| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johannes B Zimmermann, Nadine Pinder, Thomas Bruckner, Monika Lehmann, Johann Motsch, Thorsten Brenner, Torsten Hoppe-Tichy, Stefanie Swoboda, Markus A Weigand, Stefan Hofe. Adjunctive use of physostigmine salicylate (Anticholium®) in perioperative sepsis and septic shock: study protocol for a randomized, double-blind, placebo-controlled, monocentric trial (Anticholium® per Se). Trials. vol 18. issue 1. 2018-07-09. PMID:29126416. |
the cholinergic anti-inflammatory pathway (cap) represents a new approach to adjunctive therapy of septic diseases and can be pharmacologically activated by the acetylcholinesterase inhibitor physostigmine (anticholium®). |
2018-07-09 |
2023-08-13 |
Not clear |
| Matthew Umholtz, Nader D Nade. Anesthetic Immunomodulation of the Neuroinflammation in Postoperative Cognitive Dysfunction. Immunological investigations. vol 46. issue 8. 2018-05-31. PMID:29058541. |
several previous trials have attempted to prevent or treat clinical manifestation by modulation of the cholinergic system with acetylcholinesterase inhibitors, the results of which have been largely ambiguous at best. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jie Gao, Sean X Naughton, Wayne D Beck, Caterina M Hernandez, Guangyu Wu, Zhe Wei, Xiangkun Yang, Michael G Bartlett, Alvin V Terr. Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons. Neurotoxicology. vol 62. 2018-05-30. PMID:28600141. |
while the insecticidal actions and acute toxicity of cpf are attributed to its oxon metabolite (cpo) which potently inhibits the cholinergic enzyme acetylcholinesterase (ache), there is significant evidence that cpf, cpo, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to ache. |
2018-05-30 |
2023-08-13 |
rat |
| Shalini Trivedi, Priyanka Maurya, Shreesh Raj Sammi, Madan Mohan Gupta, Rakesh Pande. 5-Desmethylnobiletin augments synaptic ACh levels and nicotinic ACh receptor activity: A potential candidate for alleviation of cholinergic dysfunction. Neuroscience letters. vol 657. 2018-05-28. PMID:28780166. |
further investigation into the mechanistic aspects indicated that dn enhanced cholinergic function through down modulation of acetylcholinesterase activity at enzyme and transcript level along with upregulation of non alpha subunit, unc-29 which could be linked with enhanced nachr activity as evident from levamisole assay. |
2018-05-28 |
2023-08-13 |
caenorhabditis_elegans |
| Shreesh Raj Sammi, Shalini Trivedi, Srikanta Kumar Rath, Abhishek Nagar, Sudeep Tandon, Alok Kalra, Rakesh Pande. 1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27599497. |
to this date, the therapeutic management of cholinergic dysfunction is limited to provide symptomatic relief through the use of acetylcholinesterase (ache) inhibitors only. |
2018-05-18 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Shih-Ya Hung, Wen-Mei F. Drug candidates in clinical trials for Alzheimer's disease. Journal of biomedical science. vol 24. issue 1. 2018-05-01. PMID:28720101. |
current ad medications, memantine and acetylcholinesterase inhibitors (acheis) alleviate some of these symptoms by enhancing cholinergic signaling, but they are not curative. |
2018-05-01 |
2023-08-13 |
Not clear |
| Katarina Mis, Zoran Grubic, Paola Lorenzon, Marina Sciancalepore, Tomaz Mars, Sergej Pirkmaje. In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-01. PMID:28846617. |
acetylcholinesterase (ache) and agrin, a heparan-sulfate proteoglycan, reside in the basal lamina of the neuromuscular junction (nmj) and play key roles in cholinergic transmission and synaptogenesis. |
2018-05-01 |
2023-08-13 |
human |
| Yi Lu, Ming Zhao, Jin-Jun Liu, Xi He, Xiao-Jiang Yu, Long-Zhu Liu, Lei Sun, Li-Na Chen, Wei-Jin Zan. Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling. Journal of cellular and molecular medicine. vol 21. issue 9. 2018-04-30. PMID:28296184. |
pyridostigmine attenuated cardiac hypertrophy and improved cardiac function, which was related to improved cholinergic transmission efficiency (decreased acetylcholinesterase and increased acetylcholine), inhibition of the can/nfat3/gata4 pathway and suppression of the interaction of orai1/stim1. |
2018-04-30 |
2023-08-13 |
rat |
| Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor, Eva-Maria S Collin. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Archives of toxicology. vol 91. issue 8. 2018-04-12. PMID:27990564. |
while previous activity staining of d. japonica, which possess a discrete cholinergic nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (ache), butyrylcholinesterase (bche), or a hybrid esterase and how op exposure affects esterase activity. |
2018-04-12 |
2023-08-13 |
human |
| Yaowen Zhang, Bin Han, Yating He, Daojing Li, Xiaofeng Ma, Qiang Liu, Junwei Ha. MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. Neurochemistry international. vol 107. 2018-04-03. PMID:27940326. |
recent studies suggest that microrna-132 (mir-132) potentiates the cholinergic blockade of inflammatory reactions by targeting acetylcholinesterase (ache) and affords robust protection against ischemia-induced neuronal death. |
2018-04-03 |
2023-08-13 |
mouse |
| Manushree Bharadwaj, Carey Pope, Michael Davis, Stuart Katz, Christian Cook, Lara Maxwel. Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats. Clinical and experimental pharmacology & physiology. vol 44. issue 8. 2018-03-06. PMID:28440910. |
acetylcholinesterase inhibitors, such as pyridostigmine, can enhance parasympathetic tone by increasing cholinergic input to the heart. |
2018-03-06 |
2023-08-13 |
rat |
| Seong Min Hong, Kyong Hee Soe, Taek Hwan Lee, In Sook Kim, Young Min Lee, Beong Ou Li. Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model. Journal of agricultural and food chemistry. vol 66. issue 1. 2018-02-15. PMID:29260547. |
bv facilitated cholinergic activity by inhibiting acetylcholinesterase activity, and enhanced antioxidant enzyme activity. |
2018-02-15 |
2023-08-13 |
mouse |
| Sadudee Chotirat, Tawit Suriyo, Marianne Hokland, Peter Hokland, Jutamaad Satayavivad, Chirayu U Auewaraku. Cholinergic activation enhances retinoic acid-induced differentiation in the human NB-4 acute promyelocytic leukemia cell line. Blood cells, molecules & diseases. vol 59. 2018-01-12. PMID:27282572. |
we determined the expression of cholinergic components in leukemic cell lines by western blotting and in normal leukocyte subsets by flow cytometry and found a heterogeneous expression of choline acetyltransferase (chat), acetylcholinesterase (ache), choline transporter (cht), m3 muscarinic acetylcholine receptor (m3-machr) and α7 nicotinic acetylcholine receptor (α7-nachr). |
2018-01-12 |
2023-08-13 |
human |
| Chen Chen, Yake Zheng, Tianwen Wu, Chuanjie Wu, Xuan Chen. Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27984208. |
a morris water maze task was used to evaluate memory, the levels of acetylcholinesterase, choline acetyltransferase, acetylcholine were used to evaluate cholinergic function, and oxidative stress was assessed by measuring the enzyme activity of superoxide dismutase, glutathione peroxidase, malonic dialdehyde, and catalase. |
2018-01-11 |
2023-08-13 |
rat |
| Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Li. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29133030. |
ppd regulated cholinergic function by inhibiting scop-induced elevation of acetylcholinesterase (ache) activity, decline of choline acetyltransferase (chat) activity and decrease of acetylcholine (ach) level. |
2018-01-03 |
2023-08-13 |
mouse |
| Ondrej Soukup, Michael Winder, Uday Kumar Killi, Vladimir Wsol, Daniel Jun, Kamil Kuca, Gunnar Tobi. Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment. Current neuropharmacology. vol 15. issue 4. 2018-01-02. PMID:27281175. |
acetylcholinesterase inhibitors and drugs acting on muscarinic receptors- potential crosstalk of cholinergic mechanisms during pharmacological treatment. |
2018-01-02 |
2023-08-13 |
Not clear |
| Umit M Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin, Mustafa Ceyla. Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. Journal of biochemical and molecular toxicology. vol 31. issue 9. 2018-01-02. PMID:28613396. |
prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (ache). |
2018-01-02 |
2023-08-13 |
human |
| I Buendia, E Parada, E Navarro, R León, P Negredo, J Egea, M G Lópe. Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:26081146. |
in these patients, acetylcholinesterase inhibitors (achei) are the major drug class used for their treatment; however, they present unwanted cholinergic side effects and have provided limited efficacy in clinic. |
2017-12-22 |
2023-08-13 |
Not clear |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |