| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosa M Giraldez-Perez, Susana P Gaytan, Rosario Pasar. Cholinergic and nitrergic neuronal networks in the goldfish telencephalon. Acta neurobiologiae experimentalis. vol 73. issue 3. 2014-04-21. PMID:24129483. |
the purpose of this study was to examine pallial and subpallial cholinoceptive, cholinergic and nitrergic populations in the goldfish telencephalon by means of histochemical and immunohistochemical techniques in order to identify neurons containing acetylcholinesterase (ache), choline acetyltransferase (chat), nadph-diaphorase (nadphd), and neuronal nitric oxide synthase (nnos), and to relate their distribution to their putative functional significance. |
2014-04-21 |
2023-08-12 |
Not clear |
| Yoojin Seo, Yooyoung Shin, Hyung-Sik Kim, Insung Kang, In-Sun Hong, Soon Won Choi, Kyung-Rok Yu, Kyung-Sun Kan. Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C. Journal of neuropathology and experimental neurology. vol 73. issue 3. 2014-04-10. PMID:24487798. |
donepezil enhances purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of niemann pick disease type c. neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (ache) inhibitors (acheis) may have therapeutic potential in some neurological conditions. |
2014-04-10 |
2023-08-12 |
mouse |
| Girish Chandran, Muralidhar. Neuroprotective effect of aqueous extract of Selaginella delicatula as evidenced by abrogation of rotenone-induced motor deficits, oxidative dysfunctions, and neurotoxicity in mice. Cellular and molecular neurobiology. vol 33. issue 7. 2014-04-02. PMID:23868340. |
further, sdae also restored the activities of acetylcholinesterase and butyrylcholinesterase indicating its effect on cholinergic function. |
2014-04-02 |
2023-08-12 |
mouse |
| V D'Andrea, E Bianchi, S Taurone, F Mignini, C Cavallotti, M Artic. Cholinergic innervation of human mesenteric lymphatic vessels. Folia morphologica. vol 72. issue 4. 2014-03-28. PMID:24402754. |
therefore, our aim is to analyse the cholinergic nerve fibres of lymphatic vessels using the traditional enzymatic techniques of staining, plus the biochemical modifications of acetylcholinesterase (ache) activity. |
2014-03-28 |
2023-08-12 |
human |
| Dhrubajyoti Mukherjee, Sugato Banerje. Learning and memory promoting effects of crude garlic extract. Indian journal of experimental biology. vol 51. issue 12. 2014-03-26. PMID:24579375. |
influence of lasuna on central cholinergic activity and its antioxidant properties were also studied by estimating the cortical acetylcholinesterase (ache) activity and reduced glutathione (gsh) levels respectively. |
2014-03-26 |
2023-08-12 |
mouse |
| Katja S Kroker, Jens Moreth, Lothar Kussmaul, Georg Rast, Holger Rosenbroc. Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists. Brain research bulletin. vol 96. 2014-03-19. PMID:23639920. |
as nicotinic acetylcholine receptor (nachr) agonists directly address cholinergic neurotransmission with potential impact on glutamatergic function, they are considered as potential new symptomatic treatment options for alzheimer's disease compared to the indirectly operating acetylcholinesterase inhibitors such as the current gold standard donepezil. |
2014-03-19 |
2023-08-12 |
rat |
| Elisabet Viayna, Raimon Sabate, Diego Muñoz-Torrer. Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931440. |
another protein that seems to occupy a prominent position within the complex pathological network of ad is the enzyme acetylcholinesterase (ache), with classical and non-classical activities involved at the late (cholinergic deficit) and early (aβ aggregation) phases of the disease. |
2014-03-10 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Alexander Kalb, Clarissa von Haefen, Marco Sifringer, Annalena Tegethoff, Nadine Paeschke, Mariya Kostova, Aarne Feldheiser, Claudia D Spie. Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model. PloS one. vol 8. issue 5. 2014-02-18. PMID:23671623. |
treatments with acetylcholinesterase inhibitors enhance cholinergic transmission and may therefore act as a potential approach to prevent neuroinflammation. |
2014-02-18 |
2023-08-12 |
rat |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermin. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23648421. |
enzymes assessed in muscle tissues were related to cholinergic transmission (acetylcholinesterase [ache]), energy metabolism (lactate dehydrogenase [ldh] and nadp⁺-dependent isocitrate dehydrogenase [idh]). |
2014-02-05 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Mallory Gough, Edward T Parkin, Natalia N Nalivaeva, Anthony J Turne. The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines. The Journal of biological chemistry. vol 288. issue 36. 2014-02-04. PMID:23897820. |
in this study, we examined whether app is involved in the regulation of acetylcholinesterase (ache), which is a key protein of the cholinergic system and has been shown to accelerate amyloid fibril formation and increase their toxicity. |
2014-02-04 |
2023-08-12 |
Not clear |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
acetylcholinesterase (ache) is a key enzyme in termination of fast cholinergic transmission. |
2014-02-03 |
2023-08-12 |
mouse |
| Nitsan Maharshak, Shani Shenhar-Tsarfaty, Nimrod Aroyo, Naama Orpaz, Irene Guberman, Jonathan Canaani, Zamir Halpern, Iris Dotan, Shlomo Berliner, Hermona Sore. MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflammatory bowel diseases. vol 19. issue 7. 2014-01-22. PMID:23598815. |
microrna-132 (mir-132) targets acetylcholinesterase (ache) and potentiates the cholinergic blockade of inflammatory reactions in cultured cells and experimental mice, but the implications of this interaction to human inflammatory disease remained unexplored. |
2014-01-22 |
2023-08-12 |
mouse |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
since the participation of the cholinergic system in the immune response is well documented, the aim of this study was to evaluate the relationship between n. caninum infection and activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) during the acute and chronic phase of infection. |
2014-01-17 |
2023-08-12 |
cattle |
| M M Saghafi, M Živin, P Pregel. Galantamine as a preventive of diisopropylphosphorofluoridate toxicity effects in rat brain. Folia biologica. vol 59. issue 1. 2014-01-10. PMID:23537526. |
the aim of the present study was to evaluate the possible preventive effects of acute treatment with reversible acetylcholinesterase inhibitor galantamine against the signs of cholinergic toxic syndrome provoked by diisopropylfluorophosphate, such as hypothermia, muscular fasciculations, oral dyskinesia and decreased locomotor performance in a rat model of intoxication. |
2014-01-10 |
2023-08-12 |
rat |
| M M Saghafi, M Živin, P Pregel. Galantamine as a preventive of diisopropylphosphorofluoridate toxicity effects in rat brain. Folia biologica. vol 59. issue 1. 2014-01-10. PMID:23537526. |
the increased cholinergic cortical and hippocampal activity due to irreversible acetylcholinerase inhibition were indicated by the increased c-fos mrna autoradiographic signal and by the inhibition of acetylcholinesterase staining, respectively. |
2014-01-10 |
2023-08-12 |
rat |
| M M Saghafi, M Živin, P Pregel. Galantamine as a preventive of diisopropylphosphorofluoridate toxicity effects in rat brain. Folia biologica. vol 59. issue 1. 2014-01-10. PMID:23537526. |
galantamine by itself provoked transient and relatively weak inhibition of the acetylcholinesterase staining, while it did not induce increased c-fos mrna expression or significant behavioural signs of cholinergic toxicity. |
2014-01-10 |
2023-08-12 |
rat |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Shuuichi Mori, Kazuhiro Shigemot. Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis. Autoimmunity reviews. vol 12. issue 9. 2014-01-06. PMID:23537506. |
failure of neuromuscular transmission at pre- and postsynaptic membranes of the nmjs has been observed in both patients and animal models of musk mg. a murine model of musk-mg revealed the mechanisms underlying cholinergic hypersensitivity after administration of acetylcholinesterase inhibitors, which has also been observed in musk-mg patients. |
2014-01-06 |
2023-08-12 |
Not clear |