| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ibrahim M Shokry, John J Callanan, John Sousa, Rui Ta. Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome. Journal of visualized experiments : JoVE. issue 103. 2016-09-16. PMID:26437182. |
this hypothesis can be tested using in situ hybridization to detect the serotonin 5-ht2a receptor gene htr2a. |
2016-09-16 |
2023-08-13 |
rat |
| Ibrahim M Shokry, John J Callanan, John Sousa, Rui Ta. Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome. Journal of visualized experiments : JoVE. issue 103. 2016-09-16. PMID:26437182. |
hybridization probes used for this study include dapb (a bacterial gene coding for dihydrodipicolinate reductase), ppib (a housekeeping gene coding for peptidylprolyl isomerase b), and htr2a (a serotonin gene coding for 5-ht2a receptors). |
2016-09-16 |
2023-08-13 |
rat |
| C Anthony Altar, Joseph Carhart, Josiah D Allen, Daniel Hall-Flavin, Joel Winner, Bryan Dechair. Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies. Molecular neuropsychiatry. vol 1. issue 3. 2016-09-08. PMID:27606312. |
forty-four allelic variations were measured in genes for the cytochrome p450 (cyp) enzymes cyp2d6, cypc19, and cyp1a2, the serotonin transporter (slc6a4), and the 5-ht2a receptor (htr2a). |
2016-09-08 |
2023-08-13 |
human |
| Gitte M Knudsen, Peter S Jensen, David Erritzoe, William F C Baaré, Anders Ettrup, Patrick M Fisher, Nic Gillings, Hanne D Hansen, Lars Kai Hansen, Steen G Hasselbalch, Susanne Henningsson, Matthias M Herth, Klaus K Holst, Pernille Iversen, Lars V Kessing, Julian Macoveanu, Kathrine Skak Madsen, Erik L Mortensen, Finn Årup Nielsen, Olaf B Paulson, Hartwig R Siebner, Dea S Stenbæk, Claus Svarer, Terry L Jernigan, Stephen C Strother, Vibe G Frokjae. The Center for Integrated Molecular Brain Imaging (Cimbi) database. NeuroImage. vol 124. issue Pt B. 2016-09-06. PMID:25891375. |
the data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht4 and the 5-ht transporter (5-htt), but can easily serve other purposes. |
2016-09-06 |
2023-08-13 |
human |
| b' Yasmine Chabbi-Achengli, Tereza Coman, Corinne Collet, Jacques Callebert, Michelangelo Corcelli, Hil\\xc3\\xa8ne Lin, Rachel Rignault, Michel Dy, Marie-Christine de Vernejoul, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26968113.' |
ex vivo serotonin and agonists of the 5-ht2a and 5-ht2b receptors restored il-17 secretion from splenocytes and th17 cell differentiation in tph1(-/-) mice. |
2016-09-06 |
2023-08-13 |
mouse |
| Leslie Citrom. Cariprazine for the Treatment of Schizophrenia: A Review of this Dopamine D3-Preferring D3/D2 Receptor Partial Agonist. Clinical schizophrenia & related psychoses. vol 10. issue 2. 2016-09-01. PMID:27440212. |
cariprazine is also a partial agonist at the serotonin 5-ht1a receptor and acts as an antagonist at 5-ht2b and 5-ht2a receptors. |
2016-09-01 |
2023-08-13 |
Not clear |
| Marco Bocchio, Giulia Fucsina, Lydia Oikonomidis, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26052039. |
ex vivo patch-clamp recordings demonstrated that the depolarizing effect of 5-ht on pvins was mediated by 5-ht2a receptor. |
2016-08-25 |
2023-08-13 |
mouse |
| Marco Bocchio, Giulia Fucsina, Lydia Oikonomidis, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26052039. |
this deficit was because of reduced 5-ht2a function and not because of increased 5-ht uptake. |
2016-08-25 |
2023-08-13 |
mouse |
| Stuart A Collins, Courtney Huff, Nicolas Chiaia, Gary A Gudelsky, Bryan K Yamamot. 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26670377. |
mdma increases serotonin (5ht) release and activates 5ht2a receptors. |
2016-08-22 |
2023-08-13 |
rat |
| Marek Śmieja, Dawid Warszyck. Average Information Content Maximization--A New Approach for Fingerprint Hybridization and Reduction. PloS one. vol 11. issue 1. 2016-08-16. PMID:26784447. |
this methodology, applied to the ligands of five cognate serotonin receptors (5-ht2a, 5-ht2b, 5-ht2c, 5-ht5a, 5-ht6), proved that 100 bits selected from four non-hashed fingerprints reflect almost all structural information required for a successful in silico discrimination test. |
2016-08-16 |
2023-08-13 |
Not clear |
| Xueping Tu, Jinjing Zuo, Ke Hu, Jing Kang, Yongtian Mei, Nian Wan. Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats. Journal of molecular neuroscience : MN. vol 57. issue 3. 2016-08-10. PMID:26076739. |
the 5-ht evoked biphasic manner of hypoglossal output and hypoglossal nerve activity ltf (hltf) were 5-ht2a receptor-dependent and coupled to pkc activation. |
2016-08-10 |
2023-08-13 |
rat |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
we combined whole-cell patch clamp recordings of miniature inhibitory post-synaptic currents (mipscs) in ventrobasal thalamic neurons during local (puff) application of 5-ht in wild type (wt) or knockout mice lacking 5-ht2a receptors (5-ht2a -/-). |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
inhibition of mipscs frequency by low (10 μm) and high (100 μm) 5-ht concentrations was observed in ventrobasal neurons from 5-ht2a -/- mice. |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
in 5-ht2a -/- mice, nan-190, a specific 5-ht1a antagonist, prevented the 100 μm 5-ht inhibition while blocking h-currents that prolonged inhibition during post-puff periods. |
2016-08-05 |
2023-08-13 |
mouse |
| Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. |
the inhibitory effects of 100 μm 5-ht were enhanced in cocaine binge-treated 5-ht2a -/- mice. |
2016-08-05 |
2023-08-13 |
mouse |
| Víctor Rovira, Emilio Geijo-Barriento. Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice. PloS one. vol 11. issue 3. 2016-08-02. PMID:26930051. |
these actions of serotonin were mimicked by the activation of either 5-ht1b or 5-ht2a receptors, but not by the activation of the 5-ht1a subtype. |
2016-08-02 |
2023-08-13 |
mouse |
| Emma D Deek. Flibanserin: First Global Approval. Drugs. vol 75. issue 15. 2016-07-29. PMID:26412054. |
the drug has a high affinity for serotonin 5-ht1a and 5-ht2a receptors (5-ht1a agonist/5-ht2a antagonist) and is believed to treat hsdd by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. |
2016-07-29 |
2023-08-13 |
Not clear |
| Karen Wolf, Attila Braun, Elizabeth J Haining, Yu-Lun Tseng, Peter Kraft, Michael K Schuhmann, Sanjeev K Gotru, Wenchun Chen, Heike M Hermanns, Guido Stoll, Klaus-Peter Lesch, Bernhard Nieswand. Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. PloS one. vol 11. issue 1. 2016-07-19. PMID:26800051. |
blood 5-ht has been proposed to regulate hemostasis by acting as a vasoconstrictor and by triggering platelet signaling through 5-ht receptor 2a (5htr2a). |
2016-07-19 |
2023-08-13 |
mouse |
| François Montastruc, Aurore Palmaro, Haleh Bagheri, Laurent Schmitt, Jean-Louis Montastruc, Maryse Lapeyre-Mestr. Role of serotonin 5-HT2C and histamine H1 receptors in antipsychotic-induced diabetes: A pharmacoepidemiological-pharmacodynamic study in VigiBase. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26256010. |
we investigated potential relationships between antipsychotics׳ receptor occupancy (serotonin 5-ht1a, 5-ht2a, 5-ht2c, histamine h1, muscarinic m3, adrenergic α1, α2 or dopaminergic d2 d3 occupancies) and reports of diabetes using vigibase(®), the world health organization (who) global individual case safety report (icsr) database. |
2016-07-12 |
2023-08-13 |
Not clear |
| François Montastruc, Aurore Palmaro, Haleh Bagheri, Laurent Schmitt, Jean-Louis Montastruc, Maryse Lapeyre-Mestr. Role of serotonin 5-HT2C and histamine H1 receptors in antipsychotic-induced diabetes: A pharmacoepidemiological-pharmacodynamic study in VigiBase. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26256010. |
a significant and positive association was found between histamine h1, muscarinic m3 and serotonin 5-ht2c, 5-ht2a receptor occupancies and reports of diabetes. |
2016-07-12 |
2023-08-13 |
Not clear |