| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Hrdina, D Bakish, A Ravindran, J Chudzik, P Cavazzoni, Y D Lapierr. Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research. vol 66. issue 2-3. 1997-06-12. PMID:9075272. |
this study examined, in the largest sample of major depressives reported so far, platelet serotonergic parameters (5-ht uptake, [3h]paroxetine binding and 5-ht2a receptors measured by [3h]lsd binding) in 60 antidepressant-free depressed patients and 40 age- and gender-matched control subjects before treatment, and in 45 major depression patients during treatment with antidepressants. |
1997-06-12 |
2023-08-12 |
human |
| A Kulikov, S Aguerre, O Berton, A Ramos, P Mormede, F Chaoulof. Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152385. |
[3h]8-hydroxy-2-(di-n-pro-pylamino)tetralin binding at midbrain 5-ht1a autoreceptors and hippocampal 5-ht1a postsynaptic receptors, [3h]ketanserin binding at cortical and striatal 5-ht2a receptors and [3h]citalopram binding at midbrain and hippocampal 5-ht transporters did not vary between strains. |
1997-06-12 |
2023-08-12 |
rat |
| C M Burns, H Chu, S M Rueter, L K Hutchinson, H Canton, E Sanders-Bush, R B Emeso. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature. vol 387. issue 6630. 1997-05-29. PMID:9153397. |
the 5-ht2 family of receptors belongs to a large group of seven-transmembrane-spanning g-protein-coupled receptors and includes three receptor subtypes (5-ht2a, 5-ht(2b) and 5-ht(2c)) which are linked to phospholipase c, promoting the hydrolysis of membrane phospholipids and a subsequent increase in the intracellular levels of inositol phosphates and diacylglycerol. |
1997-05-29 |
2023-08-12 |
Not clear |
| K Hatanaka, T Nomura, K Hidaka, H Takeuchi, S Yatsugi, M Fujii, T Yamaguch. Biochemical profile of YM992, a novel selective serotonin reuptake inhibitor with 5-HT2A receptor antagonistic activity. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025110. |
biochemical profile of ym992, a novel selective serotonin reuptake inhibitor with 5-ht2a receptor antagonistic activity. |
1997-05-28 |
2023-08-12 |
human |
| K Hatanaka, T Nomura, K Hidaka, H Takeuchi, S Yatsugi, M Fujii, T Yamaguch. Biochemical profile of YM992, a novel selective serotonin reuptake inhibitor with 5-HT2A receptor antagonistic activity. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025110. |
ym992, (s)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride, exhibited the biochemical profile of a selective serotonin (5-ht) reuptake inhibitor (ssri) with 5-ht2a receptor antagonistic activity. |
1997-05-28 |
2023-08-12 |
human |
| K Hatanaka, T Nomura, K Hidaka, H Takeuchi, S Yatsugi, M Fujii, T Yamaguch. Biochemical profile of YM992, a novel selective serotonin reuptake inhibitor with 5-HT2A receptor antagonistic activity. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025110. |
ym922 showed the same high affinity as fluoxetine against the 5-ht reuptake site (ki = 21 nm) and a similar affinity to that of crazodone against the 5-ht2a receptor (ki = 86 nm). |
1997-05-28 |
2023-08-12 |
human |
| K Hatanaka, T Nomura, K Hidaka, H Takeuchi, S Yatsugi, M Fujii, T Yamaguch. Biochemical profile of YM992, a novel selective serotonin reuptake inhibitor with 5-HT2A receptor antagonistic activity. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025110. |
thus, ym992, having both selective 5-ht reuptake inhibition and 5-ht2a antagonistic activity, might show potent therapeutic activity as a novel antidepressant in comparison with conventional ssris. |
1997-05-28 |
2023-08-12 |
human |
| K Uvnäs-Moberg, V Hillegaart, P Alster, S Ahleniu. Effects of 5-HT agonists, selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025112. |
adult male sprague-dawley rats were administered the 5-ht subtype selective receptor agonists 8-oh-dpat (0.5-2.0 mg/kg), buspirone (2-8 mg/kg) (5-ht1a), tfmpp (0.125-2.0 mg/kg) (5-ht1b), doi (0.125-2.0 mg/kg) (5-ht2a) and m-cpbg (1.25-20.0 mg/kg) (5-ht3), subcutaneously. |
1997-05-28 |
2023-08-12 |
rat |
| N H Prins, M R Briejer, J A Schuurke. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. British journal of pharmacology. vol 120. issue 4. 1997-05-22. PMID:9051313. |
other antagonists at 5-ht2a receptors also surmountably inhibited the contractions to 5-ht (apparent pa2 value in parentheses): mesulergine (8.2), cinanserin (8.2), yohimbine (6.2) and mianserin (8.6). |
1997-05-22 |
2023-08-12 |
Not clear |
| N H Prins, M R Briejer, J A Schuurke. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. British journal of pharmacology. vol 120. issue 4. 1997-05-22. PMID:9051313. |
it was concluded that 5-ht induces contractions of the canine midcolon longitudinal muscle primarily by stimulation of smooth muscle 5-ht2a receptors. |
1997-05-22 |
2023-08-12 |
Not clear |
| C Saucier, P R Alber. Identification of an endogenous 5-hydroxytryptamine2A receptor in NIH-3T3 cells: agonist-induced down-regulation involves decreases in receptor RNA and number. Journal of neurochemistry. vol 68. issue 5. 1997-05-15. PMID:9109526. |
responsiveness of the endogenous 5-ht2a receptor in nontransfected cells was completely desensitized after chronic treatment (half-time = 2 h) with 1 microm 5-ht and resensitized on removal of 5-ht. |
1997-05-15 |
2023-08-12 |
Not clear |
| N Ozaki, H Manji, V Lubierman, S J Lu, J Lappalainen, N E Rosenthal, D Goldma. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. Journal of neurochemistry. vol 68. issue 5. 1997-05-15. PMID:9109547. |
a naturally occurring amino acid substitution of the human serotonin 5-ht2a receptor influences amplitude and timing of intracellular calcium mobilization. |
1997-05-15 |
2023-08-12 |
human |
| N Ozaki, H Manji, V Lubierman, S J Lu, J Lappalainen, N E Rosenthal, D Goldma. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. Journal of neurochemistry. vol 68. issue 5. 1997-05-15. PMID:9109547. |
recently, two naturally occurring amino acid substitutions were identified in the c-terminal region of the serotonin 5-ht2a receptor. |
1997-05-15 |
2023-08-12 |
human |
| T Sumiyoshi, J Ichikawa, H Y Meltze. The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 3. 1997-05-08. PMID:9138434. |
the effect of streptozotocin (stz)-induced diabetes and a combination of chronic treatment with haloperidol (hpd) on dopamine (da)d2, serotonin (5-ht) 5-ht1a and 5-ht2a receptors was investigated in rat brain. |
1997-05-08 |
2023-08-12 |
rat |
| H O Kalkman, F Schneide. Effects of ergotamine and dihydroergotamine on 5-hydroxytryptamine-2A receptors in the isolated rat aorta. Pharmacology. vol 53. issue 6. 1997-05-01. PMID:9032799. |
the 5-ht2a receptor antagonist, ketanserin (0.1 mumol/l), inhibited ergotamine (pkb 8.0) and 5-ht (pkb 8.1) induced contractions. |
1997-05-01 |
2023-08-12 |
rat |
| A Rosier, P Dupont, J Peuskens, G Bormans, R Vandenberghe, M Maes, T de Groot, C Schiepers, A Verbruggen, L Mortelman. Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging. Psychiatry research. vol 68. issue 1. 1997-04-30. PMID:9027929. |
we used [18f]altanserin and positron emission tomography (pet) to image serotonin 5-ht2a receptors in humans. |
1997-04-30 |
2023-08-12 |
human |
| P Seeman, R Corbett, H H Van To. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 2. 1997-04-15. PMID:9015795. |
these values are here given for dopamine d2 and d4 receptors, as well as for serotonin 5-ht2a receptors. |
1997-04-15 |
2023-08-12 |
rat |
| Y Eto, K Nitta, K Uchida, T Tsutsui, K Natori, A Kawashima, W Yumura, H Nihe. Anti-mitogenic effects of sarpogrelate in cultured rat mesangial cells. Life sciences. vol 60. issue 11. 1997-04-10. PMID:9076329. |
we investigated the effects of the new 5-ht2a receptor antagonist, sarpogrelate, on dna synthesis in renal mesangial cells stimulated with 5-ht in the presence and absence of platelet-derived growth factor (pdgf)-bb. |
1997-04-10 |
2023-08-12 |
rat |
| R Verheggen, S Freudenthaler, F Meyer-Dulheuer, A J Kauman. Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. British journal of pharmacology. vol 117. issue 2. 1997-04-09. PMID:8789380. |
participation of 5-ht1-like and 5-ht2a receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. |
1997-04-09 |
2023-08-12 |
human |
| R Verheggen, S Freudenthaler, F Meyer-Dulheuer, A J Kauman. Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. British journal of pharmacology. vol 117. issue 2. 1997-04-09. PMID:8789380. |
fractions of maximal 5-ht responses mediated through 5-ht1-like and 5-ht2a receptors, f1 and f2 = 1-f1, were estimated by use of the 5-ht2a-selective antagonist ketanserin. |
1997-04-09 |
2023-08-12 |
human |