| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yael Abreu-Villaça, Cláudio C Filgueiras, Alex C Manhãe. Developmental aspects of the cholinergic system. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20060019. |
in the current review, we focus on the developmental aspects associated with major components of the cholinergic system: acetylcholine, choline acetyltransferase, vesicular acetylcholine transporter, high-affinity choline transporter, acetylcholinesterase, nicotinic and muscarinic receptors. |
2011-09-09 |
2023-08-12 |
mouse |
| Andrea Wever. Localisation of pre- and postsynaptic cholinergic markers in the human brain. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20170687. |
on the cholinergic site data based on the distribution of choline acetyltransferase-immunoreactive structures are in the focus, complemented by data from acetylcholinesterase and vesicular acetylcholine transporter studies. |
2011-09-09 |
2023-08-12 |
human |
| Reinhard Schliebs, Thomas Arend. The cholinergic system in aging and neuronal degeneration. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:21145918. |
indeed, there is abundant evidence that β-amyloid may trigger cholinergic dysfunction through action on α7 nicotinic acetylcholine receptors, affecting ngf signaling, mediating tau phosphorylation, interacting with acetylcholinesterase, and specifically affecting the proteome in cholinergic neurons. |
2011-09-09 |
2023-08-12 |
Not clear |
| Anne M Valle, Zoran Radic, Brinda K Rana, Vafa Mahboubi, Jennifer Wessel, Pei-an Betty Shih, Fangwen Rao, Daniel T O'Connor, Palmer Taylo. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21493754. |
cholinergic neurotransmission in the central and autonomic nervous systems regulates immediate variations in and longer-term maintenance of cardiovascular function with acetylcholinesterase (ache) activity that is critical to temporal responsiveness. |
2011-08-30 |
2023-08-12 |
human |
| Tetsuro Konish. [Myasthenia gravis with anti-acetylcholine receptor antibody or anti-muscle specific kinase antibody]. Brain and nerve = Shinkei kenkyu no shinpo. vol 63. issue 7. 2011-08-25. PMID:21747139. |
the adverse responses to a small dose of intravenous edrophonium chloride injection may support the clinical diagnosis of musk-mg. further, only small doses of acetylcholinesterase inhibitors are administered to patients with musk-mg in order to avoid cholinergic hyperactivity. |
2011-08-25 |
2023-08-12 |
Not clear |
| Dong Hyun Kim, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee, Byung-Tae Ki. Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies. Nuclear medicine and biology. vol 38. issue 4. 2011-08-23. PMID:21531291. |
acetylcholinesterase (ache) has been an important cholinergic factor for the diagnosis of alzheimer's disease (ad), because of reduced ache activity in the postmortem brains of ad patients. |
2011-08-23 |
2023-08-12 |
mouse |
| Tayfun Turan, Hasan Basri Izgi, Saliha Ozsoy, Fatih Tanrıverdi, Mustafa Basturk, Akif Asdemir, Aslı Beşirli, Ertugrul Esel, Seher Sofuogl. The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome. Psychiatry investigation. vol 6. issue 3. 2011-07-14. PMID:20046396. |
therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (dheas) in cfs patients before and after 4-week administration of galantamine hydrobromide, a selective acetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment. |
2011-07-14 |
2023-08-12 |
Not clear |
| Véronique Bernard, Emmanuelle Girard, Anna Hrabovska, Shelley Camp, Palmer Taylor, Benoit Plaud, Eric Krejc. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20883790. |
acetylcholinesterase (ache) terminates the action of acetylcholine at cholinergic synapses thereby preventing rebinding of acetylcholine to nicotinic postsynaptic receptors at the neuromuscular junction. |
2011-07-05 |
2023-08-12 |
mouse |
| Jin Gyu Choi, Woong Mo Yang, Tong Ho Kang, Myung Sook O. Effects of optimized-SopungSunkiwon on memory impairment and enhancement. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21256184. |
acetylcholinesterase (ache) inhibition assay was performed to investigate the cholinergic antagonistic effect of oss. |
2011-07-05 |
2023-08-12 |
mouse |
| L Stan Leung, Sophie Petropoulos, Bixia Shen, Tao Luo, Ian Herrick, N Rajakumar, Jingyi M. Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics. Experimental neurology. vol 228. issue 2. 2011-06-17. PMID:21295026. |
depletion of choline-acetyltransferase (chat)-immunoreactive cells in the nbm and decrease in optical density of acetylcholinesterase (ache) staining in the frontal and visual cortices confirmed a significant decrease in nbm cholinergic neurons in lesioned as compared to control rats. |
2011-06-17 |
2023-08-12 |
rat |
| Marwan Sabbagh, Jeffrey Cumming. Progressive cholinergic decline in Alzheimer's Disease: consideration for treatment with donepezil 23 mg in patients with moderate to severe symptomatology. BMC neurology. vol 11. 2011-06-14. PMID:21299848. |
herein, we review (1) the scientific data on the importance of cholinergic deficits in alzheimer's disease treatment strategies, (2) the rationale for the use of higher-dose acetylcholinesterase inhibitors in patients with advanced disease, and (3) recent clinical evidence supporting the use of higher-dose donepezil in patients with moderate to severe alzheimer's disease. |
2011-06-14 |
2023-08-12 |
Not clear |
| Thomas Mülle. Rivastigmine in the treatment of patients with Alzheimer's disease. Neuropsychiatric disease and treatment. vol 3. issue 2. 2011-05-17. PMID:19300554. |
inhibition of the breakdown of acetylcholine by blocking the enzymes acetylcholinesterase and butyrylcholinesterase with rivastigmine improves this cholinergic depletion. |
2011-05-17 |
2023-08-12 |
Not clear |
| Greg J Norman, John S Morris, Kate Karelina, Zachary M Weil, Ning Zhang, Yousef Al-Abed, Holly M Brothers, Gary L Wenk, Valentin A Pavlov, Kevin J Tracey, A Courtney Devrie. Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368056. |
cardiac arrest also induces alterations in numerous cellular components of central cholinergic signaling, including a reduction in choline acetyltransferase enzymatic activity and the number of choline acetyltransferase-positive neurons, as well as, reduced acetylcholinesterase and vesicular acetylcholine transporter mrna. |
2011-05-13 |
2023-08-12 |
Not clear |
| Marie-Christine Pardo. Therapeutic potential of some stress mediators in early Alzheimer's disease. Experimental gerontology. vol 46. issue 2-3. 2011-04-29. PMID:20870017. |
this review discussed the involvement of glucocorticoids, corticotrophin-releasing hormone (crh) and cholinergic stress reactions, through the induction of a protective splice variant of synaptic acetylcholinesterase (ache-r), in the progression of ad symptoms and neuropathological hallmarks and the impact of lifestyle factors. |
2011-04-29 |
2023-08-12 |
mouse |
| Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih H. The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies. Journal of biomedical science. vol 18. 2011-04-28. PMID:21251245. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system, and hence, inhibition of ache has emerged as one of the most promising strategies for the treatment of ad. |
2011-04-28 |
2023-08-12 |
Not clear |
| Naoko Shimizu, Tsutomu Nakahara, Yuko Kubota, Kenji Sakamoto, Kunio Ishi. Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder. Pharmacology. vol 86. issue 5-6. 2011-04-11. PMID:20980781. |
donepezil, an inhibitor of acetylcholinesterase, is used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease. |
2011-04-11 |
2023-08-12 |
rat |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
the early stages of alzheimer's disease are characterized by cholinergic deficits and the preservation of cholinergic function through the use of acetylcholinesterase inhibitors is the basis for current treatments of the disease. |
2011-03-30 |
2023-08-12 |
rat |
| Yechun Xu, Jacques-Philippe Colletier, Martin Weik, Guangrong Qin, Hualiang Jiang, Israel Silman, Joel L Sussma. Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. Biophysical journal. vol 99. issue 12. 2011-03-28. PMID:21156143. |
the principal role of acetylcholinesterase is termination of nerve impulse transmission at cholinergic synapses, by rapid hydrolysis of the neurotransmitter acetylcholine to acetate and choline. |
2011-03-28 |
2023-08-12 |
Not clear |
| V C Moser, S Padill. Esterase metabolism of cholinesterase inhibitors using rat liver in vitro. Toxicology. vol 281. issue 1-3. 2011-03-25. PMID:21237238. |
a variety of chemicals, such as organophosphate (op) and carbamate pesticides, nerve agents, and industrial chemicals, inhibit acetylcholinesterase (ache) leading to overstimulation of the cholinergic nervous system. |
2011-03-25 |
2023-08-12 |
rat |
| Yingjun Zhao, Xiaoying Wang, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu, Jia Fan, Xianghuo H. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology (Baltimore, Md.). vol 53. issue 2. 2011-03-18. PMID:21274871. |
acetylcholinesterase (ache) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. |
2011-03-18 |
2023-08-12 |
human |