| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N V Cozzi, D E Nichol. 5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex. European journal of pharmacology. vol 309. issue 1. 1997-01-31. PMID:8864689. |
these results suggest that serotonin facilitates gaba release in cortex via 5-ht2a receptors and that the functional response of this system is resistant to serotonin depletion. |
1997-01-31 |
2023-08-12 |
rat |
| H Pert. Naturally occurring clavines: antagonism/partial agonism at 5-HT2A receptors and antagonism at alpha 1-adrenoceptors in blood vessels. Planta medica. vol 62. issue 5. 1997-01-30. PMID:8923801. |
this suggests that lysergol and 5-ht possibly bind in two slightly different orientations at the 5-ht2a receptor. |
1997-01-30 |
2023-08-12 |
rat |
| R A Padich, T C McCloskey, J H Kehn. 5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats. Psychopharmacology. vol 124. issue 1-2. 1997-01-29. PMID:8935805. |
effects of the 5-ht2a antagonist mdl 100,907 on disruption of sound and light prepulse inhibition produced by 5-ht agonists in wistar rats. |
1997-01-29 |
2023-08-12 |
rat |
| R A Padich, T C McCloskey, J H Kehn. 5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats. Psychopharmacology. vol 124. issue 1-2. 1997-01-29. PMID:8935805. |
increasing evidence suggests an important role of 5-ht, and 5-ht2a receptors in particular, in the etiology and treatment of schizophrenia. |
1997-01-29 |
2023-08-12 |
rat |
| R A Padich, T C McCloskey, J H Kehn. 5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats. Psychopharmacology. vol 124. issue 1-2. 1997-01-29. PMID:8935805. |
the present study used the selective serotonin2a (5-ht2a) antagonist and putative antipsychotic agent mdl 100,907 to evaluate the contribution of 5-ht2a receptors to the disruptions of prepulse inhibition produced by several 5-ht agonists. |
1997-01-29 |
2023-08-12 |
rat |
| S Takan. Role of 5-hydroxytryptamine in platelet thrombus formation and mechanisms of inhibition of thrombus formation by 5-hydroxytryptamine2A antagonists in rabbits. Archives internationales de pharmacodynamie et de therapie. vol 330. issue 3. 1997-01-24. PMID:8836449. |
the role of 5-hydroxytryptamine (5-ht) in platelet thrombus formation and in the mechanisms of inhibition of thrombus formation by 5-ht2a antagonists was investigated using a turbidimetric method. |
1997-01-24 |
2023-08-12 |
Not clear |
| D F Papolos, Y M Yu, E Rosenbaum, H M Lachma. Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry research. vol 63. issue 2-3. 1997-01-16. PMID:8878316. |
to understand the significance of neuronal responses in depression and lh that are mediated by serotonin (5-hydroxytryptamine, 5ht) receptors, we used intracerebroventricular injections to introduce a unique antisense oligonucleotide (aso) to the 5ht2a receptor and determined its effect on lh behavior in sprague-dawley rats as determined by an escape-avoidance strategy. |
1997-01-16 |
2023-08-12 |
rat |
| D F Papolos, Y M Yu, E Rosenbaum, H M Lachma. Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry research. vol 63. issue 2-3. 1997-01-16. PMID:8878316. |
these data support the view that central 5ht, mediated by the 5ht2a receptor, participates in regulating behaviors that are affected by inescapable stress, and that the induction of behavioral depression may be specifically regulated via serotonergic pathways that terminate in this hippocampal subfield. |
1997-01-16 |
2023-08-12 |
rat |
| J W Crayton, I Joshi, A Gulati, R C Arora, W A Wol. Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex. Brain research. vol 728. issue 2. 1997-01-15. PMID:8864491. |
the effects of corticosterone (1 mg/kg per day for 7 days) on serotonin 5-ht1a, 5-ht2a, 5-ht uptake sites, and alpha 2-adrenergic receptor sites were measured. |
1997-01-15 |
2023-08-12 |
rat |
| R A Borman, D E Burleig. Human colonic mucosa possesses a mixed population of 5-HT receptors. European journal of pharmacology. vol 309. issue 3. 1997-01-15. PMID:8874150. |
using selective 5-ht antagonists we have shown that 5-ht induces secretion in sigmoid colon via a 5-ht2a receptor. |
1997-01-15 |
2023-08-12 |
human |
| B Malinowska, E Schlicke. Mediation of the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical beta-adrenoceptors, different from beta 3-adrenoceptors. British journal of pharmacology. vol 117. issue 5. 1997-01-07. PMID:8851515. |
the effect of cgp 12177 was also not changed by brl 37344 1 mumol kg-1, zd 2079 10 mumol kg-1, cl 316243 10 mumol kg-1, the alpha 1-adrenoceptor antagonist, prazosin 1 mumol kg-1 and the 5-hydroxytryptamine 5-ht2a receptor antagonist, ketanserin 3 mumol kg-1. |
1997-01-07 |
2023-08-12 |
rat |
| D Goldman, J Lappalainen, N Ozak. Direct analysis of candidate genes in impulsive behaviours. Ciba Foundation symposium. vol 194. 1997-01-02. PMID:8862874. |
direct gene analyses have revealed non-conservative amino acid substitutions and structural variants (generally rare) at drd2, drd3 and drd4 dopamine receptors and 5-ht1a, 5-ht2a, 5-ht2c and 5-ht7 serotonin receptors. |
1997-01-02 |
2023-08-12 |
Not clear |
| J H Kehne, H J Ketteler, T C McCloskey, C K Sullivan, M W Dudley, C J Schmid. Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 2. 1996-12-26. PMID:8840347. |
these data support the conclusion that serotonin released onto 5-ht2a receptors contributes to mdma-stimulated locomotion and suggest that mdma-stimulated locomotion may be useful as an in vivo behavioral measure of 5-ht2a antagonism. |
1996-12-26 |
2023-08-12 |
rat |
| E Raviña, J Fueyo, C F Masaguer, J Negreira, J Cid, I Loza, A Honrubia, H Tristán, T G-Ferreiro, J A Fontenla, E Rosa, J M Calleja, M L De Ceballo. Synthesis and affinities for dopamine (D2) and 5-hydroxytryptamine (5-HT2A) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives. Chemical & pharmaceutical bulletin. vol 44. issue 3. 1996-12-26. PMID:8882450. |
synthesis and affinities for dopamine (d2) and 5-hydroxytryptamine (5-ht2a) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives. |
1996-12-26 |
2023-08-12 |
Not clear |
| E Raviña, J Fueyo, C F Masaguer, J Negreira, J Cid, I Loza, A Honrubia, H Tristán, T G-Ferreiro, J A Fontenla, E Rosa, J M Calleja, M L De Ceballo. Synthesis and affinities for dopamine (D2) and 5-hydroxytryptamine (5-HT2A) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives. Chemical & pharmaceutical bulletin. vol 44. issue 3. 1996-12-26. PMID:8882450. |
the affinities of these compounds for dopamine (d2) and 5-hydroxytryptamine (5-ht2a) receptors were evaluated in vitro in receptor-binding assays and in functional experiments. |
1996-12-26 |
2023-08-12 |
Not clear |
| P F Goyer, M S Berridge, E D Morris, W E Semple, B A Compton-Toth, S C Schulz, D F Wong, F Miraldi, H Y Meltze. PET measurement of neuroreceptor occupancy by typical and atypical neuroleptics. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 7. 1996-12-26. PMID:8965181. |
the goal of this study was to use pet and 11c-n-methylspiperone (11c-nmsp) to measure the difference in relative occupancy of serotonin (5-hydroxytryptamine-2 or 5-ht2a) and dopamine-2 (d2) neuroreceptors in subjects being treated with typical or atypical antipsychotic drugs. |
1996-12-26 |
2023-08-12 |
human |
| M Engelstoft, J B Hanse. Synthesis and 5HT modulating activity of stereoisomers of 3-phenoxymethyl-4-phenylpiperidines. Acta chemica Scandinavica (Copenhagen, Denmark : 1989). vol 50. issue 2. 1996-12-23. PMID:8819850. |
these compounds exhibit a pronounced steric requirement for inhibition of 5ht reuptake and binding to 5ht2a and 5ht2c receptors. |
1996-12-23 |
2023-08-12 |
Not clear |
| R A Newton, S L Phipps, T P Flanigan, N R Newberry, J E Carey, C Kumar, B McDonald, C Chen, J M Elliot. Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs. Journal of neurochemistry. vol 67. issue 6. 1996-12-23. PMID:8931486. |
stimulation of the recombinant receptors by 5-ht induced phosphoinositide hydrolysis with higher potency but lower efficacy at the 5-ht2c receptor (pec50 = 7.80 +/- 0.06) compared with the 5-ht2a receptor (pec50 = 7.30 +/- 0.08). |
1996-12-23 |
2023-08-12 |
human |
| R A Newton, S L Phipps, T P Flanigan, N R Newberry, J E Carey, C Kumar, B McDonald, C Chen, J M Elliot. Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs. Journal of neurochemistry. vol 67. issue 6. 1996-12-23. PMID:8931486. |
comparison of equipotent doses producing 20% of the maximal response induced by 5-ht revealed selective activation of the 5-ht2a receptor by lsd and to a lesser degree by doi, mescaline, and ergotamine. |
1996-12-23 |
2023-08-12 |
human |
| R Rahimian, P D Hrdin. Possible role of protein kinase C in regulation of 5-hydroxytryptamine 2A receptors in rat brain. Canadian journal of physiology and pharmacology. vol 73. issue 12. 1996-12-10. PMID:8834481. |
this study was undertaken to evaluate the effect of acute in vivo treatment with 1-(2,5-dimethoxy-4-iodo-phenyl)2-aminopropane (doi), a selective 5-hydroxytryptamine 2a/2c (5ht2a/2c) receptor agonist, on the kinetic parameters of [3h]ketanserin binding to 5ht2a receptors and on the protein kinase c (pkc) activity in subcellular fractions of rat brain tissue. |
1996-12-10 |
2023-08-12 |
rat |