| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Csaba Szigeti, Norbert Bencsik, Aurel Janos Simonka, Adam Legradi, Peter Kasa, Karoly Guly. Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: a model for Alzheimer's disease. Brain research bulletin. vol 94. 2013-10-17. PMID:23357177. |
choline acetyltransferase (chat) immunohistochemistry was applied to identify the loss of cholinergic neurons in the nbm, while acetylcholinesterase (ache) enzyme histochemistry was used to analyze the decreases in the number of cholinoceptive neurons in the nbm and the cholinergic fiber density in the fr1 and hl cortical areas in response to the nbm lesion. |
2013-10-17 |
2023-08-12 |
rat |
| De Lu Zhang, Chun Xiang Hu, Dun Hai Li, Yong Ding Li. Zebrafish locomotor capacity and brain acetylcholinesterase activity is altered by Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 138-139. 2013-10-17. PMID:23792258. |
these results demonstrate that aphantoxins can alter locomotor capacity, touch responses and distribution patterns by damaging the cholinergic system of zebrafish, and suggest that zebrafish locomotor behavior and acetylcholinesterase can be used as indicators for investigating aphantoxins and blooms in nature. |
2013-10-17 |
2023-08-12 |
human |
| Qingwei Ruan, Fang Liu, Zhanjuan Gao, Deqiu Kong, Xiaona Hu, Dongmei Shi, Zhijun Bao, Zhuowei Y. The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats. Mechanisms of ageing and development. vol 134. issue 3-4. 2013-09-30. PMID:23313706. |
acetylcholinesterase inhibitors (achei) can enhance cholinergic transmission and act as anti-inflammatory agents via immunocompetent cells expressing α-7 acetylcholine receptors (achr). |
2013-09-30 |
2023-08-12 |
rat |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
the leading alzheimer's disease (ad) therapeutics to date involves inhibitors of acetylcholinesterase (ache), which should, in principle, elevate cholinergic signaling and limit inflammation. |
2013-09-13 |
2023-08-12 |
Not clear |
| Xiao-Lei Zhu, Ning-Xi Yu, Ge-Fei Hao, Wen-Chao Yang, Guang-Fu Yan. Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations. Journal of molecular graphics & modelling. vol 41. 2013-09-10. PMID:23500627. |
acetylcholinesterase (ache) is a key enzyme of the cholinergic nervous system. |
2013-09-10 |
2023-08-12 |
mouse |
| Hitoshi Shinotoh, Shigeki Hiran. [Neuroimaging in corticobasal syndrome]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 1. 2013-09-03. PMID:23300102. |
a pet study showed decreased acetylcholinesterase (ache) activity in the fronto-parietal cortex, as well as a correlation between cortical ache activity and mini-mental state examination score in cbs patients, suggesting that cholinergic stimulant therapy may be effective for dementia in cbs. |
2013-09-03 |
2023-08-12 |
Not clear |
| Muriel Noetzli, Chin B Ea. Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease. Clinical pharmacokinetics. vol 52. issue 4. 2013-09-03. PMID:23408070. |
moreover, polymorphisms in genes of the cholinergic markers acetylcholinesterase, butyrylcholinesterase, choline acetyltransferase and paraoxonase were found to be associated with better clinical response to acetylcholinesterase inhibitors. |
2013-09-03 |
2023-08-12 |
Not clear |
| Santokh Gill, Wayne J Bowers, Jamie S Nakai, Al Yagminas, Rudi Mueller, Olga Pulid. Effects of environmentally relevant mixtures of persistent organic pollutants on the developmental neurobiology in rats. Toxicologic pathology. vol 41. issue 1. 2013-08-28. PMID:22872703. |
markers of the cholinergic system including acetylcholinesterase and the muscarinic receptors (subtypes m1-m5) were downregulated 2- to 6-fold. |
2013-08-28 |
2023-08-12 |
rat |
| Alicia M Ruggiero, Jane Wright, Shawn M Ferguson, Michelle Lewis, Katie S Emerson, Hideki Iwamoto, Michael T Ivy, Ericka C Holmstrand, Elizabeth A Ennis, C David Weaver, Randy D Blakel. Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. ACS chemical neuroscience. vol 3. issue 10. 2013-08-20. PMID:23077721. |
current therapies to enhance cns cholinergic function rely primarily on extracellular acetylcholinesterase (ache) inhibition, a pharmacotherapeutic strategy that produces dose-limiting side effects. |
2013-08-20 |
2023-08-12 |
human |
| Soo-Jeong Kim, Jun-Ho Lee, Hwan-Suck Chung, Joo-Hyun Song, Joohun Ha, Hyunsu Ba. Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 4. 2013-08-15. PMID:23946693. |
in addition, they showed enhanced acetylcholinesterase (ache)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to ampk. |
2013-08-15 |
2023-08-12 |
rat |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
acetylcholinesterase and butyrylcholinesterase share unravelling link with components of metabolic syndromes that's characterised by low levels of hdl cholesterol, obesity, high fast aldohexose levels, hyper-trigliceridaemia and high blood pressure, by regulation of cholinergic transmission and therefore the enzyme activity within a living system. |
2013-08-12 |
2023-08-12 |
Not clear |
| Gersilene Valente de Oliveira, Patrícia Xavier Lima Gomes, Fernanda Yvelize Ramos de Araújo, Silvânia Maria Mendes Vasconcelos, Hélio Vitoriano Nobre Júnior, Francisca Cléa Florenço de Sousa, David F de Lucena, Thomas N Hyphantis, André Férrer Carvalho, Danielle Silveira Macêd. Prevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23095989. |
here, based on the fact that alterations in cholinergic neurotransmission are related to td pathophysiology and that vitamins b seems to influence brain cholinergic neurotransmission, we decided to investigate the effects of vitamins b1, b6, b12 and their association, vitamin b cocktail in haloperidol-induced cholinergic alterations, evaluated by alterations in acetylcholinesterase (ache) activity, in striatum, prefrontal cortex and hippocampus, as a way to determine the participation of cholinergic neurotransmission, in these vitamins antidyskinetic mechanism. |
2013-08-02 |
2023-08-12 |
rat |
| Sanjay Sarin And Kiran Dip Gil. Potential biomarkers of dichlorvos induced neuronal injury in rats. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 3. issue 3. 2013-08-01. PMID:23899328. |
acetylcholinesterase, assayed as an index of cholinergic function, was found to decrease in both haemolysate and brain tissue. |
2013-08-01 |
2023-08-12 |
rat |
| Eugénie Carletti, Jacques-Philippe Colletier, Lawrence M Schopfer, Gianluca Santoni, Patrick Masson, Oksana Lockridge, Florian Nachon, Martin Wei. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chemical research in toxicology. vol 26. issue 2. 2013-07-29. PMID:23339663. |
tocp is metabolized to cresyl saligenin phosphate (cbdp), a potent irreversible inhibitor of butyrylcholinesterase (bche), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (ache), the off-switch at cholinergic synapses. |
2013-07-29 |
2023-08-12 |
mouse |
| Sa Rang Oh, Su-Jin Kim, Dong Hyun Kim, Jong Hoon Ryu, Eun-Mi Ahn, Ji Wook Jun. Angelica keiskei ameliorates scopolamine-induced memory impairments in mice. Biological & pharmaceutical bulletin. vol 36. issue 1. 2013-06-26. PMID:23132631. |
acetylcholinesterase (ache) activity assay was performed to investigate the cholinergic antagonistic effect of ak in the hippocampus. |
2013-06-26 |
2023-08-12 |
mouse |
| Lianguo Chen, Changjiang Huang, Chenyan Hu, Ke Yu, Lihua Yang, Bingsheng Zho. Acute exposure to DE-71: effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental toxicology and chemistry. vol 31. issue 10. 2013-06-10. PMID:22833361. |
in the cholinergic system, acetylcholinesterase activity significantly increased (10.7 and 12.4%) in the 68.7 and 227.6 µg/l exposure groups, respectively, and acetylcholine concentration accordingly decreased (60.5%) in the 227.6 µg/l exposure group. |
2013-06-10 |
2023-08-12 |
zebrafish |
| Shigeyuki Yamamoto, Yasuomi Ouchi, Daisaku Nakatsuka, Tsuyoshi Tahara, Kei Mizuno, Seiki Tajima, Hirotaka Onoe, Etsuji Yoshikawa, Hideo Tsukada, Masao Iwase, Kouzi Yamaguti, Hirohiko Kuratsune, Yasuyoshi Watanab. Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor. PloS one. vol 7. issue 12. 2013-05-30. PMID:23240035. |
we examined whether serum autoantibody against machr affected the central cholinergic system by measuring brain machr binding and acetylcholinesterase activity using positron emission tomography (pet) in cfs patients with positive [cfs(+)] and negative [cfs(-)] autoantibodies. |
2013-05-30 |
2023-08-12 |
Not clear |
| Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda, Debra Youric. Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:23000013. |
se induced by soman is a result of cholinergic system hyperactivity caused by the irreversible inhibition of acetylcholinesterase, and the subsequent increase in the amount of the neurotransmitter acetylcholine at central and peripheral sites. |
2013-05-28 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Rafael León, Antonio G Garcia, José Marco-Contelle. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease. Medicinal research reviews. vol 33. issue 1. 2013-05-14. PMID:21793014. |
approximately 100 compounds are presently been investigated directed to single targets, namely inhibitors of β and γ secretase, vaccines or antibodies that clear aβ, metal chelators to inhibit aβ aggregation, blockers of glycogen synthase kinase 3β, enhancers of mitochondrial function, antioxidants, modulators of calcium-permeable channels such as voltage-dependent calcium channels, n-methyl-d-aspartate receptors for glutamate, or enhancers of cholinergic neurotransmission such as inhibitors of acetylcholinesterase or butyrylcholinesterase. |
2013-05-14 |
2023-08-12 |
Not clear |