| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Valentina Bu\\xc5\\xa1i\\xc4\\x87, Maja Katalini\\xc4\\x87, Goran \\xc5\\xa0inko, Zrinka Kovarik, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicology letters. vol 262. 2017-02-06. PMID:27693733.' |
organophosphorus (op) nerve agents (sarin, tabun vx and soman) inhibit the enzyme acetylcholinesterase (ache, ec 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. |
2017-02-06 |
2023-08-13 |
human |
| Nikolina Maček Hrvat, Suzana Žunec, Palmer Taylor, Zoran Radić, Zrinka Kovari. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27083141. |
the high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (ache), an essential enzyme in cholinergic neurotransmission. |
2017-02-01 |
2023-08-13 |
mouse |
| Miranda L Xu, Cathy W C Bi, Ava Y Y Kong, Tina T X Dong, Yung H Wong, Karl W K Tsi. Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019979. |
here, we aimed to test if flavonoid could induce a cholinergic enzyme, acetylcholinesterase (ache), as well as bone differentiation. |
2017-01-30 |
2023-08-13 |
rat |
| F J Campoy, C J Vidal, E Muñoz-Delgado, M F Montenegro, J Cabezas-Herrera, S Nieto-Ceró. Cholinergic system and cell proliferation. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27083142. |
this review gathers information on the role of cholinergic system and specially acetylcholinesterase in cell proliferation and apoptosis. |
2017-01-30 |
2023-08-13 |
human |
| Nicolas Lenfant, Yves Bourne, Pascale Marchot, Arnaud Chatonne. Relationships of human α/β hydrolase fold proteins and other organophosphate-interacting proteins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27109753. |
because of the central role of acetylcholinesterase cholinergic neurotransmission in humans, one of the main purposes for using ops is inactivation of the enzyme by phosphorylation of the nucleophilic serine residue in the active center. |
2017-01-30 |
2023-08-13 |
human |
| Miguel A Sogorb, Encarnación Fuster, Eva Del Río, Jorge Estévez, Eugenio Vilanov. Effects of mipafox, paraoxon, chlorpyrifos and its metabolite chlorpyrifos-oxon on the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27117976. |
chlorpyrifos (cps) is an organophosphorus compound (op) capable of causing well-known cholinergic and delayed syndromes through the inhibition of acetylcholinesterase and neuropathy target esterase (nte), respectively. |
2017-01-30 |
2023-08-13 |
mouse |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Garer. The CITIRIVAD Study: CITIcoline plus RIVAstigmine in Elderly Patients Affected with Dementia Study. Clinical drug investigation. vol 36. issue 12. 2017-01-02. PMID:27587069. |
acetylcholinesterase inhibitors (acheis), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in alzheimer's disease (ad) and in mixed dementia (md), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. |
2017-01-02 |
2023-08-13 |
Not clear |
| Prabhat Singh, Bhupesh Sharm. Selective Serotonin-norepinephrine Re-uptake Inhibition Limits Renovas-cular-hypertension Induced Cognitive Impairment, Endothelial Dysfunction, and Oxidative Stress Injury. Current neurovascular research. vol 13. issue 2. 2016-12-26. PMID:26915517. |
2k1c method has increased serum nitrosative stress (reduced nitrite/nitrate level), oxidative stress (increased brain thiobarbituric acid reactive species and aortic superoxide anion content along with decreased levels of brain superoxide dismutase, glutathione, and catalase), brain inflammation (increased myeloperoxidase), cholinergic dysfunction (increased acetylcholinesterase activity) and brain damage. |
2016-12-26 |
2023-08-13 |
rat |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
we also evidenced misregulation of cholinergic anti-inflammatory system with increased acetylcholinesterase (ache) activity and decreased acetylcholine (ach) levels, contributing to the inflammatory status in pro-treated astrocytes. |
2016-12-13 |
2023-08-13 |
rat |
| Sriranjini Venkat Rao, Muralidhara, Sarat Chandra Yenisetti, Padmanabhan S Rajin. Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism. Neurotoxicology. vol 52. 2016-12-13. PMID:26705857. |
while rot elevated the activity of acetylcholinesterase (ache) in head/body regions, both the treatments caused marked diminution of ache activity and restored the dopamine levels suggesting their effectiveness to mitigate cholinergic function. |
2016-12-13 |
2023-08-13 |
drosophila_melanogaster |
| Rabindranath Lo, Nellore Bhanu Chandar, Shibaji Ghosh, Bishwajit Gangul. The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies. Molecular bioSystems. vol 12. issue 4. 2016-12-13. PMID:26879641. |
a highly toxic nerve agent, tabun, can inhibit acetylcholinesterase (ache) at cholinergic sites, which leads to serious cardiovascular complications, respiratory compromise and death. |
2016-12-13 |
2023-08-13 |
Not clear |
| Anders Allgardsson, Lotta Berg, Christine Akfur, Andreas Hörnberg, Franz Worek, Anna Linusson, Fredrik J Ekströ. Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140636. |
organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (ache). |
2016-12-13 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
the organophosphorus (op) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome-related symptoms. |
2016-11-14 |
2023-08-13 |
mouse |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
the brains were removed to assess cholinergic markers, such as choline acetyltransferase (chat) and acetylcholinesterase (ache), and to explore neurodegeneration in the ms and hippocampus, using amino-cupric silver and h&e staining. |
2016-10-19 |
2023-08-13 |
rat |
| Prabhat Singh, Bhupesh Sharm. Reversal in Cognition Impairments, Cholinergic Dysfunction, and Cerebral Oxidative Stress Through the Modulation of Ryanodine Receptors (RyRs) and Cysteinyl Leukotriene-1 (CysLT1) Receptors. Current neurovascular research. vol 13. issue 1. 2016-10-14. PMID:26500103. |
animals with bilateral carotid arteries occlusion have revealed impaired learning and memory (morris water maze), cholinergic dysfunction (increased acetylcholinesterase activity) as well as increased brain oxidative stress (reduction in brain superoxide dismutase, glutathione and catalase with an increase in thiobarbituric acid reactive substance level), with increased brain infarct size (2,3,5-triphenylterazolium chloride staining). |
2016-10-14 |
2023-08-13 |
mouse |
| Jana Zdarova Karasova, Milos Hroch, Kamil Musilek, Kamil Kuc. Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26646154. |
inhibitors of acetylcholinesterase (ache) may be used in the treatment of various cholinergic deficits, among them being myasthenia gravis (mg). |
2016-10-14 |
2023-08-13 |
Not clear |
| Marianna K Gouveia, Tarciso T Miguel, Cristiane Busnardo, América A Scopinho, Fernando M A Corrêa, Ricardo L Nunes-de-Souza, Carlos C Crestan. Dissociation in control of physiological and behavioral responses to emotional stress by cholinergic neurotransmission in the bed nucleus of the stria terminalis in rats. Neuropharmacology. vol 101. 2016-10-05. PMID:26477570. |
facilitation of local cholinergic signaling by microinjection of the acetylcholinesterase inhibitor neostigmine (0.1 nmol/100 nl) into the bnst reduced restraint-evoked pressor and tachycardiac responses and the fall in tail cutaneous temperature, without affecting the increase in plasma corticosterone. |
2016-10-05 |
2023-08-13 |
rat |
| Zehra Batool, Sadia Sadir, Laraib Liaquat, Saiqa Tabassum, Syeda Madiha, Sahar Rafiq, Sumayya Tariq, Tuba Sharf Batool, Sadia Saleem, Fizza Naqvi, Tahira Perveen, Saida Haide. Repeated administration of almonds increases brain acetylcholine levels and enhances memory function in healthy rats while attenuates memory deficits in animal model of amnesia. Brain research bulletin. vol 120. 2016-09-30. PMID:26548495. |
cholinergic function was determined in terms of hippocampal and frontal cortical acetylcholine content and acetylcholinesterase activity. |
2016-09-30 |
2023-08-13 |
rat |
| S K Tayebati, G Marucci, C Santinelli, M Buccioni, F Ament. Choline-Containing Phospholipids: Structure-Activity Relationships Versus Therapeutic Applications. Current medicinal chemistry. vol 22. issue 38. 2016-09-20. PMID:26511472. |
this paper has reviewed chemical, biological and therapeutic features of ccpls by analyzing: a) effects of exogenous ccpls, b) influence of gpc treatment on brain cholinergic neurotransmission, and c) neuroprotective effects of gpc alone or in association with acetylcholinesterase inhibitors in animal models of brain vascular injury, d) synthesis of the choline analogs, containing a short alkyl chain instead of a methyl group. |
2016-09-20 |
2023-08-13 |
Not clear |