| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert E Davis, Christoph U Correl. ITI-007 in the treatment of schizophrenia: from novel pharmacology to clinical outcomes. Expert review of neurotherapeutics. vol 16. issue 6. 2017-06-27. PMID:27042868. |
iti-007 has a unique pharmacological profile, combining potent 5-ht2a receptor antagonism with cell-type-specific dopamine and glutamate receptor modulation, plus serotonin reuptake inhibition. |
2017-06-27 |
2023-08-13 |
Not clear |
| Chang Xu, Xin-Ming Ma, Hui-Bin Chen, Meng-He Zhou, Hui Qiao, Shu-Cheng A. Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7. Neuropharmacology. vol 109. 2017-06-19. PMID:26921771. |
the aim of this study was to investigate the role of orbitofrontal 5-ht and 5-ht2a receptors in depressive-like behaviors and their associations with kal7 and dendritic spines using chronic unpredictable mild stress (cums), an established animal model of depression. |
2017-06-19 |
2023-08-13 |
rat |
| Chang Xu, Xin-Ming Ma, Hui-Bin Chen, Meng-He Zhou, Hui Qiao, Shu-Cheng A. Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7. Neuropharmacology. vol 109. 2017-06-19. PMID:26921771. |
cums had no effect on the levels of 5-ht or the 5-ht2a receptor in the ofc. |
2017-06-19 |
2023-08-13 |
rat |
| Gongliang Zhang, David Cinalli, Sarah J Cohen, Kristina D Knapp, Lisa M Rios, José Martínez-Hernández, Rafael Luján, Robert W Stackma. Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57BL/6J mice. Neuropharmacology. vol 109. 2017-06-19. PMID:27114257. |
examination of the hippocampal contribution to serotonin 5-ht2a receptor-mediated facilitation of object memory in c57bl/6j mice. |
2017-06-19 |
2023-08-13 |
mouse |
| Gongliang Zhang, David Cinalli, Sarah J Cohen, Kristina D Knapp, Lisa M Rios, José Martínez-Hernández, Rafael Luján, Robert W Stackma. Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57BL/6J mice. Neuropharmacology. vol 109. 2017-06-19. PMID:27114257. |
serotonin 5-ht2a receptors (5-ht2ar) are widely expressed throughout the hippocampus. |
2017-06-19 |
2023-08-13 |
mouse |
| Gaël Qesseveur, Anne Cécile Petit, Hai Thanh Nguyen, Lionel Dahan, Romain Colle, Samuel Rotenberg, Isabelle Seif, Pauline Robert, Denis David, Jean-Philippe Guilloux, Alain M Gardier, Céline Verstuyft, Laurent Becquemont, Emmanuelle Corruble, Bruno P Guiar. Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach. Neuropharmacology. vol 105. 2017-06-13. PMID:26764241. |
pharmacological studies have yielded valuable insights into the role of the serotonin 2a (5-ht2a) receptor in major depressive disorder (mdd) and antidepressant drugs (ads) response. |
2017-06-13 |
2023-08-13 |
mouse |
| Gaël Qesseveur, Anne Cécile Petit, Hai Thanh Nguyen, Lionel Dahan, Romain Colle, Samuel Rotenberg, Isabelle Seif, Pauline Robert, Denis David, Jean-Philippe Guilloux, Alain M Gardier, Céline Verstuyft, Laurent Becquemont, Emmanuelle Corruble, Bruno P Guiar. Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach. Neuropharmacology. vol 105. 2017-06-13. PMID:26764241. |
however, while the chronic administration of the ssris escitalopram or fluoxetine elicited a progressive increased in the firing rate of 5-ht neurons in 5-ht2a(+/+) mice, it failed to do so in 5-ht2a(-/-) mutants. |
2017-06-13 |
2023-08-13 |
mouse |
| M Y Liu, L J Zhang, M C Li. [Effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in SD rats with myocardial infarction and depression]. Zhonghua nei ke za zhi. vol 55. issue 9. 2017-06-08. PMID:27586978. |
to evaluate the effect of ginsenoside pre-treatment on serotonin (5-hydroxytryptamine, 5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter, sert) in serum, platelet lysate and brain tissue homogenates in sd rats with myocardial infarction (mi) or depression. |
2017-06-08 |
2023-08-13 |
rat |
| E M A Macedo, W C Santos, B P Sousa, E M Lopes, C A Piauilino, F V M Cunha, D P Sousa, F A Oliveira, F R C Almeid. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 49. issue 7. 2017-05-26. PMID:27332775. |
a possible mechanism of action of the analgesic effect is the involvement of 5-ht2a serotonin receptors, because ketanserin completely reversed the antinociceptive effect of the tpl/dcf association. |
2017-05-26 |
2023-08-13 |
rat |
| Meysam Amidfar, Yong-Ku Kim, Lejla Colic, Mohammad Arbabi, Gholamhossein Mobaraki, Gholamreza Hassanzadeh, Martin Walte. Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness. Nordic journal of psychiatry. vol 71. issue 4. 2017-05-26. PMID:28125323. |
neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-ht2a and 5-ht3a serotonin receptors in the pathophysiology of major depression. |
2017-05-26 |
2023-08-13 |
Not clear |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
loss of serotonin transporter function alters adp-mediated glycoprotein αiibβ3 activation through dysregulation of the 5-ht2a receptor. |
2017-05-12 |
2023-08-13 |
mouse |
| Björn Hansson, Anya Medina, Claes Fryklund, Malin Fex, Karin G Stenkul. Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells. Biochemical and biophysical research communications. vol 474. issue 2. 2017-05-10. PMID:27109474. |
serotonin (5-ht) and 5-ht2a receptor agonists suppress lipolysis in primary rat adipose cells. |
2017-05-10 |
2023-08-13 |
rat |
| Dawn Bruijnzeel, Rajiv Tando. Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27274197. |
brexpiprazole is a dopamine d-2 partial agonist with potent activity at the serotonin 5ht1a and 5ht2a and noradrenergic alpha-1b and alpha-2c receptors. |
2017-05-08 |
2023-08-13 |
Not clear |
| Anna Chang, Susan H Fo. Psychosis in Parkinson's Disease: Epidemiology, Pathophysiology, and Management. Drugs. vol 76. issue 11. 2017-04-26. PMID:27312429. |
emerging studies have focused on agents involving other neurotransmitters, including the serotonin 5-ht2a receptor inverse agonist pimavanserin, cholinesterase inhibitors, and antidepressants and anxiolytics. |
2017-04-26 |
2023-08-13 |
Not clear |
| Karolina Pytka, Grzegorz Kazek, Agata Siwek, Barbara Mordyl, Monika Głuch-Lutwin, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Małgorzata Zygmun. HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties. Pharmacology, biochemistry, and behavior. vol 146-147. 2017-04-25. PMID:27132236. |
hbk-7 showed moderate affinity for dopaminergic d2 receptor and very low for serotonergic 5-ht2a, adrenergic α2 receptors, as well as serotonin transporter. |
2017-04-25 |
2023-08-13 |
mouse |
| Anthony Markha. Pimavanserin: First Global Approval. Drugs. vol 76. issue 10. 2017-03-23. PMID:27262680. |
pimavanserin (nuplazid™) is a selective and potent serotonin 2a (5-ht2a) receptor inverse agonist and antagonist developed by acadia pharmaceuticals that has been approved in the us as a treatment for patients with hallucinations and delusions associated with parkinson's disease psychosis. |
2017-03-23 |
2023-08-13 |
Not clear |
| A Gandhimathi, R Sowdhamin. Molecular modelling of human 5-hydroxytryptamine receptor (5-HT2A) and virtual screening studies towards the identification of agonist and antagonist molecules. Journal of biomolecular structure & dynamics. vol 34. issue 5. 2017-02-23. PMID:26327576. |
molecular modelling of human 5-hydroxytryptamine receptor (5-ht2a) and virtual screening studies towards the identification of agonist and antagonist molecules. |
2017-02-23 |
2023-08-13 |
human |
| Xiao-Wen Chen, Yuan-Yuan Sun, Lei Fu, Jian-Qi L. Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27487565. |
a series of novel benzisothiazolylpiperazine derivatives combining potent dopamine d2 and d3, and serotonin 5-ht1a and 5-ht2a receptor properties were synthesized and evaluated for their potential antipsychotic properties. |
2017-02-13 |
2023-08-13 |
rat |
| Donatella Marazziti, Armando Piccinni, Stefano Baroni, Francesco Mungai, Silvio Presta, Federico Mucci, Liliana Dell'Oss. Current Trends on Antipsychotics: Focus on Asenapine. Current medicinal chemistry. vol 23. issue 21. 2017-02-06. PMID:27222264. |
in fact, asenapine shows a high affinity for the serotonin (5ht) receptor of the type 2a (5ht2a) and to a lesser extent for the dopamine receptor of the type 2 (d2), similar to other sgas. |
2017-02-06 |
2023-08-13 |
Not clear |
| Anders Ettrup, Claus Svarer, Brenda McMahon, Sofi da Cunha-Bang, Szabolcs Lehel, Kirsten Møller, Agnete Dyssegaard, Melanie Ganz, Vincent Beliveau, Louise Møller Jørgensen, Nic Gillings, Gitte Moos Knudse. Serotonin 2A receptor agonist binding in the human brain with [(11)C]Cimbi-36: Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserin. NeuroImage. vol 130. 2017-01-12. PMID:26876490. |
[(11)c]cimbi-36 is a recently developed serotonin 2a (5-ht2a) receptor agonist positron emission tomography (pet) radioligand that has been successfully applied for human neuroimaging. |
2017-01-12 |
2023-08-13 |
human |