| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J McNall, T E Mansou. Desensitization of serotonin-stimulated adenylate cyclase in the liver fluke Fasciola hepatica. Biochemical pharmacology. vol 33. issue 17. 1984-09-19. PMID:6466387. |
in control fluke particles, the activation of adenylate cyclase by 5-ht was biphasic, indicating a high and low affinity form of the 5-ht receptor with half-maximal activation constants (ka) of 0.35 and 2.8 microm respectively. |
1984-09-19 |
2023-08-12 |
Not clear |
| K Fuxe, S O Ogren, F Benfenati, L F Agnat. Central 5-HT neurons as targets for antidepressant drug action: differential modulation of 5-HT receptor populations in the central nervous system of the rat. Advances in biochemical psychopharmacology. vol 39. 1984-09-18. PMID:6235724. |
central 5-ht neurons as targets for antidepressant drug action: differential modulation of 5-ht receptor populations in the central nervous system of the rat. |
1984-09-18 |
2023-08-12 |
rat |
| O Gandolfi, D L Cheney, J S Hong, E Cost. On the neurotoxicity of chlordecone: a role for gamma-aminobutyric acid and serotonin. Brain research. vol 303. issue 1. 1984-08-21. PMID:6203618. |
since tremors elicited by chlordecone are attenuated by the administration of serotonin receptor blockers and since chlordecone increases serotonin (5-ht) turnover, we studied whether 5-ht recognition sites are modified following chlordecone administration. |
1984-08-21 |
2023-08-12 |
rat |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
using eight serotonin receptor antagonists (spiperone, metergoline, ly53857, ketanserin, trazodone, benzoctamine, 1-(1-naphthyl)piperazine, and 1-meta-methoxyphenylpiperazine), we found a significant correlation between the affinity for serotonin receptors in the rat portal vein and the ability to bind to 5ht2, but not 5ht1 receptors in rat frontal cortical membranes. |
1984-08-14 |
2023-08-12 |
rat |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
affinities of serotonin receptor antagonists were also lower when determined by antagonism of cumulative serotonin concentration-response curves compared to affinities obtained by antagonism of non-cumulative concentration-response curves. |
1984-08-14 |
2023-08-12 |
rat |
| R J Beninge. Effects of metergoline and quipazine on locomotor activity of rats in novel and familiar environments. Pharmacology, biochemistry, and behavior. vol 20. issue 5. 1984-08-07. PMID:6739514. |
to test the possibility that apparatus familiarity interacts with the effects of 5-ht manipulations on locomotor activity, this variable was manipulated in groups of rats treated with the 5-ht receptor blocker, metergoline or the agonist, quipazine. |
1984-08-07 |
2023-08-12 |
rat |
| D J Pettibone, A B Pfluege. Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: possible relation to serotonin autoreceptor function. Journal of neurochemistry. vol 43. issue 1. 1984-07-19. PMID:6726257. |
using this system, methiothepin (1-10 microm) demonstrated 5-ht autoreceptor antagonist activity by enhancing 5-ht release, while several recognized postsynaptic 5-ht receptor antagonists were inactive: mianserin, cinanserin, cyproheptadine, methysergide. |
1984-07-19 |
2023-08-12 |
rat |
| M F Sugru. Antagonism of fenfluramine-induced hyperthermia in rats by some, but not all, selective inhibitors of 5-hydroxytryptamine uptake. British journal of pharmacology. vol 81. issue 4. 1984-07-18. PMID:6722394. |
rectal temperature was unaltered by both the 5-hydroxytryptamine (5-ht) uptake inhibitors and the 5-ht receptor antagonists. |
1984-07-18 |
2023-08-12 |
rat |
| J N Hingtgen, H C Hendrie, M H Apriso. Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 20. issue 3. 1984-05-24. PMID:6608737. |
the potency of trazodone in relation to other antidepressant drugs in our behavioral model of depression paralleled their potency in displacing radioligand binding to 5-ht receptors, and gives additional support for the new hypersensitive postsynaptic serotonin receptor theory of depression. |
1984-05-24 |
2023-08-12 |
rat |
| J F McElroy, J M Miller, J S Meye. Fenfluramine, p-chloroamphetamine and p-fluoroamphetamine stimulation of pituitary-adrenocortical activity in rat: evidence for differences in site and mechanism of action. The Journal of pharmacology and experimental therapeutics. vol 228. issue 3. 1984-05-02. PMID:6323674. |
the central pca-induced elevation was prevented by pretreatment with either the 5-ht reuptake inhibitor fluoxetine or the 5-ht receptor blocker methysergide. |
1984-05-02 |
2023-08-12 |
rat |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. The involvement of 5-HT2-receptor sites in the activation of cat platelets. Thrombosis research. vol 33. issue 3. 1984-05-02. PMID:6710435. |
secondary aggregation induced by adp as well as collagen-induced aggregation are inhibited by the 5-ht receptor antagonists suggesting a primary role of 5-ht in the secondary platelet recruitment subsequent to a release reaction. |
1984-05-02 |
2023-08-12 |
rat |
| H Y Meltzer, M Lowy, A Robertson, P Goodnick, R Perlin. Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. Archives of general psychiatry. vol 41. issue 4. 1984-04-24. PMID:6422900. |
these results are consistent with the hypothesis that lithium carbonate may enhance serotonin (5-ht) receptor sensitivity, whereas tca and second-generation antidepressants diminish 5-ht receptor sensitivity. |
1984-04-24 |
2023-08-12 |
Not clear |
| R Kérouac, S St-Pierre, F Riou. Participation of mast cell 5-hydroxytryptamine in the vasoconstrictor effect of neurotensin in the rat perfused hindquarter. Life sciences. vol 34. issue 10. 1984-04-19. PMID:6422173. |
the vasoconstrictor effects of nt, compound 48/80 and 5-ht were markedly reduced by the 5-ht receptor antagonist methysergide (1 x 10(-7) g ml-1). |
1984-04-19 |
2023-08-12 |
rat |
| S Romandini, L Cervo, R Samani. Evidence that drugs increasing 5-hydroxytryptamine transmission block jumping but not wet dog shakes in morphine-abstinent rats: a comparison with clonidine. The Journal of pharmacy and pharmacology. vol 36. issue 1. 1984-03-23. PMID:6141273. |
(+)-fenfluramine, a 5-hydroxytryptamine (5-ht) releaser and uptake blocker, m-chlorophenylpiperazine (cpp), a 5-ht receptor agonist, and clonidine, an agonist at adrenoceptors, were studied for their ability to modify jumping and wet dog shakes in morphine abstinent rats. |
1984-03-23 |
2023-08-12 |
rat |
| E Adler-Graschinsk. Dual presynaptic effects of 5-hydroxytryptamine on peripheral noradrenergic synapses. Journal of autonomic pharmacology. vol 3. issue 4. 1984-03-21. PMID:6319422. |
the inhibitory effect of 5-ht on the pacemaker responses to nerve stimulation was prevented by the 5-ht receptor antagonists methysergide (1.0 microm) and pizotifen (1.0 microm) and also by the alpha-adrenoreceptor antagonist phentolamine (0.1 microm). |
1984-03-21 |
2023-08-12 |
cat |
| R Yehuda, J S Meye. A role for serotonin in the hypothalamic-pituitary-adrenal response to insulin stress. Neuroendocrinology. vol 38. issue 1. 1984-03-19. PMID:6363959. |
brain 5-ht depletion by intraventricular injection of 5,7-dihydroxytryptamine significantly attenuated the corticosterone response to insulin, while treatment with the 5-ht receptor blocker methysergide tended to have the same effects. |
1984-03-19 |
2023-08-12 |
rat |
| W Feniuk, P P Humphrey, A D Watt. 5-Hydroxytryptamine-induced relaxation of isolated mammalian smooth muscle. European journal of pharmacology. vol 96. issue 1-2. 1984-03-02. PMID:6662198. |
the results suggest that the 5-ht mediated relaxation in both preparations is mediated directly via a similar 5-ht receptor. |
1984-03-02 |
2023-08-12 |
cat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. |
1984-02-29 |
2023-08-12 |
rat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
in contrast, the symptoms of the 5-ht syndrome produced by 5-methoxy-n,n-dimethyltryptamine were blocked by pretreatment with the nonselective 5-ht receptor antagonists but not by the 5-ht2 receptor antagonists. |
1984-02-29 |
2023-08-12 |
rat |
| D Healy, P A Carney, B E Leonar. Monoamine-related markers of depression: changes following treatment. Journal of psychiatric research. vol 17. issue 3. 1984-02-14. PMID:6821276. |
changes in adrenoceptor and serotonin receptor activities, and platelet serotonin uptake, in a group of moderately depressed patients before and during treatment have been monitored. |
1984-02-14 |
2023-08-12 |
Not clear |