| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Nitsch, M Deng, J H Growdon, R J Wurtma. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. The Journal of biological chemistry. vol 271. issue 8. 1996-06-21. PMID:8626761. |
serotonin 5-ht2a and 5-ht2c receptors stimulate amyloid precursor protein ectodomain secretion. |
1996-06-21 |
2023-08-12 |
Not clear |
| J Williams, G Spurlock, P McGuffin, J Mallet, M M Nöthen, M Gill, H Aschauer, P O Nylander, F Macciardi, M J Owe. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet (London, England). vol 347. issue 9011. 1996-06-19. PMID:8622505. |
an association between schizophrenia and the t102c polymorphism of the gene for 5-hydroxytryptamine type 2a (5-ht2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. |
1996-06-19 |
2023-08-12 |
Not clear |
| R N Iyer, C W Bradberr. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613947. |
the coperfusion of selective 5-ht2a and 5-ht3 antagonists mdl 100,907 ((r-(+)-(2,3-dimethoxyphenyl)-1-[2(4-flourophenylethyl)]-4- piperidine-methanol) and mdl 72222 (3-tropanyl-3,5-dichlorobenzoate), respectively, with 5-ht failed to significantly attenuate the 5-ht induced increase of extracellular da. |
1996-06-06 |
2023-08-12 |
Not clear |
| D Goldma. Candidate genes in alcoholism. Clinical neuroscience (New York, N.Y.). vol 3. issue 3. 1996-06-04. PMID:8612062. |
structural polymorphisms were detected in five serotonin receptors (5ht1a, 5ht1db, 5ht2a, 5ht2c, and 5ht7). |
1996-06-04 |
2023-08-12 |
Not clear |
| D S Pine, G A Wasserman, J Coplan, J A Fried, Y Y Huang, S Kassir, L Greenhill, D Shaffer, B Parson. Platelet serotonin 2A (5-HT2A) receptor characteristics and parenting factors for boys at risk for delinquency: a preliminary report. The American journal of psychiatry. vol 153. issue 4. 1996-04-24. PMID:8599403. |
platelet serotonin 2a (5-ht2a) receptor characteristics and parenting factors for boys at risk for delinquency: a preliminary report. |
1996-04-24 |
2023-08-12 |
Not clear |
| D S Pine, G A Wasserman, J Coplan, J A Fried, Y Y Huang, S Kassir, L Greenhill, D Shaffer, B Parson. Platelet serotonin 2A (5-HT2A) receptor characteristics and parenting factors for boys at risk for delinquency: a preliminary report. The American journal of psychiatry. vol 153. issue 4. 1996-04-24. PMID:8599403. |
this study examined the cross-sectional association between platelet membrane serotonin 2a (5-ht2a) receptor variables in children and characteristics of their parents that place these children at risk for antisocial behavior. |
1996-04-24 |
2023-08-12 |
Not clear |
| Y Morishima, T Shiban. Evidence that 5-HT2A receptors are not involved in 5-HT-mediated thermoregulation in mice. Pharmacology, biochemistry, and behavior. vol 52. issue 4. 1996-03-27. PMID:8587916. |
three 5-ht2a receptor antagonists, ketanserin (1 mg/kg, orally), ritanserin (1 and 10 mg/kg, orally), and dv-7028 (10 mg/kg, orally), also failed to alter body temperature, although these three 5-ht2a receptor antagonists at > or = 1 mg/kg, orally, inhibited head twitch response induced by 5-htp (200 mg/kg, ip), a precursor of 5-ht. |
1996-03-27 |
2023-08-12 |
mouse |
| Y Niitsu, S Hamada, K Hamaguchi, M Mikuni, N Okad. Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo. Neuroscience letters. vol 195. issue 3. 1996-03-21. PMID:8584199. |
because of the widespread distribution pattern of 5-ht fibers and 5-ht2a receptors in the central nervous system, 5-ht is thought to play a role in the formation and maintenance of synapses that are involved in normal brain function and mechanism of plasticity. |
1996-03-21 |
2023-08-12 |
chicken |
| D Fiorella, S Helsley, D S Lorrain, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584619. |
the present study was designed to determine the effects of p-chlorophenylalanine (pcpa) and p-chloroamphetamine (pca) administration on (1) the levels of serotonin (5-hydroxytryptamine, 5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) in rat brain, (2) the sensitivity of lsd-trained rats to the stimulus effects of lsd, and (3) the maximal levels of 5-ht2a and 5-ht2c receptor mediated phosphoinositide (pi) hydrolysis in rat brain. |
1996-03-19 |
2023-08-12 |
human |
| A Kulikov, N Castanon, P Mormède, F Chaoulof. Cerebral tryptophan hydroxylase activity, and 5-HT1A receptor, 5-HT2A receptor, and 5-HT transporter binding in grouped and isolated Roman RHA and RLA rats: relationships with behaviours in two models of anxiety. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584622. |
cerebral tryptophan hydroxylase activity, and 5-ht1a receptor, 5-ht2a receptor, and 5-ht transporter binding in grouped and isolated roman rha and rla rats: relationships with behaviours in two models of anxiety. |
1996-03-19 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse (New York, N.Y.). vol 21. issue 2. 1996-03-19. PMID:8584973. |
protein kinase c inhibitors enhance the 5-ht2a receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. |
1996-03-19 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse (New York, N.Y.). vol 21. issue 2. 1996-03-19. PMID:8584973. |
previously it has been shown that excitatory effects of 5-hydroxytryptamine (5-ht) upon interneurons in the rat piriform cortex are mediated by 5-ht2a receptors. |
1996-03-19 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse (New York, N.Y.). vol 21. issue 2. 1996-03-19. PMID:8584973. |
as inhibitors of pkc selectively enhanced rather than blocked the excitation by 5-ht mediated by 5-ht2a receptors, we conclude that activation of pkc does not mediate the excitation by 5-ht of piriform cortical interneurons. |
1996-03-19 |
2023-08-12 |
rat |
| K Saitoh, M Mikuni, M Ikeda, C Yamazaki, U Tomita, K Takahash. Serotonin-induced 5-HT1A receptor desensitization in C6BU-1 glioma cells transfected with 5-HT1A receptor gene. Neuroscience letters. vol 199. issue 3. 1996-03-13. PMID:8577395. |
further, this 8-oh-dpat-induced inhibition of forskolin-stimulated activity was significantly attenuated after pre-exposure to 5-ht (10 microm) for 12 h. spiperone (10 microm), a 5-ht1a and 5-ht2a antagonist, prevented 5-ht-induced desensitization of 5-ht1a receptor, but a selective 5-ht2a receptor antagonist, ketanserin, did not. |
1996-03-13 |
2023-08-12 |
Not clear |
| K Saitoh, M Mikuni, M Ikeda, C Yamazaki, U Tomita, K Takahash. Serotonin-induced 5-HT1A receptor desensitization in C6BU-1 glioma cells transfected with 5-HT1A receptor gene. Neuroscience letters. vol 199. issue 3. 1996-03-13. PMID:8577395. |
in addition, pre-exposure to a selective 5-ht2a agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi, 10 microm), for 24 h did not alter the inhibitory effect of 8-oh-dpat on forskolin-stimulated camp accumulation in these transfected cells, suggesting that prolonged exposure to 5-ht induced 5-ht1a receptor desensitization, mediated by 5-ht1a receptor but not 5-ht2a receptors. |
1996-03-13 |
2023-08-12 |
Not clear |
| J M Zgombick, L E Schechter, S A Kucharewicz, R L Weinshank, T A Branche. Ketanserin and ritanserin discriminate between recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes. European journal of pharmacology. vol 291. issue 1. 1996-02-20. PMID:8549648. |
in [3h]5-ht competition assays, the classical 5-ht2a receptor antagonists, ritanserin and ketanserin, displayed moderate affinity (pki = 7.30 and 7.17, respectively) and marked selectivity (22- and 71-fold, respectively) for the recombinant human 5-ht1d alpha subtype relative to the 5-ht1d beta receptor. |
1996-02-20 |
2023-08-12 |
human |
| A J Sleight, N J Stam, V Mutel, P M Vanderheyde. Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities. Biochemical pharmacology. vol 51. issue 1. 1996-01-30. PMID:8534270. |
because 5-ht has high affinity for the 5-ht2a receptor when displacing [3h]-dob, the purpose of the present study was to determine whether or not the receptor could be labelled with [3h]-5-ht and what would be the effect of labelling the receptor with various radioligands having differing efficacies at the receptor. |
1996-01-30 |
2023-08-12 |
human |
| S W Watts, L Gilbert, R C Web. 5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 26. issue 6 Pt 2. 1996-01-16. PMID:7498967. |
ketanserin (5-ht2a antagonist) competitively inhibited contraction to 5-ht in arteries from normotensive rats (-log dissociation constant [mol/l]; pkb = 8.54) but not from hypertensive rats (pkb > 6.5). |
1996-01-16 |
2023-08-12 |
rat |
| S W Watts, L Gilbert, R C Web. 5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 26. issue 6 Pt 2. 1996-01-16. PMID:7498967. |
thus, under normal conditions, 5-ht2a receptors mediate contraction to 5-ht. |
1996-01-16 |
2023-08-12 |
rat |
| X C Li, J F Giot, D Kuhl, R Hen, E R Kande. Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase C. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472509. |
sequence comparison reveals that these receptors are 33.1 to 23.3% identical to the following 5-ht receptors: 5-htdro1 > 5-ht6 > 5-htlym > mouse 5-ht1b > 5-htdro2a > mouse 5-ht7 > rat 5-ht2a. |
1995-12-26 |
2023-08-12 |
mouse |