| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yves Dunant, J Miguel Cordeir. Presynaptic K(+) channels, vesicular Ca(2+)/H (+) antiport--synaptotagmin, and acetylcholinesterase, three mechanisms cutting short the cholinergic signal at neuromuscular and nerve-electroplaque junctions. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24390960. |
presynaptic k(+) channels, vesicular ca(2+)/h (+) antiport--synaptotagmin, and acetylcholinesterase, three mechanisms cutting short the cholinergic signal at neuromuscular and nerve-electroplaque junctions. |
2015-04-06 |
2023-08-12 |
Not clear |
| John Flasko. The neuronal cytoskeleton as a potential target in the developmental neurotoxicity of organophosphorothionate insecticides. Basic & clinical pharmacology & toxicology. vol 115. issue 2. 2015-03-30. PMID:24476507. |
these oxon metabolites can bind and inhibit acetylcholinesterase, thus causing acute cholinergic neurotoxicity. |
2015-03-30 |
2023-08-12 |
Not clear |
| Ademir J Schmidel, Karla L Assmann, Chariane C Werlang, Kanandra T Bertoncello, Francini Francescon, Cassiano L Rambo, Gabriela M Beltrame, Daiane Calegari, Cibele B Batista, Rachel E Blaser, Walter A Roman Júnior, Greicy M M Conterato, Angelo L Piato, Leila Zanatta, Jacir Dal Magro, Denis B Rosember. Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish. Neurotoxicology and teratology. vol 44. 2015-03-06. PMID:24893294. |
furthermore, to investigate a putative role of cholinergic signalling on atz-mediated effects, we tested whether this herbicide alters acetylcholinesterase (ache) activity in brain and muscle preparations. |
2015-03-06 |
2023-08-13 |
zebrafish |
| Manal F El-Khadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Monei. Neuroprotective effects of Citrus reticulata in scopolamine-induced dementia oxidative stress in rats. CNS & neurological disorders drug targets. vol 13. issue 4. 2015-02-23. PMID:24938777. |
brain acetylcholinesterase enzyme (ache) activity was measured to assess the central cholinergic activity. |
2015-02-23 |
2023-08-13 |
rat |
| Yoke-Chen Chang, James D Wang, Rita A Hahn, Marion K Gordon, Laurie B Joseph, Diane E Heck, Ned D Heindel, Sherri C Young, Patrick J Sinko, Robert P Casillas, Jeffrey D Laskin, Debra L Laskin, Donald R Gereck. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicology and applied pharmacology. vol 280. issue 2. 2015-02-07. PMID:25127551. |
in the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (ndh 4338) designed to target cyclooxygenase 2 (cox2), an enzyme that generates inflammatory eicosanoids, and acetylcholinesterase, an enzyme mediating activation of cholinergic inflammatory pathways in a model of sm-induced skin injury. |
2015-02-07 |
2023-08-13 |
mouse |
| Ericka C Holmstrand, David Lund, Ajeesh Koshy Cherian, Jane Wright, Rolicia F Martin, Elizabeth A Ennis, Gregg D Stanwood, Martin Sarter, Randy D Blakel. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochemistry international. vol 73. 2015-02-02. PMID:24274995. |
the hemicholinium-3 (hc-3) sensitive, high-affinity choline transporter (cht) sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary sources or from acetylcholinesterase (ache)-mediated hydrolysis of acetylcholine (ach). |
2015-02-02 |
2023-08-12 |
mouse |
| Ayush K Kapila, Helena R Watts, Tianlong Wang, Daqing M. The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer's disease development: biomarkers and preventive strategies. Journal of Alzheimer's disease : JAD. vol 41. issue 1. 2015-01-29. PMID:24577482. |
nonetheless, ad is currently still treated symptomatically with acetylcholinesterase inhibitors and nmda antagonists to improve cholinergic transmission and prevent glutamatergic excitotoxicity. |
2015-01-29 |
2023-08-12 |
Not clear |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex, as indicated by a decreased acetylcholine (ach) level and an increased acetylcholinesterase (ache) activity. |
2015-01-27 |
2023-08-13 |
mouse |
| Yifan He, Jihong Zhu, Fang Huang, Liu Qin, Wenguo Fan, Hongwen H. Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage. Neural regeneration research. vol 9. issue 22. 2015-01-19. PMID:25598781. |
when the middle-aged mice reached 8 months (middle-aged group 1) or 11 months (middle-aged group 2), and the elderly group reached 11 months, step-down passive avoidance and y-maze tests of learning and memory were performed, and the cholinergic system was examined in the hippocampus (nissl staining and acetylcholinesterase histochemistry) and basal forebrain (choline acetyltransferase immunohistochemistry). |
2015-01-19 |
2023-08-13 |
mouse |
| M Merad, W Soufi, S Ghalem, F Boukli, M H Baig, K Ahmad, Mohammad A Kama. Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059305. |
acetylcholinesterase (ache) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". |
2015-01-07 |
2023-08-12 |
Not clear |
| Javier Del Pino, Garbriela Zeballos, María José Anadon, Miguel Andrés Capo, María Jesús Díaz, Jimena García, María Teresa Frej. Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: a cholinesterase dependent mechanism. Toxicology. vol 325. 2014-12-18. PMID:25201352. |
this study proves that cadmium induces a more pronounced, but not selective, cell death on acetylcholinesterase (ache) on cholinergic neurons. |
2014-12-18 |
2023-08-13 |
Not clear |
| b' Branka Markovi\\xc4\\x87, Nevena V Radonji\\xc4\\x87, Milan Aksi\\xc4\\x87, Branislav Filipovi\\xc4\\x87, Nata\\xc5\\xa1a Petronijevi\\xc4\\x8. Long-term effects of maternal deprivation on cholinergic system in rat brain. BioMed research international. vol 2014. 2014-12-09. PMID:24711997.' |
the aim of this study was to examine long-term effects of maternal separation on acetylcholinesterase (ache) activity in different brain structures and the density of cholinergic fibers in hippocampus and retrosplenial (rs) cortex. |
2014-12-09 |
2023-08-13 |
rat |
| Helen M Campanha, Félix Carvalho, Paul M Schlosse. Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line. Toxicology letters. vol 230. issue 2. 2014-11-25. PMID:24680925. |
the classical enzymatic role of acetylcholinesterase (ache) is to terminate impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine (ach). |
2014-11-25 |
2023-08-12 |
mouse |
| Andréia Machado Cardoso, Fátima Husein Abdalla, Margarete Dulce Bagatini, Caroline Curry Martins, Fernando da Silva Fiorin, Jucimara Baldissarelli, Pauline Costa, Fábio Fernandes de Mello, Amanda Maino Fiorenza, Jonas Daci da Silva Serres, Jamile Fabbrin Gonçalves, Heloísa Chaves, Luiz Fernando Freire Royes, Adriane Belló-Klein, Vera Maria Morsch, Maria Rosa Chitolina Schetinge. Swimming training prevents alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats. American journal of hypertension. vol 27. issue 4. 2014-11-24. PMID:23479073. |
in this study, we investigated the effect of 6 weeks of swimming training on cholinergic enzyme activities (acetylcholinesterase and butyrylcholinesterase) in nω-nitro-l-arginine methyl ester hydrochloride (l-name)-induced hypertensive rats. |
2014-11-24 |
2023-08-12 |
rat |
| Ali Afrasiabi, Gholam Hossein Riazi, Shayan Abbasi, Ali Dadras, Behafarid Ghalandari, Hossein Seidkhani, Seyed Mohamad Sadegh Modaresi, Neda Masoudian, Amir Amani, Shahin Ahmadia. Synaptosomal acetylcholinesterase activity variation pattern in the presence of electromagnetic fields. International journal of biological macromolecules. vol 65. 2014-11-24. PMID:24418344. |
acetylcholinesterase (ache) is the enzyme that controls the acetylcholine (ach) concentrations in cholinergic synaptic clefts by hydrolyzing ach to choline and acetate. |
2014-11-24 |
2023-08-12 |
Not clear |
| Lalit P Chandravanshi, Rajesh S Yadav, Rajendra K Shukla, Anshuman Singh, Sarwat Sultana, Aditya B Pant, Devendra Parmar, Vinay K Khann. Reversibility of changes in brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 34. 2014-11-24. PMID:24517892. |
reversibility of changes in brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure. |
2014-11-24 |
2023-08-12 |
rat |
| María-Salud García-Ayllón, María-Letizia Campanari, María-Fernanda Montenegro, Inmaculada Cuchillo-Ibáñez, Olivia Belbin, Alberto Lleó, Karl Tsim, Cecilio J Vidal, Javier Sáez-Valer. Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA. Neurobiology of aging. vol 35. issue 7. 2014-11-17. PMID:24612677. |
in this study, we explore if ps1 participates in the processing of the cholinergic acetylcholinesterase (ache). |
2014-11-17 |
2023-08-12 |
mouse |
| Aliya Ahmad, Kalavathy Ramasamy, Siti Murnirah Jaafar, Abu Bakar Abdul Majeed, Vasudevan Man. Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24373829. |
brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory activities (cox-1, cox-2, il-1β and il10) were also assessed. |
2014-10-28 |
2023-08-12 |
rat |
| Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq, Shmuel Bana. Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24395570. |
cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (ache) and butyrylcholinesterase (bche) to hydrolyze the ache substrate acetylthiocholine. |
2014-10-28 |
2023-08-12 |
Not clear |
| Miroslav Pohank. Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Environmental toxicology and pharmacology. vol 37. issue 1. 2014-10-28. PMID:24473150. |
acetylcholinesterase (ache) is an important part of cholinergic nerves where it participates in termination of neurotransmission. |
2014-10-28 |
2023-08-12 |
human |