| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire Chevreuil, Elisabeth Polard, Eric Lemonnier, Paul Guillemot, Danièle Bentué-Ferre. [Not Available]. Therapie. vol 66. issue 2. 2016-07-12. PMID:27393647. |
its mechanism of action is different as aripiprazole is a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist. |
2016-07-12 |
2023-08-13 |
Not clear |
| A Spiacci, T de Oliveira Sergio, G S F da Silva, M L Glass, L C Schenberg, N Garcia-Cairasco, H Zangross. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience. vol 307. 2016-07-06. PMID:26319117. |
intra-dpag injection of 5-ht (20 nmol), (±)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-oh-dpat) (8 nmol), a 5-ht1a receptor agonist, or (±)-2,5-dimethoxy-4-iodo amphetamine hydrochloride (doi) (16 nmol), a preferential 5-ht2a agonist, reduced the number of upward jumps directed to the border of the experimental chamber during hypoxia, interpreted as escape attempts, without affecting the rats' locomotion. |
2016-07-06 |
2023-08-13 |
rat |
| Ling Huang, Wenjun Zhang, Xiaohua Zhang, Lei Yin, Bangyin Chen, Jinchun Son. Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics. Bioorganic & medicinal chemistry letters. vol 25. issue 22. 2016-06-28. PMID:26483200. |
the present study describes the optimization of a series of novel benzoxazole-piperidine (piperazine) derivatives combining high dopamine d2 and serotonin 5-ht1a, 5-ht2a receptor affinities. |
2016-06-28 |
2023-08-13 |
human |
| Martin Reznitsky, Per Plenge, Anders Hay-Schmid. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study. Neuroscience letters. vol 612. 2016-06-28. PMID:26683905. |
autoradiography showed that serotonin receptors 5-ht1b and 5-ht2c and the serotonin transporter were present in stn, whereas the 5-ht1a and 5-ht2a not were present. |
2016-06-28 |
2023-08-13 |
rat |
| Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. |
in long-term diabetic rats, vasoconstriction elicited by 5-ht and α-methyl-5-ht was significantly decreased by ritanserin (a 5-ht2 receptor antagonist), spiperone (a 5-ht2a receptor antagonist), and the cyclooxygenase (cox) inhibitors, indomethacin (non-selective cox inhibitor), fr 122047 or nimesulide (selective cox-1 and cox-2 inhibitors, respectively), but was not modified by pretreatment with sb 206553 (3,5-dihydro-5-methyl-n-3-pyridinylbenzo[1,2.b:4,5-b']dipyrrole(1h)-carboxamide hydrochloride), a non-selective 5-ht2c receptor antagonist, prazosin, propranolol, enalapril or losartan. |
2016-06-27 |
2023-08-12 |
rat |
| Beatriz Restrepo, Mónica García, Alicia Rodríguez-Barbero, Luis San Román, María Luisa Martin, Asunción Morá. Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. European journal of pharmacology. vol 659. issue 1. 2016-06-27. PMID:21414306. |
our data suggest that, in the in-situ autoperfused kidney of long-term diabetic rats, 5-ht vasoconstrictor action is mediated, through cyclooxygenase pathway, by local activation of 5-ht2a receptors. |
2016-06-27 |
2023-08-12 |
rat |
| Sarah L Grei. Brexpiprazole: First Global Approval. Drugs. vol 75. issue 14. 2016-06-24. PMID:26310190. |
brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1a (5-ht1a) and dopamine d2 receptors, as well as a potent antagonist of 5-ht2a receptors and noradrenergic α1b and α2c receptors. |
2016-06-24 |
2023-08-13 |
Not clear |
| Matthew E Peters, Vijay Vaidya, Lea T Drye, Davangere P Devanand, Jacobo E Mintzer, Bruce G Pollock, Anton P Porsteinsson, Paul B Rosenberg, Lon S Schneider, David M Shade, Daniel Weintraub, Jerome Yesavage, Constantine G Lyketsos, Dimitri Avramopoulo. Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences. Journal of geriatric psychiatry and neurology. vol 29. issue 2. 2016-06-16. PMID:26303700. |
six functional genetic variants were studied in the following genes: serotonin receptor 2a (htr2a-t102c), serotonin receptor 2c (htr2c-cys23ser), serotonin transporter (5htt-lpr), brain-derived neurotropic factor (bdnf-val66met), apolipoprotein e (ε2, ε3, ε4 variants), and cytochrome p450 (cyp2c19). |
2016-06-16 |
2023-08-13 |
Not clear |
| Anette Schrag, Anna Sauerbier, Kallol Ray Chaudhur. New clinical trials for nonmotor manifestations of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 11. 2016-06-09. PMID:26371623. |
large randomized, controlled trials in the last 3 years reported improvement of psychosis with the new selective serotonin 5-ht2a inverse agonist pimavanserin and of postural hypotension with the oral norepinephrine precursor droxidopa. |
2016-06-09 |
2023-08-13 |
Not clear |
| Laura C Sullivan, William P Clarke, Kelly A Ber. Atypical antipsychotics and inverse agonism at 5-HT2 receptors. Current pharmaceutical design. vol 21. issue 26. 2016-06-03. PMID:26044975. |
both the serotonin 5-ht2a and 5-ht2c receptors have demonstrated constitutive receptor activity in vitro and in vivo. |
2016-06-03 |
2023-08-13 |
Not clear |
| Tetsuya Imamura, Osamu Ishizuka, Teruyuki Ogawa, Tomonori Minagawa, Masakuni Ishikawa, Shiro Hiragata, Hitoshi Yokoyama, Masaki Nakazawa, Yoshiki Kurizaki, Osamu Nishizaw. Expression of 5-Hydroxytryptamine Receptors in Human Urinary Bladders with Benign Prostatic Hyperplasia. Advances in therapy. vol 32 Suppl 1. 2016-05-25. PMID:26391373. |
this study investigated the mrna expression pattern and distribution of 5-hydroxytryptamine (5-ht) receptors 5-ht2a, 5-ht2b, 5-ht3a, 5-ht4, and 5-ht7 within the urothelium and detrusor of normal bladder tissue and in the urothelium of bladders from patients with benign prostatic hyperplasia (bph). |
2016-05-25 |
2023-08-13 |
human |
| Fedra Najjar, Thomas Owley, Matthew W Mosconi, Suma Jacob, Kwan Hur, Stephen J Guter, John A Sweeney, Robert D Gibbons, Edwin H Cook, Jeffrey R Bisho. Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism. Journal of child and adolescent psychopharmacology. vol 25. issue 6. 2016-05-19. PMID:26262902. |
pharmacogenetic study of serotonin transporter and 5ht2a genotypes in autism. |
2016-05-19 |
2023-08-13 |
Not clear |
| Joseph McEvoy, Leslie Citrom. Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator. Clinical schizophrenia & related psychoses. vol 9. issue 4. 2016-05-12. PMID:26757416. |
brexpiprazole acts as a partial agonist at dopamine d2 and serotonin 5-ht1a receptors, and as an antagonist at serotonin 5-ht2a and at adrenergic alpha1b and alpha2c receptors. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
endogenous 5-ht exerts robust actions on the activity of pyramidal neurons in medial pfc (mpfc) via excitatory 5-ht2a and inhibitory 5-ht1a receptors, suggesting the involvement of 5-ht neurotransmission in cortical functions. |
2016-05-06 |
2023-08-13 |
mouse |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
here we examine the role of 5-ht2a receptors in the processing of emotional and cognitive signals evoked by increasing the 5-ht tone after acute blockade of the 5-ht transporter. |
2016-05-06 |
2023-08-13 |
mouse |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
overall, the present results suggest that 5-ht2a receptors play a detrimental role in long-term memory deficits mediated by an excess 5-ht in pfc. |
2016-05-06 |
2023-08-13 |
mouse |
| Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yoshihide Mitani, Hirofumi Sawada, Masakatsu Nishikawa, Ning Ma, Kazuo Maruyam. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. Journal of anesthesia. vol 29. issue 5. 2016-05-05. PMID:25931318. |
sarpogrelate hydrochloride, a serotonin 5ht2a receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. |
2016-05-05 |
2023-08-13 |
rat |
| Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yoshihide Mitani, Hirofumi Sawada, Masakatsu Nishikawa, Ning Ma, Kazuo Maruyam. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. Journal of anesthesia. vol 29. issue 5. 2016-05-05. PMID:25931318. |
the purpose of the present study was to determine if sarpogrelate hydrochloride (spg), a serotonin 5ht2a receptor antagonist, prevented the development of chronic hypoxia-induced pulmonary hypertension (ph) and hypertensive pulmonary vascular remodeling. |
2016-05-05 |
2023-08-13 |
rat |
| Seung-Ah Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Suk Cho, Tae-Jin Youn, In-Ho Chae, Hyo-Soo Kim, Sang-Hyun Kim, Dong-Ju Cho. Study design of the influence of SErotonin inhibition on patients with RENAl impairment or diabetes undergoing drug-eluting stent implantation (SERENADE) study: A multicenter, open-label, prospective, randomized study. Contemporary clinical trials. vol 43. 2016-05-04. PMID:25891091. |
sarpogrelate, a selective serotonin (5-hydroxytryptamine (ht)2a [5-ht2a]) receptor antagonist, has antiproliferative effects, reducing neointimal hyperplasia and smooth muscle cell proliferation, as well as potent antiplatelet action, inhibiting 5-ht-induced platelet aggregation. |
2016-05-04 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Julia Pintsuk, Thorsten Schäfer, Kristina Friedland, Luca Ferraro, Sergio Tanganelli, Fang Liu, Kjell Fux. Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia. Therapeutic advances in psychopharmacology. vol 6. issue 2. 2016-05-04. PMID:27141290. |
5-hydroxytryptamine 2a (5-ht2a)-d2 heteroreceptor complexes are special targets for atypical antipsychotics with high potency to block their 5-ht2a protomer signaling in view of the potential development of pathological allosteric facilitatory 5-ht2a-d2 interaction increasing d2 protomer signaling. |
2016-05-04 |
2023-08-13 |
Not clear |