| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Yamada, Y Sugimoto, T Yoshikawa, I Kimura, K Horisak. The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglycemia in rats. Life sciences. vol 57. issue 8. 1995-09-08. PMID:7637555. |
5-ht i.p.-induced hyperglycemia was strongly antagonized by the 5-ht2a receptor antagonist ketanserin. |
1995-09-08 |
2023-08-12 |
rat |
| J Yamada, Y Sugimoto, T Yoshikawa, I Kimura, K Horisak. The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglycemia in rats. Life sciences. vol 57. issue 8. 1995-09-08. PMID:7637555. |
these results suggest that the hyperglycemic effects of 5-ht are closely related to the release of adrenaline from the adrenal gland, mediated by 5-ht2a receptors. |
1995-09-08 |
2023-08-12 |
rat |
| N Bonhomme, P De Deurwaèrdere, M Le Moal, U Spampinat. Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat. Neuropharmacology. vol 34. issue 3. 1995-09-01. PMID:7543190. |
the effect induced by 1 microm 5-ht was not blocked by 10 microm (-)pindolol, a 5-ht1 receptor antagonist, 1 microm ketanserin or 10 microm cinanserin, both 5-ht2a antagonists. |
1995-09-01 |
2023-08-12 |
rat |
| I Sugihara, E J Lang, R Lliná. Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum. The European journal of neuroscience. vol 7. issue 4. 1995-08-30. PMID:7620604. |
injections of various 5-ht agonists and antagonists demonstrated that a 5-ht type-2a (5-ht2a) receptor is the main mediator for the 5-ht effect, which was very similar to the effect produced by injections of harmaline. |
1995-08-30 |
2023-08-12 |
rat |
| I Sugihara, E J Lang, R Lliná. Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum. The European journal of neuroscience. vol 7. issue 4. 1995-08-30. PMID:7620604. |
however, 5-ht and harmaline appear to have independent mechanisms since the action of harmaline was not blocked by the 5-ht2a antagonist ly53857. |
1995-08-30 |
2023-08-12 |
rat |
| S C Sealfon, L Chi, B J Ebersole, V Rodic, D Zhang, J A Ballesteros, H Weinstei. Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. The Journal of biological chemistry. vol 270. issue 28. 1995-08-25. PMID:7622478. |
related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-ht2a receptor. |
1995-08-25 |
2023-08-12 |
Not clear |
| S Davis, D J Heal, S C Stanfor. Long-lasting effects of an acute stress on the neurochemistry and function of 5-hydroxytryptaminergic neurones in the mouse brain. Psychopharmacology. vol 118. issue 3. 1995-08-23. PMID:7617818. |
sibutramine, but not saline, reduced 5-ht synthesis and 5-ht2a receptor-mediated head-twitches 3 h after the swim and increased synthesis at 7 days. |
1995-08-23 |
2023-08-12 |
mouse |
| A V Kulikov, D F Avgustinovich, V G Kolpakov, G B Maslova, N K Popov. 5-HT2A serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy. Pharmacology, biochemistry, and behavior. vol 50. issue 3. 1995-08-22. PMID:7617676. |
5-ht2a serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy. |
1995-08-22 |
2023-08-12 |
mouse |
| T Takahashi, J K Ward, S Tadjkarimi, M H Yacoub, P J Barnes, M G Belvis. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. American journal of respiratory and critical care medicine. vol 152. issue 1. 1995-08-10. PMID:7599849. |
the 5-ht3/4 and 5-ht3 antagonists, ics 205-930 and ondansetron, inhibited the effect of 5-ht competitively (pa2 values of 7.3 and 7.1, respectively); methiothepin (5-ht1/2c antagonist), ketanserin (5-ht2a antagonist), and gr 113808a (5-ht4 antagonist) had no effect. |
1995-08-10 |
2023-08-12 |
human |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
the 5-ht2a receptor subtype is the most widely studied of the 5-ht receptors in psychiatric disorders (for example, suicide, depression and schizophrenia) as well as in relation to the mechanism of action of antidepressant drugs. |
1995-07-27 |
2023-08-12 |
Not clear |
| H Pertz, S El. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. The Journal of pharmacy and pharmacology. vol 47. issue 4. 1995-07-27. PMID:7791029. |
in-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-ht2a receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-ht contractions in rat tail artery. |
1995-07-27 |
2023-08-12 |
rat |
| H Pertz, S El. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. The Journal of pharmacy and pharmacology. vol 47. issue 4. 1995-07-27. PMID:7791029. |
sarpogrelate, (r,s)-m-1, (r)-m-1 and (s)-m-1, respectively, were competitive antagonists of 5-hydroxytryptamine (5-ht) at 5-ht2a receptors of rat tail artery with calculated pa2 values of 8.53, 9.04, 9.00 and 8.81, respectively. |
1995-07-27 |
2023-08-12 |
rat |
| J Perregaard, E K Moltzen, E Meier, C Sánche. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. Journal of medicinal chemistry. vol 38. issue 11. 1995-07-18. PMID:7783131. |
additionally, these compounds had relatively high affinity for serotonin 5-ht1a and 5-ht2a, dopamine d2, and adrenergic alpha 1 receptors. |
1995-07-18 |
2023-08-12 |
rat |
| J Akiyoshi, A Nishizono, K Yamada, H Nagayama, K Mifune, I Fuji. Rapid desensitization of serotonin 5-HT2C receptor-stimulated intracellular calcium mobilization in CHO cells transfected with cloned human 5-HT2C receptors. Journal of neurochemistry. vol 64. issue 6. 1995-06-28. PMID:7760026. |
exposure to 5-ht, 1-(3-chlorophenyl)piperazine dihydrochloride (a 5-ht2c agonist), and 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (a 5-ht2c and 5-ht2a agonist) resulted in increased intracellular ca2+ levels. |
1995-06-28 |
2023-08-12 |
human |
| H Y Meltze. The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730497. |
this new strategy involves identifying drugs with strong serotonin (5-hydroxytryptamine) 5-ht2a receptor relative to dopamine d2 receptor blocking properties. |
1995-05-31 |
2023-08-12 |
Not clear |
| M Huttune. The evolution of the serotonin-dopamine antagonist concept. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730499. |
suggestions that serotonin might be involved in the cause of schizophrenia or could be a target for antipsychotic drug action began with the discovery that the antipsychotic agent clozapine is a potent serotonin 5-ht2a antagonist, as well as being a dopamine d2 antagonist. |
1995-05-31 |
2023-08-12 |
Not clear |
| M Huttune. The evolution of the serotonin-dopamine antagonist concept. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730499. |
the principle of the sdas is that the drug should be a potent serotonin 5-ht2a antagonist, with slightly less potent dopamine d2 receptor-blocking properties. |
1995-05-31 |
2023-08-12 |
Not clear |
| R Schreiber, M Brocco, V Audinot, A Gobert, S Veiga, M J Milla. (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714755. |
in this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (htw) response to the 5-hydroxytryptamine (5-ht)2a/5-ht2c agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-ht2a, 5-ht2c, d1, d2 and 5-ht1a receptors. |
1995-05-17 |
2023-08-12 |
rat |
| A S Eison, R P Freeman, V B Guss, U L Mullins, R N Wrigh. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714781. |
interactions between melatonin and serotonin type 2a (5-ht2a) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. |
1995-05-17 |
2023-08-12 |
rat |
| X Luo, D Zhang, H Weinstei. Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor. Protein engineering. vol 7. issue 12. 1995-05-16. PMID:7716154. |
we have described recently a 3-d molecular model of the transmembrane portion of the 5-ht2a type of receptor of the neurotransmitter serotonin (5-hydroxytryptamine; 5-ht), constructed from such convergent empirical and theoretical considerations, and have used it for a computational simulation of the mechanisms of ligand-induced receptor activation and signal transduction. |
1995-05-16 |
2023-08-12 |
Not clear |