| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gislaine T Rezin, Giselli Scaini, Gabriela K Ferreira, Mariane R Cardoso, Cinara L Gonçalves, Larissa S Constantino, Pedro F Deroza, Fernando V Ghedim, Samira S Valvassori, Wilson R Resende, João Quevedo, Alexandra I Zugno, Emilio L Strec. Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex. Metabolic brain disease. vol 27. issue 4. 2013-05-03. PMID:22832793. |
acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine. |
2013-05-03 |
2023-08-12 |
rat |
| G Lou, Q Zhang, F Xiao, Q Xiang, Z Su, L Zhang, P Yang, Y Yang, Q Zheng, Y Huan. Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. vol 223. 2013-05-01. PMID:22885230. |
importantly, tat-hafgf(14-154) improved the learning and memory abilities of samp8 mice in the behavioral test, and promoted the function of cholinergic system by measuring the relevant biomarkers (acetylcholine (ach) level, acetylcholinesterase (ache) and choline acetyltransferase (chat) activities). |
2013-05-01 |
2023-08-12 |
mouse |
| Mrinalini Muralidharan, Kristina Buss, Katherine E Larrimore, Nicholas A Segerson, Latha Kannan, Tsafrir S Mo. The Arabidopsis thaliana ortholog of a purported maize cholinesterase gene encodes a GDSL-lipase. Plant molecular biology. vol 81. issue 6. 2013-04-29. PMID:23430565. |
acetylcholinesterase is an enzyme that is intimately associated with regulation of synaptic transmission in the cholinergic nervous system and in neuromuscular junctions of animals. |
2013-04-29 |
2023-08-12 |
Not clear |
| Dou Yu, Devang K Thakor, Inbo Han, Alexander E Ropper, Hariprakash Haragopal, Richard L Sidman, Ross Zafonte, Steven C Schachter, Yang D Ten. Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 8. 2013-04-26. PMID:23386718. |
we hypothesize that [-]-huperzine a (hup-a), an alkaloid isolated from the club moss huperzia serrata, that is a potent reversible inhibitor of acetylcholinesterase and nmda receptors, could mitigate pain without invoking drug tolerance or dependence by stimulating cholinergic interneurons to impede pain signaling, inhibiting inflammation via microglial cholinergic activation, and blocking nmda-mediated central hypersensitization. |
2013-04-26 |
2023-08-12 |
rat |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
in this study, we show that human bacs produce acetylcholine (ach) and contain several cholinergic factors including acetylcholinesterase (ache), choline acetyltransferase (chat), choline transporter 1 (cht1, slc5a7), vesicular acetylcholine transporter (vacht, slc18a3), and nach receptors (achrs, chrnas). |
2013-04-15 |
2023-08-12 |
mouse |
| Yanhui Lu, Yoonseong Park, Xiwu Gao, Xin Zhang, Jianxiu Yao, Yuan-Ping Pang, Haobo Jiang, Kun Yan Zh. Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum. Scientific reports. vol 2. 2013-04-12. PMID:22371826. |
cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in tribolium castaneum. |
2013-04-12 |
2023-08-12 |
Not clear |
| Faezeh Koohestani, Chester M Brown, Esmail Meisam. Postnatal growth hormone deficiency in growing rats causes marked decline in the activity of spinal cord acetylcholinesterase but not butyrylcholinesterase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 7. 2013-04-03. PMID:22922167. |
the effects of growth hormone (gh) deficiency on the developmental changes in the abundance and activity of cholinesterase enzymes were studied in the developing spinal cord (sc) of postnatal rats by measuring the specific activity of acetylcholinesterase (ache), a marker for cholinergic neurons and their synaptic compartments, and butyrylcholinesterase (buche), a marker for glial cells and neurovascular cells. |
2013-04-03 |
2023-08-12 |
rat |
| Naouel Kamel, Hajer Attig, Alessandro Dagnino, Hamadi Boussetta, Mohamed Bann. Increased temperatures affect oxidative stress markers and detoxification response to benzo[a]pyrene exposure in mussel Mytilus galloprovincialis. Archives of environmental contamination and toxicology. vol 63. issue 4. 2013-03-26. PMID:22903631. |
the cholinergic system was evaluated using acetylcholinesterase (ache) activity. |
2013-03-26 |
2023-08-12 |
cat |
| Antonio M G de Diego, Silvia Lorrio, Enrique Calvo-Gallardo, Antonio G Garcí. Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 428. issue 4. 2013-03-26. PMID:23123627. |
furthermore, acetylcholinesterase staining of adrenal medulla indicated no apparent differences in the innervation by splanchnic cholinergic nerve terminals of chromaffin cells from control and app/ps1 mice. |
2013-03-26 |
2023-08-12 |
mouse |
| Kotaro Hiraoka, Nobuyuki Okamura, Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, Etsuro Mor. Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia. European neurology. vol 68. issue 3. 2013-03-08. PMID:22832236. |
[5-(11)c-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (pet), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. |
2013-03-08 |
2023-08-12 |
Not clear |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
controlled regulation of synaptic nicotinic acetylcholine receptors (achrs) and acetylcholinesterase (ache), together with maintenance of a dynamic balance between them, is a requirement for proper function of cholinergic synapses. |
2013-03-06 |
2023-08-12 |
rat |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Sally M Williamson, Christopher Moffat, Martha A E Gomersall, Nastja Saranzewa, Christopher N Connolly, Geraldine A Wrigh. Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees. Frontiers in physiology. vol 4. 2013-02-07. PMID:23386834. |
here, we investigate the behavioral effects on honeybees of exposure to a selection of pesticides that target cholinergic signaling by inhibiting acetylcholinesterase (ache). |
2013-02-07 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Vera Lucia Sardá Ribeiro, Cláudia Vanzella, Felipe dos Santos Moysés, Jaqueline Campiol Dos Santos, João Ricardo Souza Martins, Gilsane Lino von Poser, Ionara Rodrigues Siqueir. Effect of Calea serrata Less. n-hexane extract on acetylcholinesterase of larvae ticks and brain Wistar rats. Veterinary parasitology. vol 189. issue 2-4. 2013-01-24. PMID:22608349. |
acetylcholinesterase (ache), an enzyme that hydrolyses acetylcholine (ach) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. |
2013-01-24 |
2023-08-12 |
rat |
| Shazi Shakil, Rosina Khan, Shams Tabrez, Qamre Alam, Nasimudeen R Jabir, Mansour I Sulaiman, Nigel H Greig, Mohammad A Kama. Interaction of human brain acetylcholinesterase with cyclophosphamide: a molecular modeling and docking study. CNS & neurological disorders drug targets. vol 10. issue 7. 2013-01-21. PMID:21999734. |
this study describes the interaction between human acetylcholinesterase (ache), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (cp). |
2013-01-21 |
2023-08-12 |
human |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Xiaotong Liu, Dong Hyun Kim, Jong Min Kim, Se Jin Park, Mudan Cai, Dae Sik Jang, Jong Hoon Ry. The memory-ameliorating effects of Artemisia princeps var. orientalis against cholinergic dysfunction in mice. The American journal of Chinese medicine. vol 40. issue 5. 2012-12-31. PMID:22928830. |
these results suggest that aea could be an effective treatment against cholinergic dysfunction and its effect is mediated by the enhancement of the cholinergic neurotransmitter system via nmda receptor signaling or acetylcholinesterase inhibition. |
2012-12-31 |
2023-08-12 |
mouse |
| Sarven Sabunciyan, Martin J Aryee, Rafael A Irizarry, Michael Rongione, Maree J Webster, Walter E Kaufman, Peter Murakami, Andree Lessard, Robert H Yolken, Andrew P Feinberg, James B Potas. Genome-wide DNA methylation scan in major depressive disorder. PloS one. vol 7. issue 4. 2012-12-28. PMID:22511943. |
because prima1 anchors acetylcholinesterase in neuronal membranes, decreased expression could result in decreased enzyme function and increased cholinergic transmission, consistent with a role in mdd. |
2012-12-28 |
2023-08-12 |
Not clear |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |