| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Verheggen, S Freudenthaler, F Meyer-Dulheuer, A J Kauman. Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. British journal of pharmacology. vol 117. issue 2. 1997-04-09. PMID:8789380. |
in rings with intact endothelium the 5-ht2a receptor partial agonist sk&f 103829 (2,3,4,5-tetrahydro-8[methyl sulphonyl]-1h3-benzazepin-7-ol methensulphonate) contracted rings with a -log ec50, m of 5.0 and an intrinsic activity of 0.49 with respect to 5-ht; the effects were antagonized by ketanserin 1000 nm. |
1997-04-09 |
2023-08-12 |
human |
| H Matsuda, H Ushio, G P Geba, P W Askenas. Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 6. 1997-04-02. PMID:9058826. |
furthermore, in vitro depletion of 5-ht from platelets or in vivo pretreatment of recipients with a 5-ht2a receptor antagonist (ketanserin) abolished the ige-dependent cs initiation mediated by platelets. |
1997-04-02 |
2023-08-12 |
mouse |
| A M Laporte, C Doyen, I T Nevo, J Chauveau, J J Hauw, M Hamo. Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord. Journal of chemical neuroanatomy. vol 11. issue 1. 1997-03-20. PMID:8841890. |
autoradiographic mapping of serotonin 5-ht1a, 5-ht1d, 5-ht2a and 5-ht3 receptors in the aged human spinal cord. |
1997-03-20 |
2023-08-12 |
human |
| A M Laporte, C Doyen, I T Nevo, J Chauveau, J J Hauw, M Hamo. Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord. Journal of chemical neuroanatomy. vol 11. issue 1. 1997-03-20. PMID:8841890. |
quantitative autoradiography with selective radioligands was used to establish the respective distribution of serotonin 5-ht1a, 5-ht1d, 5-ht2a and 5-ht3 receptors at the cervical, thoracic and lumbar levels of the spinal cord from subjects who died at 81-94 years. |
1997-03-20 |
2023-08-12 |
human |
| B W Siegel, J Freedman, M J Vaal, B M Baro. Activities of novel aryloxyalkylimidazolines on rat 5-HT2A and 5-HT2C receptors. European journal of pharmacology. vol 296. issue 3. 1997-03-12. PMID:8904083. |
using transfected nih 3t3 mouse fibroblast cell lines expressing the rat 5-ht2a and rat 5-ht2c receptor subtypes, and techniques of 2-[125i](+)-iodolysergic acid diethylamide ([125i]lsd) binding and serotonin (5-hydroxytryptamine, 5-ht)-stimulated phosphoinositide hydrolysis, we have characterized a new structural class of 5-ht receptor ligands, the aryloxyalkylimidazolines. |
1997-03-12 |
2023-08-12 |
mouse |
| M R Budhoo, R P Harris, J M Kellu. The role of the 5-HT4 receptor in Cl- secretion in human jejunal mucosa. European journal of pharmacology. vol 314. issue 1-2. 1997-03-10. PMID:8957225. |
another 5-ht4 receptor antagonist, sc 53606 (0.1 microm), antagonized the 5-ht-induced response with a pa2 of 7.3 5-ht1-like/5-ht2 (methysergide), 5-ht1p [n-acetyl-5-hydroxytryptophyl 5-hydroxytryptophan amide (5-ht-dp], 5-ht2a (ketanserin) and 5-ht3 (ondansetron) receptor antagonists and tetrodotoxin, had no significant effect on the ec50 for 5-ht. |
1997-03-10 |
2023-08-12 |
human |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
in the cortex, the rank order of 5-ht receptor subtype bmax was 5-ht2a (low-affinity), 5-ht1a, 5-ht uptake sites, 5-ht1d, 5-ht2c, 5-ht1e/f, and 5-ht2a (high-affinity) sites. |
1997-03-05 |
2023-08-12 |
human |
| M R Pranzatelli, I Galvan, P T Tailo. Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus. Clinical neuropharmacology. vol 19. issue 6. 1997-03-05. PMID:8937789. |
in the brainstem, the rank order was 5-ht uptake sites, 5-ht1d, 5-ht2c, 5-ht1a, and 5-ht2a(l) sites. |
1997-03-05 |
2023-08-12 |
human |
| Y Imada-Shirakata, T Kotera, S Ueda, M Okum. Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Biochemical and biophysical research communications. vol 230. issue 2. 1997-03-05. PMID:9016798. |
serotonin activates electrolyte transport via 5-ht2a receptor in rat colonic crypt cells. |
1997-03-05 |
2023-08-12 |
rat |
| Y Imada-Shirakata, T Kotera, S Ueda, M Okum. Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Biochemical and biophysical research communications. vol 230. issue 2. 1997-03-05. PMID:9016798. |
the aim of this study was to demonstrate that 5-ht activates electrolyte transport directly via 5-ht2a receptor in rat colonic crypt cells. |
1997-03-05 |
2023-08-12 |
rat |
| Y Imada-Shirakata, T Kotera, S Ueda, M Okum. Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Biochemical and biophysical research communications. vol 230. issue 2. 1997-03-05. PMID:9016798. |
superfusing 5-ht (10 microm) in the bath solution increased both k+ and cl- currents, which were antagonized by the presence of ketanserin (1 microm), a selective 5-ht2a antagonist, in the bath solution. |
1997-03-05 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons. European journal of pharmacology. vol 305. issue 1-3. 1997-02-20. PMID:8813537. |
a subpopulation of interneurons in layer iii of the rat piriform cortex that are excited by 5-hydroxytryptamine (5-ht) via 5-ht2a receptors are also excited by norepinephrine via alpha 1-adrenoceptors. |
1997-02-20 |
2023-08-12 |
rat |
| D R Nyholt, R P Curtain, P T Gaffney, P Brimage, P J Goadsby, L R Griffith. Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene. Cephalalgia : an international journal of headache. vol 16. issue 7. 1997-02-18. PMID:8933989. |
migraine association and linkage analyses of the human 5-hydroxytryptamine (5ht2a) receptor gene. |
1997-02-18 |
2023-08-12 |
human |
| N K Popova, A V Kulikov, D F Avgustinovich, S N Shigantso. [The characteristics of the brain serotonin system and anxiety in the C57BL and CBA mouse strains]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 46. issue 2. 1997-02-11. PMID:8726569. |
serotonin metabolism and 5-ht2a and 5-ht1a specific binding were studied in high-aggressive c57bl and low-aggressive cba mice. |
1997-02-11 |
2023-08-12 |
mouse |
| N K Popova, A V Kulikov, D F Avgustinovich, S N Shigantso. [The characteristics of the brain serotonin system and anxiety in the C57BL and CBA mouse strains]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 46. issue 2. 1997-02-11. PMID:8726569. |
it was suggested that decreased serotonin metabolism and characteristic distribution of 5-ht2a receptors can underlie the expression of genetic predisposition to anxiety and aggression. |
1997-02-11 |
2023-08-12 |
mouse |
| M R MacLean, R A Clayton, A G Templeton, I Morecrof. Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery. British journal of pharmacology. vol 119. issue 2. 1997-02-06. PMID:8886409. |
responses to 5-ht and sumatriptan in the presence of the antagonists, methiothepin (non-selective 5-ht1+2-receptor antagonist), ketanserin (5-ht2a receptor antagonist) and the novel antagonist, gr55562 (5-ht1d receptor antagonist) were also studied. |
1997-02-06 |
2023-08-12 |
human |
| M R MacLean, R A Clayton, A G Templeton, I Morecrof. Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery. British journal of pharmacology. vol 119. issue 2. 1997-02-06. PMID:8886409. |
the 5-ht2a receptor antagonist ketanserin (10 nm, 100 nm and 1 microm) also reduced the maximum contractile response to both 5-ht and sumatriptan without affecting tissue sensitivity to these agonists. |
1997-02-06 |
2023-08-12 |
human |
| A P Albert, K M Spyer, P A Brook. The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro. British journal of pharmacology. vol 119. issue 3. 1997-02-06. PMID:8894172. |
these results are consistent with direct, postsynaptic actions of 5-ht on dvms via 5-ht2a receptors, being mediated, in part, by the reduction of k+ conductance. |
1997-02-06 |
2023-08-12 |
rat |
| S Yamawaki, A Kagaya, Y Okamoto, M Shimizu, A Nishida, Y Uchitom. Enhanced calcium response to serotonin in platelets from patients with affective disorders. Journal of psychiatry & neuroscience : JPN. vol 21. issue 5. 1997-02-03. PMID:8973051. |
in this report we have investigated the intracellular calcium (ca2+) mobilization mediated by serotonin 5-ht2a receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. |
1997-02-03 |
2023-08-12 |
human |
| N V Cozzi, D E Nichol. 5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex. European journal of pharmacology. vol 309. issue 1. 1997-01-31. PMID:8864689. |
several drugs selective for the serotonin 5-ht2a receptor were tested for their effects on spontaneous and k(+)-evoked [3h] gamma-aminobutyric acid (gaba) release from slices of rat frontal cortex. |
1997-01-31 |
2023-08-12 |
rat |