| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Benfante, Simona Di Lascio, Silvia Cardani, Diego Fornasar. Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. Aging clinical and experimental research. vol 33. issue 4. 2021-05-03. PMID:31583530. |
acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. |
2021-05-03 |
2023-08-13 |
Not clear |
| Roberta Benfante, Simona Di Lascio, Silvia Cardani, Diego Fornasar. Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. Aging clinical and experimental research. vol 33. issue 4. 2021-05-03. PMID:31583530. |
acetylcholinesterase inhibitors (achei), the symptomatic therapy in ad, attenuate and delay the cognitive deficit by enhancing cholinergic synapses. |
2021-05-03 |
2023-08-13 |
Not clear |
| Taruna Pandey, Shachi Shuchi Smita, Anjali Mishra, Shreesh Raj Sammi, Rakesh Pande. Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. Experimental gerontology. vol 138. 2021-04-27. PMID:32590127. |
the ailments related to a malfunction in cholinergic functioning currently employ the use of inhibitors for acetylcholinesterase (ache) and n-methyl-d-aspartate (nmda) receptors. |
2021-04-27 |
2023-08-13 |
human |
| Sygrid van der Zee, Martijn L T M Müller, Prabesh Kanel, Teus van Laar, Nicolaas I Bohne. Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 3. 2021-04-27. PMID:33137238. |
previous acetylcholinesterase positron emission tomography imaging studies found memory, attention, and executive function correlates of global cortical cholinergic losses. |
2021-04-27 |
2023-08-13 |
Not clear |
| Evyatar Swissa, Guy Bar-Klein, Yonatan Serlin, Itai Weissberg, Lyna Kamintsky, Arik Eisenkraft, Liran Statlender, Shai Shrot, Yossi Rosman, Ofer Prager, Alon Friedma. Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model. Neurotoxicology. vol 78. 2021-04-21. PMID:32084435. |
ops inhibit acetylcholinesterase, leading to over-stimulation of cholinergic synapses and can cause status epilepticus (se). |
2021-04-21 |
2023-08-13 |
rat |
| Samsoon Inayat, Mojtaba Nazariahangarkolaee, Surjeet Singh, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajeran. Low acetylcholine during early sleep is important for motor memory consolidation. Sleep. vol 43. issue 6. 2021-04-14. PMID:31825510. |
we trained separate groups of adult mice on the rotarod walking task and the single pellet reaching task, and after training, administered physostigmine, an acetylcholinesterase inhibitor, to increase cholinergic tone in subsequent sleep. |
2021-04-14 |
2023-08-13 |
mouse |
| Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, Gordana Mendaš, Vedran Micek, Nikolina Maček Hrvat, Maja Katalinić, Anissa Braïki, Ludovic Jean, Pierre-Yves Renard, Vesna Gabelica Marković, Zrinka Kovari. Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. ACS chemical neuroscience. vol 11. issue 7. 2021-04-14. PMID:32105443. |
nerve agents, the deadliest chemical warfare agents, are potent inhibitors of acetylcholinesterase (ache) and cause rapid cholinergic crisis with serious symptoms of poisoning. |
2021-04-14 |
2023-08-13 |
Not clear |
| Amar Pal Singh, Sapna Balayan, Vinita Hooda, R K Sarin, Nidhi Chauha. Nano-interface driven electrochemical sensor for pesticides detection based on the acetylcholinesterase enzyme inhibition. International journal of biological macromolecules. vol 164. 2021-04-12. PMID:32882280. |
the toxicity of the op pesticides arises due to their ability to inhibit the activity of acetylcholinesterase (ache), a cholinergic enzyme that is essential for the proper functioning of the central nervous system. |
2021-04-12 |
2023-08-13 |
Not clear |
| Belgin Sever, Cüneyt Türkeş, Mehlika Dilek Altıntop, Yeliz Demir, Şükrü Beydemi. Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors. International journal of biological macromolecules. vol 163. 2021-04-02. PMID:32931834. |
the utility of cholinergic replacement by acetylcholinesterase (ache) inhibitors in ad treatment has been well-documented so far. |
2021-04-02 |
2023-08-13 |
human |
| b' Antonio Zandona, Gabriela Lihtar, Nikola Marakovi\\xc4\\x87, Katarina Mi\\xc5\\xa1, Valentina Bu\\xc5\\xa1i\\xc4\\x87, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8d, Sergej Pirkmajer, Maja Katalini\\xc4\\x8. Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33138280.' |
we evaluated the potential of nine vitamin b3 scaffold-based derivatives as acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. |
2021-03-29 |
2023-08-13 |
human |
| Alberto Castagna, Ciro Manzo, Andrea Fabbo, Roberto Lacava, Carmen Ruberto, Giovanni Ruotol. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clinical drug investigation. vol 41. issue 2. 2021-03-22. PMID:33484469. |
combined therapy of memantine or acetylcholinesterase inhibitors, with cholinergic precursors such as citicoline, can be effective in alzheimer's disease. |
2021-03-22 |
2023-08-13 |
Not clear |
| Ramón Cacabelo. Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 16. issue 8. 2021-03-12. PMID:32520597. |
cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to the introduction of acetylcholinesterase inhibitors (acheis) in 1993 (tacrine) to enhance cholinergic neurotransmission as the first line of treatment against alzheimer's disease (ad). |
2021-03-12 |
2023-08-13 |
Not clear |
| A R Salem, P Martínez Pulido, F Sanchez, Y Sanchez, A J Español, M E Sale. Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors. International immunopharmacology. vol 84. 2021-03-10. PMID:32311671. |
the non-neuronal cholinergic system refers to the presence of acetylcholine, choline acetyltransferase, acetylcholinesterase and cholinergic receptors, nicotinic and muscarinic (machrs) expressed in non-neuronal cells. |
2021-03-10 |
2023-08-13 |
mouse |
| Renata P Sakata, Giorgio Antoniolli, Marcelo Lancellotti, Daniel Fabio Kawano, Euzébio Guimarães Barbosa, Wanda P Almeid. Synthesis and biological evaluation of 2'-Aminochalcone: A multi-target approach to find drug candidates to treat Alzheimer's disease. Bioorganic chemistry. vol 103. 2021-03-09. PMID:32890999. |
the physiopathology of ad is multifactorial and is mainly supported by the cholinergic and amyloid hypotheses, which allows the identification the fundamental role of some markers, such as the enzymes acetylcholinesterase (ache) and β-secretase (bace-1), and the β-amyloid peptide (aβ). |
2021-03-09 |
2023-08-13 |
Not clear |
| Nor Atiqah Jusril, Ain Nur Najihah Muhamad Juhari, Syahrul Imran Abu Bakar, Wan Mazlina Md Saad, Mohd Ilham Adena. Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32721993. |
acetylcholinesterase (ache) is an important beneficial target for ad to control cholinergic signaling deficit. |
2021-03-01 |
2023-08-13 |
Not clear |
| Anja de Lange, Ulrich Fabien Prodjinotho, Hayley Tomes, Jana Hagen, Brittany-Amber Jacobs, Katherine Smith, William Horsnell, Chummy Sikasunge, Dorit Hockman, Murray E Selkirk, Clarissa Prazeres da Costa, Joseph Valentino Raimond. Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling. PLoS neglected tropical diseases. vol 14. issue 12. 2021-02-22. PMID:33347447. |
taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling. |
2021-02-22 |
2023-08-13 |
human |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
acetylcholinesterase (ache), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. |
2021-02-16 |
2023-08-13 |
Not clear |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
the expression of acetylcholinesterase and other cholinergic components is not restricted to only brain and nerve tissues but can also be found in non-neuronal tissues like the immune system and bone tissue. |
2021-02-16 |
2023-08-13 |
Not clear |
| S D Varfolomeev, V I Bykov, S B Tsybenov. Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse. Doklady. Biochemistry and biophysics. vol 491. issue 1. 2021-01-29. PMID:32483758. |
proton blockade of acetylcholinesterase and ph-impulse in the mechanism of functioning of the cholinergic synapse. |
2021-01-29 |
2023-08-13 |
human |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
in 1-day-old embryos, we show that spinal motoneurons express presynaptic cholinergic genes including choline acetyltransferase (chata), vesicular acetylcholine transporters (vachta, vachtb), high-affinity choline transporter (hacta) and acetylcholinesterase (ache), while nicotinic acetylcholine receptor (nachr) subunits are mainly expressed in interneurons. |
2021-01-19 |
2023-08-13 |
zebrafish |