| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanshika Sinh, Youichirou Ootsuk. Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice. The journal of physiological sciences : JPS. vol 69. issue 6. 2020-05-11. PMID:31432430. |
this study determined whether blockade of 5-hydroxytryptamine 2a (5-ht2a) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. |
2020-05-11 |
2023-08-13 |
mouse |
| Gregory M James, Gregor Gryglewski, Thomas Vanicek, Neydher Berroterán-Infante, Cécile Philippe, Alexander Kautzky, Lukas Nics, Chrysoula Vraka, Godber M Godbersen, Jakob Unterholzner, Helen L Sigurdardottir, Marie Spies, René Seiger, Georg S Kranz, Andreas Hahn, Markus Mitterhauser, Wolfgang Wadsak, Andreas Bauer, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberge. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 1. 2020-03-03. PMID:30357321. |
positron emission tomography was carried out for the quantification of serotonin 1a (5-ht1a, n = 30) and 5-ht2a receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase a (mao-a, n = 32) and the serotonin transporter (5-htt, n = 24) in healthy participants. |
2020-03-03 |
2023-08-13 |
human |
| Kevin Sean Murnan. Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder. Behavioural pharmacology. vol 30. issue 2 and 3-Spec Issue. 2020-01-06. PMID:30632995. |
the 2a subtype of serotonin receptors (5-ht2a receptor) is the major excitatory serotonin receptor in the brain and has been linked to the effects of drugs that produce profound sensory and cognitive changes. |
2020-01-06 |
2023-08-13 |
Not clear |
| Frederick S Barrett, Katrin H Preller, Marcus Herdener, Petr Janata, Franz X Vollenweide. Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 11. 2019-12-20. PMID:29028939. |
classic psychedelic drugs (serotonin 2a, or 5ht2a, receptor agonists) have notable effects on music listening. |
2019-12-20 |
2023-08-13 |
Not clear |
| Hadeel M Abdelrahman, Laila M Sherief, Ashgan A Alghobashy, Sanaa M Abdel Salam, Haitham M Hashim, Nelly R Abdel Fattah, Randa H Mohame. Association of 5-HT2A receptor gene polymorphisms with gastrointestinal disorders in Egyptian children with autistic disorder. Research in developmental disabilities. vol 36C. 2019-11-20. PMID:25462508. |
we aimed to investigate whether there were any association between the -1438a/g, 102t/c and his452tyr polymorphisms of the serotonin 2a receptor gene (5-ht2a) in egyptian children with asd and gid. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshiro Okubo, Tetsuya Suhar. Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. PloS one. vol 13. issue 5. 2019-11-20. PMID:29734370. |
correction: anatomical relationships between serotonin 5-ht2a and dopamine d2 receptors in living human brain. |
2019-11-20 |
2023-08-13 |
human |
| María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Javier Garzó. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. vol 9. issue 34. 2019-11-20. PMID:29805740. |
fenfluramine diminishes nmda receptor-mediated seizures via its mixed activity at serotonin 5ht2a and type 1 sigma receptors. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ana Flávia Belchior de Andrade, Jose Gonzalez-Rodrigue. Electroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification. The Analyst. vol 144. issue 9. 2019-11-20. PMID:30839986. |
25i-nboh is a new potent serotonin 5-ht2a receptor agonist recently identified in blotter paper seizures. |
2019-11-20 |
2023-08-13 |
Not clear |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Leslie Citrome, James C Norton, Kathy Chi-Burris, George Demo. Pimavanserin for the treatment of Parkinson's disease psychosis: number needed to treat, number needed to harm, and likelihood to be helped or harmed. CNS spectrums. vol 23. issue 3. 2019-09-30. PMID:29098976. |
our aim was to describe the efficacy and tolerability of pimavanserin, a highly selective serotonin 5-ht2a receptor inverse agonist/antagonist indicated for the treatment of hallucinations and delusions associated with parkinson's disease psychosis (pdp), using the metrics of number needed to treat (nnt) and number needed to harm (nnh). |
2019-09-30 |
2023-08-13 |
Not clear |
| Peter U Hámor, Jana Šírová, Tomáš Páleníček, Magdalena Zaniewska, Věra Bubeníková-Valešová, Marek Schwend. Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30240581. |
serotonin 2a (5-ht2a) and metabotropic glutamate 2 (mglu2) receptors co-regulate psychosis-like behaviors and cognitive function in animals. |
2019-09-30 |
2023-08-13 |
rat |
| Elizabeth Fleming, Court Hul. Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition. Journal of neurophysiology. vol 121. issue 1. 2019-08-22. PMID:30281395. |
we find that 5-ht depolarizes golgi cells, likely by activating 5-ht2a receptors, but does not directly act on either granule cells or mossy fibers. |
2019-08-22 |
2023-08-13 |
rat |
| Farhana Sakloth, Elizabeth Leggett, Megan J Moerke, E Andrew Townsend, Matthew L Banks, S Stevens Negu. Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats. Experimental and clinical psychopharmacology. vol 27. issue 3. 2019-07-22. PMID:30628811. |
effects of acute and repeated treatment with serotonin 5-ht2a receptor agonist hallucinogens on intracranial self-stimulation in rats. |
2019-07-22 |
2023-08-13 |
rat |
| Yong Kee Choi, Nika Adham, Béla Kiss, István Gyertyán, Frank I Taraz. Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine. CNS spectrums. vol 22. issue 6. 2019-06-28. PMID:28059046. |
this study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-ht1a and 5-ht2a) and glutamate (nmda and ampa) receptor subtypes. |
2019-06-28 |
2023-08-13 |
Not clear |
| B Kumar, A Kuhad, A Kuha. Lumateperone: a new treatment approach for neuropsychiatric disorders. Drugs of today (Barcelona, Spain : 1998). vol 54. issue 12. 2019-05-08. PMID:30596390. |
it possesses a potent antagonistic activity at 5-hydroxytryptamine (serotonin) 2a (5-ht2a) receptors and also binds to dopamine (d1, d2) receptors with partial agonism at presynaptic d2 receptors and postsynaptic antagonism. |
2019-05-08 |
2023-08-13 |
Not clear |
| Jennifer de la Cruz, Clinton Cana. Can pimavanserin help patients with Parkinson disease psychosis? JAAPA : official journal of the American Academy of Physician Assistants. vol 32. issue 1. 2019-04-15. PMID:30589736. |
pimavanserin is a first-in-class selective serotonin 5-ht2a receptor inverse agonist approved for the treatment of parkinson disease psychosis. |
2019-04-15 |
2023-08-13 |
Not clear |
| Li Liu, Mengsi Fu, Siran Pei, Liangliang Zhou, Jing Shan. R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30585252. |
in addition, we found that r-fluoxetine induced melanin synthesis through the serotonin1a receptor (5-ht1a) and serotonin 2a receptor (5-ht2a). |
2019-04-03 |
2023-08-13 |
human |
| Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Benson O A Botchway, Marong Fan. Stimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice. Neuro-Signals. vol 25. issue 1. 2019-03-05. PMID:28977803. |
serotonin 5ht2a and 5ht1a receptors (5ht2ar, 5ht1ar) have the closest connection to anxiety-like behavior in post-traumatic stress disorder (ptsd). |
2019-03-05 |
2023-08-13 |
mouse |
| Daniel E Felsing, Noelle C Anastasio, Joanna M Miszkiel, Scott R Gilbertson, John A Allen, Kathryn A Cunningha. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PloS one. vol 13. issue 8. 2019-02-12. PMID:30157263. |
biophysical validation of serotonin 5-ht2a and 5-ht2c receptor interaction. |
2019-02-12 |
2023-08-13 |
Not clear |
| Daniel E Felsing, Noelle C Anastasio, Joanna M Miszkiel, Scott R Gilbertson, John A Allen, Kathryn A Cunningha. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PloS one. vol 13. issue 8. 2019-02-12. PMID:30157263. |
the serotonin (5-ht) 5-ht2a receptor (5-ht2ar) and 5-ht2c receptor (5-ht2cr) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-ht2ar and/or 5-ht2cr are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia). |
2019-02-12 |
2023-08-13 |
Not clear |