| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W A Wolf, L J Schut. The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia: evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326273. |
pharmacological analysis using the selective 5-ht2a antagonist, spiperone, and the nonselective 5-ht(2a/2c) antagonist, mianserin, demonstrated that over half of the 5-ht-stimulated plc activity was due to stimulation of 5-ht2c receptors as opposed to 5-ht2a receptors. |
1997-10-27 |
2023-08-12 |
rat |
| R J Goldber. Antidepressant use in the elderly. Current status of nefazodone, venlafaxine and moclobemide. Drugs & aging. vol 11. issue 2. 1997-10-23. PMID:9259175. |
nefazodone is a serotonin uptake inhibitor and serotonin 5-ht2a receptor antagonist. |
1997-10-23 |
2023-08-12 |
Not clear |
| S M Carlton, R E Coggeshal. Immunohistochemical localization of 5-HT2A receptors in peripheral sensory axons in rat glabrous skin. Brain research. vol 763. issue 2. 1997-10-23. PMID:9296571. |
the present study shows that 32% of unmyelinated axons at the dermal-epidermal junction are immunohistochemically stained with antibodies directed against the 5-ht2a receptor providing anatomical evidence that 5-ht can have a direct effect on sensory fibers in the skin. |
1997-10-23 |
2023-08-12 |
rat |
| S M Carlton, R E Coggeshal. Immunohistochemical localization of 5-HT2A receptors in peripheral sensory axons in rat glabrous skin. Brain research. vol 763. issue 2. 1997-10-23. PMID:9296571. |
furthermore, encapsulated nerve endings in pacinian corpuscles also contain reaction product following immunostaining for 5-ht2a receptors, indicating that large myelinated axons can be activated by endogenous serotonin. |
1997-10-23 |
2023-08-12 |
rat |
| D L Willins, A Y Deutch, B L Rot. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse (New York, N.Y.). vol 27. issue 1. 1997-10-21. PMID:9268067. |
serotonin 5-ht2a receptors are expressed on pyramidal cells and interneurons in the rat cortex. |
1997-10-21 |
2023-08-12 |
mouse |
| F G Boess, F J Monsma, V Meyer, C Zwingelstein, A J Sleigh. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. Molecular pharmacology. vol 52. issue 3. 1997-10-02. PMID:9284367. |
based on molecular modeling, a serine residue in transmembrane region iv of the 5-ht2a receptor has previously been proposed to interact with the n1-position of 5-ht. |
1997-10-02 |
2023-08-12 |
human |
| G Hilaire, C Bou, R Montea. Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study. European journal of pharmacology. vol 329. issue 2-3. 1997-09-25. PMID:9226402. |
upon applying the drugs to the spinal cord alone, 5-ht was found to have a dual effect on phrenic motoneuron firing: (i) a facilitatory effect mediated by 5-ht2a receptors and (ii) a depressive effect on their inspiratory discharge mediated by non-5-ht1a, non-5-ht2a, non-5-ht3 receptors, possibly of the 5-ht1b subtype. |
1997-09-25 |
2023-08-12 |
mouse |
| E Di Pasquale, A Lindsay, J Feldman, R Monteau, G Hilair. Serotonergic inhibition of phrenic motoneuron activity: an in vitro study in neonatal rat. Neuroscience letters. vol 230. issue 1. 1997-09-24. PMID:9259456. |
the changes induced by 5-ht and related agents on phrenic root discharges and membrane currents in identified phrenic motoneurons were analysed after blockade of spinal 5-ht2a receptors. |
1997-09-24 |
2023-08-12 |
rat |
| O Spigset, T Mjornda. The effect of fluvoxamine on serum prolactin and serum sodium concentrations: relation to platelet 5-HT2A receptor status. Journal of clinical psychopharmacology. vol 17. issue 4. 1997-09-22. PMID:9241009. |
we have investigated to what extent fluvoxamine alters serum prolactin and serum sodium levels and whether these effects are related to platelet 5-hydroxytryptamine 2a (5-ht2a) receptor status, as studied by [3h]lysergic acid diethylamide ([3h]lsd) binding. |
1997-09-22 |
2023-08-12 |
human |
| J T Weber, M F O'Connor, K Hayataka, N Colson, R Medora, E B Russo, K K Parke. Activity of Parthenolide at 5HT2A receptors. Journal of natural products. vol 60. issue 6. 1997-09-15. PMID:9214741. |
these results suggest that parthenolide may be a low-affinity antagonist at 5ht receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5ht2a receptor affinity. |
1997-09-15 |
2023-08-12 |
rat |
| M el Mansari, P Blie. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225283. |
5-ht and the preferential 5-ht2a receptor agonist doi and the preferential 5-ht2c receptor agonist mcpp, suppressed the quisqualate (quis)-induced activation of neurons in both structures. |
1997-09-15 |
2023-08-12 |
Not clear |
| M Goppelt-Struebe, M Stroebe. Mechanisms of serotonin-induced Ca2+ responses in mesangial cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 2. 1997-09-12. PMID:9272731. |
the l-type channel blocker verapamil, however, dose-dependently (0.1-10 microm) and specifically inhibited 5-ht-elicited ca2+ signals by interference with binding of 5-ht to 5-ht2a receptors. |
1997-09-12 |
2023-08-12 |
rat |
| D L Willins, H Y Meltze. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262333. |
the serotonin (5-ht)(2a/2c) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), the 5-ht2c agonist 6-chloro-2-[1-piperazinyl]-pyrazine and the 5-ht2a partial agonist m-chloro-phenylpiperazine (mcpp) were injected bilaterally into the medial prefrontal cortex of male rats. |
1997-09-11 |
2023-08-12 |
rat |
| D L Willins, H Y Meltze. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262333. |
doi-induced htr had an ed50 of 12.8 nmoles/0.5 microl/side and was inhibited by the 5-ht2a antagonists ketanserin and mdl 100,907 but was not blocked by pretreatment with the selective 5-ht(2c/2b) antagonist sdz ser 082. |
1997-09-11 |
2023-08-12 |
rat |
| S Graf, S K Sarn. 5-HT-induced colonic contractions: enteric locus of action and receptor subtypes. The American journal of physiology. vol 273. issue 1 Pt 1. 1997-09-03. PMID:9252511. |
prior close intra-arterial infusions of 5-ht1a/5-ht1b, 5-ht2a, 5-ht2c, and 5-ht4 receptor antagonists had no significant effect on the contractile response to 5-ht. |
1997-09-03 |
2023-08-12 |
Not clear |
| J K McQueen, H Wilson, G Fin. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105666. |
together with our previous findings, they also suggest that the sex differences in depression and the apparent psychotropic effect of e2 may be due to the action of e2 on the serotonin transporter as well as 5-ht2a receptors. |
1997-08-27 |
2023-08-12 |
rat |
| H Takeuchi, S Yatsugi, K Hatanaka, K Nakato, H Hattori, R Sonoda, K Koshiya, M Fujii, T Yamaguch. Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT2A receptor antagonistic activity. European journal of pharmacology. vol 329. issue 1. 1997-08-22. PMID:9218680. |
pharmacological studies on ym992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-ht2a receptor antagonistic activity. |
1997-08-22 |
2023-08-12 |
mouse |
| H Takeuchi, S Yatsugi, K Hatanaka, K Nakato, H Hattori, R Sonoda, K Koshiya, M Fujii, T Yamaguch. Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT2A receptor antagonistic activity. European journal of pharmacology. vol 329. issue 1. 1997-08-22. PMID:9218680. |
ym992 ((s)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride) is a novel compound that has selective serotonin (5-hydroxytryptamine, 5-ht) re-uptake inhibition and 5-ht2a receptor antagonistic activity in vivo. |
1997-08-22 |
2023-08-12 |
mouse |
| H Takeuchi, S Yatsugi, K Hatanaka, K Nakato, H Hattori, R Sonoda, K Koshiya, M Fujii, T Yamaguch. Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT2A receptor antagonistic activity. European journal of pharmacology. vol 329. issue 1. 1997-08-22. PMID:9218680. |
these results demonstrate that ym992 has 5-ht uptake inhibition and 5-ht2a receptor antagonistic activity in vivo, and suggest that ym992 may be a novel antidepressant with high efficacy in clinical use. |
1997-08-22 |
2023-08-12 |
mouse |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
to further study the influence of risperidone on central 5-ht systems, we compared its effects on dialysate 5-ht in the fc, as assessed by microdialysis, with those obtained with other antipsychotic drugs, i.e., clozapine, haloperidol, and amperozide, as well as with the selective alpha 2- or 5-ht2a receptor antagonists idazoxan or mdl 100,907, respectively. |
1997-08-13 |
2023-08-12 |
rat |