| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Eldina Rizvi\\xc4\\x87, Goran Jankovi\\xc4\\x87, Sla\\xc4\\x91ana Kosti\\xc4\\x87-Raja\\xc4\\x8di\\xc4\\x87, Miroslav M Savi\\xc4\\x8. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors. Bosnian journal of basic medical sciences. vol 17. issue 3. 2018-07-12. PMID:28628756.' |
here, we analyzed the affinity of lerimazoline for dopamine receptor d2, serotonin 5-ht1a and 5-ht2a receptors and α1-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. |
2018-07-12 |
2023-08-13 |
rat |
| R L Carhart-Harris, D J Nut. Serotonin and brain function: a tale of two receptors. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28858536. |
in this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-ht1a and 5-ht2a receptors. |
2018-05-17 |
2023-08-13 |
Not clear |
| Zsofia Majlath, Izabella Obal, Laszlo Vecse. Treatment Possibilities for Psychosis in Parkinson's Disease with An Emphasis on the Newly Approved Drug: Pimavanserin. CNS & neurological disorders drug targets. vol 16. issue 3. 2018-05-11. PMID:27719624. |
extensive research has shown that the antipsychotic effect of these drugs could be attributed to serotonin 2a receptor (5-ht2a) triggered mechanisms. |
2018-05-11 |
2023-08-13 |
Not clear |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a series of new arylpiperazinylpropyl derivatives of 8/6-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione and spiro[imidazolidine-4,1'-indene/naphthalene]-2,5-dione was synthesized and their affinity was evaluated toward serotonin 5-htia, 5-ht2a, 5-ht7 receptors, dopaminergic d2, d3 receptors, adrenergic ox, receptors, and serotonin transporter (sert). |
2018-05-03 |
2023-08-13 |
Not clear |
| Sarah E Haskell, Cecilia Lo, Mitchell E Kent, Timothy M Eggleston, Kenneth A Volk, Benjamin E Reinking, Robert D Roghai. Cardiac Outcomes After Perinatal Sertraline Exposure in Mice. Journal of cardiovascular pharmacology. vol 70. issue 2. 2018-04-27. PMID:28459713. |
sertraline-exposed mice had increased cardiac hydroxyproline content, decreased 5-ht2b receptor mrna levels, and increased 5-ht2a receptor and serotonin transporter mrna levels on postnatal day 21 (p < 0.05). |
2018-04-27 |
2023-08-13 |
mouse |
| Line Marie Nielsen, Niels Bjerre Holm, Sebastian Leth-Petersen, Jesper Langgaard Kristensen, Lars Olsen, Kristian Linne. Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH. Drug testing and analysis. vol 9. issue 5. 2018-03-12. PMID:27400739. |
the dimethoxyphenyl-n-((2-methoxyphenyl)methyl)ethanamine (nbome) compounds are potent serotonin 5-ht2a receptor agonists and have recently been subject to recreational use due to their hallucinogenic effects. |
2018-03-12 |
2023-08-13 |
human |
| Isabella Salzer, Enkhbileg Gantumur, Arsalan Yousuf, Stefan Boeh. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channels. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27511837. |
in all neurons investigated, 5ht potentiated capsaicin-evoked currents through trpv1 channels, an effect that was attenuated by antagonists at 5ht2a (4 f 4 pp), 5ht2b (sb 204741), as well as 5ht2c (rs 102221) receptors. |
2018-02-22 |
2023-08-13 |
rat |
| Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Mari. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28459524. |
the serotonin 2a (5-ht2a) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. |
2018-02-07 |
2023-08-13 |
Not clear |
| Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Mari. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS chemical neuroscience. vol 8. issue 5. 2018-02-07. PMID:28459524. |
5-ht2a receptors are a principal g protein-coupled receptor subtype mediating the excitatory effects of serotonin. |
2018-02-07 |
2023-08-13 |
Not clear |
| Min Su, Ye Ran, Xun Han, Yufei Liu, Xu Zhang, Qingche Tan, Ruisheng Li, Shengyuan Y. Rizatriptan overuse promotes hyperalgesia induced by dural inflammatory stimulation in rats by modulation of the serotonin system. The European journal of neuroscience. vol 44. issue 4. 2018-02-01. PMID:27288111. |
clinical and preclinical studies have implicated serotonin (5-ht) and the 5-ht2a receptor (5-ht2ar) in the pathogenesis of medication-overuse headache (moh). |
2018-02-01 |
2023-08-13 |
rat |
| Alba Iglesias, Sonia Lage, Maria Isabel Cadavid, Maria Isabel Loza, José Bre. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of biomolecular screening. vol 21. issue 8. 2018-01-24. PMID:27095818. |
development of a multiplex assay for studying functional selectivity of human serotonin 5-ht2a receptors and identification of active compounds by high-throughput screening. |
2018-01-24 |
2023-08-13 |
human |
| Alba Iglesias, Sonia Lage, Maria Isabel Cadavid, Maria Isabel Loza, José Bre. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of biomolecular screening. vol 21. issue 8. 2018-01-24. PMID:27095818. |
the serotonin 2a (5-ht2a) receptor regulates multiple physiological functions, is involved in the pathophysiology of schizophrenia, and serves as an important target of atypical antipsychotic drugs. |
2018-01-24 |
2023-08-13 |
human |
| Anna Rickli, Olivier D Moning, Marius C Hoener, Matthias E Liecht. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 8. 2018-01-23. PMID:27216487. |
we investigated binding affinities at human monoamine receptors and determined functional serotonin (5-hydroxytryptamine [5-ht]) 5-ht2a and 5-ht2b receptor activation. |
2018-01-23 |
2023-08-13 |
human |
| Enzo Tagliazucchi, Leor Roseman, Mendel Kaelen, Csaba Orban, Suresh D Muthukumaraswamy, Kevin Murphy, Helmut Laufs, Robert Leech, John McGonigle, Nicolas Crossley, Edward Bullmore, Tim Williams, Mark Bolstridge, Amanda Feilding, David J Nutt, Robin Carhart-Harri. Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Current biology : CB. vol 26. issue 8. 2018-01-19. PMID:27085214. |
the cortical areas showing increased global connectivity overlapped significantly with a map of serotonin 2a (5-ht2a) receptor densities (the key site of action of psychedelic drugs [4]). |
2018-01-19 |
2023-08-13 |
human |
| Tobias Buchborn, Helmut Schröder, Volker Höllt, Gisela Grecksc. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. Journal of psychopharmacology (Oxford, England). vol 28. issue 6. 2018-01-16. PMID:24785760. |
a re-balance of postsynaptic serotonin (5-ht) receptor signalling, with an increase in 5-ht1a and a decrease in 5-ht2a signalling, is a final common pathway multiple antidepressants share. |
2018-01-16 |
2023-08-13 |
rat |
| Tobias Buchborn, Helmut Schröder, Volker Höllt, Gisela Grecksc. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. Journal of psychopharmacology (Oxford, England). vol 28. issue 6. 2018-01-16. PMID:24785760. |
given that the 5-ht1a/2a agonist lysergic acid diethylamide (lsd), when repeatedly applied, selectively downregulates 5-ht2a, but not 5-ht1a receptors, one might expect lsd to similarly re-balance the postsynaptic 5-ht signalling. |
2018-01-16 |
2023-08-13 |
rat |
| A Komorowski, G M James, C Philippe, G Gryglewski, A Bauer, M Hienert, M Spies, A Kautzky, T Vanicek, A Hahn, T Traub-Weidinger, D Winkler, W Wadsak, M Mitterhauser, M Hacker, S Kasper, R Lanzenberge. Association of Protein Distribution and Gene Expression Revealed by PET and Post-Mortem Quantification in the Serotonergic System of the Human Brain. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-15. PMID:27909009. |
pet binding values and gene expression intensities were correlated for the main inhibitory (5-ht1a) and excitatory (5-ht2a) serotonin receptor, the serotonin transporter (sert) as well as monoamine oxidase-a (mao-a), using spearman's correlation coefficients (rs) in a voxel-wise and region-wise analysis. |
2018-01-15 |
2023-08-13 |
human |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
therefore in the current work, we have used a bac transgenic mouse line expressing egfp under the control of the 5-ht2a r promoter to identify the interneuron subtype(s) regulated by serotonin via 5-ht2a rs. |
2018-01-08 |
2023-08-13 |
mouse |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
we then show that these cells are depolarized and excited by serotonin acting through 5-ht2a rs and appear to belong predominantly to the perforant pathway-associated and schaffer collateral/commissural pathway-associated subtypes. |
2018-01-08 |
2023-08-13 |
mouse |
| Daniel R Wyskiel, Rodrigo Andrad. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Hippocampus. vol 26. issue 9. 2018-01-08. PMID:27328460. |
these results indicate that serotonin interneurons expressing 5-ht2a rs are localized primarily along the sr-slm border of the ca1 region and represent a newly identified target for serotonin regulation in the hippocampus. |
2018-01-08 |
2023-08-13 |
mouse |