| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jibran Y Khokhar, Rachel F Tyndal. Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 126. issue 2. 2012-07-16. PMID:22287024. |
chlorpyrifos is a commonly used insecticide that can be metabolically activated by cyp2b to the acetylcholinesterase inhibitor chlorpyrifos-oxon causing cholinergic overstimulation and neurotoxicity. |
2012-07-16 |
2023-08-12 |
human |
| Tanya Pinto, Krista L Lanctôt, Nathan Herrman. Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type. Ageing research reviews. vol 10. issue 4. 2012-06-26. PMID:21292041. |
while the etiology of bpsd has not been clearly delineated, studies assessing the benefits of acetylcholinesterase inhibitors on bpsd suggest that some of the neuropsychiatric symptoms of dementia such as agitation, apathy and psychosis may represent a specific central cholinergic deficiency syndrome. |
2012-06-26 |
2023-08-12 |
Not clear |
| Wagner Carlucci, Reginaldo Ceneviva, Sérgio Henrique Ferreira, Orlando Castro de Silv. Histological, biochemical and pharmacological characterization of the gastric muscular layer in Chagas disease. Acta cirurgica brasileira. vol 26 Suppl 2. 2012-06-19. PMID:22030819. |
to assess in vitro the correlation between the number of neurons and the sensitivity to cholinergic drugs and acetylcholinesterase activity in chagasic patients. |
2012-06-19 |
2023-08-12 |
Not clear |
| Ryohei Miyazaki, Toshihiro Ichiki, Toru Hashimoto, Jiro Ikeda, Aya Kamiharaguchi, Eriko Narabayashi, Hirohide Matsuura, Kotaro Takeda, Kenji Sunagaw. Acetylcholinesterase inhibitors attenuate angiogenesis. Clinical science (London, England : 1979). vol 123. issue 4. 2012-06-19. PMID:22369073. |
these findings suggest that cholinergic stimulation by acetylcholinesterase inhibitors suppresses angiogenesis through inhibition of pi3k-mediated il-1β induction, which is followed by reduction of vegf expression. |
2012-06-19 |
2023-08-12 |
mouse |
| Shani Ben-Ari, Keren Ofek, Shahar Barbash, Hanoch Meiri, Eugenia Kovalev, David Samuel Greenberg, Hermona Soreq, Shai Shoha. Similar cation channels mediate protection from cerebellar exitotoxicity by exercise and inheritance. Journal of cellular and molecular medicine. vol 16. issue 3. 2012-06-15. PMID:21507200. |
furthermore, exercise increased the number of acetylcholinesterase-positive fibres in the molecular layer, reduced cerebellar cytokine levels and suppressed serum acetylcholinesterase activity, suggesting anti-inflammatory protection by enhanced cholinergic signalling. |
2012-06-15 |
2023-08-12 |
mouse |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
this study has assessed the influence of 4 week treatment with two different cholinergic enhancing drugs, the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphorylcholine) or the acetylcholinesterase (ache) inhibitor galantamine on high affinity choline uptake transporter (cht) and vesicular ach transporter (vacht) expression in the brain of spontaneously hypertensive rats (shr). |
2012-06-14 |
2023-08-12 |
rat |
| Miroslav Pohank. Cholinesterases, a target of pharmacology and toxicology. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 155. issue 3. 2012-05-23. PMID:22286807. |
of the two types, butyrylcholinesterase and acetylcholinesterase (ache), ache plays the key role in ending cholinergic neurotransmission. |
2012-05-23 |
2023-08-12 |
Not clear |
| Brian C Geyer, Shani Ben Ari, Shahar Barbash, Jacqueline Kilbourne, Tsafrir S Mor, Hermona Sore. Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22093924. |
finally, in vivo administration of paraoxon or recombinant acetylcholinesterase, leading respectively to either gain or loss of cholinergic signaling, modified muscle expression of key mrna processing factors and several of their apoptosis-related targets. |
2012-05-10 |
2023-08-12 |
Not clear |
| Alessandra Antunes dos Santos, Danúbia Bonfanti dos Santos, Renata Pietsch Ribeiro, Dirleise Colle, Kaite Cristiane Peres, Júlia Hermes, Anderson Machado Barbosa, Alcir Luiz Dafré, Andreza Fabro de Bem, Kamil Kuca, Marcelo Farin. Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21723318. |
the organophosphorus (op) pesticide malathion is a highly neurotoxic compound and its toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome. |
2012-05-02 |
2023-08-12 |
mouse |
| Hanan F Aly, Fateheya M Metwally, Hanaa H Ahme. Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. Acta biochimica Polonica. vol 58. issue 4. 2012-05-02. PMID:22146133. |
also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. |
2012-05-02 |
2023-08-12 |
rat |
| Vesna A Eterović, Dinely Pérez, Antonio H Martins, Brenda L Cuadrado, Marimée Carrasco, P A Ferchmi. A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 7. 2012-04-26. PMID:21569834. |
many neurotoxic organophosphates (ops) inhibit acetylcholinesterase (ache) and as a result can cause a life threatening cholinergic crisis. |
2012-04-26 |
2023-08-12 |
Not clear |
| Michael Bubser, Nellie Byun, Michael R Wood, Carrie K Jone. Muscarinic receptor pharmacology and circuitry for the modulation of cognition. Handbook of experimental pharmacology. issue 208. 2012-04-25. PMID:22222698. |
conversely, both direct-acting muscarinic receptor agonists and indirect-acting muscarinic cholinergic agonists, such as acetylcholinesterase inhibitors, have shown cognition-enhancing properties, including improvements in normal cognitive function, reversal of cognitive deficits induced by muscarinic receptor antagonists, and attenuation of cognitive deficits in psychiatric and neurological disorders, such as alzheimer's disease and schizophrenia. |
2012-04-25 |
2023-08-12 |
Not clear |
| C Clément, R Lalonde, C Straziell. Acetylcholinesterase activity in the brain of dystonia musculorum (Dst(dt-J)) mutant mice. Neuroscience research. vol 72. issue 1. 2012-04-09. PMID:21978551. |
a quantitative histochemical cartography of brain acetylcholinesterase activity in dst(dt-j) mutants, in comparison with controls, revealed increases in the neostriatum, the habenula-interpeduncular pathway, the cholinergic pedunculopontine nucleus and its target structures, the thalamus, major regions of the basal ganglia, such as substantia nigra, ventral tegmental area, globus pallidum, and subthalamic nucleus, as well as in associated extrapyramidal regions, such as red nucleus, brainstem reticular formation, and superior colliculus. |
2012-04-09 |
2023-08-12 |
mouse |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| Pekka S Miettinen, Maija Pihlajamäki, Anne M Jauhiainen, Ina M Tarkka, Heidi Gröhn, Eini Niskanen, Tuomo Hänninen, Ritva Vanninen, Hilkka Soinine. Effect of cholinergic stimulation in early Alzheimer's disease - functional imaging during a recognition memory task. Current Alzheimer research. vol 8. issue 7. 2012-04-04. PMID:21592058. |
treatment of alzheimer's disease (ad) with acetylcholinesterase inhibitors (achei) enhances cholinergic activity and alleviates clinical symptoms. |
2012-04-04 |
2023-08-12 |
Not clear |
| A Barelli, P M Soave, M Del Vicario, R Barell. New experimental Oximes in the management of organophosphorus pesticides poisoning. Minerva anestesiologica. vol 77. issue 12. 2012-04-04. PMID:21799476. |
the main toxic mechanism of opcs is the inhibition of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), resulting in accumulation of acetylcholine (ach) at the synapse with cholinergic crisis and possible death. |
2012-04-04 |
2023-08-12 |
Not clear |
| Shuuichi Mori, Sachiho Kubo, Takuyu Akiyoshi, Shigeru Yamada, Tsuyoshi Miyazaki, Harumi Hotta, Junzo Desaki, Masahiko Kishi, Tetsuro Konishi, Yuri Nishino, Atsuo Miyazawa, Naoki Maruyama, Kazuhiro Shigemot. Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22142810. |
furthermore, musk-injected mice exhibited acetylcholinesterase (ache) inhibitor-evoked cholinergic hypersensitivity, as is observed in musk-mg patients, and a decrease in both ache and the ache-anchoring protein collagen q at postsynaptic membranes. |
2012-03-25 |
2023-08-12 |
mouse |
| Mabruka H Tarhoni, Vasanthy Vigneswara, Marie Smith, Susan Anderson, Peter Wigmore, John E Lees, David E Ray, Wayne G Carte. Detection, quantification, and microlocalisation of targets of pesticides using microchannel plate autoradiographic imagers. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:21989313. |
they share a common chemical signature that facilitates their binding and adduction of acetylcholinesterase (ache) within nerve synapses to induce cholinergic toxicity. |
2012-03-15 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Soumya Pati, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21924263. |
cholinergic markers such as acetylcholine, acetylcholinesterase, choline acetyltransferase, α-7-nicotinic acetylcholine receptor and m(1) muscarinic acetylcholine receptor were also evaluated along with neuronal morphology and dna fragmentation. |
2012-03-07 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Soumya Pati, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21924263. |
therefore, our results suggest cholinergic dysfunction is one of the mechanisms involved in hypobaric hypoxia-induced memory impairment and that acetylcholinesterase inhibitors were able to restore cholinergic function and thus improve memory function. |
2012-03-07 |
2023-08-12 |
rat |