| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Blasi, Pierluigi Selvaggi, Leonardo Fazio, Linda Antonella Antonucci, Paolo Taurisano, Rita Masellis, Raffaella Romano, Marina Mancini, Fengyu Zhang, Grazia Caforio, Teresa Popolizio, Jose Apud, Daniel R Weinberger, Alessandro Bertolin. Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25563748. |
variation in dopamine d2 and serotonin 5-ht2a receptor genes is associated with working memory processing and response to treatment with antipsychotics. |
2016-01-25 |
2023-08-13 |
human |
| Giuseppe Blasi, Pierluigi Selvaggi, Leonardo Fazio, Linda Antonella Antonucci, Paolo Taurisano, Rita Masellis, Raffaella Romano, Marina Mancini, Fengyu Zhang, Grazia Caforio, Teresa Popolizio, Jose Apud, Daniel R Weinberger, Alessandro Bertolin. Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25563748. |
dopamine d2 and serotonin 5-ht2a receptors contribute to modulate prefrontal cortical physiology and response to treatment with antipsychotics in schizophrenia. |
2016-01-25 |
2023-08-13 |
human |
| Rajeev Sakhuja, Krishnakanth Kondabolu, Tania Córdova-Sintjago, Sean Travers, Adam S Vincek, Myong Sang Kim, Khalil A Abboud, Lijuan Fang, Zhuming Sun, Clinton E Canal, Raymond G Boot. Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors. Bioorganic & medicinal chemistry. vol 23. issue 7. 2016-01-22. PMID:25703249. |
syntheses were undertaken of derivatives of (2s,4r)-(-)-trans-4-phenyl-n,n-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, pat), a stereospecific agonist at the serotonin 5-ht2c g protein-coupled receptor (gpcr), with inverse agonist activity at 5-ht2a and 5-ht2b gpcrs. |
2016-01-22 |
2023-08-13 |
human |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
on the other hand, blonanserin (0.1-0.3mg/kg), an atypical antipsychotic highly selective for dopamine d2/d3 and serotonin 5-ht2a receptors, did not affect the number of correct responses in both the easy and difficult trials. |
2016-01-19 |
2023-08-13 |
Not clear |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |
| Francesc Artiga. Developments in the field of antidepressants, where do we go now? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 5. 2016-01-13. PMID:23706576. |
this will lead to the synthesis of new agents blocking the serotonin (and possibly norepinephrine) transporter which will also activate or block 5-ht receptors playing respectively positive (e.g., postsynaptic 5-ht1a, 5-ht4) or negative (e.g., presynaptic 5-ht1a,/1b, 5-ht2a, 5-ht2c,5-ht3, etc.) |
2016-01-13 |
2023-08-12 |
Not clear |
| Antony Loebel, Leslie Citrom. Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych bulletin. vol 39. issue 5. 2016-01-12. PMID:26755968. |
in addition to full antagonist activity at dopamine d2 (k i(d2) = 1 nm) and serotonin 5-ht2a (k i(5-ht2a) = 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (k i(5-ht7) = 0.5 nm) and its partial agonist activity at 5-ht1a receptors (k i(5-ht1a) = 6.4 nm). |
2016-01-12 |
2023-08-13 |
Not clear |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Asenapine alters the activity of monoaminergic systems following its subacute and long-term administration: an in vivo electrophysiological characterization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25656272. |
taken together, asenapine had profound effects on both catecholamine systems, potently blocked 5-ht2a receptors, and enhanced 5-ht tone, effects that could be important in treatment of mood disorders and schizophrenia. |
2016-01-11 |
2023-08-13 |
Not clear |
| Tamaki Ishima, Takashi Futamura, Yuta Ohgi, Noriko Yoshimi, Tetsuro Kikuchi, Kenji Hashimot. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25687838. |
potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-ht1a and 5-ht2a receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Tamaki Ishima, Takashi Futamura, Yuta Ohgi, Noriko Yoshimi, Tetsuro Kikuchi, Kenji Hashimot. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25687838. |
the drug is known to act through a combination of partial agonistic activity at 5-hydroxytryptamine (5-ht)1a, and dopamine d2 receptors, and antagonistic activity at 5-ht2a receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jin-Yu Wang, Cun-Xian Jia, Ying Lian, Shi-Hua Sun, Ming Lyu, Andrew W. Association of the HTR2A 102T/C polymorphism with attempted suicide: a meta-analysis. Psychiatric genetics. vol 25. issue 4. 2016-01-11. PMID:26075944. |
an association between the serotonin 2a receptor (5-ht2a receptor) gene and suicidal behavior has been reported in many studies. |
2016-01-11 |
2023-08-13 |
Not clear |
| Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Kyoji Sekiguchi, Yasushi Ikarashi, Yoshio Kas. Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice. Journal of ethnopharmacology. vol 166. 2016-01-07. PMID:25732836. |
finally, we examined the density and mrna levels of serotonin 2a (5-ht2a) receptors. |
2016-01-07 |
2023-08-13 |
mouse |
| Kinshi Kato, Miho Sekiguchi, Shin-ichi Kikuchi, Shin-ichi Konn. The effect of a 5-HT2A receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-HT2A receptors in dorsal root ganglia in a rat lumbar disc herniation model. Spine. vol 40. issue 6. 2015-12-28. PMID:25584948. |
the effect of a 5-ht2a receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-ht2a receptors in dorsal root ganglia in a rat lumbar disc herniation model. |
2015-12-28 |
2023-08-13 |
rat |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
reelin influences the expression and function of dopamine d2 and serotonin 5-ht2a receptors: a comparative study. |
2015-12-15 |
2023-08-13 |
mouse |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
thus, we hypothesized that a genetic deficit in reelin would affect the expression and function of dopamine d2 and serotonin 5-ht2a receptors that are associated with the action of current antipsychotic drugs. |
2015-12-15 |
2023-08-13 |
mouse |
| M J Varela, S Lage, H J Caruncho, M I Cadavid, M I Loza, J Bre. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: a comparative study. Neuroscience. vol 290. 2015-12-15. PMID:25637489. |
we observed increased expression (p<0.05) in striatum membranes and decreased expression (p<0.05) in frontal cortex membranes for both dopamine d2 and serotonin 5-ht2a receptors from hrm compared to wtm. |
2015-12-15 |
2023-08-13 |
mouse |
| Xinli Duan, Min Zhang, Xin Zhang, Fang Wang, Ming Le. Molecular modeling and docking study on dopamine D2-like and serotonin 5-HT2A receptors. Journal of molecular graphics & modelling. vol 57. 2015-12-15. PMID:25728902. |
molecular modeling and docking study on dopamine d2-like and serotonin 5-ht2a receptors. |
2015-12-15 |
2023-08-13 |
human |