as those spontaneously emitted by the cell and those elicited by fast-ach perifusion; 3) the higher frequencies attainable peak at around 30 hz; and 4) the bovine adrenal medulla shows abundant cholinergic innervation, and chromaffin cells show strong acetylcholinesterase staining, consistent with a tight cholinergic presynaptic control of firing frequency. |
2010-02-04 |
2023-08-12 |
cattle |
| Tetsuro Konishi, Masayuki Kousaka, Kentarou Yamakawa, Masaru Matsui, Kiyoe Oht. [Effects of acetylcholinesterase inhibitors on patients with MuSK antibody positive myasthenia gravis]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 10. 2010-01-19. PMID:19999149. |
when acetylcholinesterase inhibitors medication is tried to patients with musk antibodies, if necessary, a small dosage of inhibitors should be used to avoid cholinergic hypersensitivity. |
2010-01-19 |
2023-08-12 |
Not clear |
| Jonghan Shin, Gangadharan Gireesh, Seong-Wook Kim, Duk-Soo Kim, Sukyung Lee, Yeon-Soo Kim, Masahiko Watanabe, Hee-Sup Shi. Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 49. 2010-01-19. PMID:20007462. |
furthermore, increasing cholinergic signaling by administering an acetylcholinesterase inhibitor cured the anomalies in both cholinergic theta rhythm and anxiety behavior observed in plc-beta 4(-/-) mice. |
2010-01-19 |
2023-08-12 |
mouse |
| Kelly Juliana Seibt, Renata da Luz Oliveira, Eduardo Pacheco Rico, Renato Dutra Dias, Mauricio Reis Bogo, Carla Denise Bona. Typical and atypical antipsychotics alter acetylcholinesterase activity and ACHE expression in zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 150. issue 1. 2010-01-12. PMID:19444963. |
these findings have suggested that the alterations in zebrafish acetylcholinesterase could reveal molecular mechanisms related to cholinergic signaling induced by antipsychotic treatment. |
2010-01-12 |
2023-08-12 |
zebrafish |
| K J A Rodrigues, M B Santana, J L M Do Nascimento, D L W Picanço-Diniz, L A L Maués, S N Santos, V M M Ferreira, M Alfonso, R Durán, L R F Far. Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats. Ecotoxicology and environmental safety. vol 73. issue 1. 2010-01-12. PMID:19481804. |
this would produce an alteration on the cholinergic transmission, modulating the anxiety behavior, acetylcholinesterase levels and hacu. |
2010-01-12 |
2023-08-12 |
rat |
| Bárbara Aisa, Francisco Javier Gil-Bea, Beatriz Marcos, Rosa Tordera, Berta Lasheras, Joaquín Del Río, Maria J Ramíre. Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: involvement of the HPA axis. Psychoneuroendocrinology. vol 34. issue 10. 2010-01-12. PMID:19505767. |
ms rats subjected to a cholinergic lesion by administration of the immunotoxin 192 igg-saporin, showed significant decreases in both choline acetyltransferase (chat) and acetylcholinesterase (ache) activity compared to control lesioned rats. |
2010-01-12 |
2023-08-12 |
rat |
| Julie Espallergues, Laurie Galvan, Florence Sabatier, Vanessa Rana-Poussine, Tangui Maurice, Arnaud Chatonne. Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs. Behavioural brain research. vol 206. issue 2. 2010-01-06. PMID:19766675. |
decrease in the expression or activity of acetylcholinesterase (ache) enzymatic activity results in increased cholinergic tonus in the brain and periphery, with concomitant regulations of nicotinic and muscarinic receptors expression. |
2010-01-06 |
2023-08-12 |
mouse |
| Yossi Rosman, Igor Makarovsky, Yedidia Bentur, Shai Shrot, Tsvika Dushnistky, Amir Krivo. Carbamate poisoning: treatment recommendations in the setting of a mass casualties event. The American journal of emergency medicine. vol 27. issue 9. 2010-01-06. PMID:19931761. |
carbamates, a group of reversible acetylcholinesterase inhibitors, could be potentially involved in such toxic mass casualty events because they can cause cholinergic crisis that could lead to fatality, similar to that of organophosphate poisoning. |
2010-01-06 |
2023-08-12 |
Not clear |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Alberto Ricci, Francesco Ament. Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry. Brain research. vol 1301. 2010-01-05. PMID:19748499. |
cholinergic neurotransmission markers investigated in frontal cortex, hippocampus and striatum were acetylcholine (ach), the synthesizing and catabolic enzymes choline acetyltransferase and acetylcholinesterase and the high affinity ach uptake system labeled with [(3)h]hemicholinium-3. |
2010-01-05 |
2023-08-12 |
rat |
| Rahul Deshmukh, Vivek Sharma, Sidharth Mehan, Nidhi Sharma, K L Bed. Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor. European journal of pharmacology. vol 620. issue 1-3. 2009-12-31. PMID:19699735. |
significant increase in acetylcholinesterase activity and lactate dehydrogenase levels was observed in the present model indicating cholinergic hypofunction and increase in neuronal cell damage. |
2009-12-31 |
2023-08-12 |
rat |
| Rahul Deshmukh, Vivek Sharma, Sidharth Mehan, Nidhi Sharma, K L Bed. Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor. European journal of pharmacology. vol 620. issue 1-3. 2009-12-31. PMID:19699735. |
chronic treatment with vinpocetine also reduced significantly the increase in acetylcholinesterase activity and lactate dehydrogenase levels indicating restorative capacity of vinpocetine with respect to cholinergic functions and preventing the neuronal damage. |
2009-12-31 |
2023-08-12 |
rat |