| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Engel, M Göthert, E Müller-Schweinitzer, E Schlicker, L Sistonen, P A Stadle. Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646239. |
the affinities of 16 5-hydroxytryptamine (5-ht) receptor agonists (indole derivatives) and 7 5-ht receptor antagonists for [3h]5-hydroxytryptamine [( 3h]5-ht) binding sites in rat cerebral cortex membranes were determined. |
1984-01-07 |
2023-08-12 |
rat |
| G Engel, M Göthert, E Müller-Schweinitzer, E Schlicker, L Sistonen, P A Stadle. Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646239. |
when 5-ht receptor antagonists were investigated, metitepin and metergoline showed moderate affinities for the 5-ht autoreceptors in rat brain cortex slices, whereas quipazine had only weak affinity, and ketanserin, metoclopramide, cinanserin and cyproheptadine exhibited no antagonistic property. |
1984-01-07 |
2023-08-12 |
rat |
| G Engel, M Göthert, E Müller-Schweinitzer, E Schlicker, L Sistonen, P A Stadle. Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646239. |
in binding experiments, the competition curves of most 5-ht receptor antagonists were biphasic, suggesting that the [3h]5-ht binding sites are heterogeneous. |
1984-01-07 |
2023-08-12 |
rat |
| M Hiramats. Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice. Neurochemical research. vol 8. issue 9. 1983-12-20. PMID:6415506. |
in the study here 5-ht level, [14c]5-hydroxytryptophan (5-htp) metabolism, mao activity and [3h]5-ht receptor binding were examined in the cortex, brainstem and cerebellum. |
1983-12-20 |
2023-08-12 |
mouse |
| M Hiramats. Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice. Neurochemical research. vol 8. issue 9. 1983-12-20. PMID:6415506. |
in the interictal period cortical and brainstem 5-ht level and [3h]5-ht receptor binding were significantly lower. |
1983-12-20 |
2023-08-12 |
mouse |
| M Kiraly, R C Ma, N J Du. Serotonin mediates a slow excitatory potential in mammalian celiac ganglia. Brain research. vol 275. issue 2. 1983-12-20. PMID:6605177. |
the slow depolarization evoked by either nerve stimulation or 5-ht was augmented by fluoxetine, a 5-ht reuptake blocker, and depressed by cyproheptadine, a 5-ht receptor blocker; in addition, tryptophan, a precursor of 5-ht, enhanced differentially the slow epsp. |
1983-12-20 |
2023-08-12 |
Not clear |
| E L Rodríguez Echandía, S T Broitman, M R Fóscol. Effects of the chronic ingestion of therapeutic doses of chlorimipramine on the behavioral action of agonists and antagonists of serotonin in male rats. Pharmacology, biochemistry, and behavior. vol 19. issue 2. 1983-12-20. PMID:6605538. |
the chronic ingestion of chlorimipramine (cim) or the injection of the 5-ht receptor blocker, methysergide (15 mg/kg) prevented the action of the 5-ht agonists on locomotion and resting and blocked the appearance of myoclonus. |
1983-12-20 |
2023-08-12 |
rat |
| C Rúzsás, B Mes. Opioidergic regulation of thyroid activity: possible interference with the serotonergic system. Psychoneuroendocrinology. vol 8. issue 1. 1983-09-23. PMID:6410437. |
the tsh release-inhibiting effect of enkamide was reversed by pretreatment with the serotonin synthesis inhibitor, para-chlorophenylalanine (pcpa) or with the central serotonin receptor blocker, metergoline. |
1983-09-23 |
2023-08-12 |
Not clear |
| F A Curro, S Greenber. Differential inhibition of 5-hydroxytryptamine (5-HT) mediated contraction of rat thoracic aortae by phentolamine and tolazoline: correlation with inhibition of 5-HT binding and calcium ion. Methods and findings in experimental and clinical pharmacology. vol 5. issue 2. 1983-09-23. PMID:6876942. |
the ability of phentolamine to inhibit 5-ht induced contraction may be dependent on the ability of phentolamine to bind to anionic sites of the 5-ht receptor. |
1983-09-23 |
2023-08-12 |
rat |
| F A Curro, S Greenber. Differential inhibition of 5-hydroxytryptamine (5-HT) mediated contraction of rat thoracic aortae by phentolamine and tolazoline: correlation with inhibition of 5-HT binding and calcium ion. Methods and findings in experimental and clinical pharmacology. vol 5. issue 2. 1983-09-23. PMID:6876942. |
the different pa2 values for phentolamine mediated inhibition of the responses to 5-ht and ne, and the ability of ne to poorly displace 5-ht from the rta, despite blockade of alpha receptors with tolazoline, support the possibility that the 5-ht receptor of rta differs from the alpha receptor and that phentolamine has affinity for both 5-ht and adrenergic receptors. |
1983-09-23 |
2023-08-12 |
rat |
| C M Leone, J C de Aguiar, F G Graef. Role of 5-hydroxytryptamine in amphetamine effects on punished and unpunished behaviour. Psychopharmacology. vol 80. issue 1. 1983-08-26. PMID:6408676. |
in order to assess the contribution of serotonergic (5-ht) mechanisms in the suppressant effect of amphetamine on punished responding, dose-effect curves of amphetamine on key-pecking behaviour of pigeons maintained by food presentation and punished by electric-shock were determined before and after pretreatment with methergoline, a potent and specific 5-ht receptor blocker in the central nervous system. |
1983-08-26 |
2023-08-12 |
Not clear |
| C Fornal, M Radulovack. Sleep suppressant action of fenfluramine in rats. II. Evidence against the involvement of presynaptic serotonergic mechanism. The Journal of pharmacology and experimental therapeutics. vol 225. issue 3. 1983-08-11. PMID:6223135. |
depletion of brain 5-ht by pcpa also failed to antagonize the sleep suppression caused by fenfluramine as well as that observed after administration of quipazine, a direct 5-ht receptor stimulant. |
1983-08-11 |
2023-08-12 |
rat |
| G Battaglia, M Shannon, M Titele. Modulation of brain S2 serotonin receptors by lithium, sodium and potassium chloride. Life sciences. vol 32. issue 22. 1983-07-15. PMID:6304441. |
licl was the most potent of the ionic modulators in lowering the apparent affinity of serotonin for the s2 serotonin receptor. |
1983-07-15 |
2023-08-12 |
rat |
| G Battaglia, M Shannon, M Titele. Modulation of brain S2 serotonin receptors by lithium, sodium and potassium chloride. Life sciences. vol 32. issue 22. 1983-07-15. PMID:6304441. |
these results indicated that monovalent cations modulate s2 serotonin receptor affinity for serotonin and that lithium ion is more potent than sodium or potassium. |
1983-07-15 |
2023-08-12 |
rat |
| S Meizel, K O Turne. Serotonin or its agonist 5-methoxytryptamine can stimulate hamster sperm acrosome reactions in a more direct manner than catecholamines. The Journal of experimental zoology. vol 226. issue 1. 1983-07-08. PMID:6574212. |
serotonin (50 microm) or its agonist 5-methoxytryptamine (5 microm) stimulated the acrosome reactions of golden hamster sperm within 15 min after addition to sperm capacitated in vitro for 4.5 h. the stimulation was inhibited by the serotonin receptor antagonists quipazine or cyproheptadine. |
1983-07-08 |
2023-08-12 |
Not clear |
| P Preziosi, F Cerrito, M Vacc. Effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist, mCPP. Life sciences. vol 32. issue 21. 1983-07-08. PMID:6602260. |
the effects of naloxone, an opiate "pure" receptor antagonist, on the release of prolactin and corticosterone in the rat were studied following the administration of the serotonin precursor 5-hydroxytryptophan or the serotonin receptor agonist (-) -m-chlorophenylpiperazine. |
1983-07-08 |
2023-08-12 |
rat |
| A Shenker, S Maayani, H Weinstein, J P Gree. Enhanced serotonin-stimulated adenylate cyclase activity in membranes from adult guinea pig hippocampus. Life sciences. vol 32. issue 20. 1983-06-23. PMID:6573550. |
micromolar concentrations of the known 5-ht receptor agonists, tryptamine and 5-methoxytryptamine, also stimulate camp production in this system, and their effect is not additive to that elicited by a maximal concentration of 5-ht. |
1983-06-23 |
2023-08-12 |
Not clear |
| K Kadzielaw. Antagonism of the excitatory effects of 5-hydroxytryptamine on sympathetic preganglionic neurones and neurones activated by visceral afferents. Neuropharmacology. vol 22. issue 1. 1983-06-23. PMID:6843785. |
the responses of electrophysiologically identified sympathetic preganglionic neurones (spgn) and interneurones activated by sympathetic visceral afferents (va), to iontophoretic application of 5-hydroxytryptamine (serotonin) and serotonin receptor antagonists: methysergide and cinanserin, were tested in the t3 segment of the spinal cord of the cat. |
1983-06-23 |
2023-08-12 |
cat |
| H O Kalkman, Y M Harms, E M van Gelderen, H D Batink, P B Timmermans, P A van Zwiete. Hypotensive activity of serotonin antagonists; correlation with alpha 1-adrenoceptor and serotonin receptor blockade. Life sciences. vol 32. issue 13. 1983-05-05. PMID:6300582. |
hypotensive activity of serotonin antagonists; correlation with alpha 1-adrenoceptor and serotonin receptor blockade. |
1983-05-05 |
2023-08-12 |
rat |
| M L Cohen, R W Fulle. Antagonism of vascular serotonin receptors by m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine. Life sciences. vol 32. issue 7. 1983-04-21. PMID:6827905. |
apparently these non-indole compounds affect serotonin receptors in various tissues differently, being agonists in brain but mainly antagonists at some peripheral serotonin receptor sites. |
1983-04-21 |
2023-08-12 |
rat |