| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir M Pogorelov, Ramona M Rodriguiz, Bryan L Roth, William C Wetse. The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. Frontiers in molecular biosciences. vol 10. 2023-10-30. PMID:37900918. |
the g protein biased serotonin 5-ht2a receptor agonist lisuride exerts anti-depressant drug-like activities in mice. |
2023-10-30 |
2023-11-08 |
mouse |
| Raly James Perez Custodio, Darlene Mae Ortiz, Hyun Jun Lee, Leandro Val Sayson, Mikyung Kim, Yong Sup Lee, Kyeong-Man Kim, Jae Hoon Cheong, Hee Jin Ki. Serotonin 2C receptors are also important in head-twitch responses in male mice. Psychopharmacology. 2023-10-26. PMID:37882810. |
serotonergic psychedelics exert their effects via their high affinity for serotonin (5-ht) receptors, particularly through activating 5-ht2a receptors (5-ht2ar), employing the frontal cortex-dependent head-twitch response (htr). |
2023-10-26 |
2023-11-08 |
mouse |
| Sanjay Karki, Mehdi Saadaoui, Valentin Dunsing, Stephen Kerridge, Elise Da Silva, Jean-Marc Philippe, Cédric Maurange, Thomas Lecui. Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages. Nature communications. vol 14. issue 1. 2023-09-08. PMID:37684231. |
we find that serotonin and serotonin receptors 5ht2a and 5ht2b form a signaling module that quantitatively regulates the amplitude of planar polarized myoii contractility specified by toll receptors and the gpcr cirl. |
2023-09-08 |
2023-10-07 |
chicken |
| Francesco Tortora, Abed L Hadipour, Simone Battaglia, Alessandra Falzone, Alessio Avenanti, Carmelo M Vicari. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626553. |
the results suggest that elevated levels of 5-ht enhance aversive learning, indicating that the modulation of serotonin 5-ht2a receptors regulates the expression of fear responses in humans. |
2023-08-26 |
2023-09-07 |
human |
| Ángeles Prados-Pardo, Elena Martín-González, Santiago Mora, Carlos Martín, Manuela Olmedo-Córdoba, Cristian Pérez-Fernandez, Fernando Sánchez-Santed, Margarita Moreno-Montoy. Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats. Molecular neurobiology. 2023-07-31. PMID:37523044. |
the compulsive hd rats showed cognitive inflexibility and reduced serotonin 2a (5-ht2a) receptor binding levels in the frontal cortex (fc). |
2023-07-31 |
2023-08-14 |
rat |
| Muhammad Ishrat Husain, Daniel M Blumberger, David J Castle, Nicole Ledwos, Elise Fellows, Brett D M Jones, Abigail Ortiz, Stefan Kloiber, Wei Wang, Joshua D Rosenblat, Benoit H Mulsan. Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial. BJPsych open. vol 9. issue 4. 2023-07-25. PMID:37489299. |
these effects depend on serotonin 2a (5-ht2a) receptor activation, which can be blocked by 5-ht2a receptor antagonists like ketanserin or risperidone. |
2023-07-25 |
2023-08-14 |
Not clear |
| Barbara G Ferri, Cintia O de Novais, Raquel S Bonani, Wellington A de Barros, Ângelo de Fátima, Fabiana C Vilela, Alexandre Giusti-Paiv. Psychoactive substances 25H-NBOMe and 25H-NBOH induce antidepressant-like behavior in male rats. European journal of pharmacology. 2023-07-21. PMID:37479015. |
ring-substituted phenethylamines are believed to induce psychedelic effects primarily by interacting with 5-hydroxytryptamine 2 (5-ht2a) receptors in the brain. |
2023-07-21 |
2023-08-14 |
rat |
| Rika Takaba, Daisuke Ibi, Keisuke Yoshida, Eri Hosomi, Ririna Kawase, Hiroko Kitagawa, Hirotaka Goto, Mizuki Achiwa, Kento Mizutani, Kyosuke Maede, Javier González-Maeso, Shinji Kitagaki, Masayuki Hiramats. Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice. Research square. 2023-07-18. PMID:37461593. |
serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and doi exert a hallucinatory effect through serotonin 5-ht 2a receptor (5-ht2a) activation. |
2023-07-18 |
2023-08-14 |
mouse |
| Tongjun Ma, Chenyu Li, Zeyin Nie, Huachun Miao, Feng W. Regulatory effect of electroacupuncture on hypothalamic serotonin and its receptor in rats with cerebral ischemia. Current neurovascular research. 2023-06-13. PMID:37309759. |
5-hydroxytryptamine (5-ht)/ 5-ht transporter (5-htt) and 5-ht receptor 2a (5-ht2a) are important in the treatment of cerebrovascular diseases. |
2023-06-13 |
2023-08-14 |
rat |
| Yuxiao Chen, Jie Sun, Zhen Yang, Hongyan B. Efficacy and safety of negative allosteric modulators of 5-hydroxytryptamine 2A receptors in the treatment of Alzheimer's disease psychosis: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-05-11. PMID:37166012. |
the 5-hydroxytryptamine (5-ht2a) receptors are located postsynaptically to serotonergic neurons in the frontal cortex and mediate both excitatory and inhibitory neurotransmissions. |
2023-05-11 |
2023-08-14 |
Not clear |
| Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. |
on this background, we set out to explore (1) the role of serotonin 2a (5-ht2a) and serotonin 1a (5-ht1a) receptors in the effect of psilocybin on marble burying; (2) the effect of staggered versus bolus psilocybin administration and persistence of the effect; (3) the effect of the 5-ht1a partial agonist, buspirone, on marble-burying and the head twitch response (htr) induced by psilocybin, a rodent correlate of psychedelic effects. |
2023-05-10 |
2023-08-14 |
mouse |
| Jignesh H Kamadar, D Roza Kumari, Khushal M Kapadiy. Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey. Mini reviews in medicinal chemistry. 2023-05-09. PMID:37157202. |
recent studies on serotonin 5-ht2a receptor antagonists in medicinal chemistry: a last decades survey. |
2023-05-09 |
2023-08-14 |
human |
| Jignesh H Kamadar, D Roza Kumari, Khushal M Kapadiy. Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey. Mini reviews in medicinal chemistry. 2023-05-09. PMID:37157202. |
one of the members of gpcrs is the serotonin 2a (5-ht2a) receptor, which has been associated with complex etiological mental illnesses. |
2023-05-09 |
2023-08-14 |
human |
| Akihito Takeda, Mao Fujita, Kengo Funakosh. Distribution of 5HT Receptors During the Regeneration Process After Spinal Cord Transection in Goldfish. Journal of chemical neuroanatomy. 2023-04-29. PMID:37119932. |
5ht2a was expressed at the luminal surface, suggesting that it is receptive to 5ht in the cerebrospinal fluid. |
2023-04-29 |
2023-08-14 |
Not clear |
| Ewa Ferensztajn-Rochowiak, Monika Dmitrzak-Węglarz, Aleksandra Szczepankiewicz, Maria Skibińska, Sebastian Kliwicki, Agnieszka Permoda-Pachuta, Aleksandra Suwalska, Piotr Czerski, Joanna Pawlak, Joanna Hause. Studies on candidate genes for lithium prophylaxis performed at the Poznan University of Medical Sciences. Psychiatria polska. vol 56. issue 5. 2023-04-19. PMID:37074853. |
the associations with lithium prophylactic efficacy were found for the polymorphisms in 5htt, acp1, arntl, bdnf, comt, drd1, fkbp5, fyn, glcc, nr3c1, and tim, genes, but not those in 5ht2a, 5ht2c, drd2, drd3, drd4, grin2b, gsk-3β, mmp-9, and ntrk2 genes. |
2023-04-19 |
2023-08-14 |
Not clear |
| Octavian Vasili. The pharmacogenetics of the new-generation antipsychotics - A scoping review focused on patients with severe psychiatric disorders. Frontiers in psychiatry. vol 14. 2023-03-06. PMID:36873203. |
allelic variability in genes encoding dopamine d2, d3, and serotonin, 5ht2a, 5ht2c receptors, comt, bdnf, and dopamine transporter dat1 was also associated with different adverse events or variations in the clinical efficacy of aripiprazole. |
2023-03-06 |
2023-08-14 |
Not clear |
| b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' |
expression patterns of serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a during human fetal lung development. |
2023-02-11 |
2023-08-14 |
human |
| b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' |
we analyzed the expression of the serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a at four different stages of fetal lung development from 12 to 40 weeks of gestation, divided into four groups: the pseudoglandular stage (12-16th week of development; |
2023-02-11 |
2023-08-14 |
human |
| Jiaqi Jin, Fan Xu, Yuxin Zhang, Jing Guan, Jihua F. Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor. Molecular immunology. vol 155. 2023-01-22. PMID:36682136. |
previously, we revealed a crucial role of 5-ht degradation system (5ds), consisting of 5-ht2a receptor (5-ht2ar), 5-ht synthases and monoamine oxidase a (mao-a), in ischemia-reperfusion (ir)-caused organ injury. |
2023-01-22 |
2023-08-14 |
Not clear |
| Bin Wang, Lu Cui, Qingqing Song, Moyan Liu, Jiao Kou, Shiqiang Sun, Hui Chen, Yahui Shi, Zhenlong Wu, Zhaolai Da. Excessive dietary L-tryptophan regulated amino acids metabolism and serotonin signaling in the colon of weaning piglets with acetate-induced gut inflammation. Amino acids. 2023-01-17. PMID:36648538. |
trp restored (p < 0.05) acetate-induced increase in concentrations of free aspartate, glutamate/glutamine, glycine, 5-ht, and 3-methylindole in the colon, downregulation of zonula occludens-1 and 5-ht reuptake transporter (sert) expression and upregulation of il-1β, il-8, tlr4, and 5-ht receptor 2a (htr2a) expression, and the increase in ratios of p-stat3/ stat3 and p-p65/p65 in the colon. |
2023-01-17 |
2023-08-14 |
Not clear |