| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson Oa Botchway, Marong Fan. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105836. |
5-hydroxytryptamine receptors 2a and 1a (5-ht2a and 5-ht1a receptors) are most closely related to anxiety-like behavior in post-traumatic stress disorder. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhiying Hu, Yang Yang, Keqiang Gao, John A Rudd, Marong Fan. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Experimental and therapeutic medicine. vol 11. issue 1. 2020-09-30. PMID:26889223. |
in addition, treatment with e2 and p4 was associated with increased expression levels of choline acetyltransferase and 5-hydroxytryptamine receptor 2a (5-ht2a), and decreased expression levels of the glial fibrillary acidic protein in the hippocampus of the rats. |
2020-09-30 |
2023-08-13 |
rat |
| Taichi Ochi, Natalya M Vyalova, Innokentiy S Losenkov, Diana Z Paderina, Ivan V Pozhidaev, Anton J M Loonen, German G Simutkin, Nikolay A Bokhan, Svetlana A Ivanova, Bob Wilffer. Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31956308. |
serotonin regulation of amygdala activity is attained through activation of three 5-ht2 family receptor subtypes, 5-ht2a, 5-ht2b, and 5-ht2c. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pooja Mitra, Aishwarya Rastogi, Mayank Rajpoot, Ajay Kumar, Vivek Srivastav. A QSAR model of Olanzapine derivatives as potential inhibitors for 5-HT2A Receptor. Bioinformation. vol 13. issue 10. 2020-09-29. PMID:29162966. |
recently, a numbers of marketed drugs for schizophrenia are available against dopamine d2 and serotonin 5-ht2a receptors. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earle. Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications. The primary care companion for CNS disorders. vol 22. issue 5. 2020-09-29. PMID:32942346. |
cariprazine, a dopamine d₃-preferring d₃/d₂ receptor partial agonist with serotonin 5-ht1a receptor partial agonist and serotonin 5-ht2a antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jaime Lee, Shane Thwaites, Andrea Gogos, Maarten van den Buus. Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (±)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31941052. |
pretreatment of the animals with the dopamine d1 receptor antagonist, sch23390, the dopamine d2 receptor antagonist, haloperidol, the serotonin (5-ht)1a receptor antagonist, way100635, or the 5-ht2a receptor antagonist, ketanserin, all blocked the effect of mdma, although the drugs differentially affected the individual s1 and s2 amplitudes. |
2020-09-28 |
2023-08-13 |
rat |
| Lulu Wang, Xiangcheng Fan, Jichun Han, Minxuan Cai, Xiaozhong Wang, Yan Wang, Jing Shan. Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32477107. |
brl-3a cells were treated with 1 mm free fatty acids (ffas) and/or 50 μm 5-ht, and then small interfering rna (sirna) targeting the 5-ht2a receptor (htr2a) and the pparγ pharmaceutical agonist, pioglitazone, were applied. |
2020-09-28 |
2023-08-13 |
rat |
| Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T Marguerite, Robin L Coope. The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission. Biology. vol 9. issue 8. 2020-09-28. PMID:32781679. |
at the model glutamatergic synapse of the crayfish neuromuscular junction (nmj), 5-ht primarily acts through a 5-ht2a receptor subtype to enhance transmission to the motor neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gabriel Araujo Tavares, Amada Torres, Julliet Araujo de Souz. Early Life Stress and the Onset of Obesity: Proof of MicroRNAs' Involvement Through Modulation of Serotonin and Dopamine Systems' Homeostasis. Frontiers in physiology. vol 11. 2020-09-28. PMID:32848865. |
the first pieces of evidence highlight the presence of the mir-16 in the regulation of the serotonin transporter (sert) as well as the receptors 1a (5ht1a) and 2a (5ht2a). |
2020-09-28 |
2023-08-13 |
Not clear |
| Nicholas Zareifopoulos, Maria Lagadinou, Anastasia Karela, Ourania Kyriakopoulou, Dimitrios Velissari. Neuropsychiatric Effects of Antiviral Drugs. Cureus. vol 12. issue 8. 2020-09-28. PMID:32905132. |
the pathogenetic mechanisms may involve molecular targets common to other centrally active drugs, including human monoamine oxidase-a (mao-a), serotonin receptors, gamma-aminobutyric acid (gaba) gaba-a receptors, 5-ht2a and 5-ht2c receptors and others. |
2020-09-28 |
2023-08-13 |
human |
| Christoph U Correl. Current Treatment Options and Emerging Agents for Schizophrenia. The Journal of clinical psychiatry. vol 81. issue 3. 2020-09-14. PMID:32297721. |
mechanisms of action that are under investigation include dopamine d3 antagonism/serotonin 5-ht1a partial agonism; combined dopamine, serotonin, and glutamate modulation; phosphodiesterase 10a inhibition; trace amine-associated receptor-1 (taar1) agonism plus 5-ht1a agonism; 5-ht2a inverse agonism; sigma-2/5-ht2a antagonism; d-amino acid oxidase (daao) inhibition; glycine transporter-1 inhibition; vesicular monoamine transporter-2 antagonism; mu opioid antagonism added to olanzapine; and novel long-acting injectable antipsychotic formulations. |
2020-09-14 |
2023-08-13 |
Not clear |
| Betina Elfving, Heidi Kaastrup Müller, Ignasi Oliveras, Tina Becher Østerbøg, Cristobal Rio-Alamos, Ana Sanchez-Gonzalez, Adolf Tobeña, Alberto Fernandez-Teruel, Susana Azna. Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-28. PMID:31228641. |
the inbred roman high- (rha-i) and low- (rla-i) avoidance rat strains are a congenital neurobehavioral model, with the rha-i displaying schizophrenia-related behaviors and serotonin 2a (5-ht2a) and metabotropic glutamate 2 (mglu2) receptor alterations in the prefrontal cortex (pfc). |
2020-08-28 |
2023-08-13 |
rat |
| María E Terrón-Díaz, Sara J Wright, Melina A Agosto, Olivier Lichtarge, Theodore G Wense. Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. The Journal of biological chemistry. vol 294. issue 50. 2020-07-13. PMID:31676688. |
the d2 dopamine receptor and the serotonin 5-hydroxytryptamine 2a receptor (5-ht2a) are closely-related g-protein-coupled receptors (gpcrs) from the class a bioamine subfamily. |
2020-07-13 |
2023-08-13 |
Not clear |
| Henry A Nasrallah, Rissa Fedora, Robert Morto. Successful treatment of clozapine-nonresponsive refractory hallucinations and delusions with pimavanserin, a serotonin 5HT-2A receptor inverse agonist. Schizophrenia research. vol 208. 2020-07-02. PMID:30837203. |
one such possible agent is the non-dopaminergic antipsychotic pimavanserin, an inverse agonist of serotonin 5-ht2a receptors which was recently approved for the hallucinations and delusions of parkinson's disease psychosis. |
2020-07-02 |
2023-08-13 |
Not clear |
| Mariama Jaiteh, Ismael Rodríguez-Espigares, Jana Selent, Jens Carlsso. Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity. PLoS computational biology. vol 16. issue 3. 2020-06-29. PMID:32168319. |
homology models of the d2 dopamine (d2r) and serotonin 5-ht2a receptors (5-ht2ar) were generated based on crystal structures of 16 different gpcrs. |
2020-06-29 |
2023-08-13 |
Not clear |
| Akinori Y Sato, Keisuke Tsunoda, Ryo Mizuyama, Satoshi Shimeg. Serotonin improves behavioral contrast sensitivity of freely moving rats. PloS one. vol 15. issue 3. 2020-06-23. PMID:32191757. |
our previous study demonstrated the visual responses of neurons in the primary visual cortex (v1) of anesthetized monkeys were modulated by the activation of 5-ht receptors depending on the response magnitude, in which 5-ht2a receptor-selective agonists enhanced weak visual responses but not strong responses. |
2020-06-23 |
2023-08-13 |
rat |
| Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham A. Kassir, J. John Mann, Victoria Arang. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Journal of psychiatry & neuroscience : JPN. vol 44. issue 5. 2020-06-22. PMID:31120232. |
5-ht1a receptor, 5-ht2a receptor and serotonin transporter binding in the human auditory cortex in depression serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. |
2020-06-22 |
2023-08-13 |
human |
| John Wesson Ashfor. Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-06-01. PMID:30776014. |
trazodone has a variety of effects on several monoaminergic mechanisms: a potent serotonin 5-ht2a and α1-adrenergic receptor antagonist, a weak serotonin reuptake inhibitor, and a weak antihistamine or histamine h1 receptor inverse agonist. |
2020-06-01 |
2023-08-13 |
human |
| Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécame. Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29917056. |
among the 5-ht receptors abundantly expressed in pfc, 5-ht2a receptors located in dendrites of layer v pyramidal neurons control neuronal excitability and mediate the psychotropic effects of psychedelic hallucinogens, but their impact on glutamatergic transmission and synaptic plasticity remains poorly characterized. |
2020-05-22 |
2023-08-13 |
mouse |
| Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécame. Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29917056. |
here, we show that a 20-min exposure of mouse pfc slices to serotonin or the 5-ht2a receptor agonist 2,5-dimethoxy-4-iodoamphetamine (doi) produces a long-lasting depression of evoked ampa excitatory postsynaptic currents in layer v pyramidal neurons. |
2020-05-22 |
2023-08-13 |
mouse |