| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Owens, J R Ieni, D L Knight, K Winders, C B Nemerof. The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life sciences. vol 57. issue 24. 1995-12-21. PMID:7475971. |
previous studies have shown that nefazodone is a potent antagonist of 5-ht2a receptors and binds to the serotonin transporter in vitro and in vivo. |
1995-12-21 |
2023-08-12 |
rat |
| Y Chen, L Peng, X Zhang, J U Stolzenburg, L Hert. Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells. Brain research bulletin. vol 38. issue 2. 1995-12-07. PMID:7583341. |
fluoxetine appears to act on a different subtype of receptor (the 5-ht2c receptor [in original terminology the 5-ht1c receptor]) than the one on which micromolar concentrations of serotonin are known to act in astrocytes (the 5-ht2a receptor [in original terminology the 5-ht2 receptor]). |
1995-12-07 |
2023-08-12 |
Not clear |
| Y Chen, L Peng, X Zhang, J U Stolzenburg, L Hert. Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells. Brain research bulletin. vol 38. issue 2. 1995-12-07. PMID:7583341. |
however, this study has shown that application of serotonin to these cells stimulates glycogenolysis and causes an increase in free cytosolic concentration of calcium that is not inhibited by the 5-ht2a selective antagonist, ketanserin. |
1995-12-07 |
2023-08-12 |
Not clear |
| D W Bonhaus, C Bach, A DeSouza, F H Salazar, B D Matsuoka, P Zuppan, H W Chan, R M Egle. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. British journal of pharmacology. vol 115. issue 4. 1995-11-30. PMID:7582481. |
the ligand specificity of the human 5-ht2b receptor (5-ht > ritanserin > sb 204741 > spiperone) was distinct from that of the human 5-ht2a (ritanserin > spiperone > 5-ht > sb 204741) and 5-ht2c (ritanserin > 5-ht > spiperone = sb 204741) receptors. |
1995-11-30 |
2023-08-12 |
mouse |
| E Messori, C A Rizzi, S M Candura, A Lucchelli, B Balestra, M Tonin. 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle. British journal of pharmacology. vol 115. issue 4. 1995-11-30. PMID:7582490. |
methiothepin (0.3 microm) and the 5-ht2a receptor antagonist, ketanserin (0.3 microm) produced a slight inhibition of the first phase of the 5-ht curve. |
1995-11-30 |
2023-08-12 |
Not clear |
| E Messori, C A Rizzi, S M Candura, A Lucchelli, B Balestra, M Tonin. 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle. British journal of pharmacology. vol 115. issue 4. 1995-11-30. PMID:7582490. |
these include the 5-ht2a and 5-ht4 receptors, which mediate the 5-ht high potency phase mainly by activation of purinergic transmission. |
1995-11-30 |
2023-08-12 |
Not clear |
| H Y Meltze. Role of serotonin in the action of atypical antipsychotic drugs. Clinical neuroscience (New York, N.Y.). vol 3. issue 2. 1995-11-29. PMID:7583621. |
this article reviews the effects of clozapine and related antipsychotic drugs on dopamine (da) d1, d2, and d4, and serotonin (5-ht) 5-ht2a, 5-ht2c, 5-ht3, 5-ht6, and 5-ht7 receptors, as well as its ability to modulate da and 5-ht release. |
1995-11-29 |
2023-08-12 |
Not clear |
| F Chaoulof. Regulation of 5-HT receptors by corticosteroids: where do we stand? Fundamental & clinical pharmacology. vol 9. issue 3. 1995-11-21. PMID:7557817. |
among the dozen of 5-ht receptors identified so far, four receptors (namely the 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht2c receptors)--and the 5-ht uptake system--have been the focus of studies aimed at detecting corticosteroid modulatory effects. |
1995-11-21 |
2023-08-12 |
rat |
| F Chaoulof. Regulation of 5-HT receptors by corticosteroids: where do we stand? Fundamental & clinical pharmacology. vol 9. issue 3. 1995-11-21. PMID:7557817. |
however, because the data regarding a corticosteroid control of other 5-ht receptors are either scarce and contradictory (eg 5-ht1b, 5-ht2a, 5-ht2c receptors and 5-ht uptake systems) or lacking, it is at the present time unknown whether corticosteroids exert other effects on 5-ht receptor-mediated functions, including those related to homeostasis. |
1995-11-21 |
2023-08-12 |
rat |
| M R Briejer, L M Akkermans, R A Lefebvre, J A Schuurke. Novel 5-HT2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon. European journal of pharmacology. vol 279. issue 2-3. 1995-11-06. PMID:7556392. |
after blockade of 5-ht2a, 5-ht3 and 5-ht4 receptor-mediated contractions, 5-hydroxytryptamine (5-ht) induced relaxations yielding a biphasic concentration-response curve. |
1995-11-06 |
2023-08-12 |
Not clear |
| A Dalpiaz, S Gessi, P A Borea, G Gill. Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5HT2A and 5-HT3 receptors. Life sciences. vol 57. issue 12. 1995-10-19. PMID:7674802. |
binding thermodynamics of serotonin to rat-brain 5-ht1a, 5ht2a and 5-ht3 receptors. |
1995-10-19 |
2023-08-12 |
rat |
| A Dalpiaz, S Gessi, P A Borea, G Gill. Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5HT2A and 5-HT3 receptors. Life sciences. vol 57. issue 12. 1995-10-19. PMID:7674802. |
the thermodynamic parameters delta g degrees, delta h degrees and delta s degrees of the binding equilibrium of serotonin to 5-ht1a, 5-ht2a and 5-ht3 rat-brain membrane receptors have been determined by means of affinity constant measurements at six temperatures in the range 0 -35 degrees c and van't hoff plots. |
1995-10-19 |
2023-08-12 |
rat |
| J C Poblete, E C Azmiti. Activation of glycogen phosphorylase by serotonin and 3,4-methylenedioxymethamphetamine in astroglial-rich primary cultures: involvement of the 5-HT2A receptor. Brain research. vol 680. issue 1-2. 1995-10-10. PMID:7663989. |
activation of glycogen phosphorylase by serotonin and 3,4-methylenedioxymethamphetamine in astroglial-rich primary cultures: involvement of the 5-ht2a receptor. |
1995-10-10 |
2023-08-12 |
rat |
| G Griebe. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacology & therapeutics. vol 65. issue 3. 1995-09-19. PMID:7644567. |
more than 1300 experiments were carried out in this area and they provide evidence that: (1) results obtained in ethologically based animal models of anxiety with drugs stimulating 5-ht transmission are most consistent with the classic 5-ht hypothesis of anxiety in that they show an increase in animals' emotional reactivity; (2) no category of anti-anxiety models are selectively sensitive to the anxiolytic-like effects of drugs targetting 5-ht1a, 5-ht2a or 5-ht2c receptor subtypes; (3) anxiolytic-like effects of 5-ht3 receptor antagonists, in the great part, are revealed by models based on spontaneous behaviors. |
1995-09-19 |
2023-08-12 |
Not clear |
| H Hirano, J Day, H C Fibige. Serotonergic regulation of acetylcholine release in rat frontal cortex. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643092. |
in contrast, the serotonin 5-ht2a receptor antagonist ketanserin (5 mg/kg, i.p.) |
1995-09-18 |
2023-08-12 |
rat |
| H Hirano, J Day, H C Fibige. Serotonergic regulation of acetylcholine release in rat frontal cortex. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643092. |
in contrast to previous studies that have concluded that serotonin has inhibitory actions on cortical acetylcholine release, the present results indicate that fenfluramine increases cortical acetylcholine release in vivo by its ability to enhance serotonin transmission and that serotonin produces these effects at least in part via actions at serotonin 5-ht2a receptors. |
1995-09-18 |
2023-08-12 |
rat |
| M R Briejer, L M Akkermans, J A Schuurke. Interactions of serotonin with multiple receptors and neurotransmitters in the guinea-pig isolated colon. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 1. 1995-09-14. PMID:7639614. |
by means of the neurotoxin, tetrodotoxin, the muscarinic cholinoceptor antagonist, atropine, and selective 5-ht receptor antagonists, it was shown that the contractions to 5-ht are mediated by 5-ht2a receptors, localized on the smooth muscle, and by 5-ht3 and 5-ht4 receptors, localized on cholinergic nerves. |
1995-09-14 |
2023-08-12 |
Not clear |
| B E Summer, G Fin. Estrogen increases the density of 5-hydroxytryptamine(2A) receptors in cerebral cortex and nucleus accumbens in the female rat. The Journal of steroid biochemistry and molecular biology. vol 54. issue 1-2. 1995-09-08. PMID:7632610. |
based on our finding that estradiol selectively stimulates the expression of 5-hydroxytryptamine(2a) (5-ht2a) receptor mrna in the dorsal raphe nucleus of the female rat, we investigated the effects of estradiol on the density of 5-ht2a receptors in brain. |
1995-09-08 |
2023-08-12 |
rat |
| M R Briejer, G J Veen, L M Akkermans, R A Lefebvre, J A Schuurke. Cisapride and structural analogs selectively enhance 5-hydroxytryptamine (5-HT)-induced purinergic neurotransmission in the guinea pig proximal colon. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636723. |
in the continuous presence of ketanserin (0.3 microm) and tropisetron (3 microm) to block contractions via 5-ht2a, 5-ht3 and 5-ht4 receptors, 5-ht induced relaxations that yielded a biphasic concentration-response curve. |
1995-09-08 |
2023-08-12 |
Not clear |
| W X Shi, P Nathaniel, B S Bunne. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636736. |
neither the selective 5-ht2a antagonist mdl 100907 nor depletion of endogenous 5-ht using p-chlorophenylalanine mimicked the effect of rit (i.e., attenuated quinpirole-induced inhibition). |
1995-09-08 |
2023-08-12 |
rat |