| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miroslav Pohanka, Vitezslav Vlce. Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs. Interdisciplinary toxicology. vol 7. issue 4. 2015-06-25. PMID:26109903. |
acetylcholinesterase (ache; ec 3.1.1.7) is one of the most crucial components of the cholinergic nervous system and thus many of the toxins interact with this enzyme. |
2015-06-25 |
2023-08-13 |
Not clear |
| Galina F Makhaeva, Elena V Rudakova, Nichole D Hein, Olga G Serebryakova, Nadezhda V Kovaleva, Natalia P Boltneva, John K Fink, Rudy J Richardso. Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds. Journal of applied toxicology : JAT. vol 34. issue 12. 2015-06-22. PMID:24395470. |
inhibition and aging of neuropathy target esterase (nte) by neuropathic organophosphorus (op) compounds triggers op compound-induced delayed neuropathy (opidn), whereas inhibition of acetylcholinesterase (ache) produces cholinergic toxicity. |
2015-06-22 |
2023-08-12 |
mouse |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Kathrine Eggers Pedersen, Niladri Basu, Robert Letcher, Alana K Greaves, Christian Sonne, Rune Dietz, Bjarne Styrishav. Brain region-specific perfluoroalkylated sulfonate (PFSA) and carboxylic acid (PFCA) accumulation and neurochemical biomarker responses in east Greenland polar bears (Ursus maritimus). Environmental research. vol 138. 2015-06-15. PMID:25682255. |
nine brain regions from nine polar bears were analyzed for enzyme activity (monoamine oxidase (mao), acetylcholinesterase (ache) and glutamine synthetase (gs)) and receptor density (dopamine-2 (d2), muscarinic cholinergic (machr) and gamma-butyric acid type a (gaba-a)) along with pfsa and pfca concentrations. |
2015-06-15 |
2023-08-13 |
Not clear |
| Michela Rosini, Elena Simoni, Anna Minarini, Carlo Melchiorr. Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces. Neurochemical research. vol 39. issue 10. 2015-06-08. PMID:24493627. |
we have sought to combine, in the same molecule, the neuroprotective action of n-methyl-d-aspartate receptor antagonism with the symptomatic relief offered by cholinergic activity through acetylcholinesterase inhibition. |
2015-06-08 |
2023-08-12 |
Not clear |
| Arup K Pathak, Tusar Bandyopadhya. Unbinding free energy of acetylcholinesterase bound oxime drugs along the gorge pathway from metadynamics-umbrella sampling investigation. Proteins. vol 82. issue 9. 2015-06-08. PMID:24549829. |
because of the pivotal role that the nerve enzyme, acetylcholinesterase plays in terminating nerve impulses at cholinergic synapses. |
2015-06-08 |
2023-08-12 |
Not clear |
| P A Ferchmin, Myrna Andino, Rebeca Reyes Salaman, Janaina Alves, Joyce Velez-Roman, Brenda Cuadrado, Marimeé Carrasco, Wilmarie Torres-Rivera, Annabell Segarra, Antonio Henrique Martins, Jae Eun Lee, Vesna A Eterovi. 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration. Neurotoxicology. vol 44. 2015-05-27. PMID:24928201. |
many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. |
2015-05-27 |
2023-08-13 |
rat |
| Katiucia Marques Capiotti, Daiani Almeida De Moraes, Fabiano Peres Menezes, Luiza Wilges Kist, Maurício Reis Bogo, Rosane Souza Da Silv. Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio). Behavioural brain research. vol 274. 2015-05-26. PMID:25157430. |
these data suggest that the memory impairment induced by hyperglycemia is underlined by the cholinergic dysfunction caused by the mechanisms involving the control of acetylcholinesterase function and gene expression. |
2015-05-26 |
2023-08-13 |
zebrafish |
| Nils Richter, Inka Allendorf, Oezguer A Onur, Lutz Kracht, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R Fink, Juraj Kukolj. The integrity of the cholinergic system determines memory performance in healthy elderly. NeuroImage. vol 100. 2015-05-12. PMID:24952230. |
cerebral acetylcholinesterase (ache) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (pet) and [(11)c]n-methyl-4-piperidyl acetate (mp4a). |
2015-05-12 |
2023-08-13 |
Not clear |
| Deok Jea Cha, Si Hyeock Le. Evolutionary origin and status of two insect acetylcholinesterases and their structural conservation and differentiation. Evolution & development. vol 17. issue 1. 2015-05-12. PMID:25627717. |
acetylcholinesterase (ache) plays a pivotal role in synaptic transmission in the cholinergic nervous system of most animals, including insects. |
2015-05-12 |
2023-08-13 |
Not clear |
| Alexandra I Zugno, Maria Paula Matos, Leila Canever, Daiane B Fraga, Renata D De Luca, Fernando V Ghedim, Pedro F Deroza, Mariana B de Oliveira, Felipe D Pacheco, Samira S Valvassori, Ana Maria Volpato, Josiane Budni, João Queved. Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia. Acta neuropsychiatrica. vol 26. issue 1. 2015-05-11. PMID:25142099. |
cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (ache). |
2015-05-11 |
2023-08-13 |
Not clear |
| Ji-Woon Kim, Hana Seung, Kyung Ja Kwon, Mee Jung Ko, Eun Joo Lee, Hyun Ah Oh, Chang Soon Choi, Ki Chan Kim, Edson Luck Gonzales, Jueng Soo You, Dong-Hee Choi, Jongmin Lee, Seol-Heui Han, Sung Min Yang, Jae Hoon Cheong, Chan Young Shin, Geon Ho Bah. Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism. PloS one. vol 9. issue 8. 2015-04-23. PMID:25133713. |
we found that prenatal exposure of valproic acid (vpa) induced dysregulation of cholinergic neuronal development, most notably the up-regulation of acetylcholinesterase (ache) in the prefrontal cortex of affected rat and mouse offspring. |
2015-04-23 |
2023-08-13 |
mouse |
| Cédric Lecoutey, Damien Hedou, Thomas Freret, Patrizia Giannoni, Florence Gaven, Marc Since, Valentine Bouet, Céline Ballandonne, Sophie Corvaisier, Aurélie Malzert Fréon, Serge Mignani, Thierry Cresteil, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagn. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 36. 2015-04-20. PMID:25157130. |
we show herein that rs67333 is also a submicromolar acetylcholinesterase (ache) inhibitor and therefore, could contribute, through this effect, to the restoration of the cholinergic neurotransmission that becomes altered in ad. |
2015-04-20 |
2023-08-13 |
Not clear |
| Trine Gjerløff, Tatyana Fedorova, Karoline Knudsen, Ole L Munk, Adjmal Nahimi, Steen Jacobsen, Erik H Danielsen, Astrid J Terkelsen, John Hansen, Nicola Pavese, David J Brooks, Per Borghamme. Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET. Brain : a journal of neurology. vol 138. issue Pt 3. 2015-04-20. PMID:25539902. |
acetylcholinesterase histology has been used for many years for visualizing cholinergic neurons. |
2015-04-20 |
2023-08-13 |
human |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
secretion of cytokines and the enzymes acetylcholinesterase (ache), butyrylcholinesterase (buche) and choline acetyltransferase (chat) involved in cholinergic signalling was measured in medium throughout the differentiation. |
2015-04-13 |
2023-08-13 |
human |
| Niels Steinebrunner, Carolin Mogler, Spiros Vittas, Birgit Hoyler, Catharina Sandig, Wolfgang Stremmel, Christoph Eisenbac. Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse. BMC gastroenterology. vol 14. 2015-04-13. PMID:25139304. |
this study investigates, whether pharmacologic acetylcholinesterase inhibition with neostigmine diminishes liver damage in acute liver failure via the cholinergic anti-inflammatory pathway. |
2015-04-13 |
2023-08-13 |
mouse |
| María-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K W Luk, Karl Tsim, Javier Sáez-Valer. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24318838. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic nervous system and is one of the most studied proteins in the field of alzheimer's disease (ad). |
2015-04-06 |
2023-08-12 |
Not clear |
| Katarina Gros, Giulia Parato, Sergej Pirkmajer, Katarina Mis, Matej Podbregar, Zoran Grubic, Paola Lorenzon, Tomaz Mar. Non-synaptic roles of acetylcholinesterase and agrin. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24326956. |
typical examples are acetylcholinesterase and agrin; however, for both of these, various other functions that are not related to the cholinergic system have been revealed. |
2015-04-06 |
2023-08-12 |
mouse |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot, Arnaud Chatonne. Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24390353. |
in bilaterian animals, acetylcholinesterase co-localizes with proteins of cholinergic synapses while neuroligins co-localize and may interact with proteins of excitatory glutamatergic or inhibitory gabaergic/glycinergic synapses. |
2015-04-06 |
2023-08-12 |
Not clear |