| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luis E Okamoto, Cyndya A Shibao, Alfredo Gamboa, André Diedrich, Satish R Raj, Bonnie K Black, David Robertson, Italo Biaggion. Synergistic Pressor Effect of Atomoxetine and Pyridostigmine in Patients With Neurogenic Orthostatic Hypotension. Hypertension (Dallas, Tex. : 1979). vol 73. issue 1. 2019-11-13. PMID:30571543. |
for example, norepinephrine transporter blockade with atomoxetine raises blood pressure (bp) in autonomic failure patients by increasing synaptic norepinephrine concentrations; acetylcholinesterase inhibition with pyridostigmine increases bp by facilitating ganglionic cholinergic neurotransmission to increase sympathetic outflow. |
2019-11-13 |
2023-08-13 |
Not clear |
| Md Junaid, Nazrul Islam, Md Kamal Hossain, M Obayed Ullah, Mohammad A Hali. Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease. PloS one. vol 14. issue 2. 2019-11-04. PMID:30785927. |
targeting acetylcholinesterase (ache) is one of the major strategies for ad therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. |
2019-11-04 |
2023-08-13 |
human |
| Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng L. Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity. International journal of nanomedicine. vol 14. 2019-11-01. PMID:31440049. |
acetylcholinesterase (ache) plays a critical role in the transmission of nerve impulse at the cholinergic synapses. |
2019-11-01 |
2023-08-13 |
Not clear |
| Eng Leng Saw, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30343172. |
the existence of cardiac nncs has been confirmed by the presence of cholinergic markers in the cardiomyocytes, which are crucial for synthesis (choline acetyltransferase, chat), storage (vesicular acetylcholine transporter, vacht), reuptake of choline for synthesis (high-affinity choline transporter, cht1) and degradation (acetylcholinesterase, ache) of acetylcholine (ach). |
2019-10-28 |
2023-08-13 |
Not clear |
| Jason M Uslaner, Scott D Kuduk, Marion Wittmann, Henry S Lange, Steve V Fox, Chris Min, Natasa Pajkovic, Dawn Harris, Caroline Cilissen, Chantal Mahon, Kate Mostoller, Steve Warrington, Douglas C Beshor. Preclinical to Human Translational Pharmacology of the Novel M The Journal of pharmacology and experimental therapeutics. vol 365. issue 3. 2019-10-14. PMID:29563325. |
preclinical to human translational pharmacology of the novel m the current standard of care for treating alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. |
2019-10-14 |
2023-08-13 |
human |
| Clarissa von Haefen, Marco Sifringer, Stefanie Endesfelder, Alexander Kalb, Adrián González-López, Annalena Tegethoff, Nadine Paeschke, Claudia D Spie. Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29790105. |
tissue damage and pathogen invasion during surgical trauma have been identified as contributing factors leading to neuroinflammation in the hippocampus, which can be protected by stimulation of the cholinergic anti-inflammatory pathway using the acetylcholinesterase inhibitor physostigmine. |
2019-10-02 |
2023-08-13 |
rat |
| Elspeth J Hulse, James D Haslam, Stevan R Emmett, Tom Woolle. Organophosphorus nerve agent poisoning: managing the poisoned patient. British journal of anaesthesia. vol 123. issue 4. 2019-09-20. PMID:31248646. |
op nerve agents primarily act by inhibiting the enzyme acetylcholinesterase, causing an acute cholinergic crisis; death usually occurs through respiratory failure. |
2019-09-20 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Rui Sha, Yangsheng Chen, Yali Luo, Yiyun Liu, Li Xu, Heidi Qunhui Xie, Bin Zha. Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31152735. |
acetylcholinesterase (ec3.1.1.7; ache) is a key enzyme in the cholinergic system. |
2019-08-19 |
2023-08-13 |
human |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Karin Mente, Nancy A Edwards, Demelio Urbano, Abhik Ray-Chaudhury, Diego Iacono, Ana Tereza Di Lorenzo Alho, Eduardo Joaquim Lopes Alho, Edson Amaro, Silvina G Horovitz, Mark Hallet. Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 5. 2019-08-12. PMID:29508906. |
some animal models have cholinergic neuronal loss in the striatum and increased acetylcholinesterase activity in the pedunculopontine nucleus. |
2019-08-12 |
2023-08-13 |
human |
| Yali Luo, Heidi Qunhui Xie, Yangsheng Chen, Yingjie Xia, Rui Sha, Yiyun Liu, Yongchao Ma, Tong Xu, Li Xu, Karl Wah-Keung Tsim, Bin Zha. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31100272. |
acetylcholinesterase (ec3.1.1.7; ache), an enzyme critical for cholinergic neurotransmission, is abundantly expressed in neurons and mature myotubes, and we recently found that muscle ache expression was suppressed in parallel with the inhibition of myogenic differentiation upon tcdd treatment in mouse c2c12 cells. |
2019-07-22 |
2023-08-13 |
mouse |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
acetylecholine (ach), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (ache), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. |
2019-07-22 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |
| Shaik Jeelan Basha, Penumala Mohan, Daniel Pushparaju Yeggoni, Zinka Raveendra Babu, Palaka Bhagath Kumar, Ampasala Dinakara Rao, Rajagopal Subramanyam, Amooru Gangaiah Dam. New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer's Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase. Molecular pharmaceutics. vol 15. issue 6. 2019-07-03. PMID:29745222. |
new flavone-cyanoacetamide hybrids with a combination of cholinergic, antioxidant, modulation of β-amyloid aggregation, and neuroprotection properties as innovative multifunctional therapeutic candidates for alzheimer's disease and unraveling their mechanism of action with acetylcholinesterase. |
2019-07-03 |
2023-08-13 |
Not clear |
| Nils Richter, Nora Beckers, Oezguer A Onur, Markus Dietlein, Marc Tittgemeyer, Lutz Kracht, Bernd Neumaier, Gereon R Fink, Juraj Kukolj. Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 3. 2019-06-27. PMID:29309600. |
our results indicate that rivastigmine differentially affects memory-related neural activity in patients with mild cognitive impairment and cognitively normal, age-matched adults, depending on acetylcholinesterase activity as a marker for the integrity of the cortical cholinergic system. |
2019-06-27 |
2023-08-13 |
Not clear |
| Miranda L Xu, Wilson K W Luk, Cathy W C Bi, Etta Y L Liu, Kevin Q Y Wu, Ping Yao, Tina T X Dong, Karl W K Tsi. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of neurochemistry. vol 146. issue 4. 2019-06-26. PMID:29675901. |
acetylcholinesterase (ache; ec 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. |
2019-06-26 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Miranda L Xu, Yingjie Xia, Xiangpeng Kong, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chemico-biological interactions. vol 306. 2019-06-05. PMID:31034797. |
the role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (ache), was being explored here. |
2019-06-05 |
2023-08-13 |
Not clear |
| Raj P Kapur, Philipp W Raess, Samuel Hwang, Conrad Winte. Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 20. issue 4. 2019-05-29. PMID:28649946. |
acetylcholinesterase enzymatic histochemistry (ache ehc), which highlights abnormal cholinergic nerves in the mucosa of aganglionic bowel, has been used for decades to evaluate rectal biopsies for hirschsprung disease (hscr). |
2019-05-29 |
2023-08-13 |
Not clear |
| Debapriya Garabadu, Mahima Sharm. Eugenol Attenuates Scopolamine-Induced Hippocampal Cholinergic, Glutamatergic, and Mitochondrial Toxicity in Experimental Rats. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30737653. |
additionally, eugenol attenuated scopolamine-induced hippocampal cholinergic dysfunction (decrease in acetylcholine level, increase in acetylcholinesterase activity, and decrease in density and affinity of m |
2019-05-23 |
2023-08-13 |
rat |