| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S W Watts, D A Cox, B G Johnson, D D Schoepp, M L Cohe. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. The Journal of pharmacology and experimental therapeutics. vol 271. issue 2. 1994-12-29. PMID:7965803. |
short incubations (1-60 min) of the trachea with 5-ht (10(-4) m) to minimize possible 5-ht2a receptor desensitization did not increase pi hydrolysis, whereas carbamylcholine (10(-7) to 10(-3) m) and histamine (10(-7) to 10(-4) m) did. |
1994-12-29 |
2023-08-12 |
Not clear |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by mdl 100,907, a highly selective 5-ht2a receptor antagonist. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer ii and iii in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-ht) via 5-ht2a (formerly 5-ht2) rather than 5-ht2c (formerly 5-ht1c) receptors. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
in the present study, we tested a new, highly selective 5-ht2a receptor antagonist mdl 100,907 (r-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl-ethyl)]-4- piperidine-methanol, which has a 300-fold greater affinity for 5-ht2a than 5-ht1c receptors or alpha 1-adrenoceptors) on excitatory responses of interneurons to 5-ht in rat piriform cortex slices. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
these data confirm that 5-ht2a rather than 5-ht2c receptors mediate excitation by 5-ht of interneurons in the piriform cortex. |
1994-12-08 |
2023-08-12 |
rat |
| S W Watts, K W Schenck, M L Cohe. Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea. Canadian journal of physiology and pharmacology. vol 72. issue 5. 1994-12-02. PMID:7954073. |
5-hydroxytryptamine (serotonin, 5-ht) contracts the guinea pig trachea through stimulation of 5-ht2a receptors, an effect previously reported to rapidly desensitize. |
1994-12-02 |
2023-08-12 |
rat |
| S W Watts, K W Schenck, M L Cohe. Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea. Canadian journal of physiology and pharmacology. vol 72. issue 5. 1994-12-02. PMID:7954073. |
in vitro studies investigating functional desensitization of the guinea pig tracheal 5-ht2a receptor documented that 5-ht (3 x 10(-7) m) significantly (50%) but incompletely reduced subsequent tracheal maximal contraction to 5-ht. |
1994-12-02 |
2023-08-12 |
rat |
| S W Watts, K W Schenck, M L Cohe. Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea. Canadian journal of physiology and pharmacology. vol 72. issue 5. 1994-12-02. PMID:7954073. |
the decline in 5-ht-induced contraction was most rapid in the guinea pig trachea and less so in the rat jugular vein and rat aorta, two preparations in which 5-ht induced contraction also occurred via activation of 5-ht2a receptors. |
1994-12-02 |
2023-08-12 |
rat |
| K A Berg, W P Clarke, C Sailstad, A Saltzman, S Maayan. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Molecular pharmacology. vol 46. issue 3. 1994-11-10. PMID:7935328. |
the cdnas for human 5-hydroxytryptamine (5-ht)2c and 5-ht2a receptors were stably transfected separately into parent chinese hamster ovary cells, and cell lines in which levels of transfected receptor protein expression and accumulation of inositol phosphates in response to 5-ht were comparable were chosen for study. |
1994-11-10 |
2023-08-12 |
human |
| K A Berg, W P Clarke, C Sailstad, A Saltzman, S Maayan. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Molecular pharmacology. vol 46. issue 3. 1994-11-10. PMID:7935328. |
in contrast, activation of 5-ht2a receptors with either 5-ht or (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane did not alter the 5-ht1b-like response. |
1994-11-10 |
2023-08-12 |
human |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, M Tonin. A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921600. |
the 5-ht2a receptor antagonist, ketanserin (0.01, 0.1 microm) markedly depressed the first phase and shifted the second phase to the right in a parallel manner, with some depression of the 5-ht response maximum. |
1994-11-09 |
2023-08-12 |
Not clear |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, M Tonin. A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921600. |
our results suggest that neural 5-ht2a and, to a lesser extent, 5-ht3 receptor subtypes mediate the first phase of the 5-ht curve in the guinea-pig trachea. |
1994-11-09 |
2023-08-12 |
Not clear |
| A Kanamori, K Matoba, Y Yajim. Effects of sarpogrelate on serotonin-induced increases in cytosolic Ca2+ in cultured rat mesangial cells. Life sciences. vol 55. issue 18. 1994-11-04. PMID:7934648. |
the effects of the new 5-ht2a receptor antagonist sarpogrelate on the cellular action of serotonin were examined in cultured rat mesangial cells by measuring cytosolic free calcium concentration ([ca2+]i). |
1994-11-04 |
2023-08-12 |
rat |
| A Kanamori, K Matoba, Y Yajim. Effects of sarpogrelate on serotonin-induced increases in cytosolic Ca2+ in cultured rat mesangial cells. Life sciences. vol 55. issue 18. 1994-11-04. PMID:7934648. |
these results suggest that sarpogrelate and its major metabolite (m1) act as reversible and specific 5-ht2a receptor antagonists against the contractile action of platelet-derived serotonin in mesangial cells. |
1994-11-04 |
2023-08-12 |
rat |
| S T Phillips, T de Paulis, B M Baron, B W Siegel, P Seeman, H H Van Tol, H C Guan, H E Smit. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. Journal of medicinal chemistry. vol 37. issue 17. 1994-09-22. PMID:8064797. |
5h-dibenzo[b,e][1,4]diazepine, dibenz[b,f]oxepin, and 5h-dibenzo[a,d]cycloheptene analogues of clozapine [8-chloro-11-(4-methylpiperazino)-5h- dibenzo[b,e][1,4]diazepine] were evaluated for their binding affinity to dopamine d-1, d-2, and d-4 and serotonin s-2a (5-ht2a), s-2c (5-ht2c) and s-3 (5-ht3) receptors. |
1994-09-22 |
2023-08-12 |
Not clear |
| N J Hrib, J G Jurcak, K L Burgher, P G Conway, H B Hartman, L L Kerman, J E Roehr, A T Wood. Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:7914536. |
in general, the compounds showed an affinity for dopamine d2 and serotonin 5ht2a and 5ht1a receptors. |
1994-09-12 |
2023-08-12 |
Not clear |
| S K Hemrick-Luecke, H D Snoddy, R W Fulle. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo. Life sciences. vol 55. issue 7. 1994-08-25. PMID:8041227. |
antagonism of serotonin type 2a (5ht2a) receptors, as well as inhibition of the serotonin (5ht) uptake carrier, has been suggested to contribute to the antidepressant action of nefazodone in vivo (eison et al., 1990). |
1994-08-25 |
2023-08-12 |
mouse |
| S K Hemrick-Luecke, H D Snoddy, R W Fulle. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo. Life sciences. vol 55. issue 7. 1994-08-25. PMID:8041227. |
1990) reporting nefazodone to be an antagonist at 5ht2a receptors, but fail to show inhibition of the 5ht uptake carrier in the same dose range. |
1994-08-25 |
2023-08-12 |
mouse |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
for example, the guinea pig trachea and rat aorta markedly contract in response to serotonin via activation of 5-ht2a receptors. |
1994-08-18 |
2023-08-12 |
rat |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
these data are consistent with the more profound contractile response to serotonin in guinea pig versus rat trachea and suggest that differences in tracheal contractility to serotonin correlate with the density of 5-ht2a receptor mrna. |
1994-08-18 |
2023-08-12 |
rat |