| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| António José Gabriel, Maria Rosário Almeida, Maria Helena Ribeiro, João Durães, Miguel Tábuas-Pereira, Ana Cristina Pinheiro, Rui Pascoal, Isabel Santana, Inês Baldeira. Association between butyrylcholinesterase and cerebrospinal fluid biomarkers in Alzheimer's disease patients. Neuroscience letters. vol 641. 2017-12-12. PMID:28108398. |
the deficit of cholinergic activity is one of the main findings in alzheimer's disease (ad), and is related to the synthesis of acetylcholine, and the hydrolysing enzymes, acetylcholinesterase and butyrylcholinesterase (buche). |
2017-12-12 |
2023-08-13 |
Not clear |
| Sandeep Kondakala, Jung Hwa Lee, Matthew K Ross, George E Howel. Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. Toxicology and applied pharmacology. vol 337. 2017-12-12. PMID:29097212. |
male c57bl/6j mice were fed normal or high-fat diet for 4weeks and administered a single dose of vehicle or cps (2.0mg/kg; oral gavage) to assess cholinergic (acetylcholinesterase activities) and non-cholinergic (carboxylesterase and endocannabinoid hydrolysis) endpoints. |
2017-12-12 |
2023-08-13 |
mouse |
| Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 36. issue 2. 2017-12-07. PMID:29199596. |
behavioral parameters (morris water maze test) along with biochemical parameters (hippocampus and frontal cortex) such as acetylcholinesterase (ache), catalase, and glutathione (gsh) levels were assessed to correlate cognitive function with cholinergic transmission and oxidative stress. |
2017-12-07 |
2023-08-13 |
rat |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| D K Rieger, A A Dos Santos, C Suñol, M Farin. Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons. Journal of toxicology and environmental health. Part A. vol 80. issue 19-21. 2017-11-16. PMID:28849997. |
the neurotoxic effects are attributed mainly to acetylcholinesterase (ache) enzyme inhibition, which is responsible for cholinergic manifestations in individuals acutely exposed to op. |
2017-11-16 |
2023-08-13 |
mouse |
| Asante R Kamkwalala, Paul A Newhous. Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease. Current Alzheimer research. vol 14. issue 4. 2017-10-04. PMID:27697062. |
beyond acetylcholinesterase inhibitors: novel cholinergic treatments for alzheimer's disease. |
2017-10-04 |
2023-08-13 |
human |
| Asante R Kamkwalala, Paul A Newhous. Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease. Current Alzheimer research. vol 14. issue 4. 2017-10-04. PMID:27697062. |
currently, the most widely prescribed treatment for ad is acetylcholinesterase inhibitor medications, which work by partially blocking the degradation of acetylcholine in the synapse and enabling more of the neurotransmitter to reach and activate cholinergic receptors. |
2017-10-04 |
2023-08-13 |
human |
| Yuko Hara, Yumiko Motoi, Keigo Hikishima, Hiroshi Mizuma, Hirotaka Onoe, Shin-Ei Matsumoto, Montasir Elahi, Hideyuki Okano, Shigeki Aoki, Nobutaka Hattor. Involvement of the Septo-Hippocampal Cholinergic Pathway in Association with Septal Acetylcholinesterase Upregulation in a Mouse Model of Tauopathy. Current Alzheimer research. vol 14. issue 1. 2017-10-02. PMID:27335039. |
involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy. |
2017-10-02 |
2023-08-13 |
mouse |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |
| Mariana Matias, Samuel Silvestre, Amílcar Falcao, Gilberto Alve. Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders. Mini reviews in medicinal chemistry. vol 17. issue 6. 2017-09-12. PMID:27834131. |
moreover, several hybrid compounds have also been designed for the treatment of neurodegenerative diseases focusing primarily on alzheimer's disease by targeting the cholinergic neurotransmission, as acetylcholinesterase inhibitors, and the amyloid β-protein deposition. |
2017-09-12 |
2023-08-13 |
Not clear |
| Angela Rampa, Serena Montanari, Letizia Pruccoli, Manuela Bartolini, Federico Falchi, Alessandra Feoli, Andrea Cavalli, Federica Belluti, Silvia Gobbi, Andrea Tarozzi, Alessandra Bis. Chalcone-based carbamates for Alzheimer's disease treatment. Future medicinal chemistry. vol 9. issue 8. 2017-09-12. PMID:28498775. |
in this picture, the recent reformulation of the cholinergic hypothesis renewed the interest for acetylcholinesterase inhibitors. |
2017-09-12 |
2023-08-13 |
Not clear |
| Sophie J Bradley, Julie-Myrtille Bourgognon, Helen E Sanger, Nicholas Verity, Adrian J Mogg, David J White, Adrian J Butcher, Julie A Moreno, Colin Molloy, Timothy Macedo-Hatch, Jennifer M Edwards, Jurgen Wess, Robert Pawlak, David J Read, Patrick M Sexton, Lisa M Broad, Joern R Steinert, Giovanna R Mallucci, Arthur Christopoulos, Christian C Felder, Andrew B Tobi. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. The Journal of clinical investigation. vol 127. issue 2. 2017-09-07. PMID:27991860. |
the current frontline symptomatic treatment for alzheimer's disease (ad) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. |
2017-09-07 |
2023-08-13 |
mouse |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Patrick Masson, Florian Nacho. Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28542985. |
organophosphorus agents (ops) irreversibly inhibit acetylcholinesterase (ache) causing a major cholinergic syndrome. |
2017-09-07 |
2023-08-13 |
Not clear |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Sen-Zhi Zhu, Wei-Ping Huang, Lin-Qiang Huang, Yong-Li Han, Qian-Peng Han, Gao-Feng Zhu, Miao-Yun Wen, Yi-Yu Deng, Hong-Ke Zen. Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. Neuroscience letters. vol 631. 2017-07-26. PMID:27400829. |
to elucidate the role of the cholinergic nervous system in sae, hippocampal choline acetyltransferase, muscarinic acetylcholine receptor-1, acetylcholinesterase and acetylcholine were evaluated in lps-induced sepsis rats. |
2017-07-26 |
2023-08-13 |
rat |
| Sen-Zhi Zhu, Wei-Ping Huang, Lin-Qiang Huang, Yong-Li Han, Qian-Peng Han, Gao-Feng Zhu, Miao-Yun Wen, Yi-Yu Deng, Hong-Ke Zen. Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. Neuroscience letters. vol 631. 2017-07-26. PMID:27400829. |
furthermore, therapeutic effects of the acetylcholinesterase inhibitor huperzine a (hupa) on the hippocampal cholinergic nervous function and neuroinflammation were evaluated. |
2017-07-26 |
2023-08-13 |
rat |