| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
the levels of dopamine, tyrosine hydroxylase (th), serotonin or 5-hydroxytryptamine (5-ht) receptor 1a and b (5-htr1a and 5-htr1b), and 5-ht1b were significantly increased in scz patients, while the levels of gamma-aminobutyric acid (gaba), 5-ht transporter (5-htt), and 5-ht receptor 2a (5-htr2a) were decreased. |
2019-01-16 |
2023-08-13 |
human |
| F Jiménez-Trejo, I Coronado-Mares, M Boeta, I González-Santoyo, R Vigueras-Villaseñor, C Arriaga-Canon, L A Herrera, M Tapia-Rodrígue. Identification of serotoninergic system components in stallion sperm. Histology and histopathology. vol 33. issue 9. 2019-01-10. PMID:29658099. |
therefore, using both immunofluorescence and western blot techniques, we searched for and found some serotonin markers such as 5-ht, 5-ht1b, 5-ht2a, 5-ht₃ receptors, both tph1 and maoa enzymes, and serotonin transporter (5-htt) in stallion sperm. |
2019-01-10 |
2023-08-13 |
Not clear |
| Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Park, Sangkyu Park, Hail Ki. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nature communications. vol 9. issue 1. 2018-12-19. PMID:30446669. |
here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2a (htr2a) signaling. |
2018-12-19 |
2023-08-13 |
mouse |
| A S Tsybko, T V Ilchibaeva, D V Bazovkina, V S Naumenk. [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy]. Molekuliarnaia biologiia. vol 52. issue 2. 2018-12-11. PMID:29695693. |
the chronic activation of 5-ht1a receptor downregulated 5-ht1a gene expression, as well as the expression of the gene that encodes tryptophan hydroxylase 2, a key enzyme of 5-ht biosynthesis, in the midbrain and the expression of the gene that encodes the 5-ht2a receptor in the frontal cortex of cba, but not c57bl/6 mice. |
2018-12-11 |
2023-08-13 |
mouse |
| Solange Glória, João Marques, Joana Feiteiro, Helena Marcelino, Ignacio Verde, Elisa Cairrã. Tributyltin role on the serotonin and histamine receptors in human umbilical artery. Toxicology in vitro : an international journal published in association with BIBRA. vol 50. 2018-10-15. PMID:29580985. |
moreover, at long term exposures, the arteries treated with 100 μm of tbt do not have contraction capacity when 5-ht is added, and the gene expression of 5-ht2a receptor decrease. |
2018-10-15 |
2023-08-13 |
human |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
prior work using a contractility bioassay determined that the serotonin (5-ht) receptor subtype 5-ht2a is present in bovine lateral saphenous veins and plays a role in ergot alkaloid (ea)-induced vascular contraction in steers grazing endophyte-infected (epichloë coenophiala) tall fescue (lolium arundinaceum). |
2018-10-09 |
2023-08-13 |
cattle |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Marwa Ahmed Amin Atallah, Samah M Elaidy, Mona K Tawfi. Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β Pharmacological reports : PR. vol 70. issue 3. 2018-10-09. PMID:29660654. |
serotonin (5-ht) through its hscs-expressed receptors, especially 5-ht2a and 7, shows crucial events in fibrogenesis of chronic liver diseases. |
2018-10-09 |
2023-08-13 |
rat |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
liraglutide, a glp-1 receptor agonist, which decreases hypothalamic 5-ht2a receptor expression, reduces appetite and body weight independently of serotonin synthesis in mice. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
a recent report suggested that brain-derived serotonin (5-ht) is critical for maintaining weight loss induced by glucagon-like peptide-1 (glp-1) receptor activation in rats and that 5-ht2a receptors mediate the feeding suppression and weight loss induced by glp-1 receptor activation. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
these findings suggest that liraglutide reduces appetite and body weight independently of 5-ht synthesis in mice, whereas glp-1 receptor activation downregulates the gene expression of hypothalamic 5-ht2a receptors. |
2018-09-24 |
2023-08-13 |
mouse |
| Michael P Bogenschutz, Stephen Ros. Therapeutic Applications of Classic Hallucinogens. Current topics in behavioral neurosciences. vol 36. 2018-09-20. PMID:28512684. |
this chapter reviews what is known about the therapeutic uses of the serotonergic or classic hallucinogens, i.e., psychoactive drugs such as lsd and psilocybin that exert their effects primarily through agonist activity at serotonin 2a (5ht2a) receptors. |
2018-09-20 |
2023-08-13 |
human |
| David A Martin, Charles D Nichol. The Effects of Hallucinogens on Gene Expression. Current topics in behavioral neurosciences. vol 36. 2018-09-20. PMID:28677095. |
the immediate and acute effects on both behaviors and network connectivity are likely mediated by effector pathways downstream of serotonin 5-ht2a receptor activation. |
2018-09-20 |
2023-08-13 |
Not clear |
| Alia Sadiq, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Muhammad Qasim Hayat, Sheeba Murad, Saeid Amini-Ni. The Role of Serotonin during Skin Healing in Post-Thermal Injury. International journal of molecular sciences. vol 19. issue 4. 2018-09-05. PMID:29596386. |
whereas, fluoxetine (a selective serotonin reuptake inhibitor) and ketanserin (serotonin receptor 2a inhibitor) reversed these effects. |
2018-09-05 |
2023-08-13 |
mouse |
| Jegath C Athilingam, Roy Ben-Shalom, Caroline M Keeshen, Vikaas S Sohal, Kevin J Bende. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. eLife. vol 6. 2018-08-22. PMID:29206101. |
here, we show that serotonin (5ht), which is known to regulate gamma power, acts via 5ht2a receptors to suppress an inward-rectifying potassium conductance in fsis. |
2018-08-22 |
2023-08-13 |
mouse |
| Kenmei Mizutani, Shigeru Sonoda, Hideaki Wakit. Ritanserin, a serotonin-2 receptor antagonist, inhibits functional recovery after cerebral infarction. Neuroreport. vol 29. issue 1. 2018-07-31. PMID:29135714. |
here, the role of 5-ht was verified using ritanserin, a potent 5-ht2a receptor antagonist, and protein expression and modification were analyzed to further understand the association between paralysis recovery and molecular mechanisms in the brain. |
2018-07-31 |
2023-08-13 |
rat |
| Iris Lim, Russ Chess-Williams, Donna Seller. 5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals. European journal of pharmacology. vol 818. 2018-07-27. PMID:29104045. |
5-ht2a receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-ht in young and old animals. |
2018-07-27 |
2023-08-13 |
Not clear |
| Cristy A Ku, Renee C Ryals, Dan Jiang, Aaron S Coyner, Kyle K Weller, Wrik Sinha, Bryan M Robb, Paul Yang, Mark E Pennes. The Role of ERK1/2 Activation in Sarpogrelate-Mediated Neuroprotection. Investigative ophthalmology & visual science. vol 59. issue 1. 2018-07-27. PMID:29368005. |
to characterize the mediators of 5-ht2a serotonin receptor-driven retinal neuroprotection. |
2018-07-27 |
2023-08-13 |
Not clear |
| Stefano Fortinguerra, Alessandro Buriani, Vincenzo Sorrenti, Michele Lenzi, Pietro Giust. Molecular network-selected pharmacogenomics in a case of bipolar spectrum disorder. Pharmacogenomics. vol 18. issue 18. 2018-07-24. PMID:29173093. |
results from the pharmacogenomic analysis were consistent with the pharmacological history and indicate mutations associated with low monoaminergic tone, but also a hyperactive 5ht2a receptor, a feature that associates to a high probability of developing a bipolar condition, especially under 5-hydroxytryptamine potentiating pharmacology. |
2018-07-24 |
2023-08-13 |
Not clear |
| Patricia Pilkinton, Carlos Berry, Seth Norrholm, Al Bartolucci, Badari Birur, Lori L Davi. An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder. Psychopharmacology bulletin. vol 46. issue 2. 2018-07-16. PMID:27738377. |
asenapine is a novel atypical antipsychotic that possesses a high serotonin (5-ht2a) to dopamine (d2) affinity ratio and alpha-adrenergic antagonism, which may be advantageous in treating ptsd. |
2018-07-16 |
2023-08-13 |
Not clear |