| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
as an initial step to define the function of 5-ht transmission in the insula, we quantified the proportion of specific neuronal populations of the insula expressing 5-ht1a or 5-ht2a. |
2021-07-08 |
2023-08-13 |
mouse |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
these observations suggest that most glutamatergic neurons can respond to 5-ht through 5-ht1a or 5-ht2a in the insula, and that 5-ht directly affects a limited number of gabaergic neurons. |
2021-07-08 |
2023-08-13 |
mouse |
| Ying Wang, Johnson Joseph, Yinli Gao, Baichun Hu, Xiaohui Geng, Di Wu, Jian Wang, Fengjiao Zhan. Revealing the interaction modes of 5-HT2A receptor antagonists and the Structure-Based virtual screening from FDA and TCMNP database. Journal of biomolecular structure & dynamics. vol 39. issue 10. 2021-07-02. PMID:32406337. |
5-hydroxytryptamine 2a (5-ht2a) receptor is emerging as an important target for numerous psychoactive drugs due to its imperative roles in psychological diseases. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yafei Kang, Wei Zhang, Yahui Lv, Suping Cai, Hanxiao Xu, Jijun Wang, Liyu Huan. Effects of the 5-HT2A and DRD3 genotypes on cortical morphology and functional connectivity density in drug-naïve first episode schizophrenia. Schizophrenia research. vol 216. 2021-06-17. PMID:31813806. |
the 5-hydroxytryptamine 2a receptor (5-ht2a) and dopamine d3 receptor (drd3) have been extensively studied as promising candidate genes for schizophrenia. |
2021-06-17 |
2023-08-13 |
human |
| Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Ki. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Endocrinology and metabolism (Seoul, Korea). vol 35. issue 2. 2021-06-11. PMID:32615731. |
serotonin regulates de novo lipogenesis in adipose tissues through serotonin receptor 2a. |
2021-06-11 |
2023-08-13 |
Not clear |
| Zied Oueghlani, Laurent Juvin, François M Lambert, Laura Cardoit, Gilles Courtand, Frédérique Masmejean, Jean-René Cazalets, Grégory Barrièr. Serotonergic modulation of sacral dorsal root stimulation-induced locomotor output in newborn rat. Neuropharmacology. vol 170. 2021-06-03. PMID:31634501. |
at later stages, serotonin (5-ht) and quipazine (5-ht2a receptor agonist) at concentrations sub-threshold for direct locomotor network activation promoted sacral stimulation-induced fictive locomotion. |
2021-06-03 |
2023-08-13 |
rat |
| Zied Oueghlani, Laurent Juvin, François M Lambert, Laura Cardoit, Gilles Courtand, Frédérique Masmejean, Jean-René Cazalets, Grégory Barrièr. Serotonergic modulation of sacral dorsal root stimulation-induced locomotor output in newborn rat. Neuropharmacology. vol 170. 2021-06-03. PMID:31634501. |
the 5-ht2a receptor antagonist ketanserin could reverse the agonist's action but was ineffective when fictive locomotion was already expressed in the absence of 5-ht (mainly before p2). |
2021-06-03 |
2023-08-13 |
rat |
| Nagara Takao, Toshiya Murai, Hironobu Fujiwar. Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine. BMJ case reports. vol 14. issue 4. 2021-05-14. PMID:33849886. |
previous animal studies have reported that antipsychotics increase serotonin 5-ht2a receptor density in the striatum and that 5-ht2a receptor blockers suppress dopamine-sensitive psychomotor activity, which may be linked to the pathophysiology of dsp. |
2021-05-14 |
2023-08-13 |
Not clear |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (tph1) rs1799913, serotonin transporter (slc6a4) 5-httlpr, and serotonin receptor 2a (htr2a) rs6311, were evaluated for association with suicidal ideation (si) and with recovery from si in a psychiatric inpatient population. |
2021-04-05 |
2023-08-13 |
Not clear |
| Silvia Vicenzi, Lisa Foa, Robert J Gasperin. Serotonin functions as a bidirectional guidance molecule regulating growth cone motility. Cellular and molecular life sciences : CMLS. vol 78. issue 5. 2021-03-29. PMID:32939562. |
extracellular gradients of 50 µm serotonin elicited attraction, mediated by the serotonin 5-ht2a receptor while 100 µm serotonin elicited repulsion mediated by the 5-ht1b receptor. |
2021-03-29 |
2023-08-13 |
Not clear |
| Xiaohan Li, Linlin He, Jinting Liu, Wenxuan Guo, Quanhe Wang, Pengpeng Fang, Xing Yang, Mengfei Zhang, Chunlan Wang, Pingyuan Gon. The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553368. |
inspired by the links between serotonin functions and affective disorders, this study investigated associations of the serotonin receptor 2a (5-ht2a) gene with alexithymia and mental health. |
2021-02-15 |
2023-08-13 |
Not clear |
| Katarzyna Kamińska, Paweł Świt, Kamilla Male. 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOME): A Harmful Hallucinogen Review. Journal of analytical toxicology. vol 44. issue 9. 2021-02-04. PMID:32128596. |
these substances are a new class of potent serotonin 5-ht2a receptor agonist hallucinogens with potential harmful effects. |
2021-02-04 |
2023-08-13 |
Not clear |
| Matheus Libarino-Santos, Ana Catherine Gomes de Santana Santos, Elisangela G Cata-Preta, Thaísa Barros-Santos, Nina Rosa Nunes Brandão, Aurea Lorena Nunes Borges, Renan Santos-Baldaia, André W Hollais, Marilia A Baldaia, Laís F Berro, Eduardo A V Marinho, Roberto Frussa-Filho, Alexandre J Oliveira-Lim. Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice. Drug and alcohol dependence. vol 208. 2021-01-18. PMID:31954952. |
evidence suggests that aripiprazole, a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist, show significant efficacy in reducing alcohol use. |
2021-01-18 |
2023-08-13 |
mouse |
| P Campos-Bedolla, R De-La-Cruz-Negrete, M H Vargas, E Torrejón-González, D Mejía-Mendoza, A Islas-Hernández, P Segura-Medina, G Córdoba-Rodríguez, S Orozco-Suárez, J L Arreola-Ramíre. Allergic sensitization increases contractile responses to 5-HT in guinea pig aorta. Physiological research. vol 69. issue 1. 2020-11-04. PMID:31852196. |
we concluded that in this guinea pig model of asthma, allergic sensitization is not confined to airways, but also affects arterial contractile responses to 5-ht; changes in the expression of the 5-ht2a receptor appear not to be involved in this phenomenon. |
2020-11-04 |
2023-08-13 |
Not clear |
| David Nutt, David Erritzoe, Robin Carhart-Harri. Psychedelic Psychiatry's Brave New World. Cell. vol 181. issue 1. 2020-10-16. PMID:32243793. |
outcomes of neuroscience and clinical research into 5-hydroxytryptamine 2a (5-ht2a) receptor agonists, such as psilocybin, show promise for addressing a range of serious disorders, including depression and addiction. |
2020-10-16 |
2023-08-13 |
Not clear |
| Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Ki. Erratum: Correction of Figure. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Endocrinology and metabolism (Seoul, Korea). vol 35. issue 3. 2020-10-06. PMID:32759630. |
serotonin regulates de novo lipogenesis in adipose tissues through serotonin receptor 2a. |
2020-10-06 |
2023-08-13 |
Not clear |
| Michael A Ruderman, Susan B Powell, Mark A Geye. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. Journal of young investigators. vol 19. issue 13. 2020-10-01. PMID:25346645. |
significant interaction and reversal effects between ka and the serotonin/2a (5-ht2a) system - the serotonin sub-type associated with classical psychedelics - were observed in three bpm measures. |
2020-10-01 |
2023-08-13 |
mouse |
| Ayça Kiliç, Evrim Erten, Armağan Özdemi. Tardive Blepharospasm and Meige Syndrome during Treatment with Quetiapine and Olanzapine. Noro psikiyatri arsivi. vol 52. issue 2. 2020-10-01. PMID:28360708. |
atypical antipsychotics have less extrapyramidal side effects because of a weak dopamine d2 receptor binding affinity or a strong antagonistic effect to serotonin 5-ht2a receptor and have been known to cause less tardive dyskinesia than typical antipsychotics. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. |
there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). |
2020-10-01 |
2023-08-13 |
Not clear |
| Raquel Romay-Tallon, Erin Kulhawy, Kyle J Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M Olivares, Lisa E Kalynchuk, Hector J Carunch. Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30374301. |
naïve depression patients show alterations in serotonin transporter (sert) and serotonin 2a (5ht2a) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. |
2020-10-01 |
2023-08-13 |
human |