| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Campos-Bedolla, E G Torrejón-González, D Mendoza-Mejía, M H Vargas, P Segura-Medina, V Carbajal-Salinas, A Rodríguez-Márquez, A Valeria Martínez-Silv. Role of 5-HT2 receptors family in the allergy-induced increased aorta contractile responses to 5-HT. Physiological research. 2022-12-22. PMID:36545875. |
we found that tcb-2 (5-ht2a agonist) and way161503 (5-ht2c agonist) induced aorta contractions resembling those elicited by 5-ht but less intense (~43% and ~25%, respectively). |
2022-12-22 |
2023-08-14 |
Not clear |
| P Campos-Bedolla, E G Torrejón-González, D Mendoza-Mejía, M H Vargas, P Segura-Medina, V Carbajal-Salinas, A Rodríguez-Márquez, A Valeria Martínez-Silv. Role of 5-HT2 receptors family in the allergy-induced increased aorta contractile responses to 5-HT. Physiological research. 2022-12-22. PMID:36545875. |
in conclusion, we found that allergic sensitization increased the aorta contractile responses to 5-ht, partly mediated by enhanced responses of 5-ht2a receptors, which was unrelated to changes in the expression of these receptors. |
2022-12-22 |
2023-08-14 |
Not clear |
| João P F Kurita, Anderson H F F Leão, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, Débora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience. 2022-12-22. PMID:36548050. |
the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. |
2022-12-22 |
2023-08-14 |
rat |
| Allyson S Munneke, Tuhin S Chakraborty, Saige S Porter, Christi M Gendron, Scott D Pletche. The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Frontiers in aging. vol 3. 2022-12-19. PMID:36531741. |
the serotonin receptor 5-ht2a modulates lifespan and protein feeding in the conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions. |
2022-12-19 |
2023-08-14 |
Not clear |
| Allyson S Munneke, Tuhin S Chakraborty, Saige S Porter, Christi M Gendron, Scott D Pletche. The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Frontiers in aging. vol 3. 2022-12-19. PMID:36531741. |
here, we show that serotonin signaling through the 5-ht2a receptor influences lifespan, behavior, and physiology in |
2022-12-19 |
2023-08-14 |
Not clear |
| Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschyt. Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430623. |
in rodents, the serotonin precursor, 5-hydroxytryptophan (5-htp) and psilocybin induce a characteristic 5-ht2a receptor (5-ht2ar)-mediated head twitch response (htr), which is correlated with the human psychedelic trip. |
2022-11-26 |
2023-08-14 |
mouse |
| Filiz İzci, Eda Ülger, Sinem Yolc. Manic Episode as a Result of Adding Trazodone to a Patient under Escitalopram Treatment. Alpha psychiatry. vol 22. issue 1. 2022-11-25. PMID:36426205. |
one of these is trazodone, which is an antidepressant that exhibits hypnotic effect by the effect of histamine h1 receptor antagonist and 5-ht2a stimulation, which is a serotonin transporter protein inhibitor and 5-ht2a and 5ht2c antagonist. |
2022-11-25 |
2023-08-14 |
Not clear |
| Elena Martín-González, Manuela Olmedo-Córdoba, Pilar Flores, Margarita Moreno-Montoy. Differential neurobiological markers in phenotype-stratified rats modeling high or low vulnerability to compulsive behavior: A narrative review. Current neuropharmacology. 2022-11-22. PMID:36411566. |
specifically, we reviewed preclinical studies on sip, that have assessed the effects of serotonergic, dopaminergic, and glutamatergic drugs; leading to the description of the neurobiological markers, such as the key role of the serotonin 5-ht2a receptor and glutamatergic signaling in a phenotype vulnerable to compulsivity as high drinker hd rats selected by sip. |
2022-11-22 |
2023-08-14 |
rat |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-08-14 |
mouse |
| Mona Darwish, Dragana Bugarski-Kirola, Julie Passarell, Joel Owen, David Jaworowicz, Daryl DeKarske, Srdjan Stankovi. Pimavanserin Exposure-Response Analyses in Patients With Schizophrenia: Results From the Phase 2 ADVANCE Study. Journal of clinical psychopharmacology. 2022-10-03. PMID:36190440. |
pimavanserin is a selective serotonin 5-ht2a receptor inverse agonist/antagonist being investigated in patients with negative symptoms of schizophrenia. |
2022-10-03 |
2023-08-14 |
Not clear |
| S Parker Singleton, Andrea I Luppi, Robin L Carhart-Harris, Josephine Cruzat, Leor Roseman, David J Nutt, Gustavo Deco, Morten L Kringelbach, Emmanuel A Stamatakis, Amy Kuceyesk. Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape. Nature communications. vol 13. issue 1. 2022-10-03. PMID:36192411. |
serotonin 2a (5-ht2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. |
2022-10-03 |
2023-08-14 |
Not clear |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Jean E M Ramirez, Ahmed B Alarabi, Fadi T Khasawneh, Fatima Z Alshboo. A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955928. |
a novel antibody targeting the second extracellular loop of the serotonin 5-ht2a receptor inhibits platelet function. |
2022-08-12 |
2023-08-14 |
Not clear |
| Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawad. Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents. Journal of visualized experiments : JoVE. issue 185. 2022-08-08. PMID:35938802. |
by using this system, it was demonstrated that phm recapitulates the serotonin (5-hydroxytryptamine, hereafter referred to as 5-ht) receptor subtype 2a (5-ht2a) signaling in the prefrontal cortex (pfc) neurons of mice. |
2022-08-08 |
2023-08-14 |
mouse |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Filipa Viegas, Tiago Ferreira, Cláudia Campo. Using Cariprazine to Ameliorate Negative Symptoms and Metabolic Side Effects of Clozapine and Paliperidone - Clinical Cases. Neuropsychiatric disease and treatment. vol 18. 2022-06-17. PMID:35712695. |
it presents distinct pharmacodynamic properties, such as d3/d2 partial agonism, preferential binding to d3 receptors, antagonism at the serotonin 5-ht2a and 5-ht2b receptors, partial agonism at 5-ht1a receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). |
2022-06-17 |
2023-08-14 |
Not clear |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry. vol 13. 2022-05-16. PMID:35573352. |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-08-13 |
Not clear |
| Błażej D Pędzich, Sarah Rubens, Mehdi Sekssaoui, Anouk Pierre, Andries Van Schuerbeek, Philippe Marin, Joel Bockaert, Emmanuel Valjent, Carine Bécamel, Dimitri De Bunde. Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-04-22. PMID:35449450. |
the serotonin 2a (5-ht2a) receptor is a key target underlying the effects of psychedelics on emotional arousal but its role in fear processing remains controversial. |
2022-04-22 |
2023-08-13 |
mouse |
| Sanne Beerens, Jochen Winterer, David Lukacsovich, Csaba Földy, Christian Wozn. Transcriptomically-guided pharmacological experiments in neocortical and hippocampal NPY-positive GABAergic interneurons. eNeuro. 2022-04-19. PMID:35437266. |
specifically, although the application of 5ht led to a depolarisation of both auditory and ca3 npy-positive neurons, the 5ht2a receptor antagonist ketanserin only reversed membrane potential changes in auditory npy-positive neurons. |
2022-04-19 |
2023-08-13 |
mouse |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology. 2022-04-13. PMID:35416690. |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-08-13 |
Not clear |