| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-htaa) in serum and hypothalamus, and the reduced expressions of 5-ht1a receptor and 5-ht2a receptor in hypothalamus were observed after af and fluoxetine oral administration indicating that af-mediated antidepressant-like effect may be related to the normalization of serotonergic system. |
2016-05-03 |
2023-08-13 |
rat |
| Rocco A Zoccali, Antonio Bruno, Maria Rosaria Anna Muscatell. Efficacy and safety of sertindole in schizophrenia: a clinical review. Journal of clinical psychopharmacology. vol 35. issue 3. 2016-04-19. PMID:25830594. |
it has a high affinity for dopamine d2, serotonin 5-ht2a and 5-ht2c, and α1 adrenergic receptors. |
2016-04-19 |
2023-08-13 |
Not clear |
| Noelle C Anastasio, Sonja J Stutz, Latham H L Fink, Sarah E Swinford-Jackson, Robert M Sears, Ralph J DiLeone, Kenner C Rice, F Gerard Moeller, Kathryn A Cunningha. Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:26120876. |
serotonin (5-ht) 5-ht2a receptor (5-ht2ar):5-ht2cr imbalance in medial prefrontal cortex associates with motor impulsivity. |
2016-04-19 |
2023-08-13 |
rat |
| Anna Gomółka, Agnieszka Ciesielska, Martyna Z Wróbel, Andrzej Chodkowski, Jerzy Kleps, Maciej Dawidowski, Agata Siwek, Małgorzata Wolak, Katarzyna Stachowicz, Anna Sławińska, Gabriel Nowak, Grzegorz Satała, Andrzej J Bojarski, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Paweł Skowronek, Jadwiga Turło, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5. European journal of medicinal chemistry. vol 98. 2016-04-12. PMID:26043160. |
affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-ht1a, 5-ht2a receptors and serotonin transporter (sert) was evaluated in an in vitro radioligand binding assay. |
2016-04-12 |
2023-08-13 |
mouse |
| Xavier Viñals, Estefanía Moreno, Laurence Lanfumey, Arnau Cordomí, Antoni Pastor, Rafael de La Torre, Paola Gasperini, Gemma Navarro, Lesley A Howell, Leonardo Pardo, Carmen Lluís, Enric I Canela, Peter J McCormick, Rafael Maldonado, Patricia Robled. Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. PLoS biology. vol 13. issue 7. 2016-04-12. PMID:26158621. |
cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid cb1 and serotonin 5-ht2a receptors. |
2016-04-12 |
2023-08-13 |
mouse |
| Satoko Baba, Takeshi Enomoto, Tomoko Horisawa, Takashi Hashimoto, Michiko On. Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837930. |
in the present study, we investigated the d3 receptor binding of blonanserin, a dopamine d2/d3 and serotonin 5-ht2a receptors antagonist, in vitro and in vivo. |
2016-04-05 |
2023-08-13 |
human |
| Lijian Ding, Shan He, Wei Wu, Haixiao Jin, Peng Zhu, Jinrong Zhang, Tingting Wang, Ye Yuan, Xiaojun Ya. Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists. Molecules (Basel, Switzerland). vol 20. issue 9. 2016-04-05. PMID:26404234. |
5-hydroxytryptamine type 2a (5-ht2a) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies. |
2016-04-05 |
2023-08-13 |
Not clear |
| H Bonilla-Jaime, G Guadarrama-Cruz, F J Alarcon-Aguilar, O Limón-Morales, G Vazquez-Palacio. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. Journal of natural medicines. vol 69. issue 4. 2016-04-01. PMID:26062718. |
the animals were pretreated with a 5-ht1a receptor antagonist (way-100635, 0.5 mg/kg), a 5-ht2a receptor antagonist (ketanserin, 5 mg/kg), a β-noradrenergic receptor antagonist (propranolol, 200 mg/kg), and with a α2-noradrenergic receptor antagonist (yohimbine, 1 mg/kg) alone or combined with the extract and pretreated with a serotonin synthesis inhibitor (pcpa) before treatment with 8-oh-dpat + the extract of t. lucida. |
2016-04-01 |
2023-08-13 |
rat |
| Neely Ivgy-May, Frank Ruwe, Andrew Krystal, Thomas Rot. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep medicine. vol 16. issue 7. 2016-03-21. PMID:26047892. |
esmirtazapine (org 50081), a medication that binds with high affinity to serotonin 5-ht2a and histamine-1 receptors, was evaluated as a potential treatment for insomnia. |
2016-03-21 |
2023-08-13 |
Not clear |
| Mei-Yan Liu, Yan-Ping Ren, Wan-Lin Wei, Guo-Xiang Tian, Guo L. Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression. Chinese medical journal. vol 128. issue 14. 2016-03-15. PMID:26168831. |
changes of serotonin (5-ht), 5-ht2a receptor, and 5-ht transporter in the sprague-dawley rats of depression, myocardial infarction and myocardial infarction co-exist with depression. |
2016-03-15 |
2023-08-13 |
rat |
| Mei-Yan Liu, Yan-Ping Ren, Wan-Lin Wei, Guo-Xiang Tian, Guo L. Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression. Chinese medical journal. vol 128. issue 14. 2016-03-15. PMID:26168831. |
to evaluate whether serotonin (5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter [sert]) are associated with different disease states of depression, myocardial infarction (mi) and mi co-exist with depression in sprague-dawley rats. |
2016-03-15 |
2023-08-13 |
rat |
| N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. |
however, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-ht transporter, 5-ht1a, and 5-ht3 receptor genes, though it reduced 5-ht2a receptor gene expression in the hypothalamus. |
2016-03-08 |
2023-08-13 |
mouse |
| N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. |
we revealed risk da and 5-ht neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-o-methyltransferase, and d1 receptor in the nigrostriatal system; d1 and 5-ht2a receptors in the hypothalamus; and monoamine oxidase a (mao a) in the frontal cortex). |
2016-03-08 |
2023-08-13 |
mouse |
| Latham H L Fink, Noelle C Anastasio, Robert G Fox, Kenner C Rice, F Gerard Moeller, Kathryn A Cunningha. Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25666313. |
individual differences in impulsive action reflect variation in the cortical serotonin 5-ht2a receptor system. |
2016-03-08 |
2023-08-13 |
rat |
| Shuji Gamoh, Tasuku Kanai, Naoko Tanaka-Totoribe, Masamichi Ohkura, Masachika Kuwabara, Eisaku Nakamura, Atsuko Yokota, Tetsuo Yamasaki, Akiko Watanabe, Masahiro Hayashi, Shouichi Fujimoto, Ryuichi Yamamot. Water-soluble jack-knife prawn extract inhibits 5-hydroxytryptamine-induced vasoconstriction and platelet aggregation in humans. Food & function. vol 6. issue 2. 2016-03-01. PMID:25464143. |
first, we evaluated the effect of water-soluble ocean resource extracts on the response to 5-ht in hek293 cells which have forcibly expressed cyan fluorescent protein-fused 5-ht2a receptors (5-ht2a-cfp). |
2016-03-01 |
2023-08-13 |
human |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. |
a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2016-02-26 |
2023-08-13 |
mouse |
| Filiz Civil Arslan, Emel Korkmaz Uysal, Evrim Ozkorumak, Ahmet Tiryak. Trazodone induced galactorrhea: a case report. General hospital psychiatry. vol 37. issue 4. 2016-02-23. PMID:25920951. |
trazodone is a heterocyclic antidepressant that exerts its effect via the inhibition of selective serotonin reuptake and the antagonism of 5-ht2a and 5-ht2c receptors. |
2016-02-23 |
2023-08-13 |
Not clear |
| N S Hunter, K C Anderson, A Co. Pimavanserin. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 11. 2016-02-11. PMID:26744739. |
pimavanserin (acp-103) is a selective inverse agonist of the 5-hydroxytryptamine 2a (5-ht2a) receptor intended to treat patients with parkinson's disease psychosis (pdp). |
2016-02-11 |
2023-08-13 |
Not clear |
| Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała, Adriana-Luminita Finaru, Agnès Chartier, Gilles Tamagnan, David Alagille, Andrzej J Bojarski, Séverine Morisset-Lopez, Franck Suzenet, Gérald Guillaume. Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain. Journal of medicinal chemistry. vol 58. issue 20. 2016-02-02. PMID:26348247. |
rational design, pharmacomodulation, and synthesis of dual 5-hydroxytryptamine 7 (5-ht7)/5-hydroxytryptamine 2a (5-ht2a) receptor antagonists and evaluation by [(18)f]-pet imaging in a primate brain. |
2016-02-02 |
2023-08-13 |
Not clear |
| James G Pfau. Treatment for hypoactive sexual desire. Cell. vol 163. issue 3. 2016-02-01. PMID:26496594. |
flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-ht1a autoreceptors and block postsynaptic action of serotonin at 5-ht2a receptors. |
2016-02-01 |
2023-08-13 |
Not clear |