| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets. 2022-03-25. PMID:35331126. |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-08-13 |
Not clear |
| Xiao Cui Yuan, Yu-Ying Wang, Li-Xia Tian, Xiang-Ji Yan, Yi-Xiao Guo, Yu-Long Zhao, Sani Sa'idu Baba, Hong Jia, Hui-Sheng Wang, Man Li, Fu-Quan Hu. Spinal 5-HT2A Receptor is Involved in Electroacupuncture Inhibition of Chronic Pain. Molecular pain. 2022-03-04. PMID:35240891. |
5-ht2a is a g protein-coupled receptor and it is involved in 5-ht descending pain modulation system. |
2022-03-04 |
2023-08-13 |
mouse |
| Jacqueline Chyr, Haoran Gong, Xiaobo Zho. DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer's Disease. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204697. |
these drugs target important brain receptors involved in memory, learning, and cognition, including serotonin 5-ht2a, dopamine d2, and orexin receptors. |
2022-02-25 |
2023-08-13 |
Not clear |
| Christoph U Correll, Anissa Abi-Dargham, Oliver Howe. Emerging Treatments in Schizophrenia. The Journal of clinical psychiatry. vol 83. issue 1. 2022-02-16. PMID:35172048. |
positive phase 2 trial results indicating efficacy and safety of the taar1 agonist ulotaront (sep-363856) and of the muscarinic m1/m4 agonist karxt (xanomeline plus trospium) for total, positive, and negative symptoms in patients with acute exacerbation of schizophrenia, and of the serotonin 5-ht2a agonist/antagonist pimavanserin in patients with schizophrenia and predominant negative symptoms for negative symptom control are encouraging. |
2022-02-16 |
2023-08-13 |
Not clear |
| Hector Vargas-Perez, Taryn Elizabeth Grieder, Derek van der Koo. Neural Plasticity in the Ventral Tegmental Area, Aversive Motivation during Drug Withdrawal and Hallucinogenic Therapy. Journal of psychoactive drugs. 2022-02-04. PMID:35114904. |
recent studies point out that serotonin (5-hydroxytryptamine, 5-ht) receptors, especially the 2a (5-ht2a) subtype, play an important role in bdnf-related neural plasticity in the vta. |
2022-02-04 |
2023-08-13 |
Not clear |
| Colleen Synan, Carrie Bowen, David J Heal, Christelle Froger-Colléaux, Patrick M Beardsley, Nina Dedic, Seth C Hopkins, Una Campbell, Kenneth S Kobla. Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats. Drug and alcohol dependence. vol 231. 2022-01-16. PMID:35033729. |
unlike available antipsychotics, the efficacy of ulotaront is not mediated by blockade of dopamine d2 or serotonin 5-ht2a receptors. |
2022-01-16 |
2023-08-13 |
rat |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| Manoj K Doss, Maxwell B Madden, Andrew Gaddis, Mary Beth Nebel, Roland R Griffiths, Brian N Mathur, Frederick S Barret. Models of psychedelic drug action: modulation of cortical-subcortical circuits. Brain : a journal of neurology. 2021-12-13. PMID:34897383. |
human and animal studies of psychedelic drug action in the brain have demonstrated the involvement of the serotonin 2a (5-ht2a) receptor and the cerebral cortex in acute psychedelic drug action, but different models have evolved to try to explain the impact of 5-ht2a activation on neural systems. |
2021-12-13 |
2023-08-13 |
human |
| J L Britt, R R Powell, C McMahan, T F Bruce, S K Ducket. The effect of ergot alkaloid exposure during gestation on the microscopic morphology and vasculature of the ovine placenta. Journal of histotechnology. vol 44. issue 4. 2021-12-04. PMID:33913402. |
ergot alkaloids, a class of mycotoxins associated with ergotism, act as agonists on serotonin (5ht) receptors, specifically 5ht2a, which mediate smooth muscle contraction and vasoconstriction. |
2021-12-04 |
2023-08-13 |
Not clear |
| Guy A Higgins, Edward M Seller. 5-HT Progress in brain research. vol 259. 2021-11-24. PMID:33541678. |
this chapter focusses on approaches targeted to the serotonin (5-ht) system, namely, selective serotonin reuptake inhibitors (ssri's) which served a pioneer role in the investigation of serotoninergic modulators in human smoking cessation trials; and secondly drugs selectively interacting with the 5-ht2a and 5-ht2c receptor systems. |
2021-11-24 |
2023-08-13 |
human |
| Kinsley Tate, Brenna Kirk, Alisia Tseng, Abigail Ulffers, Karen Litw. Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex. International journal of molecular sciences. vol 22. issue 19. 2021-11-08. PMID:34638815. |
cortical spheroids also appropriately express serotonin receptors, such as synaptic 5-ht2a and glial 5-ht5a. |
2021-11-08 |
2023-08-13 |
human |
| Romina Gonzalez-Pons, Kiera McRae, Janice M Thompson, Stephanie W Watt. 5-HT7 Receptor Restrains 5-HT-induced 5-HT2A Mediated Contraction in the Isolated Abdominal Vena Cava. Journal of cardiovascular pharmacology. vol 78. issue 2. 2021-10-29. PMID:34029269. |
the 5-ht2a receptor agonists tcb-2 and nboh were more potent in the aorta compared with 5-ht but less efficacious, serving as partial agonists. |
2021-10-29 |
2023-08-13 |
rat |
| Karimah Best, Dena H Tran, Camille Bulte, Avelino C Verceles, Miriam B Michae. Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report. Cureus. vol 13. issue 10. 2021-10-22. PMID:34659926. |
antipsychotic medications are used in the management of schizophrenia. antipsychotic medications treat both positive and negative symptoms via the dopamine d2 receptor and serotonin 5-ht2a blockade pathway. |
2021-10-22 |
2023-08-13 |
Not clear |
| Marianna Mazza, Giuseppe Marano, Gianandrea Traversi, Gabriele Sani, Luigi Janir. Evidence on the New Drug Lumateperone (ITI-007) for Psychiatric and Neurological Disorders. CNS & neurological disorders drug targets. vol 19. issue 4. 2021-09-06. PMID:32479249. |
lumateperone (iti-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5ht2a receptors, dopamine d2 and d1 receptors and the serotonin transporter. |
2021-09-06 |
2023-08-13 |
Not clear |
| Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-König, Deborah Janowitz, Hans J Grab. Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. Psychiatry research. vol 298. 2021-08-19. PMID:33567384. |
specifically, genetic polymorphisms of the serotonin receptors 5-ht1a and 5-ht2a were found to be associated with alexithymia. |
2021-08-19 |
2023-08-13 |
human |
| Yang Lyu, Daniel E L Promislow, Scott D Pletche. Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster. Communications biology. vol 4. issue 1. 2021-08-12. PMID:34131274. |
importantly, these effects are mediated by serotonin signaling, as a mutation in serotonin receptor 2a (5-ht2a) eliminated the effects of nutrient choice. |
2021-08-12 |
2023-08-13 |
drosophila_melanogaster |
| Yang Lyu, Daniel E L Promislow, Scott D Pletche. Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster. Communications biology. vol 4. issue 1. 2021-08-12. PMID:34131274. |
our data suggest that the behavioral or perceptual consequences of exposure to individual macronutrients, involving serotonin signaling through 5-ht2a, qualitatively change the state of metabolic networks throughout the organism from one that is highly connected and robust to one that is fragmented, fragile, and vulnerable to perturbations. |
2021-08-12 |
2023-08-13 |
drosophila_melanogaster |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-08-13 |
Not clear |
| Jeffery L Cummings, D P Devanand, Stephen M Stah. Dementia-related psychosis and the potential role for pimavanserin. CNS spectrums. 2021-07-30. PMID:32811586. |
pimavanserin, an atypical antipsychotic, is a selective serotonin inverse agonist/antagonist at 5-ht2a receptors. |
2021-07-30 |
2023-08-13 |
Not clear |
| Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. |
similarly, ligands of the serotonin 2a receptor (5-ht2a) were shown to alter anxiety level. |
2021-07-08 |
2023-08-13 |
mouse |