| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Maria Fossati, Simona Candiani, Marie-Therese Nödl, Luca Maragliano, Maria Pennuto, Pedro Domingues, Fabio Benfenati, Mario Pestarino, Letizia Zull. Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE? Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25112677. |
acetylcholinesterase (ache) is a glycoprotein with a key role in terminating synaptic transmission in cholinergic neurons of both vertebrates and invertebrates. |
2016-05-17 |
2023-08-13 |
Not clear |
| Abhinav Grover, Ashutosh Shandilya, Vibhuti Agrawal, Virendra S Bisaria, Durai Sunda. Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment. Journal of biomolecular structure & dynamics. vol 29. issue 4. 2016-04-23. PMID:22208270. |
enhancement of the central cholinergic function by the inhibition of acetylcholinesterase is a prominent clinically effective approach for the treatment of ad. |
2016-04-23 |
2023-08-12 |
human |
| Marcelo Gomes Granja, Luis Eduardo Gomes Braga, Raul Carpi-Santos, Leandro de Araujo-Martins, Nilson Nunes-Tavares, Karin C Calaza, Aline Araujo Dos Santos, Elizabeth Giestal-de-Arauj. IL-4 Induces Cholinergic Differentiation of Retinal Cells In Vitro. Cellular and molecular neurobiology. vol 35. issue 5. 2016-03-28. PMID:25682112. |
our results show that il-4 treatment (50 u/ml) for 48 h increases the levels of the cholinergic transporters vacht and cht1, the acetylcholinesterase activity, and the number of chat-positive cells. |
2016-03-28 |
2023-08-13 |
rat |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| K Petro. Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639720. |
acetylcholinesterase (ache) inhibitors are widely used in medicine for pharmacological correction of cholinergic neurotransmission pathologies such as myasthenia gravis (mg) and alzheimer's disease [1, 2]. |
2016-03-15 |
2023-08-13 |
Not clear |
| Mahendra P Kashyap, Vivek Kumar, Abhishek K Singh, Vinay K Tripathi, Sadaf Jahan, Ankita Pandey, Ritesh K Srivastava, Vinay K Khanna, Aditya B Pan. Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity. Molecular neurobiology. vol 51. issue 2. 2016-03-14. PMID:24859382. |
the decreased acetylcholinesterase activity, dopaminergic, and cholinergic receptors and increased acetylcholine levels in the differentiating neuronal cells indicate the vulnerability of these cells towards mcp-induced neurotoxicity. |
2016-03-14 |
2023-08-13 |
human |
| Pierre Bohn, Fabienne Gourand, Cyril Papamicaël, Méziane Ibazizène, Martine Dhilly, Vincent Gembus, Florent Alix, Mihaela-Liliana Ţînţaş, Francis Marsais, Louisa Barré, Vincent Levache. Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25695305. |
with the aim of improving the efficiency of marketed acetylcholinesterase (ache) inhibitors in the symptomatic treatment of alzheimer's disease, plagued by adverse effects arising from peripheral cholinergic activation, this work reports a biological evaluation of new central ache inhibitors based on an original "bio-oxidizable" prodrug strategy. |
2016-03-07 |
2023-08-13 |
mouse |
| Sufang Zhang, Qian Xiao, Weidong L. Olfactory dysfunction and neurotransmitter disturbance in olfactory bulb of transgenic mice expressing human A53T mutant α-synuclein. PloS one. vol 10. issue 3. 2016-03-03. PMID:25799501. |
furthermore compared to wildtype littermates, in olfactory bulb of αsyna53t mice at 10 months old we detected a marked decrease of cholinergic neurons in mitral cell layer and a decrease of acetylcholinesterase activity, while dopaminergic neurons were found increased in glomerular layer, accompanied with an increase of tyrosine hydroxylase protein. |
2016-03-03 |
2023-08-13 |
mouse |
| Rimpi B Arora, Kushal Kumar, Rahul R Deshmuk. FK506 attenuates intracerebroventricular streptozotocin-induced neurotoxicity in rats. Behavioural pharmacology. vol 24. issue 7. 2016-03-03. PMID:26057771. |
malondialdehyde and nitrite glutathione levels, as well as acetylcholinesterase activity, were determined to evaluate oxidative stress and cholinergic functions. |
2016-03-03 |
2023-08-13 |
rat |
| Fen Liu, Yong Li, Rong Jiang, Cheng Nie, Zhenguo Zeng, Ning Zhao, Caixue Huang, Qiang Shao, Chengzhi Ding, Cheng Qing, Liang Xia, Erming Zeng, Kejian Qia. miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway. Experimental lung research. vol 41. issue 5. 2016-02-26. PMID:26052826. |
we hypothesized that mir-132 attenuated lipopolysaccharide (lps)-induced inflammation of alveolar macrophages by targeting acetylcholinesterase (ache) and enhancing the acetylcholine (ach)-mediated cholinergic anti-inflammatory response. |
2016-02-26 |
2023-08-13 |
Not clear |
| Tong Li, Ying Yu, Hongliu Ca. Effects of brain-derived neurotrophic factor-pretreated neuron stem cell transplantation on Alzheimer's disease model mice. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26885166. |
the ad mouse model was constructed and effects of bdnf+nsc transplant group and traditional nsc transplant group were compared using the four indicators: conditions of learning and memory ability recovery tested by morris water maze (mwm), number of basal forebrain cholinergic neurons, expression of synaptophysin, and number of acetylcholinesterase (ache)-positive fibers detected by chemical staining. |
2016-02-17 |
2023-08-13 |
mouse |
| Kiranpreet Kaur, Marit Jørgensen Bakke, Frank Nilsen, Tor Einar Horsber. Identification and Molecular Characterization of Two Acetylcholinesterases from the Salmon Louse, Lepeophtheirus salmonis. PloS one. vol 10. issue 5. 2016-02-03. PMID:25938836. |
acetylcholinesterase (ache) is an important enzyme in cholinergic synapses. |
2016-02-03 |
2023-08-13 |
Not clear |
| Fan-Shiu Tsai, Lung-Yuan Wu, Shu-Er Yang, Hao-Yuan Cheng, Chin-Chuan Tsai, Chi-Rei Wu, Li-Wei Li. Ferulic acid reverses the cognitive dysfunction caused by amyloid β peptide 1-40 through anti-oxidant activity and cholinergic activation in rats. The American journal of Chinese medicine. vol 43. issue 2. 2016-01-14. PMID:25807957. |
this study also elucidates the role of anti-oxidant enzymes and cholinergic marker acetylcholinesterase (ache) in the reversal of fa from aβ1-40-induced cognitive deficits in rats. |
2016-01-14 |
2023-08-13 |
rat |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. |
2015-12-09 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathogenesis of alzheimer disease. |
2015-12-09 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
the mostly used therapy of alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. |
2015-12-09 |
2023-08-13 |
Not clear |
| Adriana C Werner, Miriele C Ferraz, Edson H Yoshida, Natalia Tribuiani, Jean A A Gautuz, Monique N Santana, Bruna A Dezzotti, Vanessa G de Miranda, Ameris L Foramiglio, Sandro Rostelato-Ferreira, Renata V da Silva Tavares, Stephen Hyslop, Yoko Oshima-Franc. The facilitatory effect of Casearia sylvestris Sw. (guaçatonga) fractions on the contractile activity of mammalian and avian neuromuscular apparatus. Current pharmaceutical biotechnology. vol 16. issue 5. 2015-12-07. PMID:25751174. |
the methanolic fraction was chosen for further assays to assess the involvement of: 1) presynaptic sites (axons or nerve terminals), 2) postsynaptic sites (cholinergic receptors, sarcolemma or t-tubules), and 3) the synaptic cleft (acetylcholinesterase enzyme). |
2015-12-07 |
2023-08-13 |
mouse |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |
| Roger M Lane, Taher Darreh-Shor. Understanding the beneficial and detrimental effects of donepezil and rivastigmine to improve their therapeutic value. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25408210. |
inhibition of acetylcholinesterase (ache) in damaged but functional cholinergic synapses in the brains of dementia patients increases intrasynaptic ach. |
2015-11-09 |
2023-08-13 |
Not clear |