| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
in contrast, although rat aorta contracted more dramatically to serotonin than guinea pig aorta, rat aorta possessed a similar concentration of 5-ht2a receptor specific mrna as compared to guinea pig aorta. |
1994-08-18 |
2023-08-12 |
rat |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
these studies documenting 5-ht2a receptor mrna in rat trachea and guinea pig aorta, two tissues that do not markedly contract in response to serotonin indicate that 5-ht2a receptor mrna although present, has not resulted in a receptor capable of mediating a contractile response in these tissues. |
1994-08-18 |
2023-08-12 |
rat |
| E H Cook, K E Fletcher, M Wainwright, N Marks, S Y Yan, B L Leventha. Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. Journal of neurochemistry. vol 63. issue 2. 1994-08-12. PMID:8035173. |
primary structure of the human platelet serotonin 5-ht2a receptor: identify with frontal cortex serotonin 5-ht2a receptor. |
1994-08-12 |
2023-08-12 |
human |
| M Pompeiano, J M Palacios, G Mengo. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:8028479. |
distribution of the serotonin 5-ht2 receptor family mrnas: comparison between 5-ht2a and 5-ht2c receptors. |
1994-08-08 |
2023-08-12 |
rat |
| M Pompeiano, J M Palacios, G Mengo. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:8028479. |
because of their similarities, serotonin 5-ht2, 5-ht1c, and the recently described 5-ht2f receptors have been classified as members of the 5-ht2 receptor family, and they have been renamed 5-ht2a, 5-ht2c and 5-ht2b, respectively. |
1994-08-08 |
2023-08-12 |
rat |
| K A Berg, W P Clarke, Y Chen, B J Ebersole, R D McKay, S Maayan. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Molecular pharmacology. vol 45. issue 5. 1994-06-23. PMID:8190100. |
this effect of 5-ht was blocked by 10 nm ketanserin as well as by 10 nm spiperone, indicating a response mediated by the 5-ht2a receptor subtype. |
1994-06-23 |
2023-08-12 |
rat |
| P H Boeijinga, H W Boddek. Serotonergic modulation of neurotransmission in the rat subicular cortex in vitro: a role for 5-HT1B receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 6. 1994-04-20. PMID:8133898. |
the responses to 5-ht were also unaffected by pretreatment with the 5-ht1a selective antagonist nan-190 (10(-6) mol/l), the 5-ht2a antagonist ketanserin (10(-6) mol/l) or the 5-ht3/5-ht4 antagonist ics 205-930 (10(-6) mol/l). |
1994-04-20 |
2023-08-12 |
rat |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
the affinity of bimu-1 for sigma-2 binding sites (ki = 32 nm) was 200-fold greater than that for sigma-1 binding sites (ki = 6.3 microm), dopamine (d1 and d2), other serotonin (5-ht1a, 5-ht2a, 5-ht2c) and muscarinic (m1, m2, m3 and m4) receptors (ki > 10 microm). |
1994-01-06 |
2023-08-12 |
Not clear |
| D J McKenna, S J Peroutk. Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 10. 1989-11-14. PMID:2795135. |
we conclude that 125i-r-(-)doi labels a novel 5-ht binding site subtype (tentatively designated the 5-ht2a binding site) that is present in rat cortex but is either absent or minimally present in bovine cortex. |
1989-11-14 |
2023-08-11 |
rat |